Article
Biochemistry & Molecular Biology
Vittoria Ventura, Magda Viani, Francesco Bianchi, Miriana d'Alessandro, Piersante Sestini, Elena Bargagli
Summary: Patients with pulmonary fibrosis experience early oxyhemoglobin desaturation under effort, limiting their exercise ability and quality of life. Recent studies have shown that outpatient oxygen administration significantly improves stress dyspnoea and quality of life in hypoxemic patients. The authors tested the hypothesis that correcting hypoxemia could reduce the increase in respiratory effort during the 6 min walking test.
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Tarun Virmani, Girish Kumar, Reshu Virmani, Ashwani Sharma, Kamla Pathak
Summary: This article provides updated information on the treatment of COPD, with a focus on nanocarrier-based approaches and the potential of gene therapy and stem cell therapy to combat COPD.
Review
Biochemistry & Molecular Biology
Jun Watanabe, Kazuhiko Kotani, Alejandro Gugliucci
Summary: Overall, patients with COPD had lower PON1 activity, indicating impaired PON1-related antioxidant defense in COPD. Further studies are needed.
Article
Environmental Sciences
L. I. Yun Xiao, W. A. N. G. Jun, W. U. Bo, L. I. N. Fang, T. A. N. Chun Ting, Y. U. Gang Gang, N. I. E. Shan, Z. H. A. O. Ran Ran, X. U. Bo
Summary: This study evaluated the effect of maximal oxygen pulse (O2Pmax) on patients with chronic obstructive pulmonary disease (COPD) and confirmed its predictive effect on acute exacerbations of COPD (AECOPD). The results showed that O2Pmax was associated with exercise capacity, ventilatory conditions, gas exchange efficiency, and dyspnea symptoms, and could be used to predict AECOPD.
BIOMEDICAL AND ENVIRONMENTAL SCIENCES
(2022)
Article
Medicine, General & Internal
James Anderson, Tiffany Hoang, Karen Hay, George Tay
Summary: The study revealed a correlation between oxygen overuse and adverse events in hospitalized patients with hypercapnic COPD. Oxygen prescription rates were suboptimal, and patients with over-oxygenation had a higher risk of adverse events.
INTERNAL MEDICINE JOURNAL
(2021)
Article
Respiratory System
Taehwa Kim, Sungchul Huh, Jae Heun Chung, Yun Seong Kim, Ra Yu Yun, Onyu Park, Seung Eun Lee
Summary: This study aimed to analyze the association between diaphragm function variables and forced expiratory volume in the first second (FEV1) among COPD patients, and to estimate the clinical significance of diaphragm function in the correlation between COPD severity and lung function. The results showed that the right diaphragmatic forced excursion had a significant correlation with FEV1, and the analysis based on the cut-off value of right diaphragmatic forced excursion demonstrated a significant difference between groups. The data suggest that diaphragmatic function should be taken into consideration when interpreting pulmonary function tests.
BMC PULMONARY MEDICINE
(2023)
Article
Respiratory System
Jingzhou Zhang, Dawn L. DeMeo, Edwin K. Silverman, Barry J. Make, R. Chad Wade, J. Michael Wells, Michael H. Cho, Brian D. Hobbs
Summary: The study found that in COPD patients, factors associated with increased risk of secondary polycythemia included male sex, current smoking, severe hypoxemia, impaired DLCO, and enrollment at the Denver clinical center. Continuous or nocturnal supplemental oxygen use was associated with decreased risk of polycythemia.
BMC PULMONARY MEDICINE
(2021)
Review
Medicine, Research & Experimental
Ailin Yang, Ganggang Yu, Yanjun Wu, Haoyan Wang
Summary: Beta-2 adrenergic receptors play crucial roles in the pathogenesis and treatment of COPD. Progress has been made in studying these receptors, and drugs targeting beta 2-AR are rapidly being developed, which are expected to improve symptoms and prognosis for COPD patients.
Article
Respiratory System
Christa M. Todoroff, Michael J. Berry
Summary: This study aimed to determine whether specific body composition measures are significantly associated with physical function and exercise capacity in patients with chronic obstructive pulmonary disease. Results showed that, after controlling for disease severity, appendicular lean mass, total body fat mass, and sex can further predict peak oxygen consumption, 6-minute walk distance, and self-reported physical function in these patients. This suggests that body composition measures have predictive value for exercise capacity and physical function in patients with chronic obstructive pulmonary disease.
COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
(2023)
Article
Integrative & Complementary Medicine
Danielle A. Baxter, Meaghan E. Coyle, Catherine J. Hill, Christopher Worsnop, Johannah L. Shergis
Summary: The study aimed to investigate the feasibility of implementing a manual therapy technique (muscle energy technique, MET) in a hospital pulmonary rehabilitation program for patients with moderate to severe COPD. The results showed that it is feasible to use MET as an adjunct to PR in a hospital setting, with satisfactory recruitment rates and no adverse events related to the MET component of the intervention.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2023)
Review
Medicine, General & Internal
Tim Raveling, Judith Vonk, Fransien M. Struik, Roger Goldstein, Huib A. M. Kerstjens, Peter J. Wijkstra, Marieke L. Duiverman
Summary: Chronic non-invasive ventilation (NIV) can improve arterial blood gases and health-related quality of life in stable COPD patients, while also benefiting post-exacerbation COPD patients in terms of blood gases and admission-free survival. However, the overall impact on exercise capacity and mortality remains uncertain across both populations.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Cardiac & Cardiovascular Systems
Patricia Faria Camargo, Luciana Ditomaso-Luporini, Luiz Carlos Soares de Carvalho Jr, Cassia da Luz Coulart, Polliana Batista dos Santos, Rayane Sebold, Meliza Goi Roscani, Renata Goncalves Mendes, Audrey Borghi-Silva
Summary: The overlap of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea syndrome (OSA) impairs functional capacity and cardiac autonomic control, leading to worse clinical outcomes.
Article
Cardiac & Cardiovascular Systems
Rola Khedraki, Jacob Abraham, Orvar Jonsson, Kunjan Bhatt, Hesham R. R. Omar, Mosi Bennett, Arvind Bhimaraj, Ashrith Guha, Patrick McCann, Evan D. D. Muse, Monique Robinson, Andrew J. J. Sauer, Andrew Cheng, Samantha Bagsic, Marat Fudim, J. Thomas Heywood, Maya Guglin
Summary: In this multicenter study, we investigated the relationship between pulmonary artery pressure (PAP) at rest and post-exercise in heart failure patients with a CardioMEMS sensor. The results showed a significant increase in PAP after exercise, especially in patients with higher baseline pressures.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Arjun B. Chatterjee
ANNALS OF INTERNAL MEDICINE
(2015)
Letter
Respiratory System
Christina R. Bellinger, Arjun B. Chatterjee, Norman Adair, Tim Houle, Irtaza Khan, Edward Haponik
Article
Medicine, General & Internal
Peter E. Morris, Michael J. Berry, D. Clark Files, J. Clifton Thompson, Jordan Hauser, Lori Flores, Sanjay Dhar, Elizabeth Chmelo, James Lovato, L. Douglas Case, Rita N. Bakhru, Aarti Sarwal, Selina M. Parry, Pamela Campbell, Arthur Mote, Chris Winkelman, Robert D. Hite, Barbara Nicklas, Arjun Chatterjee, Michael P. Young
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2016)
Article
Respiratory System
Irtaza Khan, Arjun B. Chatterjee, Christina R. Bellinger, Edward Haponik
Article
Environmental Sciences
Maria C. Mirabelli, Arjun B. Chatterjee, Dana C. Mora, Thomas A. Arcury, Jill N. Blocker, Haiying Chen, Joseph G. Grzywacz, Antonio J. Marin, Mark R. Schulz, Sara A. Quandt
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
(2015)
Article
Allergy
Maria C. Mirabelli, Suzanne F. Beavers, W. Dana Flanders, Arjun B. Chatterjee
Article
Respiratory System
Maria C. Mirabelli, Suzanne F. Beavers, Arjun B. Chatterjee
Article
Respiratory System
Christina R. Bellinger, Arjun B. Chatterjee, Norman Adair, Tim Houle, Irtaza Khan, Edward Haponik
Article
Cardiac & Cardiovascular Systems
Maria C. Mirabelli, Suzanne F. Beavers, Arjun B. Chatterjee, Jeanne E. Moorman
RESPIRATORY MEDICINE
(2013)
Article
Public, Environmental & Occupational Health
Gregory D. Kearney, Arjun B. Chatterjee, Jennifer Talton, Haiying Chen, Sara A. Quandt, Phillip Summers, Thomas A. Arcury
JOURNAL OF AGROMEDICINE
(2014)
Article
Respiratory System
Christina R. Bellinger, Irtaza Khan, Arjun B. Chatterjee, Edward F. Haponik
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2017)
Article
Respiratory System
Andrew M. Namen, Arjun Chatterjee, Karen E. Huang, Steven R. Feldman, Edward F. Haponik
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2016)
Article
Public, Environmental & Occupational Health
Joanne C. Sandberg, Jennifer W. Talton, Sara A. Quandt, Haiying Chen, Maria Weir, Walkiria R. Doumani, Arjun B. Chatterjee, Thomas A. Arcury
JOURNAL OF IMMIGRANT AND MINORITY HEALTH
(2014)
Article
Respiratory System
Ali S. Wahla, Arjun Chatterjee, Irtaza I. Khan, John F. Conforti, Edward Haponik
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2014)
Article
Respiratory System
Stacey M. Miller, Christina R. Bellinger, Arjun Chatterjee
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2013)