Article
Ophthalmology
Hana A. Mansour, Sami H. Uwaydat, Maurizio Parodi, Ignasi Jurgens, William Smiddy, Abdallah A. Allabban, Stephen G. Schwartz, Robert E. Foster, Javier Ascaso, Marta Suarez Leoz, Silvana Belotto, Javier Mateo, Nuria Olivier-Pascual, Luiz H. Lima, Amparo Navea, Elena Maria Rodriguez Neila, Rosa Arroyo Castillo, Angel Salinas Alaman, Ahmad M. Mansour
Summary: The purpose of this study was to analyze the recovery course of foveal microstructures in eyes with nonsurgical healing of full-thickness macular hole (FTMH). The results showed that the recovery sequences proceeded from the outer nuclear layer (ONL) to the deeper layers, with best spectacle-corrected visual acuity correlating with the restoration of outer retinal layer integrity.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Hiroshi Kunikata, Masayuki Yasuda, Naoko Aizawa, Urara Osada, Koji M. Nishiguchi, Toshiaki Abe, Toru Nakazawa
Summary: The study aimed to evaluate retinal vessel density and retinal sensitivity after macular hole surgery with the superior inverted internal limiting membrane flap technique. Results showed that there was lower recovery of retinal sensitivity in the superior sector, suggesting that internal limiting membrane peeling might affect the postoperative visual function.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Giancarlo Sborgia, Alfredo Niro, Marco Coassin, Luigi Sborgia, Francesco D'Oria, Valentina Pastore, Valeria Albano, Tiziana Trittol, Alessandra Sborgia, Francesco Boscia, Giovanni Alessio
Summary: The inverted internal limiting membrane-flap technique may be effective in treating full-thickness macular hole complicating idiopathic macular telangiectasia type 2, leading to closure of the macular hole, improved visual acuity, retinal sensitivity, and fixation stability. Microperimetry can be a useful tool to analyze functional changes in these patients post-surgery.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jakub J. Kaluzny, Przemyslaw Zabel, Martyna Kaluzna, Aleksander Lamkowski, Damian Jaworski, Krzysztof Woznicki, Katarzyna Zabel
Summary: The study found that a larger area of internal limiting membrane (ILM) peeling during pars plana vitrectomy for a full-thickness macular hole is associated with lower retinal sensitivity in the central macula.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Biology
Daniel Duck-Jin Hwang
Summary: This study explored the use of spectral-domain optical coherence tomography (OCT) biomarkers to predict short-term anatomical improvement in diabetic macular edema (DME) patients who did not respond to anti-vascular endothelial growth factor (anti-VEGF) treatment and received dexamethasone (DEX) injections. The results showed that OCT parameters such as optical density (ODN) and optical density ratio (ODR) of the outer nuclear layer (ONL) cysts were correlated with changes in central macular thickness (CMT) after DEX injection, suggesting that these biomarkers could be useful in predicting short-term CMT responses after DEX injection in anti-VEGF non-responders.
Article
Ophthalmology
Varsha Alex, Vasileios Papastavrou, Evan H. Walker, Andrew C. Browning, Baljean Dhillon, Shyamanga Borooah
Summary: This study aimed to investigate the baseline and longitudinal microperimetry characteristics in foveal-sparing atrophic late-onset retinal degeneration. Microperimetry using the Nidek MP-1 micro-perimeter was performed. The study found significant decreases in macular sensitivity over time in patients with late-onset retinal degeneration.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Yue Qi, Pengyou Yan, Wenying Fan, Ningli Wang, An Li Duan
Summary: A retrospective study was conducted to compare the outcomes of vitrectomy with and without fovea-sparing internal limiting membrane (ILM) peeling for highly myopic eyes with retinoschisis and foveal detachment. The results showed that fovea-sparing ILM peeling had better anatomical outcomes in resolving foveoschisis and foveal detachment compared to non-ILM peeling, while both procedures had similar visual functional outcomes.
Article
Health Care Sciences & Services
Sunjin Hwang, Min-Ho Kang, Mincheol Seong, Heeyoon Cho, Yong-Un Shin
Summary: This study compared the OCTA findings between eyes with nearly recovered and partially recovered outer retina after FTMH surgery. It was found that the partially recovered group had a significantly higher choriocapillaris flow-void area at six months postoperatively, while the nearly recovered group showed better choroidal vascular flow. Vision at six months postoperatively correlated with the ratio of the operated eye's choriocapillaris flow-void area to the fellow eye.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Ophthalmology
I-Hsin Ma, Chung-May Yang, Yi-Ting Hsieh
Summary: The study reported on anatomical characteristics of wide-based foveal pit and its possible associations with macular diseases. Eyes with wide-based foveal pits demonstrated larger FAZ and wider RAT, indicating a predisposition to idiopathic epiretinal membrane formation. Fellow eyes of these cases also showed a tendency towards epiretinal membrane and macular hole formation.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Alessandra Sborgia, Giacomo Boscia, Alfredo Niro, Luca Landini, Valentina Pastore, Valeria Albano, Marina Piepoli, Rossella Donghia, Stefano Dore, Pasquale Viggiano, Rosa Buonamassa, Camilla Di Pardo, Teresa Molfetta, Marco Coassin, Roberto Dell'Omo, Francesco Boscia, Giovanni Alessio, Giancarlo Sborgia
Summary: The inverted ILM-flap technique combined with cataract surgery significantly improves visual acuity and retinal sensitivity after the closure of high myopic macular holes. Pre-operative visual acuity and retinal sensitivity at central 12 degrees may predict post-surgical visual acuity.
FRONTIERS IN MEDICINE
(2023)
Article
Ophthalmology
Yen-Chih Chen, San-Ni Chen
Summary: The study reported a rare complication related to fovea-sparing internal limiting membrane peeling technique, termed as isolated central epiretinal membrane. Among five patients, one had high myopia with foveoschisis, while others had vitreomacular traction or proliferative diabetic retinopathy.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Luca Ventre, Matteo Fallico, Antonio Longo, Guglielmo Parisi, Andrea Russo, Vincenza Bonfiglio, Paola Marolo, Paolo Caselgrandi, Teresio Avitabile, Enrico Borrelli, Michele Reibaldi
Summary: This study compared the efficacy of conventional internal limiting membrane peeling with inverted flap technique in treating small-to-medium idiopathic macular hole. The results showed that conventional ILM peeling group had better final macular sensitivity, but there were no significant differences between the two groups in terms of visual acuity improvement, hole closure, and optical coherence tomography findings.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Philipp L. Mueller, Alexandru Odainic, Tim Treis, Philipp Herrmann, Adnan Tufail, Frank G. Holz, Maximilian Pfau
Summary: Through a machine-learning approach integrating imaging and patient data, accurate prediction of retinal function can be achieved. The inclusion of limited FCP data improved prediction accuracy, making it a potential surrogate marker for evaluating treatment effects or disease progression.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Siying Li, Rui Hua, Zuoqian Jing, Lele Huang, Lei Chen
Summary: This study investigated the correlation between best corrected visual acuity (BCVA) and retinal microstructural parameters detected by optical coherence tomography (OCT) in diabetic retinopathy macular edema (DRME). The results showed that central foveal thickness (CFT), fracture distances of the external limiting membrane (ELM) and junction between the inner and outer segments (IS/OS) were negatively correlated with BCVA. Additionally, there was a significant difference in BCVA among patients with different types of retinal edema.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Ophthalmology
Rino Frisina, Luigi Tozzi, Irene Gius, Elisabetta Pilotto, Edoardo Midena
Summary: Integrated assessment of SW-FAF/microperimetry provides important information on LMH damage and postoperative recovery. Double-inverted EP and ILM flap technique is safe and effective for LMH treatment, improving BCVA and reducing hyper-FAF area postoperatively.
ACTA OPHTHALMOLOGICA
(2022)
Article
Biochemical Research Methods
Lijie Zhang, Rongyao Dong, Robert J. Zawadzki, Pengfei Zhang
Summary: Optoretinogram, utilizing OCT to measure retinal functions, is a potentially useful tool for quantifying retinal health alterations. This study improved accuracy by collecting volumetric data and developing a 3D registration approach, revealing novel functional signals and enabling monitoring of local and global functional changes in rodent eyes.
JOURNAL OF BIOPHOTONICS
(2022)
Review
Optics
Danuta M. Sampson, Adam M. Dubis, Fred K. Chen, Robert J. Zawadzki, David D. Sampson
Summary: The visualization and assessment of retinal microvasculature are crucial in the study and treatment of eye and systemic diseases. However, the current methods and analysis of OCTA imaging lack consistency, hindering progress. This paper proposes steps to standardize OCTA imaging, including imaging protocols, data analysis methods, metrics, reporting, and clinical practice, to address these limitations.
LIGHT-SCIENCE & APPLICATIONS
(2022)
Article
Medicine, Research & Experimental
Sook Hyun Chung, Tzu-Ni Sin, Brian Dang, Taylor Ngo, Therlinder Lo, Daniella Lent-Schochet, Ratheesh K. Meleppat, Robert J. Zawadzki, Glenn Yiu
Summary: This study compares the effectiveness of using single versus paired gRNAs in the CRISPR-Cas9 system to target the Vegfa gene. Paired gRNAs increased gene ablation rates in human cells but did not enhance VEGF suppression in mouse eyes. Using two gRNAs for genome editing may increase the risk of off-target effects.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Ophthalmology
Ratheesh K. Meleppat, Christopher R. Fortenbach, Yifan Jian, Esteban Soto Martinez, Karen Wagner, Bobeck S. Modjtahedi, Monica J. Motta, Deepa L. Ramamurthy, Ivan R. Schwab, Robert J. Zawadzki
Summary: In vivo evaluation of the structural morphology and vascular plexuses of the neurosensory retina and choroid across vertebrate species was performed using SS-OCT and SS-OCTA imaging. The results showed that the retinal morphology and vascular plexuses varied among different species. These methods can be used to evaluate retinal diseases in various species.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2022)
Article
Optics
Kari V. Vienola, Denise Valente, Robert J. Zawadzki, Ravi S. Jonnal
Summary: Optoretinography (ORG) is a noninvasive and objective tool for testing neural function in the retina. It has the potential to transform ophthalmic care and clinical trials of therapeutics for visual function. The article presents an alternative approach that monitors the velocity of retinal features instead of tracking their positions, reducing the complexity and cost of position-based methods.
Article
Optics
Soohyun Lee, Stacey S. Choi, Ratheesh K. Meleppat, Robert J. Zawadzki, Nathan Doble
Summary: This article describes a high-speed, adaptive optics partially confocal multi-spot ophthalmoscope (AO-pcMSO) that utilizes a digital micromirror device (DMD) in the illumination channel and a fast 2D CMOS camera. The camera is synchronized with the DMD to project multiple AO-corrected spots onto the human retina simultaneously. Spatial filtering on each raw retinal image acts as an array virtual pinholes. The parallel projection scheme achieves a frame acquisition rate of 250 fps and improves contrast by 2-3 fold compared to a standard flood illumination architecture. Partially confocal images of the human retina reveal cone and rod photoreceptors at various retinal eccentricities.
Article
Biochemical Research Methods
Pengfei Zhang, Daniel J. Wahl, Jacopo Mocci, Eric B. Miller, Stefano Bonora, Marinko Sarunic, Robert J. Zawadzki
Summary: Optical coherence tomography (OCT) and scanning laser ophthalmoscopy (SLO), invented in the 1980s, have greatly advanced in vivo retinal diagnostics in ophthalmology clinics and vision science research. Adaptive optics (AO) technology improves the resolution and sensitivity of SLO and OCT systems by correcting ocular aberrations. Integrating OCT into an existing mouse retinal AO-SLO system allows for multi-modal AO-enhanced imaging of the living mouse eye with high acquisition speed and resolution.
BIOMEDICAL OPTICS EXPRESS
(2023)
Proceedings Paper
Instruments & Instrumentation
Hang Chan Jo, Robert J. Zawadzki, Dae Yu Kim
Summary: Adaptive optics (AO) is a technique that compensates for aberration in optical imaging systems. Previous research has focused on improving AO performance through the use of spherical mirrors and off-axis designs.
OPTICAL SYSTEM ALIGNMENT, TOLERANCING, AND VERIFICATION XIV
(2022)
Meeting Abstract
Ophthalmology
Robert J. Zawadzki, Ratheesh K. Meleppat, Denise Valente, Soohyun Lee, Kari V. Vienola, Pengfei Zhang, Ravi S. Jonnal, Nathan Doble
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Kari V. Vienola, Robert J. Zawadzki, Ravi S. Jonnal
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Subeen Park, Hang Chan Jo, Kyoung Min Lee, Da Young Song, Robert J. Zawadzki, Dae Yu Kim, Seok Hwan Kim, Jae Hun Kim
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Ewelina Pijewska, Kari V. Vienola, Michal Meina, Pengfei Zhang, Ratheesh K. Meleppat, Maciej Szkulmowski, Ravi S. Jonnal, Robert J. Zawadzki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Christopher Loh, Pengfei Zhang, Ratheesh K. Meleppat, Oscar Ramos-Soto, Sandra E. Balderas-Mata, Robert J. Zawadzki, Susanna S. Park
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Ratheesh K. Meleppat, Kaitryn Ronning, Sarah J. Karlen, J. KarlenMarie E. Burns, Robert J. Zawadzki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Meeting Abstract
Ophthalmology
Jessicca Cho, Pengfei Zhang, Sarah J. Karlen, Nicholas Marsh-Armstrong, Anna La Torre, Robert J. Zawadzki
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)