Article
Veterinary Sciences
Yentel Mateo-Otero, Marc Yeste, Anna Damato, Elisa Giaretta
Summary: This review discusses the impact of cryopreservation on the redox balance of pig oocytes, focusing on the relevance of non-enzymatic and enzymatic antioxidant defenses. It also considers the regulation of gene expression in response to oxidative stress. Finally, the effects of supplementing maturation and vitrification media with exogenous non-enzymatic antioxidants are discussed.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Roberto Gualtieri, Guruprasad Kalthur, Vincenza Barbato, Maddalena Di Nardo, Satish Kumar Adiga, Riccardo Talevi
Summary: Mitochondria play a crucial role in cell metabolism and ATP synthesis, while also being responsible for generating ROS and maintaining calcium homeostasis. Dysfunction in mitochondria can lead to oxidative stress, affecting cell function. Assisted reproductive technologies and cryopreservation may compromise mitochondrial function, impacting reproductive outcomes by affecting sperm and oocyte quality and fertilization dynamics.
Review
Cell Biology
Beijia Cao, Jianpeng Qin, Bo Pan, Izhar Hyder Qazi, Jiangfeng Ye, Yi Fang, Guangbin Zhou
Summary: Oocyte cryopreservation induces oxidative stress and reduces the developmental potential of oocytes. While oocytes have intrinsic antioxidant systems, cryopreservation still causes oxidative damage. Exogenous antioxidants, such as melatonin and resveratrol, can reduce oxidative damage. This review discusses the analysis of oxidative stress induced by oocyte cryopreservation, the impact of antioxidants against oxidative damage, and their underlying mechanisms, providing a reference for improving the efficiency of oocyte cryopreservation.
Article
Environmental Sciences
Xiaofei Jiao, Andressa Gonsioroski, Jodi A. Flaws, Huanyu Qiao
Summary: Exposure to iodoacetic acid (IAA) has adverse effects on mouse oocyte maturation, including metaphase I arrest, polar-body-extrusion failure, abnormal spindle assembly, and chromosome misalignment. IAA exposure increases ROS levels, induces DNA damage, and mediates maturation failure in oocytes through oxidative stress.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Shishi Li, Yier Zhou, Qiongxiao Huang, Xiaohua Fu, Ling Zhang, Fang Gao, Zhen Jin, Limei Wu, Chongyi Shu, Xirong Zhang, Weihai Xu, Jing Shu
Summary: The study found that iron overload in the peritoneal fluid of endometriosis patients can lead to abnormalities in mouse embryo development, mainly through disrupting blastocyst formation, inducing lipid peroxidation, and causing mitochondrial damage to induce embryonic ferroptosis. Furthermore, the ferroptosis inhibitor Fer-1 can alleviate the cytotoxicity caused by iron overload.
CELL DEATH DISCOVERY
(2021)
Article
Reproductive Biology
Tianjie Li, Changyu Liu, Xiumei Zhen, Yang Yu, Jie Qiao
Summary: ActD blocks oocyte maturation at the MI stage by inhibiting chromosome separation and spindle assembly, possibly through inducing nuclear DNA damage and disrupting the mitochondrial function in oocytes.
BIOLOGY OF REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Patricia Cosme, Ana B. Rodriguez, Maria Garrido, Javier Espino
Summary: Infertility is a growing global public health concern that has socio-psychological implications for couples. Advances in reproductive medicine have led to successful treatments like assisted reproductive techniques (ART), but the search for new therapeutic tools to improve success rates is ongoing. Recent research has focused on the antioxidant properties of pineal indolamine melatonin and its role in reproductive physiology, suggesting it may be a promising agent to counteract the negative effects of oxidative stress in fertility treatments. This narrative review aims to summarize the current state of research on melatonin's importance in reproductive physiology and evaluate its potential use in ART to improve fertility success rates.
Article
Oncology
Yongdong Dai, Xiang Lin, Na Liu, Libing Shi, Feng Zhuo, Qianmeng Huang, Weijia Gu, Fanxuan Zhao, Yi Zhang, Yinli Zhang, Yinbin Pan, Songying Zhang
Summary: Endometriosis is a common gynecological disorder that causes female infertility. Excessive oxidative stress in ovaries of endometriosis patients induced senescence of cumulus granulosa cells. Our research analyzed the transcriptomic and metabolomic profiles of follicles in a mouse model of endometriosis and in patients with endometriosis, and investigated the potential function of changed metabolites in granulosa cells.
JOURNAL OF PATHOLOGY
(2023)
Review
Medicine, General & Internal
Eric Han, David B. Seifer
Summary: Oocyte cryopreservation (OC) is a process of stimulating ovarian follicles, retrieving follicular fluid, isolating and vitrifying mature oocytes. It has been increasingly used as an option for future biologic children for patients undergoing gonadotoxic therapies. Planned OC, also known as elective OC, is growing in popularity to overcome age-related fertility decline. This review discusses medically indicated and planned OC, focusing on the physiology, technique, timing, financial considerations, and outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Ghina Ghazeeri, Christine Beyrouthy, Lina El-taha, May Abiad, Duaa Fahs
Summary: This study aims to assess Lebanese women's awareness and acceptance of egg freezing and found that factors such as age, marital status, and fertility affect women's attitudes towards the technology. Medical egg freezing is widely accepted and the main indication for social egg freezing is to assist women who struggle to find a suitable partner during their peak fertile years. Concerns about safety and future fertility are among the factors that limit women's decision to undergo the procedure.
Article
Reproductive Biology
Xiaofei Jiao, Ning Liu, Yiding Xu, Huanyu Qiao
Summary: The study found that PFNA exposure has toxic effects on mouse oocyte maturation in vitro, inhibiting germinal vesicle breakdown and polar body extrusion, inducing abnormal spindle assembly and damaged mitochondria, leading to oxidative stress, DNA damage, and early-stage apoptosis.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Obstetrics & Gynecology
A. Tsafrir, H. Holzer, T. Miron-Shatz, T. Eldar-Geva, M. Gal, I Ben-ami, N. Dekel, A. Weintruab, D. Goldberg, O. Schonberger, N. Srebnik, J. Hyman
Summary: Most women who underwent planned oocyte cryopreservation did so because they didn't want to become pregnant without a partner. While the majority of those who attempted to conceive were successful, some eventually chose to use donor spermatozoa for conception.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Pharmacology & Pharmacy
Peipei Qiao, Yingbing Zhang, Ying Yang, Ru Meng, Zhiming Xu, Xianlei Jiang, Yong Zhang, Chengtu Zhang, Jianmin Su
Summary: Isoniazid (INH) significantly impairs meiotic progression, increases oxidative stress, induces apoptosis, and disrupts mitochondrial function in mouse oocytes. These effects ultimately lead to reduced fertility and damage to the mammalian reproductive system.
Article
Biochemistry & Molecular Biology
Marika Cordaro, Angela Trovato Salinaro, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Livia Interdonato, Roberto Crea, Roberta Fusco, Salvatore Cuzzocrea, Rosanna Di Paola, Vittorio Calabrese
Summary: Hidrox(R) treatment reduces the area and oxidative damage-related alterations of endometrial implants in endometriosis, as well as alleviates pain behaviors.
Article
Obstetrics & Gynecology
Jennifer K. Blakemore, James A. Grifo, Shannon M. DeVore, Brooke Hodes-Wertz, Alan S. Berkeley
Summary: This study evaluated the outcomes of patients undergoing planned oocyte cryopreservation, finding that 38.1% of patients took action with their cryopreserved oocytes, while 58.9% did not use them. Further research with larger cohorts and epidemiological comparisons to current egg freezing patients are needed.
FERTILITY AND STERILITY
(2021)
Article
Andrology
A. Agarwal, R. Sharma, A. Singh, S. Gupta, R. Sharma
Meeting Abstract
Urology & Nephrology
Rakesh Sharma, Ashok Agarwal, Ahmet Ayaz, Edmund Sabanegh
JOURNAL OF UROLOGY
(2015)
Editorial Material
Urology & Nephrology
Ashok Agarwal, Rakesh Sharma
Article
Urology & Nephrology
Ashok Agarwal, Reecha Sharma, Sajal Gupta, Rakesh Sharma
Article
Urology & Nephrology
Ashok Agarwal, Rakesh Sharma, Damayanthi Durairajanayagam, Zhihong Cui, Ahmet Ayaz, Sajal Gupta, Belinda Willard, Banu Gopalan, Edmund Sabanegh
Article
Genetics & Heredity
Rakesh Sharma, Gulfam Ahmad, Sandro C. Esteves, Ashok Agarwal
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2016)
Editorial Material
Urology & Nephrology
Ashok Agarwal, Sandro C. Esteves, Sajal Gupta, Rakesh Sharma, Stefan Du Plessis, Edmund Sabanegh
Article
Obstetrics & Gynecology
Ahmad Majzoub, Nicholas N. Tadros, A. Scott Polackwich, Rakesh Sharma, Ashok Agarwal, Edmund Sabanegh
FERTILITY AND STERILITY
(2017)
Article
Obstetrics & Gynecology
Ashok Agarwal, Shubhadeep Roychoudhury, Rakesh Sharma, Sajal Gupta, Ahmad Majzoub, Edmund Sabanegh
REPRODUCTIVE BIOMEDICINE ONLINE
(2017)
Article
Andrology
S. Ribeiro, R. Sharma, S. Gupta, Z. Cakar, C. De Geyter, A. Agarwal
Article
Andrology
A. Agarwal, R. Henkel, R. Sharma, N. N. Tadros, E. Sabanegh
Article
Andrology
S. Gunes, A. Agarwal, R. Henkel, A. M. Mahmutoglu, R. Sharma, S. C. Esteves, A. Aljowair, D. Emirzeoglu, A. Alkhani, L. Pelegrini, A. Joumah, E. Sabanegh
Article
Andrology
M. Arafa, A. Agarwal, S. Al Said, A. Majzoub, R. Sharma, K. B. Bjugstad, K. AlRumaihi, H. Elbardisi
Article
Andrology
A. Agarwal, R. Sharma, R. Henkel, S. Roychoudhury, S. C. Sikka, S. du Plessis, Y. B. Sarda, C. Speyer, M. Nouh, C. Douglas, Z. Kayali, A. Elshaer, E. Sabanegh
Article
Andrology
G. Ahmad, A. Agarwal, S. C. Esteves, R. Sharma, M. Almasry, A. Al-Gonaim, G. AlHayaza, N. Singh, L. Al Kattan, W. M. Sannaa, E. Sabanegh
