Article
Pharmacology & Pharmacy
Lei Fang, Ying Yan, Zhengxin Xu, Zhenpeng He, Shuting Zhou, Xin Jiang, Fan Wu, Xiaoling Yuan, Tong Zhang, Duonan Yu
Summary: Tectochrysin demonstrates efficacy in treating mouse asthma by reducing airway inflammation, inhibiting Th2 cytokine production, and enhancing antioxidant defenses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
David Charles, Lee A. Gethings, James F. Potts, Peter G. J. Burney, Vanessa Garcia-Larsen
Summary: This study aimed to identify potential candidate markers of polyphenol intake in human serum and found that serum profiling for these compounds might improve the accuracy of determining flavonoid intake.
SCIENTIFIC REPORTS
(2021)
Article
Respiratory System
Bakari Ibrahim, Djamal Achour, Farid Zerimech, Patricia de Nadai, Valerie Siroux, Anne Tsicopoulos, Regis Matran, Vanessa Granger, Rachel Nadif
Summary: In non-severe asthma, TSLP may be an interesting cytokine and its determinants of circulating levels could be considered in asthma management.
Article
Medicine, General & Internal
Hannah Lishman, Nathan C. Nickel, Hind Sbihi, Max Xie, Abdullah Mamun, Bei Yuan Zhang, Caren Rose, Patricia Janssen, Ashley Roberts, Meghan B. Azad, Stuart Turvey, David M. Patrick
Summary: This study aims to investigate the relationship between infant antibiotic use and the risk of allergic conditions in children. The analysis will be conducted on data from children born in British Columbia and Manitoba over a 10-year period. The findings will be published in scientific journals and presented at conferences.
Article
Immunology
Sharon Van Nevel, Judith van Ovost, Gabriele Holtappels, Natalie De Ruyck, Nan Zhang, Harald Braun, Tania Maes, Claus Bachert, Olga Krysko
Summary: This study investigates the role of neutrophils in allergic airway inflammation in BALB/c and C57BL/6 mice exposed to Alternaria alternata. The findings demonstrate that BALB/c mice show a neutrophilic response to Alt extract, while C57BL/6 mice exhibit eosinophilic infiltration as the main response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Respiratory System
Sanna Toppila-Salmi, Riikka Lemmetyinen, Sebastien Chanoine, Jussi Karjalainen, Juha Pekkanen, Jean Bousquet, Valerie Siroux
Summary: Male sex, smoking, NERD, comorbidities, and >= 2 siblings were identified as independent risk factors for self-reported severe asthma. The effects of these factors appear to be cumulative, with each additional risk factor gradually increasing the risk of severe asthma.
BMC PULMONARY MEDICINE
(2021)
Article
Allergy
Samuel Cerps, Asger Sverrild, Sangeetha Ramu, Juan Jose Nieto-Fontarigo, Hamid Akbarshahi, Mandy Menzel, Cecilia Andersson, Sofia Tillgren, Morten Hvidtfeldt, Celeste Porsbjerg, Lena Uller
Summary: This study found that exposure to house dust mite (HDM) affected the anti-viral and anti-bacterial responses in airway epithelial cells of allergic asthma patients, potentially leading to asthma exacerbations. However, HDM exposure did not affect the release of TSLP, a driver of T2 inflammation.
Article
Medicine, General & Internal
Cecilie Svanes, Ane Johannessen, Randi Jacobsen Bertelsen, Shyamali Dharmage, Bryndis Benediktsdottir, Lennart Braback, Thorarinn Gislason, Mathias Holm, Oskar Jogi, Caroline J. Lodge, Andrei Malinovschi, Jesus Martinez-Moratalla, Anna Oudin, Jose Luis Sanchez-Ramos, Signe Timm, Christer Janson, Francisco Gomez Real, Vivi Schlunssen
Summary: The RHINESSA cohort aims to investigate the impact of exposures before conception and in previous generations on health and disease, particularly allergies and respiratory health. Data collected so far suggests that parental environment and male prepuberty may play important roles in asthma and lung function. Future plans include follow-up studies and linkage with health registries.
Article
Public, Environmental & Occupational Health
Abate Bekele Belachew, Aino K. Rantala, Maritta S. Jaakkola, Timo T. Hugg, Reija Ruuhela, Jaakko Kukkonen, Jouni J. K. Jaakkola
Summary: This study found that a decrease in average winter temperature is associated with an increased risk of developing new asthma. A cold winter with below normal temperatures increases the risk of new asthma by 41% in the following year.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Respiratory System
Subhabrata Moitra, Anne-Elie Carsin, Michael J. Abramson, Simone Accordini, Andre F. S. Amaral, Josep Anto, Roberto Bono, Lidia Casas Ruiz, Isa Cerveri, Leda Chatzi, Pascal Demoly, Sandra Dorado-Arenas, Bertil Forsberg, Frank Gilliland, Thorarinn Gislason, Jose A. Gullon, Joachim Heinrich, Mathias Holm, Christer Janson, Rain Jogi, Francisco Gomez Real, Debbie Jarvis, Benedicte Leynaert, Dennis Nowak, Nicole Probst-Hensch, Jose Luis Sanchez-Ramos, Chantal Raherison-Semjen, Valerie Siroux, Stefano Guerra, Manolis Kogevinas, Judith Garcia-Aymerich
Summary: This study is the first to show that adults with asthma have a higher risk of developing obesity compared to those without asthma, especially among non-atopic individuals, those with longer disease duration, or those taking oral corticosteroids.
Article
Environmental Sciences
Rachael E. Rush, Karen C. Dannemiller, Samuel J. Cochran, Sarah R. Haines, Luis Acosta, Adnan Divjan, Andrew G. Rundle, Rachel L. Miller, Matthew S. Perzanowski, Tara L. Croston, Brett J. Green
Summary: This study analyzed bedroom floor dust samples from homes in New York City and found significant associations between Vishniacozyma victoriae (V. victoriae) and factors such as carpeting, humidity, seasons, and pets. Additionally, V. victoriae concentrations were lower in homes with children who have asthma, especially among non-seroatopic children.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2022)
Article
Respiratory System
Bright Nwaru, Holly Tibble, Syed A. Shah, Rebecca Pillinger, Susannah McLean, Dermot P. Ryan, Hilary Critchley, David B. Price, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, Aziz Sheikh
Summary: The study found that the use of hormonal contraceptives may reduce the risk of severe asthma exacerbation in reproductive-age women with asthma, and longer duration of use was associated with better outcomes.
Article
Allergy
Christian J. Carlsson, Morten A. Rasmussen, Susanne B. Pedersen, Ni Wang, Jakob Stokholm, Bo L. Chawes, Klaus Bonnelykke, Hans Bisgaard
Summary: The study found that upper airway immune mediator levels were altered during episodes of asthma-like symptoms, and levels of TNF-alpha, CCL22, and IL-10 may predict the response to azithromycin treatment.
Review
Allergy
Mariana Farraia, Ines Paciencia, Francisca Castro Mendes, Joao Cavaleiro Rufo, Mohamed Shamji, Ioana Agache, Andre Moreira
Summary: This study aimed to assess the preventive role of allergen immunotherapy (AIT) in asthma onset. The findings suggest a potential preventive effect of AIT in asthma onset, particularly in children completing 3 years of therapy and in mono-sensitized patients.
Article
Respiratory System
Hajar Ali, Collin Brooks, Julian Crane, Richard Beasley, Stephen Holgate, Peter Gibson, Philip Pattemore, Yu-Chieh Tzeng, Thorsten Stanley, Neil Pearce, Jeroen Douwes
Summary: Non-eosinophilic asthma (NEA) demonstrates heightened capsaicin sensitivity compared to non-asthmatics, while eosinophilic asthma (EA) does not show significant differences. Sensory nerve reactivity may play an important role in the pathophysiology of NEA.
BMJ OPEN RESPIRATORY RESEARCH
(2021)
Review
Respiratory System
Bo Lundback, Helena Backman, Jan Lotvall, Eva Ronmark
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2016)
Article
Chemistry, Analytical
Deborah L. M. Rupert, Ganesh V. Shelke, Gustav Emilsson, Virginia Claudio, Stephan Block, Cecilia Lasser, Andreas Dahlin, Jan O. Lotvall, Marta Bally, Vladimir P. Zhdanov, Fredrik Hook
ANALYTICAL CHEMISTRY
(2016)
Article
Engineering, Biomedical
Taral R. Lunavat, Su Chul Jang, Lisa Nilsson, Hyun Taek Park, Gabriela Repiska, Cecilia Lasser, Jonas A. Nilsson, Yong Song Gho, Jan Lotvall
Article
Allergy
Mary Kampe, Maria Vosough, Andrei Malinovschi, Mohammad Alimohammadi, Kjell Alving, Bertil Forsberg, Jan Lotvall, Roelinde Middelveld, Barbro Dahlen, Christer Janson
Article
Allergy
Linda Ekerljung, Roxana Mincheva, Stig Hagstad, Anders Bjerg, Gunilla Telg, Georgios Stratelis, Jan Lotvall
Article
Multidisciplinary Sciences
Taral R. Lunavat, Lesley Cheng, Berglind O. Einarsdottir, Roger Olofsson Bagge, Somsundar Veppil Muralidharan, Robyn A. Sharples, Cecilia Lasser, Yong Song Gho, Andrew F. Hill, Jonas A. Nilsson, Jan Lotvall
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Allergy
Roxana Mincheva, Linda Ekerljung, Apostolos Bossios, Bo Lundback, Jan Lotvall
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2018)
Review
Cell Biology
Oscar P. B. Wiklander, Meadhbh A. Brennan, Jan Lotval, Xandra O. Breakefield, Samir EL Andaloussi
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Cell Biology
Elisa Lazaro-Ibanez, Cecilia Lasser, Ganesh Vilas Shelke, Rossella Crescitelli, Su Chul Jang, Aleksander Cvjetkovic, Anais Garcia-Rodriguez, Jan Lotvall
JOURNAL OF EXTRACELLULAR VESICLES
(2019)
Article
Cell Biology
Su Chul Jang, Rossella Crescitelli, Aleksander Cvjetkovic, Valerio Belgrano, Roger Olofsson Bagge, Karin Sundfeldt, Takahiro Ochiya, Raghu Kalluri, Jan Lotvall
JOURNAL OF EXTRACELLULAR VESICLES
(2019)
Article
Biochemistry & Molecular Biology
Patricia Ramos-Ramirez, Carina Malmhall, Kristina Johansson, Mikael Adner, Jan Lotvall, Apostolos Bossios
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Editorial Material
Cell Biology
Giovanni Camussi, Jan Lotvall
JOURNAL OF EXTRACELLULAR VESICLES
(2023)
Article
Cell Biology
Davide Zabeo, Aleksander Cvjetkovic, Cecilia Lasser, Martin Schorb, Jan Lotvall, Johanna L. Hoog
JOURNAL OF EXTRACELLULAR VESICLES
(2017)
Article
Oncology
Elisa Lazaro-Ibanez, Taral R. Lunavat, Su Chul Jang, Carmen Escobedo-Lucea, Jorge Oliver-De La Cruz, Pia Siljander, Jan Lotvall, Marjo Yliperttula
Article
Cell Biology
Carolina Soekmadji, Andrew F. Hill, Marca H. Wauben, Edit I. Buzas, Dolores Di Vizio, Chris Gardiner, Jan Lotvall, Susmita Sahoo, Kenneth W. Witwer
JOURNAL OF EXTRACELLULAR VESICLES
(2018)