Respect the anaerobic nature of stem cells to exploit their potential in regenerative medicine

Metabolic Makeover for HSCs

(2013) Matthew R. Warr et al.   Cell Stem Cell

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

(2013) Wen-Mei Yu et al.   Cell Stem Cell

Cord blood-derived CD34+ hematopoietic cells with low mitochondrial mass are enriched in hematopoietic repopulating stem cell function

(2013) D. Romero-Moya et al.   HAEMATOLOGICA

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

Pharmacologic stabilization of HIF-1  increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation

(2012) C. E. Forristal et al.   BLOOD

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Clinical-Scale Cultures of Cord Blood CD34+ Cells to Amplify Committed Progenitors and Maintain Stem Cell Activity

(2011) Zoran Ivanovic et al.   CELL TRANSPLANTATION

Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells

(2011) Alessandro Prigione et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Very low oxygen concentration (0.1%) reveals two FDCP-Mix cell subpopulations that differ by their cell cycling, differentiation and p27KIP1 expression

(2010) A V Guitart et al.   CELL DEATH AND DIFFERENTIATION

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Regulation of Gene Expression in Protozoa Parasites

(2010) Consuelo Gomez et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Notch-mediated expansion of human cord blood progenitor cells capable of rapid myeloid reconstitution

(2010) Colleen Delaney et al.   NATURE MEDICINE

Hypoxia Enhances the Generation of Induced Pluripotent Stem Cells

(2009) Yoshinori Yoshida et al.   Cell Stem Cell

Hypoxia or in situ normoxia: The stem cell paradigm

(2009) Zoran Ivanovic   JOURNAL OF CELLULAR PHYSIOLOGY

Bmi1 regulates mitochondrial function and the DNA damage response pathway

(2009) Jie Liu et al.   NATURE

Enhancement of human embryonic stem cell pluripotency through inhibition of the mitochondrial respiratory chain

(2009) S. Varum et al.   Stem Cell Research

The Relationship Between Pluripotency and Mitochondrial DNA Proliferation During Early Embryo Development and Embryonic Stem Cell Differentiation

(2009) J. M. Facucho-Oliveira et al.   Stem Cell Reviews and Reports

Signal control of hematopoietic stem cell fate: Wnt, Notch, and Hedgehog as the usual suspects

(2008) Clint Campbell et al.   CURRENT OPINION IN HEMATOLOGY

TSC–mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

(2008) Chong Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE