Causes and consequences of chromosome segregation error in preimplantation embryos

Assessing the true incidence of mosaicism in preimplantation embryos

(2017) Maria Vera-Rodriguez et al.   FERTILITY AND STERILITY

Detection of segmental aneuploidy and mosaicism in the human preimplantation embryo: technical considerations and limitations

(2017) Nathan R. Treff et al.   FERTILITY AND STERILITY

Translocations, inversions and other chromosome rearrangements

(2017) Scott J. Morin et al.   FERTILITY AND STERILITY

Diagnosis and clinical management of duplications and deletions

(2017) Antonio Capalbo et al.   FERTILITY AND STERILITY

Detailed investigation into the cytogenetic constitution and pregnancy outcome of replacing mosaic blastocysts detected with the use of high-resolution next-generation sequencing

(2017) Santiago Munné et al.   FERTILITY AND STERILITY

Analysis of implantation and ongoing pregnancy rates following the transfer of mosaic diploid–aneuploid blastocysts

(2017) Elpida Fragouli et al.   HUMAN GENETICS

Mitotic spindle disruption in human preimplantation embryos activates the spindle assembly checkpoint but not apoptosis until Day 5 of development

(2017) K. Jacobs et al.   MOLECULAR HUMAN REPRODUCTION

Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy

(2017) Alexandra L. Nguyen et al.   MOLECULAR HUMAN REPRODUCTION

A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use

(2017) Norbert Gleicher et al.   Reproductive Biology and Endocrinology

Mechanisms of Aneuploidy in Human Eggs

(2017) Alexandre Webster et al.   TRENDS IN CELL BIOLOGY

Differential regulation of H3S10 phosphorylation, mitosis progression and cell fate by Aurora Kinase B and C in mouse preimplantation embryos

(2017) Wenzhi Li et al.   Protein & Cell

Mechanisms of Mitotic Spindle Assembly

(2016) Sabine Petry   Annual Review of Biochemistry

The PLK4–STIL–SAS-6 module at the core of centriole duplication

(2016) Christian Arquint et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Aneuploidy Detection and mtDNA Quantification in Bovine Embryos with Different Cleavage Onset Using a Next-Generation Sequencing-Based Protocol

(2016) Miroslav Hornak et al.   CYTOGENETIC AND GENOME RESEARCH

Cell Size Determines the Strength of the Spindle Assembly Checkpoint during Embryonic Development

(2016) Matilde Galli et al.   DEVELOPMENTAL CELL

On becoming accepting of the imperfectionsin mammalian embryogenesis

(2016) David F. Albertini   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining

(2016) Peter Ly et al.   NATURE CELL BIOLOGY

Micronucleus formation causes perpetual unilateral chromosome inheritance in mouse embryos

(2016) Cayetana Vázquez-Diez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accuracy of preimplantation genetic screening (PGS) is compromised by degree of mosaicism of human embryos

(2016) Norbert Gleicher et al.   Reproductive Biology and Endocrinology

Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

(2016) Helen Bolton et al.   Nature Communications

Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development

(2016) Sadanori Watanabe et al.   Cell Reports

Nucleus downscaling in mouse embryos is regulated by cooperative developmental and geometric programs

(2016) Elina Tsichlaki et al.   Scientific Reports

Tripolar mitosis in human cells and embryos: Occurrence, pathophysiology and medical implications

(2015) Beata Kalatova et al.   ACTA HISTOCHEMICA

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

(2015) Mitchell L. Leibowitz et al.   Annual Review of Genetics

Human embryos commonly form abnormal nuclei during development: a mechanism of DNA damage, embryonic aneuploidy, and developmental arrest

(2015) Daniel H. Kort et al.   HUMAN REPRODUCTION

Chromosome segregation regulation in human zygotes: altered mitotic histone phosphorylation dynamics underlying centromeric targeting of the chromosomal passenger complex

(2015) C. van de Werken et al.   HUMAN REPRODUCTION

Thirty years of search and capture: The complex simplicity of mitotic spindle assembly

(2015) Rebecca Heald et al.   JOURNAL OF CELL BIOLOGY

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos

(2015) R. C. McCoy et al.   SCIENCE

DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age

(2015) Petros Marangos et al.   Nature Communications

DNA damage induces a meiotic arrest in mouse oocytes mediated by the spindle assembly checkpoint

(2015) Josie K. Collins et al.   Nature Communications

Prediction model for aneuploidy in early human embryo development revealed by single-cell analysis

(2015) Maria Vera-Rodriguez et al.   Nature Communications

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Spindle Assembly Checkpoint Acquisition at the Mid-Blastula Transition

(2015) Maomao Zhang et al.   PLoS One

Zygotic Genome Activation During the Maternal-to-Zygotic Transition

(2014) Miler T. Lee et al.   Annual Review of Cell and Developmental Biology

The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans

(2014) Tyl H. Taylor et al.   HUMAN REPRODUCTION UPDATE

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation

(2014) S. F. Bakhoum et al.   Cancer Discovery

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

A non-canonical mode of microtubule organization operates throughout pre-implantation development in mouse

(2013) Katie Howe et al.   CELL CYCLE

Molecular causes of aneuploidy in mammalian eggs

(2013) K. T. Jones et al.   DEVELOPMENT

Spindle Formation in the Mouse Embryo Requires Plk4 in the Absence of Centrioles

(2013) Paula A. Coelho et al.   DEVELOPMENTAL CELL

The origin and impact of embryonic aneuploidy

(2013) Elpida Fragouli et al.   HUMAN GENETICS

The spindle assembly checkpoint works like a rheostat rather than a toggle switch

(2013) Philippe Collin et al.   NATURE CELL BIOLOGY

Cytoplasmic Volume Modulates Spindle Size During Embryogenesis

(2013) M. C. Good et al.   SCIENCE

Molecular origin of mitotic aneuploidies in preimplantation embryos

(2012) Eleni Mantikou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

4D imaging reveals a shift in chromosome segregation dynamics during mouse pre-implantation development

(2012) Kazuo Yamagata et al.   CELL CYCLE

Lagging chromosomes entrapped in micronuclei are not 'lost' by cells

(2012) Yun Huang et al.   CELL RESEARCH

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Human pre-implantation embryo development

(2012) K. K. Niakan et al.   DEVELOPMENT

Abnormal chromosome segregation at early cleavage is a major cause of the full-term developmental failure of mouse clones

(2012) Eiji Mizutani et al.   DEVELOPMENTAL BIOLOGY

The effect of GM-CSF on development and aneuploidy in murine blastocysts

(2012) A. Elaimi et al.   HUMAN REPRODUCTION

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development

(2012) Aurélien Courtois et al.   JOURNAL OF CELL BIOLOGY

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Aneuploidy Detection in Pigs Using Comparative Genomic Hybridization: From the Oocytes to Blastocysts

(2012) Miroslav Hornak et al.   PLoS One

Maternally recruited Aurora C kinase is more stable than Aurora B to support mouse oocyte maturation and early development

(2012) K. Schindler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Intracellular Scaling

(2011) Daniel L. Levy et al.   Annual Review of Cell and Developmental Biology

Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development

(2011) G. Fernandez-Miranda et al.   DEVELOPMENT

A role for Aurora C in the chromosomal passenger complex during human preimplantation embryo development

(2011) Margarida Avo Santos et al.   HUMAN REPRODUCTION

Cytoskeletal analysis of human blastocysts by confocal laser scanning microscopy following vitrification

(2011) K. Chatzimeletiou et al.   HUMAN REPRODUCTION

Chromosomal mosaicism in human preimplantation embryos: a systematic review

(2011) Jannie van Echten-Arends et al.   HUMAN REPRODUCTION UPDATE

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of Mitotic Spindle Length

(2010) Gohta Goshima et al.   Annual Review of Cell and Developmental Biology

The perpetual movements of anaphase

(2010) Helder Maiato et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanisms of Chromosomal Instability

(2010) Sarah L. Thompson et al.   CURRENT BIOLOGY

Is aneuploidy a defense mechanism to prevent maternity later in a woman’s life

(2010) Marc-André Sirard   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Centrioles, Centrosomes, and Cilia in Health and Disease

(2009) Erich A. Nigg et al.   CELL

Force and Length in the Mitotic Spindle

(2009) Sophie Dumont et al.   CURRENT BIOLOGY

A shift from kinesin 5-dependent metaphase spindle function during preimplantation development in mouse

(2009) G. FitzHarris   DEVELOPMENT

Incidence of chromosomal mosaicism in morphologically normal nonhuman primate preimplantation embryos

(2009) Cathérine Dupont et al.   FERTILITY AND STERILITY

Ab ovo or de novo? Mechanisms of centriole duplication

(2009) Jadranka Loncarek et al.   MOLECULES AND CELLS

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Chromosome instability is common in human cleavage-stage embryos

(2009) Evelyne Vanneste et al.   NATURE MEDICINE

Evidence for an Upper Limit to Mitotic Spindle Length

(2008) Martin Wühr et al.   CURRENT BIOLOGY

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Viability of frozen-thawed human embryos with one–two blastomeres lysis

(2008) Xiaoying Zheng et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS