Article
Medicine, General & Internal
Shungo Nishiyama, Takeshi Iwase
Summary: The study evaluated the surgical outcomes of PPV with the inverted ILM flap technique for treating FTMH in 3 patients with MacTel type 2. Results showed successful closure of FTMH in 3 cases, with 2 patients maintaining closed FTMH and improved vision, while 1 patient experienced FTMH reopening and vision deterioration. The inverted ILM flap technique may be effective and safe but cannot prevent FTMH reopening with retinal atrophy progression.
Article
Ophthalmology
Hiroshi Kunikata, Masayuki Yasuda, Naoko Aizawa, Urara Osada, Koji M. Nishiguchi, Toshiaki Abe, Toru Nakazawa
Summary: The study aimed to evaluate retinal vessel density and retinal sensitivity after macular hole surgery with the superior inverted internal limiting membrane flap technique. Results showed that there was lower recovery of retinal sensitivity in the superior sector, suggesting that internal limiting membrane peeling might affect the postoperative visual function.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Luca Ventre, Matteo Fallico, Antonio Longo, Guglielmo Parisi, Andrea Russo, Vincenza Bonfiglio, Paola Marolo, Paolo Caselgrandi, Teresio Avitabile, Enrico Borrelli, Michele Reibaldi
Summary: This study compared the efficacy of conventional internal limiting membrane peeling with inverted flap technique in treating small-to-medium idiopathic macular hole. The results showed that conventional ILM peeling group had better final macular sensitivity, but there were no significant differences between the two groups in terms of visual acuity improvement, hole closure, and optical coherence tomography findings.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Akira Hirata, Keiko Mine, Ken Hayashi
Summary: Patients who undergo temporal inverted internal limiting membrane (ILM) flap technique for macular hole (MH) show good postoperative outcomes with improved visual acuity and closure of MH. The area of the ILM flap decreases significantly between 1 and 6 months postoperatively, with some patients experiencing flap contraction. Younger age and larger ILM flap area at 1 month postoperatively are correlated with ILM flap contraction.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Alessandra Sborgia, Giacomo Boscia, Alfredo Niro, Luca Landini, Valentina Pastore, Valeria Albano, Marina Piepoli, Rossella Donghia, Stefano Dore, Pasquale Viggiano, Rosa Buonamassa, Camilla Di Pardo, Teresa Molfetta, Marco Coassin, Roberto Dell'Omo, Francesco Boscia, Giovanni Alessio, Giancarlo Sborgia
Summary: The inverted ILM-flap technique combined with cataract surgery significantly improves visual acuity and retinal sensitivity after the closure of high myopic macular holes. Pre-operative visual acuity and retinal sensitivity at central 12 degrees may predict post-surgical visual acuity.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Tsung-Tien Wu, Kai-Ling Peng
Summary: This study evaluated the long-term outcomes of using the inverted internal limiting membrane (ILM) flap technique for idiopathic macular hole (MH) closure. Among eyes that maintained flap closure at 1 month postoperatively, 50% achieved complete MH closure after undergoing fluid-gas exchange (FGE) treatment at 2 months. These eyes had better final vision and foveal restoration compared to eyes that did not undergo FGE treatment.
Article
Ophthalmology
Jakub J. Kaluzny, Przemyslaw Zabel, Martyna Kaluzna, Aleksander Lamkowski, Damian Jaworski, Krzysztof Woznicki, Katarzyna Zabel
Summary: The study found that a larger area of internal limiting membrane (ILM) peeling during pars plana vitrectomy for a full-thickness macular hole is associated with lower retinal sensitivity in the central macula.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Nathalie Bleidissel, Julia Friedrich, Julian Klaas, Nikolaus Feucht, Chris Patrick Lohmann, Mathias Maier
Summary: The study demonstrates the favorable morphological and functional outcomes of the I-ILM flap technique in treating large idiopathic full-thickness macular holes, with a 100% closure rate and significant improvement in BCVA over a 12-month follow-up period. Better preoperative BCVA, complete restoration of ELM, higher MHI, and smaller MH base diameter are associated with greater improvements in BCVA.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Xianggui Wang, Ying Zhu, Huizhuo Xu
Summary: This study retrospectively analyzed the surgical outcomes of different procedures in treating macular hole retinal detachment in patients with high myopia. The results showed that PPV combined with inverted multi-layer ILM flap achieved better anatomical outcomes compared to ILM peeling technique, but there was no significant advantage in functional outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Tadashi Mizuguchi, Masayuki Horiguchi, Sayaka Kakehi, Yasuki Ito
Summary: This study investigates the influence of an excess inverted internal limiting membrane flap on postoperative visual acuity and macular morphology in patients with idiopathic macular hole. The results showed that the postoperative morphology of the inverted ILM flap did not affect postoperative best-corrected visual acuity or central retinal thickness.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Medicine, General & Internal
Alessandra Sborgia, Alfredo Niro, Valentina Pastore, Valeria Albano, Giacomo Boscia, Marina Piepoli, Camilla Di Pardo, Lorenzo Accurso Tagano, Marta Zerbinati, Luca Landini, Maria Grazia Pignataro, Giovanni Petruzzella, Rossella Donghia, Abdullah S. Alqahtani, Marco Coassin, Roberto Dell'Omo, Francesco Boscia, Giovanni Alessio, Giancarlo Sborgia
Summary: This study compared the functional outcomes of biofeedback training and standard care in patients who underwent successful inverted ILM-flap for high myopic macular holes. The results showed that biofeedback training can improve visual acuity and fixation stability better than standard care over the course of one year.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Ophthalmology
Irini Chatziralli, Genovefa Machairoudia, Dimitrios Kazantzis, George Theodossiadis, Panagiotis Theodossiadis
Summary: The inverted internal limiting membrane (ILM) flap technique is an effective method for treating myopic macular holes, demonstrating high closure rates but varying degrees of visual acuity improvement. However, potential complications may include MH reopening or persistence, development of retinal detachment, choroidal detachment, ocular hypertension, and chorioretinal atrophy.
SURVEY OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Xiujuan Zhao, Huiying Song, Silvia Tanumiharjo, Yanbing Wang, Yuqing Chen, Shida Chen, Xia Huang, Bingqian Liu, Ping Lian, Lin Lu
Summary: This study aimed to compare the efficacy of macular buckling (MB) alone versus combined internal limiting membrane (ILM) inversion flap for the treatment of full-thickness macular hole (FTMH)-associated macular detachment (MD) in patients with high myopia. The results showed that patients treated with MB combined with the ILM flap inversion technique had better postoperative visual acuity and a higher rate of macular hole closure. Therefore, combination surgery is recommended.
Article
Ophthalmology
Sunil Ruparelia, Raman Tuli, John S. Y. Park, Nir Shoham-Hazon, Efraim Berco
Summary: The inverted internal limiting membrane flap technique for macular hole closure without postoperative face-down positioning has shown a high success rate in this study. Most patients achieved anatomical and functional success, with significant improvements in visual acuity. Larger prospective studies are needed to further explore this technique.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Sayaka Kakehi, Tadashi Mizuguchi, Atsuhiro Tanikawa, Masayuki Horiguchi
Summary: This study investigated the efficacy of a modified internal limiting membrane (ILM) flap technique combined with vitreous surgery for treating macular holes. The results showed that this technique was effective in closing macular holes and improving visual acuity.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Francesco D'Oria, Rosa Buonamassa, Tiziana Rizzo, Francesco Boscia, Giovanni Alessio, Silvana Guerriero
Summary: The purpose of this study was to determine the prevalence of bacterial and fungal infections in the eyes and evaluate their antibiotic susceptibility at a tertiary referral eye care hospital in Bari, Italy. The findings showed that bacterial infections, primarily caused by Gram-positive bacteria like Staphylococcus species, were the most common, followed by fungal infections. The study also revealed a high level of in vitro resistance to multiple antibiotics.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Claudio Furino, Valeria Albano, Michela Mangione, Roberta Galati, Maria D'Addario, Michele Reibaldi, Francesco Boscia, Giovanni Alessio
Summary: This pilot study explores the use of optical coherence tomography angiography (OCT-A) in evaluating the dry macula of neovascular age-related macular degeneration (nAMD) treated with a treat-and-extend (T&E) aflibercept regimen. The study suggests that OCT-A may be useful in determining the optimal approach for adjusting injection intervals based on changes in CNV size.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Valeria Albano, Rosanna Dammacco, Alessia Manni, Dario Sisto, Antonio Iaffaldano, Alberto Mavilio, Giovanni Alessio, Maria Trojano, Damiano Paolicelli
Summary: SD-OCT was used to evaluate the proportion of different macular ganglion cell-inner plexiform layer complex (mGCIP) defect patterns in multiple sclerosis patients without a history of optic neuritis (MSNON). The study found that a significant thinning of the mGCIP with inner defects was commonly observed in MSNON patients.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Alfredo Niro, Francesco Pignatelli, Matteo Fallico, Alessandra Sborgia, Fedele Passidomo, Samuele Gigliola, Annalisa Nacucchi, Giancarlo Sborgia, Giacomo Boscia, Giovanni Alessio, Francesco Boscia, Giuseppe Addabbo, Michele Reibaldi, Teresio Avitabile
Summary: The prevention and management of ocular surface infections pose great challenges for ophthalmologists, particularly due to the spread of antimicrobial resistance. Polyhexamethylene biguanide hydrochloride (PHMB) is a broad-spectrum antiseptic with excellent tolerance and a low-risk profile. Its physicochemical action on the phospholipid membrane and DNA replication or repair mechanism hinders the development of resistant bacterial strains.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Nutrition & Dietetics
Sara De Nucci, Roberta Zupo, Rossella Donghia, Fabio Castellana, Domenico Lofu, Simona Aresta, Vito Guerra, Ilaria Bortone, Luisa Lampignano, Giovanni De Pergola, Madia Lozupone, Rossella Tatoli, Giancarlo Sborgia, Sarah Tirelli, Francesco Panza, Tommaso Di Noia, Rodolfo Sardone
Summary: A study on the eating habits of older adults in the Mediterranean found that higher consumption of coffee and wine, as well as intake of PUFAs, zinc, and coumarins can protect against physical frailty in aging.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Correction
Nutrition & Dietetics
Sara De Nucci, Roberta Zupo, Rossella Donghia, Fabio Castellana, Domenico Lofu, Simona Aresta, Vito Guerra, Ilaria Bortone, Luisa Lampignano, Giovanni De Pergola, Madia Lozupone, Rossella Tatoli, Giancarlo Sborgia, Sarah Tirelli, Francesco Panza, Tommaso Di Noia, Rodolfo Sardone
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Ophthalmology
Giacomo Boscia, Giancarlo Sborgia, Alfredo Niro, Stefano Dore, Luca Landini, Giacomo Scotti, Francesco Boscia
Summary: We report a surgical technique involving human amniotic membrane (hAM) patch implant to treat unresolved Optic disc pit maculopathy (ODPM) after unsuccessful inverted Inner Limiting Membrane (ILM)-flap technique. The hAM patch remained detectable over the pit for the entire 6-months follow-up and the ODPM gradually resolved with partial visual acuity recovery.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Biology
Andrea De Luca, Alessandro Ferraro, Chiara De Gregorio, Mariateresa Laborante, Marco Coassin, Roberto Sgrulletta, Antonio Di Zazzo
Summary: Dry eye disease is a common and debilitating condition that affects millions of people worldwide. Recent advancements in diagnostic technology for DED have led to the development of several new devices.
Article
Ophthalmology
Luigi Sborgia, Valeria Albano, Giancarlo Sborgia, Francesco Boscia, Giovanni Alessio
Summary: We present a rare case of Citrobacter koseri culture-positive endophthalmitis in a postvitrectomy silicone oil-filled eye. The patient had undergone a vitrectomy with silicone oil tamponade previously. Culture tests of aqueous, silicone oil, and vitreous taps were positive for Citrobacter koseri. This rare condition is not well documented, but our case had successful outcomes with silicone oil removal, intraoperative intravitreal antibiotic injection, and silicone oil reinjection.
CASE REPORTS IN OPHTHALMOLOGICAL MEDICINE
(2023)
Review
Ophthalmology
Ali Nowrouzi, Francesco D'Oria, Jorge L. Alio del Barrio, Jorge L. Alio
Summary: Background: Anterior and posterior chamber phakic intraocular lenses (pIOLs) implantation is a viable refractive surgical option for keratoconus patients with high anisometropia, contact lens intolerance, or a preference for spectacle and contact lens independence. They are effective in correcting anisometropia in stable keratoconus cases or following corneal procedures such as intrastromal corneal ring segments (ICRS), collagen cross-linking (CXL), and keratoplasty. Combined procedures with ICRS or topography/wavefront-guided transepithelial PRK (with or without CXL) can be done in conjunction with pIOLs implantation to improve visual acuity. Aim: To analyze the scientific evidence published within the last 10 years (from 2012 onwards) regarding the safety and efficacy of pIOLs for keratoconus patients' visual and refractive rehabilitation. Results: There were no randomized controlled trials, but satisfactory visual rehabilitation was achieved with both anterior and posterior chamber pIOLs, with good safety and efficacy. Conclusion: pIOLs implantation is a valid refractive therapeutic approach for correcting stable keratoconus with moderate-to-high refractive errors, especially anisometropia associated with regular or mildly irregular astigmatism, and good visual acuity.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Marco Coassin, Alessandro Arrigo, Federico Ricci, Raffaella Rosa, Roberto Gattegna, Alessandro Pupino, Jose Manuel Benitez Del Castillo, Stefano Bonini
Summary: The technological breakthroughs in mini-invasive vitreo-retinal surgery have improved the perioperative management and outcomes for millions of patients. Common procedures include vitrectomy, episcleral surgery, intravitreal injections, and laser photocoagulation. Postoperative side effects may include ocular surface disbalance and discomfort symptoms.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ali Nowrouzi, Jorge L. Alio del Barrio, Francesco D'Oria, Nabil Ragaei Kamel, Jorge L. Alio
Summary: The purpose of this study was to investigate the visual performance of patients with unilateral cataracts after unilateral implantation of an extended depth-of-focus intraocular lens (IOL). The results showed that patients achieved good uncorrected distance visual acuity and corrected near visual acuity at 6 months postoperatively, and they reported satisfaction with the visual outcomes.
JOURNAL OF REFRACTIVE SURGERY
(2023)
Article
Ophthalmology
Saad Abdulrahman J. Al-Amri, Jorge L. Alio, Roberto Milan-Castillo, Francesco D'Oria, Antonio Martinez-Abad, Pilar Yebana, Nuria Subirana, Ziyad Al-Harbi, Ana B. Plaza-Puche, Jorge L. Alio del Barrio
Summary: This study evaluated the clinical retinal optical image quality after implantation of an extended depth of focus intraocular lens (EDOF IOL) and compared it with monofocal and trifocal IOLs. The results showed that the EDOF and monofocal IOLs had comparable retinal image quality, while the trifocal IOLs were most affected by residual refractive errors.
JOURNAL OF REFRACTIVE SURGERY
(2023)
