Review
Obstetrics & Gynecology
Brid Ni Dhonnabhain, Nagla Elfaki, Kyra Fraser, Aviva Petrie, Benjamin P. Jones, Srdjan Saso, Paul J. Hardiman, Natalie Getreu
Summary: This study compares obstetric outcomes in cancer patients who undergo cryopreservation of reproductive cells or tissues before gonadotoxic therapy. The results indicate that cryopreservation of oocytes, embryos, and ovarian tissue has similar effectiveness in terms of clinical pregnancy and live birth rates. However, ovarian tissue cryopreservation is associated with a significantly lower miscarriage rate compared to embryo cryopreservation.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Dalila Invernici, Marco Reschini, Laura Benaglia, Edgardo Somigliana, Giulia Galati, Irene La Vecchia, Paola Vigano', Paolo Vercellini
Summary: This study found that endometriosis does not significantly affect the success of IVF, except for an increased risk of unexpected poor response.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Medicine, Research & Experimental
Que Wu, Gaizhen Ru, Wanfen Xiao, Qian Wang, Zhiling Li
Summary: A study on ovarian cryopreservation and transplantation in a murine model showed a decrease in oocyte numbers, abnormal endocrine function of ovarian grafts, dysfunctional mitochondria and DNA damage in the oocytes after transplantation. However, these adverse phenotypes were partially or completely resolved within 21 days of transplantation.
Article
Obstetrics & Gynecology
S. J. Leathersich, C. S. Roche, M. Walls, E. Nathan, R. J. Hart
Summary: Does the season of oocyte retrieval affect live birth rates in frozen embryo transfers? A study found that frozen embryo transfers resulting from oocytes retrieved in summer have a 30% higher odds of live birth compared to those retrieved in autumn, regardless of the season at the time of embryo transfer.
HUMAN REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Konstantinos Sfakianoudis, Evangelos Maziotis, Eleni Karantzali, Georgia Kokkini, Sokratis Grigoriadis, Amelia Pantou, Polina Giannelou, Konstantina Petroutsou, Christina Markomichali, Maria Fakiridou, Michael Koutsilieris, Byron Asimakopoulos, Konstantinos Pantos, Mara Simopoulou
Summary: Developmental arrest of the preimplantation embryo is a multifactorial condition involving embryonic and parental factors, with genetic origins analyzed from both perspectives. This systematic review provides valuable insights into the molecular drivers of developmental arrest, laying the groundwork for further research in the field. The variety and complexity of factors contributing to developmental arrest make it difficult to prioritize one definitive cause.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Naomi Nakagata, Satohiro Nakao, Nobuyuki Mikoda, Katsuma Yamaga, Toru Takeo
Summary: This study used an inverted microscope to observe the process of fertilization and subsequent development of frozen-thawed rat sperm in vitro. It was found that the sperm attached to the zona pellucida 2-3 hours after thawing, penetrated into the oocytes after 3-5 hours, and formed pronuclei in the cytoplasm 5-9 hours after insemination. The frozen-thawed sperm from SD, Wistar, LE, and F344 strains showed higher fertility rates, while the sperm from the BN strain exhibited lower motility and fertility rates.
Review
Biochemistry & Molecular Biology
Seongmin Kim, Sung-Woo Kim, Soo-Jin Han, Sanghoon Lee, Hyun-Tae Park, Jae-Yun Song, Tak Kim
Summary: Fertility preservation is an emerging discipline with substantial clinical value for young cancer patients. Chemotherapy and radiation can harm ovarian function, with oxidative stress and oocyte radiosensitivity being identified as main causes of ovarian damage. The importance of oncofertility strategies that consider various factors for high-quality care for young female cancer patients is highlighted in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Dunja M. Baston-Bust, Alexandra P. Bielfeld
Summary: Counseling children on fertility preservation before gonadotoxic treatment helps in decision-making for vulnerable patients. Referral to specialists should be optimized with easy contact information and clear information about available options.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Obstetrics & Gynecology
Laura Lotz, Anna Dietl, Inge Hoffmann, Anrdreas Mueller, Stefanie Burghaus, Matthias Wilhelm Beckmann, Ralf Dittrich
Summary: This study investigates the association between endometriosis and premature menopause, and finds that endometriosis can occur in women after premature menopause. The study results show a pregnancy rate of 41.2% and a live birth rate of 35.3% after transplantation.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Obstetrics & Gynecology
He Li, Xiaoxi Sun, Junyi Yang, Lu Li, Wenbi Zhang, Xiang Lu, Junling Chen, Hua Chen, Min Yu, Wei Fu, Xiandong Peng, Jiazhou Chen, Ernest Hung Yu Ng
Summary: The study compared immediate and delayed frozen embryo transfers following a stimulated IVF cycle and found that immediate FET resulted in significantly higher ongoing pregnancy and live birth rates. This suggests that immediate FET may be more effective after a stimulated IVF cycle.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Dunja M. Baston-Buest, Iwona Scheliga, Alexandra P. Bielfeld
Summary: Establishing and maintaining a new cryobank for ovarian tissue in a university setting requires prior notice of at least 1 year for financial, spatial, lab equipment, and employee planning. The newly founded team should introduce themselves to hospitals and health systems via mail, flyers, and symposia, and provide potential referrers with standard operating procedures and advice. Internal audits should be conducted in the first year to prevent difficulties.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Udayanga Sanath Kankanam Gamage, Shu Hashimoto, Yuki Miyamoto, Tatsuya Nakano, Masaya Yamanaka, Akiko Koike, Manabu Satoh, Yoshiharu Morimoto
Summary: This study investigates the supplementation of autologous adipose stem cell mitochondria in vitrified and warmed oocytes and finds that this supplementation can restore damaged mitochondrial quality and enhance embryo developmental capacity.
Article
Obstetrics & Gynecology
Yong Zhu, Feng Zhang, Hua Chen, Xiaoxi Sun, Feng Jiang
Summary: This retrospective study aimed to uncover the effects of using frozen sperm and embryos on the outcomes of in vitro fertilization treatments. The results showed that using frozen embryos and frozen sperm increased the clinical pregnancy rate, live birth rate, and low birth weight rate. The study also found accumulative effects of frozen gametes. These findings are important for both clinical and basic research.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Gilad Karavani, Koral Vedder, Einat Gutman-Ido, Raizl Gruda Sussman, Neta Goldschmidt, Talya Mordechai-Daniel, Assaf Ben-Meir, Tal Imbar
Summary: Chemotherapy exposure does not affect the in vitro maturation (IVM) potential of immature oocytes retrieved from ovarian tissue cryopreservation (OTC), but rather depends on the patient's age. Successful retrieval of immature oocytes from ovarian tissue is negatively affected by chemotherapy and its timing.
HUMAN REPRODUCTION
(2023)
Article
Agriculture, Dairy & Animal Science
Adel R. Moawad, Ali Salama, Magdy R. Badr, Mohamed Fathi
Summary: Supplementation of L-Carnitine (LC) during in vitro maturation (IVM) of canine oocytes improves maturation, fertilization, and preimplantation embryo development rates following IVF and in vitro culture (IVC).
Review
Andrology
Damayanthi Durairajanayagam, Ashok Agarwal, Chloe Ong, Pallavi Prashast
ASIAN JOURNAL OF ANDROLOGY
(2014)
Editorial Material
Medicine, General & Internal
Sandro C. Esteves, Ashok Agarwal
Article
Obstetrics & Gynecology
Samuel James Alexander Dobson, Maria Teresita Lao, Essarn Michael, Alex C. Varghese, Kannamannadiar Jayaprakasan
FERTILITY AND STERILITY
(2018)
Review
Urology & Nephrology
Sandro C. Esteves, Rakesh K. Sharma, Jaime Gosalvez, Ashok Agarwal
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2014)
Review
Endocrinology & Metabolism
Rakesh Sharma, Kelly R. Biedenharn, Jennifer M. Fedor, Ashok Agarwal
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2013)
Article
Endocrinology & Metabolism
Rakesh Sharma, Ashok Agarwal, Gayatri Mohanty, Alaa J. Hamada, Banu Gopalan, Belinda Willard, Satya Yadav, Stefan du Plessis
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2013)
Article
Endocrinology & Metabolism
Ashok Agarwal, Eva Tvrda, Rakesh Sharma
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2014)
Article
Endocrinology & Metabolism
Ashok Agarwal, Rakesh K. Sharma, Reecha Sharma, Mourad Assidi, Adel M. Abuzenadah, Saad Alshahrani, Damayanthi Durairajanayagam, Edmund Sabanegh
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2014)
Review
Obstetrics & Gynecology
Rakesh K. Sharma, Ali Azeem, Ashok Agarwal
REPRODUCTIVE SCIENCES
(2013)
Article
Andrology
Ashok Agarwal, Aditi Mulgund, Rakesh Sharma, Edmund Sabanegh
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2014)
Review
Biotechnology & Applied Microbiology
Sajal Gupta, Jana Ghulmiyyah, Rakesh Sharma, Jacques Halabi, Ashok Agarwal
BIOMED RESEARCH INTERNATIONAL
(2014)
Review
Andrology
Ashok Agarwal, Gurpriya Virk, Chloe Ong, Stefan S. du Plessis
WORLD JOURNAL OF MENS HEALTH
(2014)
Article
Physiology
R. Saha, S. Roychoudhury, K. Kar, A. C. Varghese, P. Nandi, G. D. Sharma, G. Formicki, P. Slama, A. Kolesarova
PHYSIOLOGICAL RESEARCH
(2019)
Article
Reproductive Biology
Sreyashi Mitra, Alex C. Varghese, Syamsundar Mandal, Sayantan Bhattacharyya, Parag Nandi, Syed M. Rahman, Kushal Kumar Kar, Rinku Saha, Shubhadeep Roychoudhury, Nabendu Murmu
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Food Science & Technology
Rinku Saha, Shubhadeep Roychoudhury, Kushal Kumar Kar, Alex C. Varghese, Parag Nandi, Sreyashi Mitra, Nabendu Murmu, Peter Massanyi, Adriana Kolesarova
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES
(2018)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)