The protective activity of genistein against bone and cartilage diseases

Genistein, a natural isoflavone rich in soybean and leguminous plants, has been shown various biological effects, such as anti-inflammation, anti-oxidation, anti-cancer, and bone/cartilage protection. Due to the structural similarity to estrogen, genistein exhibits estrogen-like activity in protecting against osteoporosis and osteoarthritis. Furthermore, genistein has been considered as an inhibitor of tyrosine kinase, which has been found to be dysregulated in the pathological development of osteoporosis, osteoarthritis, and intervertebral disc degeneration (IDD). Many signaling pathways, such as MAPK, NF-kappa B, and NRF2/HO-1, are involved in the regulatory activity of genistein in protecting against bone and cartilage diseases. The potential molecular mechanisms of genistein in therapeutic management of bone and cartilage diseases have been investigated, but remain to be fully understood. In this article, we mainly discuss the current knowledge of genistein in protecting against bone and cartilage diseases, such as osteoporosis, osteoarthritis, rheumatoid arthritis (RA), and IDD.

Automated summary

Genistein, a natural isoflavone, exhibits various biological effects and has been investigated for its potential therapeutic benefits in bone and cartilage diseases. It shows estrogen-like activity in protecting against osteoporosis and osteoarthritis, and also acts as an inhibitor of tyrosine kinase involved in pathological development of these diseases. Multiple signaling pathways are involved in its regulatory activity, but the molecular mechanisms are not fully understood yet.