Article
Pharmacology & Pharmacy
N. Turktekin, C. Karakus, R. Ozyurt
Summary: This study compared the effectiveness of calcium gluconate and cabergoline therapy in preventing ovarian hyperstimulation syndrome (OHSS). The results showed that calcium gluconate treatment is not effective in preventing OHSS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Zhonglu Ren, Yunfei Gao, Yue Gao, Guanmei Liang, Qian Chen, Sijia Jiang, Xiaoxue Yang, Cuixia Fan, Haizhen Wang, Jing Wang, Yi-Wu Shi, Chaoqun Xiao, Mei Zhong, Xinping Yang
Summary: The study found that early-onset severe preeclampsia and late-onset severe preeclampsia have different molecular mechanisms, with the former associated with metabolism-related pathways and the latter with immune-related pathways. Some key transcription factors may be driving the widespread gene dysregulation in both early-onset and late-onset patients.
Article
Cardiac & Cardiovascular Systems
Parisa Torabi, Giulia Rivasi, Viktor Hamrefors, Andrea Ungar, Richard Sutton, Michele Brignole, Artur Fedorowski
Summary: The age at first syncope impacts the final diagnosis, with a bimodal distribution of first-ever syncope incidence. Older patients are more likely to present recent syncope with orthostatic hypotension and carotid sinus syndrome being more common. In patients with early-onset syncope, vasovagal and complex syncope are more common.
EUROPEAN HEART JOURNAL
(2022)
Review
Cell Biology
Thibaut Gauvrit, Hamza Benderradji, Luc Buee, David Blum, Didier Vieau
Summary: As the population ages, the incidence of neurodegenerative disorders, particularly Alzheimer's disease, has increased dramatically. AD is a complex disease affected by both genetic and environmental factors, with epigenetic mechanisms playing a role. Early environmental exposure and epigenetic mechanisms may influence the development of late-onset AD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Obstetrics & Gynecology
Ginevra Mills, Michael H. Dahan
Summary: In the study, the use of GnRH antagonists in GnRH agonist cycles was found to reduce the risk of developing moderate and severe OHSS by promoting luteolysis and downregulating VEGF production and receptor response, thereby decreasing vascular permeability.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Review
Infectious Diseases
Alberto Berardi, Viola Trevisani, Antonella Di Caprio, Jenny Bua, Mariachiara China, Barbara Perrone, Rossella Pagano, Laura Lucaccioni, Silvia Fanaro, Lorenzo Lughetti, Licia Lugli, Roberta Creti
Summary: Group B streptococcus (GBS) infection remains a leading cause of sepsis, pneumonia, and meningitis in infants, with early onset cases decreasing due to widespread use of intrapartum antibiotics, leading to late-onset infections as common presentation. The pathogenesis, mode of transmission, and risk factors for LOGBS are unclear, hindering effective prevention efforts.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Clinical Neurology
Salvatore Spina, Renaud La Joie, Cathrine Petersen, Amber L. Nolan, Deion Cuevas, Celica Cosme, Mackenzie Hepker, Ji-Hye Hwang, Zachary A. Miller, Eric J. Huang, Anna M. Karydas, Harli Grant, Adam L. Boxer, Maria Luisa Gorno-Tempini, Howard J. Rosen, Joel H. Kramer, Bruce L. Miller, William W. Seeley, Gil D. Rabinovici, Lea T. Grinberg
Summary: Co-pathologies are important in the expression of the clinical phenotype of Alzheimer's disease, with differences in neuropathological diagnoses between early-onset and late-onset patients. Late-onset Alzheimer's disease is more likely to have LATE, hippocampal sclerosis, argyrophilic grain disease, and vascular brain injury.Sex does not significantly impact the number of co-pathologies present.
Article
Obstetrics & Gynecology
Usama M. Fouda, Hesham S. Elshaer, Gamal G. Youssef, Amal Hanafy, Waleed M. Mehrem, Mohamed A. Youssef, Mona Farouk, Hala Nabil
Summary: The study found that calcium infusion and cabergoline are equally effective in preventing OHSS in IVF patients, with no adverse effects on reproductive outcomes. This suggests that calcium infusion can be a cost-effective option for minimizing OHSS incidence in high-risk IVF patients.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Clinical Neurology
Valeria Isella, Daniele Licciardo, Giulia Nastasi, Valentina Impagnatiello, Francesca Ferri, Cristina Mapelli, Cinzia Crivellaro, Monica Musarra, Sabrina Morzenti, Ildebrando Appollonio, Carlo Ferrarese
Summary: Late-onset and early-onset dementia exhibit neurobiological and clinical differences. This study compared the clinical and FDG-PET features of posterior cortical atrophy (PCA), the visual variant of Alzheimer's disease, between late-onset and early-onset cases. The results showed that the main difference between the two groups was a higher prevalence of Balint-Holmes symptoms in the early-onset cases, which was associated with severe bilateral occipito-temporo-parietal hypometabolism. In the late-onset cases, there was a reduction of FDG uptake mainly in the right posterior regions. Age was found to be correlated with metabolism in different brain regions.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Franz Felix Konen, Malte Johannes Hannich, Philipp Schwenkenbecher, Matthias Grothe, Konrad Gag, Konstantin Fritz Jendretzky, Stefan Gingele, Kurt-Wolfram Suhs, Torsten Witte, Thomas Skripuletz, Marie Suesse
Summary: This study investigated the cerebrospinal fluid analysis and immune response in patients with early and late onset multiple sclerosis. The results showed that there was no difference in the frequency of cerebrospinal fluid-specific oligoclonal bands between early and late onset multiple sclerosis patients. However, the sensitivity of positive cerebrospinal fluid free light chains kappa fraction was lower in late onset progressive multiple sclerosis patients. The MRZ reaction had the same frequency of positivity in both early and late onset multiple sclerosis patients.
Review
Surgery
Alexandra M. Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura d'Allens, Caterina Allmer, Andrea Alvarez, Rocio Anula, Mihailo Andric, Sam Atallah, Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Brendan Bebington, Andrew Beggs, Felipe Bellolio, Melissa-Rose Bennett, Anton Berdinskikh, Vicki Bevan, Sebastiano Biondo, Gabriele Bislenghi, Marc Bludau, Adam Boutall, Nelleke Brouwer, Carl Brown, Christiane Bruns, Daniel D. Buchanan, Pamela Buchwald, Jacobus W. A. Burger, Nikita Burlov, Michela Campanelli, Maylis Capdepont, Michele Carvello, Hwee-Hoon Chew, Dimitri Christoforidis, David Clark, Marta Climent, Kyle G. Cologne, Tomas Contreras, Roland Croner, Ian R. Daniels, Giovanni Dapri, Justin Davies, Paolo Delrio, Quentin Denost, Michael Deutsch, Andre Dias, Andre D'Hoore, Evgeniy Drozdov, Daniel Duek, Malcolm Dunlop, Adam Dziki, Aleksandra Edmundson, Sergey Efetov, Alaa El-Hussuna, Brodie Elliot, Sameh Emile, Eloy Espin, Martyn Evans, Seraina Faes, Omar Faiz, Fergal Fleming, Caterina Foppa, George Fowler, Matteo Frasson, Nuno Figueiredo, Tim Forgan, Frank Frizelle, Shamil Gadaev, Jose Gellona, Tamara Glyn, Jianping Gong, Barisic Goran, Emma Greenwood, Marianne G. Guren, Stephanie Guillon, Ida Gutlic, Dieter Hahnloser, Heather Hampel, Ann Hanly, Hirotoshi Hasegawa, Lene Hjerrild Iversen, Andrew Hill, James Hill, Jiri Hoch, Michael Hoffmeister, Roel Hompes, Luis Hurtado, Fabiano Iaquinandi, Ugne Imbrasaite, Rumana Islam, Mehrenah Dorna Jafari, Yukihide Kanemitsu, Aleksei Karachun, Ahmer A. Karimuddin, Deborah S. Keller, Justin Kelly, Rory Kennelly, Gleb Khrykov, Peter Kocian, Cherry Koh, Neils Kok, Katrina A. Knight, Joep Knol, Christos Kontovounisios, Hartwig Korner, Zoran Krivokapic, Irmgard Kronberger, Hidde Maarten Kroon, Marius Kryzauskas, Said Kural, Miranda Kusters, Zaher Lakkis, Timur Lankov, Dave Larson, Gyorgy Lazar, Kai-Yin Lee, Suk Hwan Lee, Jeremie H. Lefevre, Anna Lepisto, Christopher Lieu, Lynette Loi, Craig Lynch, Helene Maillou-Martinaud, Annalisa Maroli, Sean Martin, Anna Martling, Klaus E. Matzel, Julio Mayol, Frank McDermott, Guillaume Meurette, Monica Millan, Martin Mitteregger, Andrei Moiseenko, John R. T. Monson, Stefan Morarasu, Konosuke Moritani, Gabriela Moslein, Martino Munini, Caio Nahas, Sergio Nahas, Ionut Negoi, Anastasia Novikova, Misael Ocares, Koji Okabayashi, Alexandra Olkina, Luis Onate-Ocana, Jaime Otero, Cihan Ozen, Ugo Pace, Guilherme Pagin Sao Juliao, Lidiia Panaiotti, Yves Panis, Demetris Papamichael, Jason Park, Swati Patel, Juan Carlos Patron Uriburu, Miguel Pera, Rodrigo O. Perez, Alexei Petrov, Frank Pfeffer, P. Terry Phang, Tomas Poskus, Heather Pringle, David Proud, Ivana Raguz, Nuno Rama, Shahnawaz Rasheed, Manoj J. Raval, Daniela Rega, Christoph Reissfelder, Juan Carlos Reyes Meneses, Frederic Ris, Stefan Riss, Homero Rodriguez-Zentner, Campbell S. Roxburgh, Avanish Saklani, Andrea Jimenez Salido, Tarik Sammour, Deborah Saraste, Martin Schneider, Ryo Seishima, Aleksandar Sekulic, Toni Seppala, Kieran Sheahan, Rebecca Shine, Alexandra Shlomina, Guiseppe S. Sica, Tongplaew Singnomklao, Leandro Siragusa, Neil Smart, Alejandro Solis, Antonino Spinelli, Roxane D. Staiger, Michael J. Stamos, Scott Steele, Michael Sunderland, Ker-Kan Tan, Pieter J. Tanis, Paris Tekkis, Biniam Teklay, Sabrina Tengku, Marta Jimenez-Toscano, Petr Tsarkov, Matthias Turina, Alexis Ulrich, Bruna B. Vailati, Meike van Harten, Cornelis Verhoef, Satish Warrier, Steve Wexner, Hans de Wilt, Benjamin A. Weinberg, Cameron Wells, Albert Wolthuis, Evangelos Xynos, Nancy You, Alexander Zakharenko, Justino Zeballos, Des C. Winter
Summary: The incidence of early-onset colorectal cancer is increasing globally, with unique clinical, pathological, and molecular characteristics compared to late-onset disease. While genetic predisposition plays a role, most cases are sporadic and the full spectrum of implicated sequence variations remains unknown. Potential risk factors include a Westernized diet, obesity, antibiotic usage, and alterations in the gut microbiome. Despite early-onset patients being more likely to receive treatment, their oncological outcomes are comparable to older patients.
Article
Neurosciences
Meiling Liu, Ben Chen, Xiaomei Zhong, Min Zhang, Qiang Wang, Huarong Zhou, Zhangying Wu, Le Hou, Qi Peng, Si Zhang, Minfeng Yang, Gaohong Lin, Yuping Ning
Summary: There is a difference in odor identification (OI) dysfunction between patients with late onset depression (LOD) and early onset depression (EOD), with LOD patients exhibiting worse OI. Additionally, OI dysfunction is not significantly correlated with cognitive function in LOD patients.
Article
Multidisciplinary Sciences
Alina Miron, Sorcha Ni Dhubhghaill, Viridiana Kocaba, Martine J. J. Jager, Gerrit R. J. Melles, Silke Oellerich
Summary: In this study, the migration of peripheral corneal endothelial cells was observed in vitro with and without a ROCK-inhibitor. Cultured corneal endothelial graft rims demonstrated both single regions and collective areas of cell migration, regardless of the presence or absence of ROCK-inhibition. Cell migration started after 4±2 days and continued for at least 29 days. The presence of a ROCK-inhibitor seemed to contribute to a more regular cell morphology of migrating cells, while a distinct late-onset and fast-growing cell population appeared in some rims.
Article
Pediatrics
Natasha S. Ching, Jim P. Buttery, Emily Lai, Andrew C. Steer, Jane Standish, Joel Ziffer, Andrew J. Daley, Richard Doherty
Summary: The study found no association between breastfeeding and the increased risk of LOGBS. Breast milk should not be tested for GBS during the initial episode of LOGBS.
Article
Immunology
Michelle Broekhuizen, Emilie Hitzerd, Thierry P. P. van den Bosch, Jasper Dumas, Robert M. Verdijk, Bas B. van Rijn, A. H. Jan Danser, Casper H. J. van Eijck, Irwin K. M. Reiss, Dana A. M. Mustafa
Summary: This study revealed distinct immunological alterations in early-onset preeclampsia compared to late-onset preeclampsia, with reduced expression of complement and Toll-like receptor associated genes, as well as decreased numbers of mast cells and M2 macrophages in early-onset preeclampsia placentas. Tailored treatments for each subtype may be desirable based on the differing immune profiles observed.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
