Article
Biochemistry & Molecular Biology
Paulo H. C. Mesquita, Donald A. Lamb, Joshua S. Godwin, Shelby C. Osburn, Bradley A. Ruple, Johnathon H. Moore, Christopher G. Vann, Kevin W. Huggins, Andrew D. Fruge, Kaelin C. Young, Andreas N. Kavazis, Michael D. Roberts
Summary: The study found that 6 weeks of resistance training reduced oxidative damage and increased antioxidant enzyme activities in skeletal muscle of older adults. The responses of older adults to resistance training involve multi-level control (transcriptional, post-transcriptional, and post-translational) of the redox status of skeletal muscle.
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, ALi Jihad-Jebbar, Soraya L. Valles, Jose M. Estrela
Summary: Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by motor neuron degeneration leading to muscle weakness and paralysis. Mitochondrial dysfunction plays a significant role in ALS pathophysiology, affecting disease progression. Research indicates that targeting mitochondrial biology may offer potential therapeutic approaches to slow down ALS progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Jose Lopez-Martinez, Damian Escribano, Alba Ortin-Bustillo, Lorena Franco-Martinez, Luis Guillermo Gonzalez-Arostegui, Jose Joaquin Ceron, Camila Peres Rubio
Summary: This study aimed to evaluate the changes in salivary biomarkers of redox status in pigs with experimentally induced sepsis. The results showed that sepsis caused significant changes in various antioxidant capacity markers in pig saliva, suggesting the potential use of these biomarkers for monitoring pig health.
Article
Biochemistry & Molecular Biology
Belinda J. Dunning, Arno R. Bourgonje, Marian L. C. Bulthuis, Jan Alexander, Jan O. Aaseth, Anders Larsson, Harry van Goor, Urban Alehagen
Summary: This study aimed to evaluate the effect of supplementation with selenium and coenzyme Q10 on serum free thiols and to study associations with the risk of cardiovascular mortality in elderly community-dwelling individuals. The results showed that supplementation with selenium and coenzyme Q10 significantly improved serum free thiol levels and reduced the risk of cardiovascular mortality in elderly individuals.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Helen T. McKenna, Katie A. O'Brien, Bernadette O. Fernandez, Magdalena Minnion, Adam Tod, Ben D. McNally, James A. West, Julian L. Griffin, Michael P. Grocott, Michael G. Mythen, Martin Feelisch, Andrew J. Murray, Daniel S. Martin
Summary: This study demonstrates rapid, specific and coordinated changes in cellular respiratory machinery, intermediary metabolism, and redox response in critically ill patients, with different trajectories in survivors and non-survivors. Differences in survival rates and metabolic activities were observed between survivors and non-survivors at 48 hours and day 7. Increases in oxidative stress and reductive drive were evident in critically ill patients, with non-survivors showing greater oxidative pressure and vascular inflammation compared to survivors.
Article
Biochemistry & Molecular Biology
Arno R. Bourgonje, Antonius T. Otten, Mehdi Sadaghian Sadabad, Julius Z. H. von Martels, Marian L. C. Bulthuis, Klaas Nico Faber, Harry van Goor, Gerard Dijkstra, Hermie J. M. Harmsen
Summary: Riboflavin supplementation did not significantly change the systemic redox status in healthy individuals. However, observed changes in albumin-adjusted free thiol levels were negatively associated with changes in C-reactive protein levels. Additionally, albumin-adjusted free thiols were independently associated with the relative abundances of faecal F. prausnitzii, suggesting a potential host redox-microbiota interaction.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Muthusamy Ramakrishnan, Pradeep K. Papolu, Lakkakula Satish, Kunnummal Kurungara Vinod, Qiang Wei, Anket Sharma, Abolghassem Emamverdian, Long-Hai Zou, Mingbing Zhou
Summary: The redox status of the cell plays a crucial role in regulating epigenetic modifications and gene expression in plants. Oxidative stress caused by excessive reactive oxygen species alters the redox status of the cell, which in turn modulates intracellular epigenetic changes and affects plant growth and stress response.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Paola Montes, Ana Guerra-Librero, Paloma Garcia, Maria Elena Cornejo-Calvo, Maria del Senor Lopez, Tomas de Haro, Laura Martinez-Ruiz, Germaine Escames, Dario Acuna-Castroviejo
Summary: This study investigated the impact of the hypomethylating agent 5-azacitidine on the redox status and inflammation in MDS patients. The results showed that MDS patients had a lower redox status and higher CAT activity compared to healthy subjects. The progression of the disease was associated with increased GPx activity, GSSG/GSH ratio, LPO, and AOPP levels, and decreased CAT activity. The study also found changes in pro-inflammatory cytokines and plasma nitrite plus nitrate levels, but no association between inflammation and oxidative stress was observed.
Article
Biochemistry & Molecular Biology
Zoi Skaperda, Ioannis D. Kyriazis, Fotios Tekos, Maria Alvanou, Paraskevi-Maria Nechalioti, Sotiria Makri, Angeliki Argyriadou, Sotiria Vouraki, Theodoros Kallitsis, Maria Kourti, Valasi Irene, Georgios Arsenos, Demetrios Kouretas
Summary: The study aimed to assess the resting values of oxidative stress in lambs and kids reared in Greece and the correlation between redox biomarkers in blood and other tissues. The results showed that lambs and kids at different weight categories had varying levels of antioxidant defense systems. Blood redox biomarkers were associated with the ones measured in other tissues. These findings suggest that blood antioxidant parameters can be used as potential biomarkers to predict tissue antioxidant status and improve meat quality.
Article
Agriculture, Dairy & Animal Science
Mostafa A. Saleh, M. H. Rateb, Elham A. Abd-Allah, Ghada A. E. Mohamed
Summary: The study evaluated the redox status in the blood of sheep infected with T. verrucosum, with results showing increased TPx and decreased TAC in infected sheep, indicating an oxidative stress state that worsens with lesion severity.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Article
Biochemistry & Molecular Biology
Rui Jia, Long Wang, Yiran Hou, Wenrong Feng, Bing Li, Jian Zhu
Summary: This study evaluated the effects of different stocking densities on the growth, physiological parameters, redox status, and lipid metabolism of Micropterus salmoides in an integrated rice-fish farming system. The results showed that high stocking density inhibited growth, caused physiological responses, oxidative stress, and abnormal hepatic lipid metabolism in the fish.
Review
Multidisciplinary Sciences
Jinshan Zhao, Fan Zhao, Junmeng Yuan, Huawei Liu, Yang Wang
Summary: Oxidative stress is an imbalance between oxidation and antioxidation, leading to damage to DNA, proteins, and lipids. The gut microbiota plays a crucial role in regulating oxidative stress through its metabolites. Probiotics have gained scientific interest for their ability to modulate gut microbiota and oxidative stress.
Review
Biochemistry & Molecular Biology
Anand Thirupathi, Yaodong Gu, Zsolt Radak, Ricardo A. Pinho
Summary: This article discusses the redox-based perspectives of the entire system during COVID-19 infection, including how redox-based molecules impact the replication of the virus and the host's immune response. Understanding the mechanisms related to redox can provide support and strategies for the treatment of COVID-19.
Article
Biochemistry & Molecular Biology
Marko Miladinov, Jovana Rosic, Katarina Eric, Azra Guzonjic, Jelenko Jelenkovic, Natasa Bogavac-Stanojevic, Ivan Dimitrijevic, Jelena Kotur-Stevuljevic, Goran Barisic
Summary: This study investigates the significance of SLFN11 and PD-L1 proteins and redox status parameters as prognostic biomarkers in CRC patients. The results show that patients with higher OXY-SCOREs and higher levels of serum SLFN11 have significantly shorter survival.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Karolina Janion, Joanna Katarzyna Strzelczyk, Katarzyna Weronika Walkiewicz, Krzysztof Biernacki, Angelika Copija, Elzbieta Szczepanska, Ewa Nowakowska-Zajdel
Summary: Oxidative stress is believed to have a significant impact on colorectal cancer. This study found that levels of MDA and TAS were significantly lower in CRC patients compared to the control group, while TOS levels were significantly higher. Furthermore, the study revealed a correlation between MDA levels and the location of the primary tumor and the left and right sides of the colon.
Article
Agriculture, Dairy & Animal Science
Priscila Chediek Dall'Acqua, Giovana Barros Nunes, Cintia Rodrigues da Silva, Patricia Kubo Fontes, Marcelo Fabio Gouveia Nogueira, Flavia Lombardi Lopes, Marcia Marinho, Gisele Zoccal Mingoti
REPRODUCTION IN DOMESTIC ANIMALS
(2019)
Article
Agriculture, Dairy & Animal Science
W. B. Rodrigues, A. S. Silva, J. C. B. Silva, N. A. Anache, K. C. Silva, C. J. T. Cardoso, W. R. Garcia, P. Sutovsky, E. Nogueira
Article
Agriculture, Dairy & Animal Science
E. Nogueira, M. R. Silva, J. C. B. Silva, U. P. G. Abreu, N. A. Anache, K. C. Silva, C. J. T. Cardoso, P. Sutovsky, W. B. Rodrigues
Article
Agriculture, Dairy & Animal Science
Alexandre de Oliveira Bezerra, Alessandra Corallo Nicacio, Gilberto Romeiro de Oliveira Menezes, Rodrigo da Costa Gomes, Luiz Otavio Campos da Silva, Nathalia Alves de Souza Rocha-Frigoni, Gisele Zoccal Mingoti, Beatriz Caetano da Silva Leao, Eliane Vianna da Costa e Silva, Eriklis Nogueira
ANIMAL REPRODUCTION SCIENCE
(2019)
Article
Agriculture, Multidisciplinary
Christopher Junior Tavares Cardoso, Ana Caroline Bini de Lima, Wilian Aparecido Leite da Silva, Mirela Brochado Souza-Caceres, Daniela Moraes Pereira, Marcus Vinicius Morais de Oliveira, Eriklis Nogueiras, Fabiana de Andrade Melo-Sterza
SEMINA-CIENCIAS AGRARIAS
(2019)
Article
Reproductive Biology
Guilherme Fazan Rossi, Erika Aline Ribeiro Dias, Natalia Marins Bastos, Dayane Priscila Vrisman, Naiara Nantes Rodrigues, Roberta Vantini, Joaquim Mansano Garcia, Flavia Fernanda Simili, Enilson Geraldo Ribeiro, Roberta Carrilho Canesin, Maria Eugenia Zerlotti Mercadante, Camila P. Freitas-Dell'Aqua, Fabio Morato Monteiro, Gisele Zoccal Mingoti
Article
Cell Biology
Elisa Mariano Pioltine, Camila Bortoliero Costa, Lais Barbosa Latorraca, Fernanda Fagali Franchi, Priscila Helena dos Santos, Gisele Zoccal Mingoti, Fabiola Freitas de Paula-Lopes, Marcelo Fabio Gouveia Nogueira
Summary: The study showed that adding 200μM of TUDCA to IVM medium reduced ROS production and increased the abundance of transcripts related to antioxidant activity in oocytes and embryos. However, a high concentration of TUDCA (1,000μM) was toxic to oocytes, decreasing nuclear maturation rate, mitochondrial activity, and increasing ER stress and cellular apoptosis related transcripts. Treatment with 200μM of TUDCA was associated with greater resistance to oxidative stress and indirectly with ER stress relief in bovine oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Natalia Marins Bastos, Guilherme Fazan Rossi, Beatriz Caetano da Silva Leao, Fernanda Negrao, Christina Ramires Ferreira, Dayane Priscila Vrisman, Naiara Nantes Rodrigues, Mariana Furtado Zorzetto, Camila De Paula Freitas-Dell'Aqua, Roberta Vantini, Fabio Morato Monteiro, Maria Eugenia Zerlotti Mercadante, Marcos Nogueira Eberlin, Vera Fernanda Martins Hossepian de Lima, Gisele Zoccal Mingoti
Summary: This study aimed to investigate the effects of long-term dietary supplementation of young Nellore bulls with rumen-protected polyunsaturated fatty acids on semen quality and intracytoplasmic lipid content in resulting embryos. The results showed that PUFA supplementation negatively affected semen quality but did not impact sperm fertilizing ability in vitro, while the paternal diet influenced the lipid content in embryos.
Article
Multidisciplinary Sciences
Vitor Bonetti Valente, Diovana de Melo Cardoso, Giseli Mitsuy Kayahara, Giovana Barros Nunes, Kellen Cristine Tjioe, Eder Ricardo Biasoli, Glauco Issamu Miyahara, Sandra Helena Penha Oliveira, Gisele Zoccal Mingoti, Daniel Galera Bernabe
Summary: Chronic stress can increase levels of stress hormones like norepinephrine and cortisol, which can lead to DNA damage in oral keratinocytes. In a study using a human oral keratinocyte cell line, it was found that pre-treatment with a beta-adrenergic blocker could reverse the DNA damage induced by stress hormones. These findings suggest that stress hormones may play a role in oral carcinogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Developmental Biology
Jesus Alfonso Sanchez Viafara, Gisvani Lopes de Vasconcelos, Renata Maculan, Nadja Gomes Alves, Marcos Brandao Dias Ferreira, Mateus Jose Sudano, Gisele Zoccal Mingoti, Giovana Barros Nunes, Renato Ribeiro de Lima, Roberti Martins Drumond, Raphael Nunes dos Santos, Marcos Nogueira Eberlin, Fernanda Negrao, Jasmin, Mariana Aragao M. Donato, Christina A. Peixoto, Jose Camisao de Souza
Summary: The effect of L-165041 on decreasing apoptosis and intracellular lipid content in fresh and vitrified-warmed in vitro-produced bovine embryos was assessed. It was found that L-165041 can improve development and cryopreservation of the embryos.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Luana Teixeira Rodrigues Rossi, Giovana Barros Nunes, Cintia Rodrigues da Silva, Hugo de Rossi, Priscila Helena dos Santos, Marcelo Fabio Gouveia Nogueira, Pedro Henrique Benites Aoki, Gisele Zoccal Mingoti
Summary: The use of giant unilamellar vesicles (GUVs) as microcarriers in in vitro culture is safe and effective in preventing the increase of reactive oxygen species (ROS) in embryonic cells. GUVs are sensitive to oxidative stress and can release cysteine slowly to prolong its presence in the culture medium.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Hugo De Rossi, Camila Bortoliero Costa, Luana Teixeira Rodrigues-Rossi, Giovana Barros Nunes, Doris Spinosa Cheles, Isabella Maran Pereira, Daniele F. O. Rocha, Eloi Feitosa, Ana Valeria Colnaghi Simionato, Gisele Zoccal Mingoti, Pedro Henrique Benites Aoki, Marcelo Fabio Gouveia Nogueira
Summary: This study evaluated the effect of multilamellar vesicles (MLVs) on in vitro-produced bovine embryos (IVPEs). The study found that MLVs had a stable structure, did not reduce blastocyst production, and modulated the lipid profile of the embryonic cell membrane.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Guilherme Fazan Rossi, Natalia Marins Bastos, Dayane Priscila Vrisman, Naiara Nantes Rodrigues, Roberta Vantini, Joaquim Mansano Garcia, Erika Aline Ribeiro Dias, Flavia Fernanda Simili, Andre Lasmar Guimaraes, Roberta Carrilho Canesin, Maria Eugenia Zerlotti Mercadante, Camila de Paula Freitas-Dell'Aqua, Flavia Regina Florencio de Athayde, Fabio Morato Monteiro, Gisele Zoccal Mingoti
Summary: The growth and reproductive parameters of young Nellore bulls with divergent RFI were evaluated. The low RFI bulls exhibited higher initial and final body weights, and had improved velocity parameters in thawed semen. However, there was no enhancement in in vitro sperm fertilizing ability.
ANIMAL REPRODUCTION
(2022)
Article
Agronomy
Ernest Schillings Neto, Eriklis Nogueira, Rodrigo Jardim, Urbano Gomes Pinto de Abreu, Fabiana Andrade de Melo Sterza, Aiesca Oliveira Pellegrin, Raquel Soares Juliano