Bioactive compounds of Eriocaulon sieboldianum blocking proliferation and inducing apoptosis of HepG2 cells might be involved in Aurora kinase inhibition

Aurora-A signaling is activated in advanced stage of squamous cell carcinoma of head and neck cancer and requires osteopontin to stimulate invasive behavior

(2015) Chih-Yen Chien et al.   Oncotarget

Aurora Kinase Inhibitor PHA-739358 Suppresses Growth of Hepatocellular Carcinoma In Vitro and in a Xenograft Mouse Model

(2015) Daniel Benten et al.   NEOPLASIA

WLIP derived from Lasiosphaera fenzlii Reich exhibits anti-tumor activity and induces cell cycle arrest through PPAR-γ associated pathways

(2014) Jingjing Meng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases

(2014) Jean-Christophe Carry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antioxidant and Nitrite-Scavenging Capacities of Phenolic Compounds from Sugarcane (Saccharum officinarum L.) Tops

(2014) Jian Sun et al.   MOLECULES

Structure of Aurora B–INCENP in complex with barasertib reveals a potential transinhibitory mechanism

(2014) Fabio Sessa et al.   Acta Crystallographica Section F-Structural Biology Communications

S39, a novel Aurora B kinase inhibitor, shows potent antineoplastic activity in human Hela cervical cancer cell line

(2013) Jie Li et al.   BIOTECHNOLOGY LETTERS

Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling

(2012) Dung-Fang Lee et al.   Cell Stem Cell

The dietary flavonoid luteolin inhibits Aurora B kinase activity and blocks proliferation of cancer cells

(2012) Fang Xie et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Inhibition of Aurora-B kinase activity confers antitumor efficacy in preclinical mouse models of early and advanced gastrointestinal neoplasia

(2012) DENIS G. ALFEREZ et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Hepatocellular carcinoma

(2012) Alejandro Forner et al.   LANCET

Mitotic Failures in Cancer: Aurora B Kinase and its Potential Role in the Development of Aneuploidy

(2012) Katalin Hegyi et al.   PATHOLOGY & ONCOLOGY RESEARCH

Antioxidant activity of the halophyte Limonium tetragonum and its major active components

(2011) Jung Im Lee et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Abstract 5776: Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells

(2011) Stephanie Geuns-Meyer et al.   CANCER RESEARCH

Aurora B kinase inhibition in mitosis: Strategies for optimizing the use of Aurora kinase inhibitors such as AT9283

(2011) Jayne Curry et al.   CELL CYCLE

The flavonoid eupatorin inactivates the mitotic checkpoint leading to polyploidy and apoptosis

(2011) Anna-Leena Salmela et al.   EXPERIMENTAL CELL RESEARCH

Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway

(2011) Hee-Jin Kim et al.   FEBS LETTERS

Chemical analysis of Eriocaulon buergerianum and adulterating species by high-performance liquid chromatography with diode array detection and electrospray ionization tandem mass spectrometry

(2011) Xue Qiao et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Chemical constituents and allelopathic and antioxidant activities ofAlchorneopsis floribundaMüll. Arg. (Euphorbiaceae)

(2011) Elenilze Figueiredo Batista et al.   NATURAL PRODUCT RESEARCH

Eriocaulon buergerianum extract protects PC12 cells and neurons in zebrafish against 6-hydroxydopamine-induced damage

(2011) Meiwei Wang et al.   Chinese Medicine

Aurora kinase inhibitors as anticancer molecules

(2010) Hiroshi Katayama et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Hispidulin, a small flavonoid molecule, suppresses the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2-mediated PI3K/Akt/mTOR signaling pathway

(2010) Lijun He et al.   CANCER SCIENCE

Aurora-A kinase inhibitor scaffolds and binding modes

(2010) Aixia Yan et al.   DRUG DISCOVERY TODAY

3,3′,4,5,5′-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress

(2010) Haitao Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Aurora A contributes to p150gluedphosphorylation and function during mitosis

(2010) Pierre Romé et al.   JOURNAL OF CELL BIOLOGY

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

(2010) Nicholas D. Adams et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatocellular carcinoma: a global view

(2010) Ju Dong Yang et al.   Nature Reviews Gastroenterology & Hepatology

Aurora kinase inhibitor ZM447439 induces apoptosis via mitochondrial pathways

(2009) Minglun Li et al.   BIOCHEMICAL PHARMACOLOGY

A new flavonol derivative from Fagopyrum dibotrys

(2009) Jian Zhang et al.   CHEMISTRY OF NATURAL COMPOUNDS

p53 is critical for the Aurora B kinase inhibitor-mediated apoptosis in acute myelogenous leukemia cells

(2009) Takayuki Ikezoe et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Hepatocellular Carcinoma Incidence, Mortality, and Survival Trends in the United States From 1975 to 2005

(2009) Sean F. Altekruse et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted therapy for hepatocellular carcinoma

(2009) Hans Christian Spangenberg et al.   Nature Reviews Gastroenterology & Hepatology

Concomitant inhibition of Mdm2-p53 interaction and Aurora kinases activates the p53-dependent postmitotic checkpoints and synergistically induces p53-mediated mitochondrial apoptosis along with reduced endoreduplication in acute myelogenous leukemia

(2008) K. Kojima et al.   BLOOD

The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma

(2008) Zhong-Zhe Lin et al.   JOURNAL OF HEPATOLOGY

Antibacterial phenolic components from Eriocaulon buergerianum

(2008) Jing-Jing Fang et al.   PHYTOCHEMISTRY

Aurora kinases as targets for cancer therapy

(2007) Giannis Mountzios et al.   CANCER TREATMENT REVIEWS