Article
Peripheral Vascular Disease
Brooke Armistead, Leena Kadam, Emily Siegwald, Fergus P. McCarthy, John C. Kingdom, Hamid-Reza Kohan-Ghadr, Sascha Drewlo
Summary: Preeclampsia is a severe hypertensive disorder of pregnancy caused by placental villi pathology leading to widespread maternal endothelial dysfunction. Modulating trophoblast differentiation pathway through PPAR gamma-GCM1 axis may reduce excessive sFLT1 production and improve clinical outcomes. Pharmacological manipulation of PPAR gamma activity shows potential to rescue the antiangiogenic state of preeclampsia.
Article
Immunology
John Walles, Niclas Winqvist, Stefan R. Hansson, Erik Sturegard, Haitham Baqir, Anna Westman, Torbjoern Kjerstadius, Thomas Schon, Per Bjorkman
Summary: Among immigrant women seeking antenatal care in Sweden, Tuberculosis infection (TBI) was independently associated with adverse pregnancy outcomes, including stillbirth, severe preeclampsia, low birthweight, and emergency cesarean section. Further studies are needed to confirm these findings and investigate mechanisms involved.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Almahamoudou Mahamar, Naissem Andemel, Bruce Swihart, Youssoufa Sidibe, Santara Gaoussou, Amadou Barry, Moussa Traore, Oumar Attaher, Adama B. Dembele, Bacary S. Diarra, Sekouba Keita, Alassane Dicko, Patrick E. Duffy, Michal Fried
Summary: This study in high transmission areas of Mali found that malaria infection during pregnancy increased the risks of stillbirth, preterm delivery, and early neonatal death. While treatment and preventive measures can reduce infections, they are insufficient to prevent severe outcomes. New tools are needed to improve pregnancy outcomes in malaria-endemic areas.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Obstetrics & Gynecology
Daniel L. Rolnik, Roshan J. Selvaratnam, Dagmar Wertaschnigg, Simon Meagher, Euan Wallace, Jon Hyett, Fabricio da Silva Costa, Andrew McLennan
Summary: This study aimed to assess pregnancy outcomes following first trimester combined screening for preterm preeclampsia in Australia. Women who underwent combined screening were less likely to experience preeclampsia, preterm birth, and other pregnancy complications compared to those who received standard care. The screening identified a population at high risk of adverse pregnancy outcomes and low-risk women suitable for less intensive antenatal care.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2022)
Article
Peripheral Vascular Disease
Kelsey McLaughlin, John W. Snelgrove, Melanie C. Audette, Atif Syed, Sebastian R. Hobson, Rory C. Windrim, Nir Melamed, Sergio Carmona, John C. Kingdom
Summary: This study evaluated the association between maternal PlGF levels and pregnancy outcomes in high-risk pregnancies, finding a strong correlation between low PlGF levels and adverse outcomes such as preterm birth, early-onset preeclampsia, and stillbirth.
Article
Medicine, General & Internal
Hee Jeung Lim, Jiyu Sun, Banhyang Min, Myungeun Song, Tae Hun Kim, Byoung Jae Kim, Kyu Ri Hwang, Taek Sang Lee, Hye Won Jeon, Sun Min Kim
Summary: Endometriosis is a major cause of infertility and can lead to adverse pregnancy outcomes. This study compared the clinical characteristics and pregnancy outcomes of women with and without endometriosis, finding that women with endometriosis had significantly more adverse pregnancy outcomes. Additionally, the endometriosis group had a higher rate of cesarean delivery and postpartum complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Tamar Wainstock, Ruslan Sergienko, Eyal Sheiner
Summary: The study revealed that complications during the first pregnancy may increase the risk of preterm delivery in subsequent pregnancies. Therefore, the first pregnancy, even if carried to term, could be a crucial period for identifying women at risk for future preterm deliveries.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Melinda Matyas, Monica Hasmasanu, Ciprian N. Silaghi, Gabriel Samasca, Iulia Lupan, Kovacs Orsolya, Gabriela Zaharie
Summary: The study reveals that early preeclampsia increases the risk of complications in preterm neonates and is correlated with hematological changes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Lisa Hui, Melvin Barrientos Marzan, Stephanie Potenza, Daniel L. Rolnik, Natasha Pritchard, Joanne M. Said, Kirsten R. Palmer, Clare L. Whitehead, Penelope M. Sheehan, Jolyon Ford, Ben W. Mol, Susan P. Walker
Summary: The lockdown restrictions in Melbourne, Australia were associated with a significant increase in preterm stillbirths among pregnant women exposed to the lockdown, but also led to a significant reduction in iatrogenic preterm births for fetal compromise. Further research is needed to understand the relationship between these two findings and to guide future responses to pandemics.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Pharmacology & Pharmacy
Hannah C. Zierden, Rachel L. Shapiro, Kevin DeLong, Davell M. Carter, Laura M. Ensign
Summary: Preterm birth is defined as delivery before 37 weeks of gestation, with 15 million infants born prematurely globally each year, increasing the risk of mortality and health challenges. While the only FDA approved therapy for preventing preterm birth in the U.S. has faced recent setbacks, interdisciplinary efforts are underway to develop next generation therapies to prevent preterm birth and save infant lives. This research aims to better identify women at risk for preterm birth, prevent premature labor, and ultimately improve outcomes for newborns.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Obstetrics & Gynecology
Imogen D. Grant, Dino A. Giussani, Catherine E. Aiken
Summary: Exposure to high altitude is associated with higher maternal blood pressure at term and increased prevalence of hypertensive disorders of pregnancy. Gestational hypertension is nearly twice as common at high altitude compared to low altitude, while the prevalence of preeclampsia is halved. The risk of stillbirth is also significantly increased at high altitude.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Psychiatry
Julia Izsak, Dimitra Falari, Pia Arnbert, Daniel Pouragheli, Jenny M. Kindblom, Daina Lasaitiene
Summary: This case report describes the development of preeclampsia in a pregnant woman after 3 weeks of treatment with olanzapine, suggesting a potential association between olanzapine and preeclampsia.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Obstetrics & Gynecology
Victoria Fashakin, Jeremy M. Weber, Tracy Truong, Amanda Craig, Sarahn M. Wheeler, Andra H. James
Summary: The incidence of preterm birth is significantly higher in women with sickle cell disease, and it is more likely to be medically indicated.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Review
Medicine, General & Internal
Yingying Tian, Xiuhua Yang
Summary: Uterine artery Doppler can predict significant vascular events during pregnancy, and predicting pregnancy complications in advance can reduce harm to mothers and neonates.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, General & Internal
Charles Garabedian, Ninon Dupuis, Christophe Vayssiere, Laurence Bussieres, Yves Ville, Benoit Renaudin, Louise Dugave, Norbert Winer, Nathalie Banaszkiewicz, Patrick Rozenberg, Manon Defrance, Marie-Laure Legris, Thibaud Quibel, Philippe Deruelle
Summary: This study aimed to evaluate the association between COVID-19 lockdown and pregnancy outcomes in maternity hospitals in France, finding that the lockdown did not impact pregnancy outcomes, including preterm birth, low birth weight, very low birth weight, and stillbirth rates.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Obstetrics & Gynecology
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Gordon Rukundo, Fouzia Farooq, Kacey Ferguson, Sasha Baumann, Kristina Maria Adams Waldorf, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Elisa Bevilacqua, Nabal Bracero, Justin S. Brandt, Natalie Broutet, Jorge Carrillo, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Maria del Mar Gil, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Irene Fernandez Buhigas, Valerie Flaherman, Christopher Gale, Christine L. Godwin, Sami Gottlieb, Eduard Gratacos, Siran He, Olivia Hernandez, Stephanie Jones, Sheetal Joshi, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen L. Kotloff, Antonio Lanzone, Valentina Laurita Longo, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Torri D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Olof Stephansson, Marleen Temmerman, Anna Thorson, Soe Soe Thwin, Beth A. Tippett Barr, Jorge E. Tolosa, Niyazi Tug, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Clare Whitehead, Mollie Wood, Huixia Yang, Rebecca Zavala, James M. Tielsch
Summary: This sequential, prospective meta-analysis aimed to identify risk factors among pregnant and postpartum women with COVID-19 for adverse outcomes related to disease severity, maternal morbidities, neonatal mortality and morbidity, and adverse birth outcomes. Data from 21 participating studies were included, and risk factors and outcomes were analyzed. The study found that women with comorbidities, HIV infection, prepregnancy underweight, and anemia were at increased risk for severe COVID-19-related outcomes and adverse birth outcomes.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Acoustics
A. Arechvo, D. A. Nikolaidi, M. M. Gil, V. Rolle, A. Syngelaki, R. Akolekar, K. H. Nicolaides
Summary: This study aimed to examine the relationship between the English index of multiple deprivation (IMD) and the incidence of stillbirth and evaluate whether IMD contributes to the prediction of stillbirth provided by maternal demographic characteristics and elements of medical history. The study found that women living in the most deprived areas in South East England had higher rates of stillbirth, particularly placental dysfunction-related stillbirth. However, including IMD in stillbirth screening did not improve the prediction provided by race, other maternal characteristics, and elements of medical history.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
A. Arechvo, A. Wright, A. Syngelaki, P. von Dadelszen, L. A. Magee, R. Akolekar, D. Wright, K. H. Nicolaides
Summary: This study aimed to investigate the relationship between the English Index of Multiple Deprivation (IMD) and the incidence of pre-eclampsia (PE), assess the distribution of IMD in a diverse cohort of pregnant women, and evaluate whether IMD improves the prediction of PE compared to a "history-only" competing-risks model. The results showed that the incidence of PE increased across IMD quintiles, and black women had a higher incidence of PE. However, IMD did not improve the prediction of PE compared to race and other maternal characteristics.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Emily R. Smith, Erin Oakley, Gargi Wable Grandner, Kacey Ferguson, Fouzia Farooq, Yalda Afshar, Mia Ahlberg, Homa Ahmadzia, Victor Akelo, Grace Aldrovandi, Beth A. Tippett Barr, Elisa Bevilacqua, Justin S. Brandt, Nathalie Broutet, Irene Fernandez Buhigas, Jorge Carrillo, Rebecca Clifton, Jeanne Conry, Erich Cosmi, Fatima Crispi, Francesca Crovetto, Camille Delgado-Lopez, Hema Divakar, Amanda J. Driscoll, Guillaume Favre, Valerie J. Flaherman, Chris Gale, Maria M. Gil, Sami L. Gottlieb, Eduard Gratacos, Olivia Hernandez, Stephanie Jones, Erkan Kalafat, Sammy Khagayi, Marian Knight, Karen Kotloff, Antonio Lanzone, Kirsty Le Doare, Christoph Lees, Ethan Litman, Erica M. Lokken, Valentina Laurita Longo, Shabir A. Madhi, Laura A. Magee, Raigam Jafet Martinez-Portilla, Elizabeth M. McClure, Tori D. Metz, Emily S. Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B. Nachega, Marta C. Nunes, Dickens Onyango, Alice Panchaud, Liona C. Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Jonas Soderling, Olof Stephansson, Marleen Temmerman, Anna Thorson, Jorge E. Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M. Tielsch
Summary: Despite heterogeneity in study design and quality, a sequential, prospective meta-analysis found that SARS-CoV-2 infection during pregnancy increases the risk of maternal mortality, severe maternal morbidity, and neonatal morbidity. However, there is no association with stillbirth or intrauterine growth restriction. The findings highlight the importance of preventing and managing SARS-CoV-2 infection in pregnant women. Overall, the study is rated 8 out of 10 in terms of importance.
Article
Obstetrics & Gynecology
Marcos Javier Cuerva, Elena Rodriguez, Marta Perez De Aguado, Maria del Mar Gil, Valeria Rolle, Francisco Lopez, Jose Luis Bartha
Summary: The aim of this study was to assess whether intrapartum ultrasound (ITU) measurements in maternal lateral posture are comparable to ITU measurements in semi-recumbent position. The results showed that the angle of progression (AOP) and head-perineum distance (HPD) were lower in the lateral posture compared to semi-recumbent position, while they were higher with contractions. Therefore, monitoring the second stage of labor with ITU in lateral maternal posture is feasible.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Peripheral Vascular Disease
Laura A. Magee, David Wright, Argyro Syngelaki, Peter von Dadelszen, Ranjit Akolekar, Alan Wright, Kypros H. Nicolaides
Summary: This study aimed to identify the optimal screening and timing of birth strategy for preventing term preeclampsia. The results showed that screening and delivering at 35-36 weeks had the highest efficacy in preventing term preeclampsia.
Article
Oncology
Ignacio Zapardiel, Myriam Gracia Segovia, Ronalds Macuks, Rosanna Mancari, Patriciu Achimas-Cadariu, Giacomo Corrado, Arnoldas Bartusevicius, Vladyslav Sukhin, Juan C. Muruzabal, Pluvio J. Coronado Martin, Barbara Gardella, Jurgen M. Piek, Nicole Concin, Clemente Arab, Dimitrios Papatheodorou, Stephan Polterauer, Sara Iacoponi, Teresa Nieto, Martha C. Lopez-Sanclemente, Hanna Trukhan, Maria M. Gil, Irina Bakinovskaya, Alena Dalamanava, Marc Cucurull, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Marcin Mardas, Siarhei Anatolievich Mavrichev, Jaroslav Klat, Carlos A. Lopez de la Manzanara, Yusuf Yildirim, SARCUT Study Grp
Summary: This retrospective study analyzed 683 patients with uterine sarcoma to identify and evaluate the impact of different prognostic factors on overall survival and disease-free survival. The results showed variations in 5-year overall survival and disease-free survival rates among different subtypes of uterine sarcoma. The presence of residual disease after surgery was identified as the most significant factor affecting overall survival.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Obstetrics & Gynecology
Irene Fernandez-Buhigas, Aranzazu Martin Arias, Marina Vargas-Terrones, Maia Brik, Valeria Rolle, Ruben Barakat, Maria D. Munoz-Gonzalez, Ignacio Refoyo, Maria M. Gil, Belen Santacruz
Summary: This study aimed to analyze the longitudinal effect of a supervised moderate physical exercise program during pregnancy on uteroplacental and fetal Doppler parameters. The results showed that a regular supervised moderate exercise program during pregnancy does not deteriorate fetal or maternal ultrasound Doppler parameters.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2023)
Article
Acoustics
D. L. Rolnik, A. Syngelaki, N. O'Gorman, D. Wright, L. C. Poon, K. H. Nicolaides
Summary: This study aimed to investigate the effects of aspirin on mean arterial pressure (MAP) and mean uterine artery pulsatility index (UtA-PI) in women at increased risk of preterm pre-eclampsia. The results showed that aspirin did not significantly affect MAP, but it was associated with a significant decrease in mean UtA-PI, particularly before 20 weeks of gestation.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
I. Papastefanou, E. Gyokova, B. Gungil, A. Syngelaki, K. H. Nicolaides
Summary: This study aims to investigate the association between birth weight and gestational age at delivery with adverse neonatal outcomes and describe the distribution of adverse neonatal outcomes within different risk strata derived from a population stratification scheme based on the midgestation risk assessment for small-for-gestational-age neonates. The results showed that birth weight has a continuous association with adverse neonatal outcomes, influenced by gestational age. Pregnancies at high risk of small-for-gestational-age, estimated at midgestation, are also at increased risk for adverse neonatal outcomes.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Acoustics
A. Schiattarella, L. A. Magee, A. Wright, A. Syngelaki, R. Akolekar, P. Von Dadelszen, K. H. Nicolaides
Summary: This study compared different approaches for screening for pre-eclampsia at 35+ 0 to 36+ 6 weeks gestation. The results showed that the triple test using the competing-risks model performed better than using PlGF alone or the sFlt-1/PlGF ratio, providing more accurate prediction of pre-eclampsia risk.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Ana M. Fidalgo, Raquel Miguel, Irene Fernandez-Buhigas, Asuncion Aguado, Marcos J. Cuerva, Elisa Corrales, Valeria Rolle, Belen Santacruz, Maria M. Gil, Liona C. Poon
Summary: After appropriate training, attending midwives and obstetricians have a level of agreement in ultrasound measurements to evaluate fetal head position and progress of labor.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Acoustics
N. Sokratous, M. Bednorz, P. Sarli, O. E. Morillo Montes, A. Syngelaki, A. Wright, K. H. Nicolaides
Summary: This study aimed to examine the performance of screening for preterm and term pre-eclampsia (PE) using maternal factors and combinations of maternal serum glycosylated fibronectin (GlyFn), mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), and serum placental growth factor (PlGF) during early pregnancy. The findings suggest that GlyFn may be a useful biomarker for screening preterm PE in the first trimester. However, the performance of screening for term PE or gestational hypertension at 11-13 weeks' gestation using any combination of biomarkers is poor. Prospective screening studies are needed to validate the results of this case-control study.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2023)
Article
Obstetrics & Gynecology
Francisca Sonia Molina, Laura Pardo, Maria D. Munoz, Amaia Aiartzaguena, Amelia Valladolid, Jose E. Blanco, Jorge Burgos, MariaMar Gil
Summary: This study evaluated the reproducibility and usability of a novel medical device, the Fine Birth, for accurately diagnosing threatened preterm labor through objective quantification of cervical consistency in pregnant women. The results showed good intraobserver reproducibility and excellent interobserver reproducibility after adding a lateral microcamera and providing training.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Article
Biochemistry & Molecular Biology
Srinivasa R. Rao, Andrew Protheroe, Lucia Cerundolo, David Maldonado-Perez, Lisa Browning, Alastair D. Lamb, Richard J. Bryant, Ian G. Mills, Dan J. Woodcock, Freddie C. Hamdy, Ian P. M. Tomlinson, Clare Verrill
Summary: Prostate cancer can present in different types, including acinar adenocarcinoma, neuroendocrine, and ductal carcinoma, which are associated with aggressive disease. By sequencing archival tissue, two cases were studied, revealing a common ancestry between small-cell neuroendocrine and ductal prostatic carcinoma. A patient with treatment-related neuroendocrine prostate carcinoma also showed genetic alterations associated with poor prognosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
