Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement

Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

(2014) Jingchuan Sun et al.   GENES & DEVELOPMENT

Multiple Functions for Mcm2–7 ATPase Motifs during Replication Initiation

(2014) Sukhyun Kang et al.   MOLECULAR CELL

Origin Licensing Requires ATP Binding and Hydrolysis by the MCM Replicative Helicase

(2014) Gideon Coster et al.   MOLECULAR CELL

Prereplication-complex formation: a molecular double take?

(2014) Hasan Yardimci et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CMG helicase and DNA polymerase   form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication

(2014) L. D. Langston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the crystal structure of an active MCM hexamer

(2014) Justin M Miller et al.   eLife

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

(2014) Alessandro Costa et al.   eLife

A conserved MCM single-stranded DNA binding element is essential for replication initiation

(2014) Clifford A Froelich et al.   eLife

Cdc45 Protein-Single-stranded DNA Interaction Is Important for Stalling the Helicase during Replication Stress

(2013) Irina Bruck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA

(2013) Jingchuan Sun et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RecJ-like protein from Pyrococcus furiosus has 3′–5′ exonuclease activity on RNA: implications for proofreading of 3′-mismatched RNA primers in DNA replication

(2013) Hui Yuan et al.   NUCLEIC ACIDS RESEARCH

DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding

(2013) Anna Szambowska et al.   NUCLEIC ACIDS RESEARCH

The PS1 Hairpin of Mcm3 Is Essential for Viability and for DNA Unwinding In Vitro

(2013) Simon K. W. Lam et al.   PLoS One

The Minichromosome Maintenance Replicative Helicase

(2013) S. D. Bell et al.   Cold Spring Harbor Perspectives in Biology

Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase   in rolling circle DNA synthesis

(2012) Y.-H. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote

(2012) Artem Y. Lyubimov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cdc45: the missing RecJ ortholog in eukaryotes?

(2011) Luis Sanchez-Pulido et al.   BIOINFORMATICS

Eukaryotic Origin-Dependent DNA Replication In Vitro Reveals Sequential Action of DDK and S-CDK Kinases

(2011) Ryan C. Heller et al.   CELL

Selective Bypass of a Lagging Strand Roadblock by the Eukaryotic Replicative DNA Helicase

(2011) Yu V. Fu et al.   CELL

Structural and Functional Insights into the DNA Replication Factor Cdc45 Reveal an Evolutionary Relationship to the DHH Family of Phosphoesterases

(2011) Ivet Krastanova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

(2011) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The structural basis for MCM2–7 helicase activation by GINS and Cdc45

(2011) Alessandro Costa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A novel DNA nuclease is stimulated by association with the GINS complex

(2011) Zhuo Li et al.   NUCLEIC ACIDS RESEARCH

Steric exclusion and wrapping of the excluded DNA strand occurs along discrete external binding paths during MCM helicase unwinding

(2011) Brian W. Graham et al.   NUCLEIC ACIDS RESEARCH

Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding

(2010) Aaron S Brewster et al.   BMC MOLECULAR BIOLOGY

Activation of the MCM2-7 Helicase by Association with Cdc45 and GINS Proteins

(2010) Ivar Ilves et al.   MOLECULAR CELL

Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing

(2009) Dirk Remus et al.   CELL

A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

(2009) Agnieszka Gambus et al.   EMBO JOURNAL

Assembly of the Cdc45-Mcm2-7-GINS complex in human cells requires the Ctf4/And-1, RecQL4, and Mcm10 proteins

(2009) J.-S. Im et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

(2009) C. Evrin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-electron microscopy reveals a novel DNA-binding site on the MCM helicase

(2008) Alessandro Costa et al.   EMBO JOURNAL

The Mcm2-7 Complex Has In Vitro Helicase Activity

(2008) Matthew L. Bochman et al.   MOLECULAR CELL

Crystal structure of a near-full-length archaeal MCM: Functional insights for an AAA+ hexameric helicase

(2008) A. S. Brewster et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA