Article
Engineering, Environmental
Ruixia Han, Jitao Lv, Suhuan Zhang, Shuzhen Zhang
Summary: The study found that surface structure significantly affects the microbial dissimilatory iron reduction and aerobic oxidation processes, with HNP producing more Fe(II) than HNR during reduction, and HNR showing higher ROS production efficiency during oxidation.
Review
Biotechnology & Applied Microbiology
Shaily Tyagi, Anshuman Shah, Kesiraju Karthik, Maniraj Rathinam, Vandna Rai, Nidhee Chaudhary, Rohini Sreevathsa
Summary: Climate change has increased the incidence of pests and pathogens on plants, leading to a need for effective management strategies. Plants respond to stresses by regulating cellular mechanisms through complex signaling networks. Reactive oxygen species (ROS) play a crucial role in maintaining normal plant activities and improving stress management. This review explores the signaling and management of ROS during oxidative bursts caused by plant interactions with pathogens and herbivores. The findings highlight the molecular changes and important roles of ROS in phyto-pathogen/herbivore interactions, providing insights into tackling biotic stresses and developing stress management strategies.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jiajian Cao, Chunhua Wang, Ning Hao, Toru Fujiwara, Tao Wu
Summary: In this review, we summarize the perceptions and responses of ER stress and oxidative protein folding in plants and analyze the production and signaling of ROS under ER stress in detail. This provides a theoretical basis for reducing ER stress and improving crop survival rate.
Review
Biochemistry & Molecular Biology
Veronika Merc, Michaela Frolikova, Katerina Komrskova
Summary: Integrins are a type of cell adhesion receptor involved in interactions between cells, between cells and the extracellular matrix, and between cells and pathogens. They play crucial roles in signal transduction pathways and are able to transmit signals into and out of cells. Integrins have been found not only on somatic cells but also on germ cells, where they are known to be essential for important physiological events such as sperm-oocyte fusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Junmin Zhang, Dongzhu Duan, Zi-Long Song, Tianyu Liu, Yanan Hou, Jianguo Fang
Summary: Regulating intracellular ROS levels may be an effective strategy for cancer prevention or treatment. This can be achieved through chemoprevention to reduce ROS production pathways, or through ROS-mediated anticancer therapy to stimulate ROS clearance, ultimately inhibiting tumor growth.
MEDICINAL RESEARCH REVIEWS
(2021)
Review
Cell Biology
Wjdan S. Bafleh, Haia M. R. Abdulsamad, Sally M. Al-Qaraghuli, Riwa Y. El Khatib, Rawdah Taha Elbahrawi, Azhar Mohamud Abdukadir, Shaima M. Alsawae, Zakia Dimassi, Hamdan Hamdan, Junaid Kashir
Summary: The recent COVID-19 pandemic has brought about significant changes in various fields, including society, law, economics, science, and medicine. The use of mRNA-based vaccines has been approved for the first time by drug regulatory authorities to combat the outbreak. While this represents a novel application of mRNA technology in vaccination medicine, the introduction of RNA into cells to produce molecules is not a new concept. It has been commonly practiced in research to manipulate oocytes and embryos and has potential therapeutic and diagnostic applications in combating infertility. This article describes the potential clinical applications, advantages, and limitations of mRNA-based platforms, and discusses how recent advances driven by the pandemic can benefit infertility treatment. Future directions for enhancing RNA therapeutics in reproductive biology, specifically in oocyte and embryo delivery, are also presented.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biology
Tsutomu Shimura, Rina Totani, Hyougo Ogasawara, Keiki Inomata, Megumi Sasatani, Kenji Kamiya, Akira Ushiyama
Summary: This study investigates the impact of oxygen concentration on the response of mitochondria to X-ray radiation and fibroblast activation in tumor microenvironment formation. The results suggest that high oxygen levels enhance the effects of radiation on mitochondria and fibroblast activation. Lower oxygen concentration can mitigate radiation damage and fibroblast activation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Pamela A. Kakimoto, Julian David C. Serna, Vitor de Miranda Ramos, Antonio Zorzano, Alicia J. Kowaltowski
Summary: Exposure to toxic levels of fatty acids leads to cell damage and death, contributing to the pathogenesis of the metabolic syndrome. Lipotoxicity induces changes in mitochondrial morphology and increases glycolytic flux in cells, while oxidative phosphorylation remains unchanged.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Sanghamitra Das, Petr Slama, Shubhadeep Roychoudhury
Summary: Reactive nitrogen species (RNS) play important roles in male reproduction, but excessive levels can impair fertility by affecting testicular functions and compromising semen quality. High RNS levels lead to abnormalities in germ cells and gametes, and severely impact maturation and fertilization processes. Conventional semen analyses are not reliable predictors for assisted reproductive technology outcomes in cases of male infertility, highlighting the need for novel assessment and treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Environmental
Guoqiang Zhao, Binbin Wu, Xiaoshan Zheng, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: We have discovered an unrecognized tidal source of reactive oxygen species (ROS) and demonstrated the generation of ROS in coastal surface soil during tidal processes. The fluctuation of redox potential and dissolved oxygen concentration follows a similar pattern to the production of ROS.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Masuko Ushio-Fukai, Dipankar Ash, Sheela Nagarkoti, Eric J. Belin de Chantemele, David J. R. Fulton, Tohru Fukai
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play important roles as signaling molecules at physiological levels, but excess levels are associated with cardiovascular disease. Cells regulate ROS and RNS levels by controlling metabolic pathways, with implications for disease treatment strategies.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Luisa M. Sandalio, Aurelio M. Collado-Arenal, Maria C. Romero-Puertas
Summary: Plant peroxisomes are dynamic organelles participating in a variety of metabolic processes and cell responses to the environment. This review focuses on the interactions and effects of reactive species such as ROS, RNS, CRS, and SRS in peroxisomes, as well as their role in regulating the redox/ROS homeostasis and plasticity of peroxisomes. The review also highlights the important role of H2O2-dependent peroxisomal retrograde signaling and discusses the specific peroxisomal footprint.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Environmental
Guoqiang Zhao, Mengxi Tan, Binbin Wu, Xiaoshan Zheng, Ruoxuan Xiong, Baoliang Chen, Andreas Kappler, Chiheng Chu
Summary: Tidal-induced redox oscillations can activate thermodynamically stable iron minerals into a metastable phase for enhanced ROS production.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Reproductive Biology
Yoku Kato, Yuki Ohshima, Aiko Sasaki, Eri Yoshikawa, Hua Xu, Yoshikazu Nagao
Summary: This study investigates the promoting effect of cumulus cell secretions on the fertilization capacity of sperm during in vitro fertilization. The results show that progesterone, hyaluronate, and metabolic events secreted by cumulus cells can enhance sperm fertilization capacity.
Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Developmental Biology
L. A. Frank, R. D. Rose, M. R. Anastasi, T. C. Y. Tan, M. F. Barry, J. G. Thompson, H. M. Brown
REPRODUCTION FERTILITY AND DEVELOPMENT
(2019)
Article
Agriculture, Dairy & Animal Science
Sandra Soto-Heras, Maria-Teresa Paramio, Jeremy G. Thompson
ANIMAL REPRODUCTION SCIENCE
(2019)
Review
Reproductive Biology
Megan Lim, Hannah M. Brown, Karen L. Kind, Jeremy G. Thompson, Kylie R. Dunning
BIOLOGY OF REPRODUCTION
(2019)
Article
Multidisciplinary Sciences
Sandra Soto-Heras, Irene Menendez-Blanco, Maria-Gracia Catala, Dolors Izquierdo, Jeremy G. Thompson, Maria-Teresa Paramio
Article
Biochemical Research Methods
Hanna J. McLennan, Avishkar Saini, Georgina M. Sylvia, Erik P. Schartner, Kylie R. Dunning, Malcolm S. Purdey, Tanya M. Monro, Andrew D. Abell, Jeremy G. Thompson
JOURNAL OF BIOPHOTONICS
(2020)
Review
Obstetrics & Gynecology
Dulama Richani, Kylie R. Dunning, Jeremy G. Thompson, Robert B. Gilchrist
Summary: Metabolism is crucial for oocyte quality, with glucose being essential for COC maturation and energy production. Mitochondria are the main ATP source in oocytes, while cumulus cells play a vital role in maintaining ATP levels. New insights in oocyte lipid metabolism and innovative strategies in IVM have shown positive effects on oocyte competence.
HUMAN REPRODUCTION UPDATE
(2021)
Article
Genetics & Heredity
Megan Lim, Hannah M. Brown, Ryan D. Rose, Jeremy G. Thompson, Kylie R. Dunning
Summary: Hemoglobin and 2,3-BPG may have a role in the maturation of cumulus-oocyte complexes (COCs). The study found that in vitro maturation (IVM) increases the expression of Bpgm within COCs compared to in vivo. Decreased oxygen concentration and the addition of hemoglobin affected Bpgm expression, but not to the levels observed in vivo.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Annie Whitty, Karen L. Kind, Kylie R. Dunning, Jeremy G. Thompson
Summary: This study found that under low oxygen conditions (7%), oocyte developmental competence is negatively impacted when glucose availability is limited. However, under low oxygen with high glucose concentration or adequate availability, developmental rates can be restored to levels seen in 20% oxygen groups. This highlights the importance of considering glucose concentration and physical culture conditions when comparing the effects of different oxygen concentrations during in vitro maturation.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Genetics & Heredity
Suliman H. Yagoub, Jeremy G. Thompson, Antony Orth, Kishan Dholakia, Brant C. Gibson, Kylie R. Dunning
Summary: This study designed and fabricated a micrometer scale device to simplify the intracytoplasmic sperm injection procedure, aiming to improve embryo production and reduce variability among operators. The device demonstrated successful embryo culture and microinjection capabilities without the need for a holding pipette, enhancing traceability and efficiency in the process.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Genetics & Heredity
Carl A. Campugan, Megan Lim, Darren J. X. Chow, Tiffany C. Y. Tan, Tong Li, Avishkar A. Saini, Antony Orth, Philipp Reineck, Erik P. Schartner, Jeremy G. Thompson, Kishan Dholakia, Kylie R. Dunning
Summary: Our study investigates the impact of different wavelengths of light on the development of embryos. We found that exposure to the yellow wavelength led to a significant reduction in the number of embryos developing to the blastocyst stage. Increased DNA damage was observed in embryos exposed to the blue, green, or red wavelengths. Only the red wavelength showed a significant decrease in total cell number. Additionally, pregnancy rates were significantly reduced and weight at weaning was significantly higher when embryos were exposed to the red and yellow wavelengths respectively. Our results highlight the wavelength-specific and energy-dependent effects of light on embryo development.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Genetics & Heredity
Suliman H. Yagoub, Megan Lim, Tiffany C. Y. Tan, Darren J. X. Chow, Kishan Dholakia, Brant C. Gibson, Jeremy G. Thompson, Kylie R. Dunning
Summary: A novel photopolymerized device is presented for housing and preserving oocytes and embryos during vitrification, simplifying the procedure and improving traceability.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Correction
Genetics & Heredity
Suliman H. Yagoub, Megan Lim, Tiffany C. Y. Tan, Darren J. X. Chow, Kishan Dholakia, Brant C. Gibson, Jeremy G. Thompson, Kylie R. Dunning
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Multidisciplinary Sciences
Hanna J. McLennan, Adam J. Blanch, Samuel J. Wallace, Lesley J. Ritter, Shauna L. Heinrich, David K. Gardner, Kylie R. Dunning, Marty J. Gauvin, Allison K. Love, Jeremy G. Thompson
Summary: This study introduces a microfluidic chip that is designed and completely 3D-printed using two-photon polymerization (2PP). It consists of ten channels and ten retrievable cell sample seats, which can enhance cell-surface interactions at the nanoscale and support cell culture. This technology provides the precision needed for nanoliter fluidic devices constructed from multiple interlocking parts.
SCIENTIFIC REPORTS
(2023)
Article
Endocrinology & Metabolism
Dulama Richani, Katherine Constance, Shelly Lien, David Agapiou, William A. Stocker, Mark P. Hedger, William L. Ledger, Jeremy G. Thompson, David M. Robertson, David G. Mottershead, Kelly L. Walton, Craig A. Harrison, Robert B. Gilchrist
Article
Developmental Biology
M. Lim, H. M. Brown, K. L. Kind, J. Breen, M. R. Anastasi, L. J. Ritter, E. K. Tregoweth, D. T. Dinh, J. G. Thompson, K. R. Dunning
REPRODUCTION FERTILITY AND DEVELOPMENT
(2019)