Article
Veterinary Sciences
Mona Saleh, Abdel-Azeem S. Abdel-Baki, Mohamed A. Dkhil, Mansour El-Matbouli, Saleh Al-Quraishy
Summary: The study demonstrates the crucial role of heat shock protein 90 (HSP90) in the growth and development of Ichthyophthirius multifiliis, suggesting it as a potential therapeutic target. By using antisense oligonucleotides to knock down the HSP90 gene, it was shown that the growth and development of the parasite were significantly limited, and the infectivity of treated parasites was reduced in fish.
BMC VETERINARY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Gema Fernandez-Rivas, Belen Rivaya, Nona Romani, Jun Hao Wang Wang, Mireya Alcaide, Lurdes Matas
Summary: The SediMAX2 automated microscope shows high sensitivity and specificity in detecting intestinal parasitic infections, making it a reliable diagnostic tool.
SCIENTIFIC REPORTS
(2021)
Review
Pathology
Blaine A. Mathison, Bobbi S. Pritt
Summary: The landscape of parasitic infections in the United States has undergone significant changes over the past century. While some infections have been eliminated, others remain a public health risk. This article discusses the biology, diagnostic histopathological features, and epidemiology of endemic parasitic infections commonly seen in anatomical pathology preparations. © 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights reserved.
Review
Chemistry, Medicinal
Cal Koger-Pease, Dilhan J. J. Perera, Momar Ndao
Summary: Despite the devastating impact and widespread occurrence of parasitic diseases globally, vaccines against parasites have been slower to develop compared to vaccines against viral and bacterial infections. One of the main challenges is the lack of vaccine strategies that can induce the complex and multifaceted immune responses required to eliminate parasitic persistence. Adenovirus (AdV) vectors have emerged as a potential solution for complex diseases like parasitic infections by driving CD8+ T cell responses, which are known to be important in immunity against many parasitic organisms. This review discusses recent advances in AdV-vectored vaccines targeting five major human parasitic diseases: malaria, Chagas disease, schistosomiasis, leishmaniasis, and toxoplasmosis. The use of AdV-vectored vaccines shows promise in tackling the historically challenging goal of developing vaccines for parasitic diseases.
Article
Microbiology
Brice Autier, Jean-Pierre Gangneux, Florence Robert-Gangneux
Summary: The diagnosis of intestinal parasitic infections commonly relies on microscopic examination, but the ParaFlo(R) assays offer improved reliability and ease of use. When compared to routine methods, ParaFlo(R) showed similar performance in protozoa detection but slightly poorer performance in helminth detection.
Review
Parasitology
Claudio Bandi, Jairo Alfonso Mendoza-Roldan, Domenico Otranto, Alessandro Alvaro, Viviane Noll Louzada-Flores, Massimo Pajoro, Ilaria Varotto-Boccazzi, Matteo Brilli, Alessandro Manenti, Emanuele Montomoli, Gianvincenzo Zuccotti, Sara Epis
Summary: Leishmania parasites have the ability to subvert the immune response of mammalian phagocytes and exploit them as a mode of transport to lymphoid tissues. The non-pathogenic reptile-associated Leishmania tarentolae could potentially be used as a vaccine platform and vehicle for the production of antigens and delivery to dendritic cells and lymph nodes.
PARASITES & VECTORS
(2023)
Article
Public, Environmental & Occupational Health
Jorge Aruni Chura, Fabio Macchioni, Federica Furzi, Victor Balboa, Erika Mercado, Jose Gomez, Patricia Rojas Gonzales, Veronica Poma, Armando Loup, Mimmo Roselli, Percy Halkier, Antonio Montresor, Piero Olliaro, Alessandro Bartoloni, Michele Spinicci, Simona Gabrielli
Summary: The study assessed the prevalence of protozoa and helminth infection among school-age children in different ecological zones of La Paz, Bolivia. The overall prevalence of intestinal parasites was 82.2%, with protozoa (80%) being more common than helminths (23.3%). The study revealed the importance of sanitation and deworming programs in reducing parasitic infections among children.
Article
Biodiversity Conservation
Silvia De Michelis, Claudio De Liberato, Cristina Amoruso, Corrado Battisti, Monica Carosi
Summary: In this report, we analyzed nutria fecal samples in a small coastal wetland in Central Italy to study eukaryote endoparasites. We found five taxa, with a dominant occurrence of nematodes of the genus Strongyloides. Additionally, we reported the presence of a bronchopulmonary strongyle nematode and protozoans of the genus Cryptosporidium, which were previously unrecorded in nutria in Italy.
Article
Biochemistry & Molecular Biology
Aleksandra Glowacka, Pawel Bieganowski, Ewelina Jurewicz, Wieslawa Lesniak, Tomasz Wilanowski, Anna Filipek
Summary: S100A10, a Ca2+-binding protein, is involved in various cellular and extracellular processes. Its main roles include regulating plasminogen conversion to plasmin via interaction with annexin A2 and influencing neurotransmitter binding through interaction with 5-HT1B receptor, impacting depressive symptoms. Strict control of S100A10 expression is crucial due to its involvement in tumor progression and neurotransmitter regulation. Our study reveals a new regulatory mechanism of S100A10 expression by the transcription factor GRHL2 through direct binding to specific sites in the gene.
Article
Biotechnology & Applied Microbiology
Derrick Shih-Wei Chuang, James C. Liao
Summary: This study revealed the important role of phosphoketolase (Xpk) in primary metabolism of cyanobacteria, particularly in energy regulation and dark conditions. Additionally, Xpk is involved in the pathway producing ATP from glycogen to acetate. Deletion of xpk leads to glucose secretion under dark, anaerobic conditions.
METABOLIC ENGINEERING
(2021)
Editorial Material
Public, Environmental & Occupational Health
Eli Schwartz, Bradley A. Connor
Summary: Persistent abdominal symptoms in returning travellers are a common complaint, but there is limited evidence to support the causes and potential aetiologies. New molecular stool-testing techniques and accurate clinical studies may fill this gap in knowledge, leading to more successful management of this common and challenging problem.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Franziska Hentzschel, Matthew P. Gibbins, Charalampos Attipa, Dario Beraldi, Christopher A. Moxon, Thomas D. Otto, Matthias Marti
Summary: This study provides a comprehensive analysis of rodent P. berghei infection using flow cytometry and single-cell RNA sequencing. The researchers identified CD71 as a host receptor for reticulocyte invasion and found that parasites adapt metabolically to the host cell environment. Transcriptional analysis and functional assays revealed the importance of nutrient-dependent tropism for gametocyte formation in reticulocytes.
Review
Cell Biology
Angela Arabiotorre, Vytas A. Bankaitis, Aby Grabon
Summary: Phosphoinositides are crucial phospholipids in eukaryotes that play important roles in the life processes and signal transduction pathways of apicomplexan parasites. Apicomplexans offer a valuable experimental system for studying the evolution and regulation of phosphoinositide signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Aileen Julia Riesle, Meijiang Gao, Marcus Rosenblatt, Jacques Hermes, Helge Hass, Anna Gebhard, Marina Veil, Bjorn Gruening, Jens Timmer, Daria Onichtchouk
Summary: This study investigates the combinatorial mechanisms of genome activation and shows that zebrafish genome activators Pou5f3 and Nanog exhibit different roles in the activation process. They act as pioneer-like transcription factors on synergistic enhancers, promoting histone acetylation and transcription activation. However, on antagonistic enhancers, one of the factors acts as a non-pioneer-like transcription factor, competing with the activator and blocking its effects. This activator-blocker mechanism restricts widespread transcriptional activation and prevents premature expression of late developmental genes in early embryos.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Chao Wang, Jonathan Leavenworth, Chao Zhang, Zhichao Liu, Katherine Y. Yuan, Yicun Wang, Guangxin Zhang, Shuaibin Wang, Xuelian Cui, Yue Zhang, Sejong Bae, Jiangbing Zhou, Lizhong Wang, Runhua Liu
Summary: In prostate cancer, high expression of eIF4A1 is regulated by DNA methylation and it plays an oncogenic role through the BRD2 signaling pathway.
Article
Microbiology
Moises Martinez-Castillo, Rosa Elena Cardenas-Guerra, Rossana Arroyo, Anjan Debnath, Mario Alberto Rodriguez, Myrna Sabanero, Fernando Flores-Sanchez, Fernando Navarro-Garcia, Jesus Serrano-Luna, Mineko Shibayama
FUTURE MICROBIOLOGY
(2017)
Article
Dentistry, Oral Surgery & Medicine
Marcos A. Muniz-Lino, Mariana Rodriguez-Vazquez, Bibiana Chavez-Munguia, Josue Z. Ortiz-Garcia, Lorena Gonzalez-Lopez, Fidel C. Hernandez-Hernandez, Carlos Liceaga-Escalera, Alejandro Garcia-Munoz, Mario A. Rodriguez
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2017)
Article
Immunology
Javier Cazares-Apatiga, Christian Medina-Gomez, Bibiana Chavez-Munguia, Mercedes Calixto-Galvez, Esther Orozco, Carlos Vazquez-Calzada, Aaron Martinez-Higuera, Mario A. Rodriguez
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2017)
Article
Parasitology
Mario A. Rodriguez, Aaron Martinez-Higuera, Martha I. Valle-Solis, Mario Hernandes-Alejandro, Bibiana Chavez-Munguia, Ana H. Figueroa-Gutierrez, Andres Salas-Casas
PARASITOLOGY RESEARCH
(2018)
Article
Immunology
Tania Dominguez-Fernandez, Mario Alberto Rodriguez, Virginia Sanchez Monroy, Consuelo Gomez Garcia, Olivia Medel, David Guillermo Perez Ishiwara
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Immunology
Martha Valle-Solis, Jeni Bolanos, Esther Orozco, Miriam Huerta, Guillermina Garcia-Rivera, Andres Salas-Casas, Bibiana Chavez-Munguia, Mario A. Rodriguez
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2018)
Article
Cell Biology
Rosario Javier-Reyna, Sarita Montano, Guillermina Garcia-Rivera, Mario Alberto Rodriguez, Arturo Gonzalez-Robles, Esther Orozco
CELLULAR MICROBIOLOGY
(2019)
Editorial Material
Immunology
Anjan Debnath, Mario Alberto Rodriguez, Serge Ankri
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Juan Ramon Padilla-Mendoza, Arturo Contis-Montes de Oca, Mario Alberto Rodriguez, Mavil Lopez-Casamichana, Jeni Bolanos, Laura Itzel Quintas-Granados, Octavio Daniel Reyes-Hernandez, Fabiola Fragozo-Sandoval, Aldo Arturo Resendiz-Albor, Claudia Vanessa Arellano-Gutierrez, Israel Lopez-Reyes
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Parasitology
Christian Medina-Gomez, Jeni Bolanos, Jessica Borbolla-Vazquez, Susana Munguia-Robledo, Esther Orozco, Mario A. Rodriguez
Summary: Protein arginine methylation is involved in regulating various cellular events, with the protozoa parasite Entamoeba histolytica possessing four PRMTs, one of which is an atypical PRMT (EhPRMTA) that plays a role in heat shock and erythrophagocytosis processes.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Mariana Rodriguez-Vazquez, Marcos Agustin Muniz-Lino, Mineko Shibayama, Roberto Onner Cruz-Tapia, Javier Portilla-Robertson, Josue Zuriel Ortiz-Garcia, Ana Laura Martinez-Ricardez, Carlos Liceaga-Escalera, Mario A. Rodriguez
Summary: The study aimed to identify differentially expressed membrane proteins in ameloblastomas and dentigerous cysts, with chaperonin Hsp60 identified as a potential target for ameloblastoma treatment due to its overexpression and possible involvement in ameloblastoma development.
JOURNAL OF ORAL BIOSCIENCES
(2021)
Review
Parasitology
Mario Alberto Rodriguez
Summary: Arginine methylation is a post-translational modification that plays a significant role in protozoan parasites, particularly in pathogenicity-related events. Several PRMTs have been identified in these parasites and are involved in cell growth, stress response, stage transitions, and virulence.
Article
Immunology
Gretter Gonzalez-Blanco, Guillermina Garcia-Rivera, Patricia Talmas-Rohana, Ester Orozco, Jose Manuel Galindo-Rosales, Cristina Velez, Odila Salucedo-Cardenas, Elisa Azuara-Liceaga, Mario Alberto Rodriguez-Rodriguez, Tomoyoshi Nozaki, Jesus Valdes
Summary: E. histolytica is a pathogen causing intestinal amebiasis and liver abscesses, and metronidazole is the main treatment drug. However, metronidazole-resistant strains have been reported recently, posing challenges for amebiasis eradication. RNA metabolism-related genes were found to be associated with the virulence of the parasite, and the 84KQ domain plays a critical role in splicing inhibition and intron retention. Surprisingly, the deletion of the 84KQ domain increased splicing and enhanced the virulence of the parasite.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Susana Munguia-Robledo, Esther Orozco, Guillermina Garcia-Rivera, Jeni Bolanos, Jesus Valdes, Elisa Azuara-Liceaga, Mario Alberto Rodriguez
Summary: Lysine methylation, catalyzed by PKMTs, is involved in epigenetics and signaling pathways and may participate in virulence of protozoa parasites. This study found that EhPKMT2 is involved in cellular events such as phagocytosis and heat shock and has effects on cell growth, migration, and cytopathic effect, suggesting it as a potential therapeutic target for amebiasis.
Article
Biotechnology & Applied Microbiology
Juan Ramon Padilla-Mendoza, Lucia Angelica Gomez-Lopez, Mavil Lopez-Casamichana, Elisa Irene Azuara-Liceaga, Enoc Mariano Cortes-Malagon, Lilia Lopez-Canovas, Octavio Daniel Reyes-Hernandez, Mario Alberto Rodriguez, Jose Bonilla-Delgado, Israel Lopez-Reyes
BIOMED RESEARCH INTERNATIONAL
(2020)