Article
Cardiac & Cardiovascular Systems
J. Alberto Neder
Summary: Cardiopulmonary exercise testing (CPET) is not widely used or understood in respiratory medicine, and there are various controversies and limitations in its interpretation. This article critically discusses deeply entrenched beliefs about CPET and provides approaches for performance and interpretation. To advance the understanding and utility of CPET in pulmonology, further research is needed.
RESPIRATORY MEDICINE
(2023)
Article
Critical Care Medicine
Amany F. Elbehairy, Nesma M. Geneidy, Mona S. Elhoshy, Doha Elsanhoury, Mohamed K. Elfeky, Asmaa Abd-Elhameed, Alexander Horsley, Denis E. O. 'Donnell, Nashwa H. Abd-Elwahab, Mahmoud I. Mahmoud
Summary: The reduced exercise capacity in untreated OSAHS patients may be related to pulmonary gas exchange abnormalities during exercise and resting systemic vascular dysfunction.
Article
Cardiac & Cardiovascular Systems
Marco Guazzi, Matthias Wilhelm, Martin Halle, Emeline Van Craenenbroeck, Hareld Kemps, Rudolph A. de Boer, Andrew J. S. Coats, Lars Lund, Donna Mancini, Barry Borlaug, Gerasimos Filippatos, Burkert Pieske
Summary: Patients with heart failure with preserved ejection fraction (HFpEF) commonly experience exercise intolerance and dyspnoea. Various factors contribute to the limited exercise capacity, including impaired cardiac and peripheral vascular function, reduced pulmonary vascular reserve, skeletal muscle dysfunction, and iron deficiency/anaemia. However, the current algorithms/scores for HFpEF diagnosis do not consider the objective measures of exercise performance. This clinical consensus statement aims to highlight the role of exercise testing in HFpEF and its pathophysiological, clinical, and prognostic insights. Additionally, combining echocardiography and/or invasive haemodynamic evaluation with cardiopulmonary exercise testing is essential for assessing, quantifying, and differentiating the origin of dyspnoea and exercise impairment.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Respiratory System
Ioannis T. Farmakis, Luca Valerio, Stefano Barco, Eva Alsheimer, Ralf Ewert, George Giannakoulas, Lukas Hobohm, Karsten Keller, Anna C. Mavromanoli, Stephan Rosenkranz, Timothy A. Morris, Stavros V. Konstantinides, Matthias Held, Daniel Dumitrescu
Summary: This study investigated the association between exercise limitation assessed by cardiopulmonary exercise testing (CPET) and clinical, echocardiographic, laboratory abnormalities, and quality of life (QoL) after pulmonary embolism (PE). The results showed that abnormal exercise capacity of cardiopulmonary origin is common after PE and is associated with clinical and haemodynamic impairment, as well as long-term QoL reduction. CPET can be considered for selected patients with persisting symptoms after PE to identify candidates for closer follow-up and possible therapeutic interventions.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Virginia L. Mihalick, Justin M. Canada, Ross Arena, Antonio Abbate, Danielle L. Kirkman
Summary: The outbreak of COVID-19 has led to multi-organ damage and reduced cardiorespiratory fitness, while decreased physical activity exacerbates the risk of cardiopulmonary disease. CP exercise testing is crucial in clinical practice and rehabilitation, but precautions need to be taken due to its aerosol generating nature. Recommendations have been provided to prevent the transmission of SARS-CoV-2 during CPET testing.
PROGRESS IN CARDIOVASCULAR DISEASES
(2021)
Article
Sport Sciences
Dan M. Cooper, Ronen Bar-Yoseph, Robert Liem, Thomas G. Keens, Susanna A. McColley, Shlomit Radom-Aizik
Summary: This study developed a terminology harmonization model (THEMES DAM) for pediatric cardiopulmonary exercise testing (CPET) and surveyed the current state of CPET centers in the United States. The results highlight the need for improved interoperability among centers to better adapt to changing health environments and promote innovation in CPET research and clinical application.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Guazzi, Barry Borlaug, Marco Metra, Maurizio Losito, Francesco Bandera, Eleonora Alfonzetti, Sara Boveri, Tadafumi Sugimoto
Summary: The study revisited and implemented the exercise gas exchange Weber and ventilatory classifications in heart failure patients, finding that exercise cardiac output decreased progressively, mean pulmonary arterial pressure/cardiac output slope increased, and mitral regurgitation increased. Weber and ventilatory classifications were independently associated with outcome, with worse prognosis when severe ventilatory inefficiency was combined.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Physiology
Bryce N. Balmain, Andrew R. Tomlinson, James P. MacNamara, Satyam Sarma, Benjamin D. Levine, Linda S. Hynan, Tony G. Babb
Summary: Calculating physiological dead space with and without a VDM correction yields quantitively and qualitatively different results, which could have impact on the interpretation of gas exchange efficiency in HFpEF. Further investigation is required to uncover the clinical consequences and the mechanism(s) explaining the increase in VD/VTVDM during exercise in HFpEF.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Psychology, Biological
Jake S. Ashton, James W. Roberts, Caroline J. Wakefield, Don P. M. MacLaren, Simon Marwood, James J. Malone
Summary: Prolonged exercise can lead to a decline in cognitive function, but medium chain triglycerides (MCTs) can provide energy for the brain and promote chronic physiological adaptations. This study found that MCT supplementation enhanced cognitive performance before exercise and offset the cognitive decline caused by exercise.
PHYSIOLOGY & BEHAVIOR
(2023)
Article
Multidisciplinary Sciences
Masatsugu Abe, Kai Ushio, Yuri Ishii, Yuki Nakashima, Daisuke Iwaki, Kouki Fukuhara, Makoto Takahashi, Yukio Mikami
Summary: This study investigated a simple measurement method for the anaerobic threshold (AT) using percutaneous oxygen saturation (SpO(2)) and pulse rate (PR) with a pulse oximeter. The findings suggest that the SpO(2)-Slope method with a pulse oximeter may be a useful and simple method to determine AT compared to conventional methods.
SCIENTIFIC REPORTS
(2022)
Article
Critical Care Medicine
J. Alberto Neder, Miranda Kirby, Giles Santyr, Marina Pourafkari, Reginald Smyth, Devin B. Phillips, Sophie Crinion, Juan Pablo de-Torres, Denis E. O'Donnell
Summary: In patients with COPD, impaired gas-exchange efficiency, caused by abnormal alveolar ventilation or capillary perfusion, leads to dyspnea and exercise intolerance. Treatment options targeting the increased neurochemical afferent activity resulting from gas-exchange inefficiency are limited. This review proposes two clinical research focuses to deepen the understanding of pulmonary gas-exchange inefficiency and activity-related dyspnea in COPD and evaluate pharmacologic treatments for improvement.
Article
Horticulture
John Ertle, Chieri Kubota
Summary: Low evaporative conditions in indoor farms lead to tipburn of lettuce, which affects the appearance and economic value of the crop. Differences in tipburn sensitivity among cultivars are not significantly correlated with morphology or anthocyanin content.
Article
Multidisciplinary Sciences
Lennart T. Bach, Veronica Tamsitt, Jim Gower, Catriona L. Hurd, John A. Raven, Philip W. Boyd
Summary: The study highlights ocean afforestation as an important method for CO2 removal, but biogeochemical feedback mechanisms reduce its efficiency. Additionally, the increased ocean albedo due to floating Sargassum may have a greater impact on climate change, indicating the importance of considering multifaceted Earth-system feedback mechanisms when evaluating carbon dioxide removal methods.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Dariusz Jastrzebski, Beata Toczylowska, Elzbieta Zieminska, Aleksandra Zebrowska, Sabina Kostorz-Nosal, Elzbieta Swietochowska, Camillo Di Giulio, Dariusz Ziora
Summary: This study found that short-term, in-hospital exercise training benefits patients with sarcoidosis by improving their physical function, with positive effects on their lipid profile. It suggests that lipid profiling could become a new prognostic method to assess the effects of pulmonary rehabilitation in patients with sarcoidosis.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Keisuke Miki, Kazuyuki Tsujino, Ryoji Maekuara, Takanori Matsuki, Mari Miki, Hisako Hashimoto, Hiroyuki Kagawa, Takahiro Kawasaki, Tomoki Kuge, Hiroshi Kida
Summary: In COPD patients, the severity of exertional respiratory acidosis is correlated with the V'(E)-V'(CO2) slope and Delta FO2 during exercise. Delta FO2 may play a key role in identifying ventilatory inefficiency and oxygen availability.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Respiratory System
Raphael Borie, Caroline Kannengiesser, Katerina Antoniou, Francesco Bonella, Bruno Crestani, Aurelie Fabre, Antoine Froidure, Liam Galvin, Matthias Griese, Jan C. Grutters, Maria Molina-Molina, Venerino Poletti, Antje Prasse, Elisabetta Renzoni, Jasper van der Smagt, Coline H. M. van Moorsel
Summary: The discovery of gene mutations that cause pulmonary fibrosis confirms the genetic predisposition to this condition. While genetic sequencing is already part of routine clinical practice for familial pulmonary fibrosis cases in some countries, it has not been widely incorporated into interstitial lung disease services and lacks international consensus.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Allergy
Bas Smits, Sigune Goldacker, Suranjith Seneviratne, Marion Malphettes, Hilary Longhurst, Omar E. Mohamed, Carla Witt-Rautenberg, Lucy Leeman, Eva Schwaneck, Isabelle Raymond, Kilifa Meghit, Annette Uhlmann, Christine Winterhalter, Joris van Montfrans, Marion Klima, Sarita Workman, Claire Fieschi, Lorena Lorenzo, Sonja Boyle, Shamin Onyango-Odera, Suzanne Price, Marc Schmalzing, Valerie Aurillac, Antje Prasse, Ieneke Hartmann, Jennifer J. Meerburg, Mariette Kemner-van de Corput, Harm Tiddens, Bodo Grimbacher, Peter Kelleher, Smita Y. Patel, Anne-Sophie Korganow, Jean-Francois Viallard, Hans-Peter Tony, Claire Bethune, Hendrik Schulze-Koops, Torsten Witte, Aarnoud Huissoon, Helen Baxendale, Sofia Grigoriadou, Eric Oksenhendler, Siobhan O. Burns, Klaus Warnatz
Summary: This study analyzed the effect of high-dose corticosteroids on granulomatous and lymphocytic interstitial lung disease (gl-ILD) using high-resolution computed tomography (HRCT) scans and pulmonary function tests (PFT). The results showed that high-dose corticosteroid treatment significantly improved HRCT scores and lung function, achieving long-term remission in 42% of patients with gl-ILD. However, low-dose maintenance therapy was not beneficial and had poor efficacy in relapsing disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Farida Ahangari, Nathan L. Price, Shipra Malik, Maurizio Chioccioli, Thomas Barnthaler, Taylor S. Adams, Jooyoung Kim, Sai Pallavi Pradeep, Shuizi Ding, Carlos Cosmos Jr., Kadi-Ann S. Rose, John E. McDonough, Nachelle R. Aurelien, Gabriel Ibarra, Norihito Omote, Jonas C. Schupp, Giuseppe DeIuliis, Julian A. Villalba Nunez, Lokesh Sharma, Changwan Ryu, Charles S. Dela Cruz, Xinran Liu, Antje Prasse, Ivan Rosas, Raman Bahal, Carlos Fernandez-Hernando, Naftali Kaminski
Article
Medicine, General & Internal
Toby M. Maher, Paul Ford, Kevin K. Brown, Ulrich Costabel, Vincent Cottin, Sonye K. Danoff, Irene Groenveld, Eric Helmer, R. Gisli Jenkins, Julie Milner, Geert Molenberghs, Bjorn Penninckx, Matthew J. Randall, Bernt Van den Blink, Ann Fieuw, Charlotte Vandenrijn, Sanda Rocak, Ineke Seghers, Lixin Shao, Amit Taneja, Garrit Jentsch, Timothy R. Watkins, Wim A. Wuyts, Michael Kreuter, Nadia Verbruggen, Niyati Prasad, Marlies S. Wijsenbeek
Summary: This study aimed to assess the efficacy and safety of the autotaxin inhibitor ziritaxestat in patients with idiopathic pulmonary fibrosis (IPF). The study found that ziritaxestat did not improve clinical outcomes compared with placebo in patients with IPF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Rheumatology
Martin Aringer, Dirk Koschel, Thomas Doerner, Philipp Sewerin, Antje Prasse, Torsten Witte
Summary: Sjogren's syndrome is a potential autoimmune cause of interstitial lung disease. The diagnostic pathway for this syndrome is not well-defined compared to other autoimmune diseases. Subjective sicca symptoms and specific autoantibodies have limitations in their sensitivity and/or specificity as screening tests. To address this, a consensus has been developed to include additional antibodies and objective measures in the diagnosis.
ZEITSCHRIFT FUR RHEUMATOLOGIE
(2023)
Article
Respiratory System
Juergen Behr, Francesco Bonella, Andreas Guenther, Dirk Koschel, Antje Prasse, David Pittrow, Jens Klotsche, Michael Kreuter
Summary: This study is a long-term registry aimed to describe the characteristics, management, and course of newly diagnosed patients with fibrosing interstitial lung disease (fILD) in Germany. So far, 360 patients have been enrolled, and a total of 900 patients are planned to be included over three years. The registry will provide important data on patient characteristics, management, and trajectories, and allow for comparisons with other countries.
BMC PULMONARY MEDICINE
(2023)
Correction
Respiratory System
Juergen Behr, Francesco Bonella, Bjoern C. Frye, Andreas Guenther, Lars Hagmeyer, Joerg Henes, Philipp Klemm, Dirk Koschel, Michael Kreuter, Gabriela Leuschner, Dennis Nowak, Antje Prasse, Bernd Quadder, Helmut Sitter, Ulrich Costabel
Article
Respiratory System
[Anonymous]
Summary: The evaluation of ILD patients involves assessing clinical, radiological, and histopathological data. This position statement from ILD experts provides guidance on diagnostic modalities to be used, including clinical assessment, rheumatological evaluation, radiological examinations, histopathologic sampling, and multidisciplinary team discussions.
Editorial Material
Respiratory System
Jurgen Behr, Melanie Berger, Torsten Gerriet Blum, Francesco Bonella, Julien Dinkel, Sven Glaeser, Lars Hagmeyer, Nikolaus Kneidinger, Dirk Koschel, Antje Prasse, Hortense Slevogt, Elvira Stacher-Priehse, Holger Woehrle, Michael Kreuter
Summary: The SARS-CoV-2 pandemic has had a significant impact on the diagnosis and treatment of ILDs. Viral pneumonias caused by the delta variant exacerbated pre-existing ILDs and led to the discovery of previously subclinical ILDs. The effect of SARS-CoV-2 infection on the progression of ILDs is unpredictable and poses challenges to medical professionals.
Article
Respiratory System
Juergen Behr, Francesco Bonella, Bjoern C. Frye, Andreas Guenther, Lars Hagmeyer, Joerg Henes, Philipp Klemm, Dirk Koschel, Michael Kreuter, Gabriela Leuschner, Dennis Nowak, Antje Prasse, Bernd Quadder, Helmut Sitter, Ulrich Costabel
Article
Medicine, Research & Experimental
Martin Kolb, Kevin R. Flaherty, Rafael S. Silva, Antje Prasse, Carlo Vancheri, Heiko Mueller, Kamila Sroka-Saidi, Athol U. Wells, INBUILD Trial Investigators
Summary: The study found that nintedanib consistently slowed the rate of decline in forced vital capacity (FVC) in patients with progressive pulmonary fibrosis. The effectiveness of nintedanib in reducing the progression of interstitial lung disease (ILD) was also consistent across subgroups based on different baseline characteristics. This supports the use of nintedanib as a treatment for progressive pulmonary fibrosis.
ADVANCES IN THERAPY
(2023)
Letter
Critical Care Medicine
Jonas C. Schupp, Edward P. Manning, Maurizio Chioccioli, Jan C. Kamp, Leonard Christian, Changwan Ryu, Erica Herzog, Mark P. Kuehnel, Antje Prasse, Naftali Kaminski, Danny D. Jonigk, Robert J. Homer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Jannik Ruwisch, Tobias Welte, Antje Prasse
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2023)
Article
Medicine, General & Internal
Sandra Freitag-Wolf, Jonas C. Schupp, Bjoern C. Frye, Annegret Fischer, Raihanatul Anwar, Robert Kieszko, Violeta Mihailovic-Vucinic, Janusz Milanowski, Dragana Jovanovic, Gernot Zissel, Elena Bargagli, Paola Rottoli, Dragos Bumbacea, Rene Jonkers, Ling-Pei Ho, Karoline I. Gaede, Anna Dubaniewicz, Ben G. Marshall, Andreas Guenther, Martin Petrek, Michael P. Keane, Sigridur O. Haraldsdottir, Francesco Bonella, Christian Grah, Tatjana Peros-Golubicic, Zamir Kadija, Stefan Pabst, Christian Grohe, Janos Strausz, Martina Safrankova, Ann Millar, Jiri Homolka, Wim A. Wuyts, Lisa G. Spencer, Michael Pfeifer, Dominique Valeyre, Venerino Poletti, Hubertus Wirtz, Antje Prasse, Stefan Schreiber, Astrid Dempfle, Joachim Mueller-Quernheim
Summary: This study investigated the association of genetic markers with different phenotypes using meta-analysis. The results showed no significant genetic association in the overall cohort, but confirmed the association of acute onset with TNF and reported a new association with HLA polymorphism in the Serbian sub-cohort. The study also suggested that gene-environment interactions may influence the clinical phenotype and different geographic regions may have distinct genetic links and environmental factors.
FRONTIERS IN MEDICINE
(2023)
Article
Respiratory System
Matthias Grott, Cosmas D. D. Wimmer, Michael Kreuter, Antje Prasse, Martin E. E. Eichhorn, Florian Eichhorn, Felix J. F. Herth, Benjamin Seeliger, Katharina Kriegsmann, Werner Schmidt, Katharina Koenigsfeld, Patrick Zardo, Hauke Winter
Summary: In our propensity score matching analysis, we found that surgical lung biopsy performed under spontaneous ventilation is associated with faster postprocedural recovery in patients with nonclassified interstitial lung disease (nILD). However, there was no observed reduction in postoperative acute exacerbation of interstitial lung disease (AE-ILD) or 30-/90-day mortality.