Review
Veterinary Sciences
Manuel Morales-Yuste, Joaquina Martin-Sanchez, Victoriano Corpas-Lopez
Summary: Dogs are the main host of Leishmania infantum, which causes canine leishmaniasis, a disease that is incurable and transmitted through the bite of sandflies. Advances in molecular techniques and vaccines have been made for diagnosis and prevention, although the development of an ideal drug to eliminate the parasite is still awaited. Public health implications of the disease are fundamental.
VETERINARY SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Olga Kammona, Evgenia Tsanaktsidou
Summary: Leishmaniasis, a prevalent parasitic infection in neglected tropical diseases, lacks efficient diagnostic tools and treatments, posing a serious threat to public health in low- and middle-income countries. Nanotechnology may offer novel approaches to enhance disease detection, therapy, and prevention.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Immunology
Maryam Akbari, Ahmad Oryan, Gholamreza Hatam
Summary: Leishmaniasis is a parasitic disease transmitted by sand fly vectors, causing a range of clinical features. Current treatments lack an effective vaccine, with chemotherapy being toxic and expensive. Immunotherapy has emerged as an alternative treatment option, aiming to reduce the toxicity of drugs and drug resistance.
IMMUNOLOGY LETTERS
(2021)
Review
Genetics & Heredity
Yali Liu, Harry Cheuk-Hay Lau, Wing Yin Cheng, Jun Yu
Summary: Colorectal cancer (CRC) is a common and deadly form of cancer, with both genetic and environmental factors playing a role in its development. Dysbiosis in the gut microbiome has been identified as a risk factor for CRC. Recent data has shown that the gut microbiome is directly involved in DNA damage, inflammation, and drug resistance in CRC, suggesting that modulating the gut microbiome could be a powerful tool in prevention and therapy. This article provides an overview of the relationship between the gut microbiome and CRC, explores the mechanisms of colorectal tumorigenesis, and discusses the potential of bacterial species as clinical biomarkers.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Review
Genetics & Heredity
Yawei Li, Xin Wu, Ping Yang, Guoqian Jiang, Yuan Luo
Summary: The recent development of imaging and sequencing technologies has brought systematic advances in the clinical study of lung cancer. However, the human mind is limited in effectively handling and utilizing the enormous amounts of accumulated data. Machine learning-based approaches play a critical role in integrating and analyzing these large and complex datasets to enhance various aspects of lung cancer diagnosis and therapy. This review provides an overview of machine learning-based approaches in early detection, auxiliary diagnosis, prognosis prediction, and immunotherapy practice of lung cancer, as well as highlighting the challenges and opportunities for future applications.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2022)
Article
Microbiology
Lilian Motta Cantanhede, Cristiane Batista Mattos, Ana Karoline Cruz, Yoda Janaina Ikenohuchi, Flavia Goncalves Fernandes, Enmanuella Helga Ratier Terceiro Medeiros, Cipriano Ferreira da Silva-Junior, Elisa Cupolillo, Gabriel Eduardo Melim Ferreira, Ricardo de Godoi Mattos Ferreira
Summary: The northern region of Brazil has the highest number of mucosal leishmaniasis cases, which are associated with factors such as parasite species and Leishmania RNA virus 1. Laboratory diagnosis poses a challenge for health services in this region.
Article
Public, Environmental & Occupational Health
Liuxue Wang, Meng Hu, Xusheng Wu, Limin Ma, Haiping Yang
Summary: English is becoming increasingly important. According to statistics, learning Chinese can improve people's communicative ability and cultural literacy. Therefore, it is crucial to strengthen Chinese learning and promotion.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Review
Oncology
Julien Taieb, Magali Svrcek, Romain Cohen, Debora Basile, David Tougeron, Jean-Marc Phelip
Summary: Microsatellite unstable colorectal cancers are characterized by DNA mismatch repair deficiency and have prognostic and predictive implications. Immune checkpoint inhibitors have shown remarkable effectiveness in this type of cancer, but resistance remains a challenge.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Infectious Diseases
Marileia Chaves Andrade, Paulo Rogerio Ferreti Bonan, Edson Hilan, Nelson Pereira Marques, Silvio Fernando Guimaraes-Carvalho, Hercilio Martelli
Summary: The study found that during the COVID-19 pandemic, clinic visits for leishmaniasis in Brazil significantly increased, with a rise in tegumentary leishmaniasis and a decrease in visceral leishmaniasis consultations. Despite the negative impact of COVID-19 on health promotion and monitoring, expanding information can minimize its effects on neglected diseases.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Maria del Carmen De Lama-Odria, Luis J. Del Valle, Jordi Puiggali
Summary: Drug delivery systems based on hydroxyapatite nanoparticles (HAp NPs) have great potential in cancer treatment due to their superior properties and easy functionalization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Preeti Ranjan, Vikash Kumar Dubey
Summary: Leishmaniasis is a parasitic disease that disproportionately affects impoverished and developing countries. The socioeconomic background of the affected region is a significant factor that influences the severity of the disease. The emergence of drug-resistant Leishmania poses a serious threat to current treatment options, necessitating a reevaluation of drug choices. Targeted therapy combined with immunotherapy appears to be a promising strategy for combating the disease.
Article
Medicine, General & Internal
Qiuping Liang, Xiaogong Liang, Dengwei Hong, Yuan Fang, Lanlan Tang, Jiao Mu, Xiaoli Tan, Feng Chen
Summary: In this study, two patients with unprovoked and recurrent high fever were admitted to the hospital. Despite antibiotic treatment, their condition did not improve. No pathogen was found in bone marrow aspiration smears, but Leishmania-specific nucleic acid sequences were successfully detected in their peripheral blood using metagenomic next-generation sequencing (mNGS). After targeted treatment for visceral leishmaniasis, mNGS showed a decrease in the reads number of Leishmania sequence. This study demonstrates the feasibility of mNGS in detecting Leishmania spp. in peripheral blood samples and suggests its potential for evaluating therapeutic effect.
FRONTIERS IN MEDICINE
(2023)
Article
Immunology
Yiping Li, Xiaoqin Li, Yufei Yang, Xuehan Qiao, Qing Tao, Chen Peng, Miao Han, Kebin Dong, Min Xu, Deqiang Wang, Gaohua Han
Summary: This study explores the potential application of genes associated with hereditary metabolic diseases in the diagnosis and treatment of gastric cancer. The findings suggest that these genes could serve as useful markers for diagnosis and prognosis of gastric cancer, as well as predicting patients' response to treatment. Additionally, the study reveals the impact of these genes on immune biomarkers, highlighting their importance in predicting immunotherapy response and survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xuemei Wang, Shengbo Li, Siqi Wang, Shuo Zheng, Zhenbing Chen, Heng Song
Summary: Smart nanomaterials offer a new approach to improve the safety and effectiveness of combined anti-cancer immunotherapy by delivering multiple proteins to cells, enabling imaging, and combining various treatment methods.
Review
Microbiology
Sara Scarpini, Arianna Dondi, Camilla Totaro, Carlotta Biagi, Fraia Melchionda, Daniele Zama, Luca Pierantoni, Monia Gennari, Cinzia Campagna, Arcangelo Prete, Marcello Lanari
Summary: Visceral Leishmaniasis (VL) is a potentially lethal disease caused by a parasitic infection. The effectiveness of treatment may vary depending on the geographical area and the specific parasite species. Recent advancements in drug therapy have improved treatment outcomes for VL.