Article
Cell Biology
Gangping Tu, Wenzhe Gao, Ying Li, Yating Dian, Bingyang Xue, Li Niu, Xiao Yu, Hongwei Zhu
Summary: S100A16, highly expressed in pancreatic cancer tissues, might be associated with poor prognosis. By analyzing gene expression differences, clinical characteristics, and establishing a risk score system, the study successfully predicted the survival time of patients with PDAC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Kaidi Zhao, Zhou Ma, Wei Zhang
Summary: This study reveals that SPP1 is overexpressed in cervical cancer tissues and is associated with prognosis and immune cell infiltration, suggesting its potential as a prognostic biomarker for cervical cancer patients.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Kaidi Zhao, Yuexiong Yi, Zhou Ma, Wei Zhang
Summary: INHBA is highly expressed in cervical cancer and significantly associated with poor prognosis. It is also correlated with immune cell infiltration.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Linjie Zhang, Yizhang Deng, Jingbang Yang, Wuguo Deng, Liren Li
Summary: A neurotransmitter receptor-related gene signature was constructed to predict the survival, immune microenvironment, and treatment response of colorectal cancer patients. The signature genes were enriched in cellular metabolic-related pathways and correlated with immunosuppressive cell infiltration and chemotherapy response.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Genetics & Heredity
Yuansheng Lin, Hao Zhou, Shengjun Li
Summary: This study analyzed multiple databases and found evidence that BTN3A2 may serve as a prognosis biomarker for LUAD. High expression of BTN3A2 may influence the prognosis of LUAD through immune invasion. Additionally, the study suggests that hsa-miR-17-5p may be a miRNA target of BTN3A2.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Xiangyu Sun, Xin Fu, Shouping Xu, Pengfei Qiu, Zhidong Lv, Mingke Cui, Qiang Zhang, Yingying Xu
Summary: This study investigated the expression of OLR1 in breast cancer tissues and its correlation with clinical outcomes, finding that OLR1 upregulation was associated with worse prognosis and tumor infiltration. Additionally, OLR1 may regulate immunity-related pathways, particularly macrophage polarization, affecting the survival of breast cancer patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Hao Xu, Chen Xiong, Yuan Chen, Chi Zhang, Dousheng Bai
Summary: Rad51, a DNA-repair-related gene, is found to be overexpressed in hepatocellular carcinoma (HCC) patients and associated with clinical severity, prognosis, and immune infiltration. It serves as a valuable biomarker for liver cancer prognosis and has significant correlations with immune infiltrations.
Article
Oncology
Songshan Feng, Zhijie Xu, Jinwu Peng, Mingyu Zhang
Summary: This study comprehensively analyzed the AlkB family in GBM and found that high expression of ALKBH2 and ALKBH8 was associated with poor overall survival in GBM patients. Furthermore, the AlkB family was found to be closely related to DNA damage repair, cell metabolism, cell proliferation, and tumor immune infiltration in GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Zidan Zhao, Tsz Kin Mak, Yuntao Shi, Huaping Huang, Mingyu Huo, Changhua Zhang
Summary: In this study, a lncRNA prognostic model related to DNA damage repair was constructed, and it was found that gastric cancer patients in the low-risk group had better overall survival. The study also discovered that patients in the low-risk group who received immunotherapy had a better prognosis. This work provides a foundation for improving the prognosis and response to immunotherapy among patients with gastric cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Han Qiao, Hong Yin, Yan Feng, Huaping Tang
Summary: The study reveals that RCSD1 is expressed at low levels in most tumors, but its high expression is associated with good patient survival. The co-expression network of RCSD1 is mainly involved in the regulation of immune response and plays a significant role in the tumor microenvironment and immune infiltrating cells in lung cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yan Du, Shuang Hou, Zhou Chen, Wancheng Li, Xin Li, Wence Zhou
Summary: PKP3 is upregulated in pancreatic cancer tissues and is associated with a negative prognosis. It promotes the progression, migration, and invasive capacity of pancreatic cancer cells, and is involved in the regulation of the PI3K-Akt and MAPK signaling pathways. It inhibits CD8+ T-cell infiltration and immune cytokine expression in the tumor microenvironment. PKP3 is identified as a prospective independent predictive indicator and a potential target for immunotherapy in pancreatic cancer.
Article
Immunology
Jing Yang, Hui Wei, Mengxiao Liu, Taobi Huang, Xidong Fang, Xiangqing Ren, Hao Yuan, Ya Zheng, Yuping Wang, Yongning Zhou
Summary: This study found that high expression of HAMP is associated with poor prognosis in gastric cancer, and HAMP affects the survival rate of patients with gastric cancer through immune cell infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Genetics & Heredity
Yaodong He, Yunshan Li, Junwei Xiang, Xu Huang, Mingyu Zhao, Yuanyin Wang, Ran Chen
Summary: Tyrosine kinase 2 (TYK2) is overexpressed in head and neck squamous cell carcinoma (HNSCC) and is associated with tumor growth, prognosis, and immune infiltration. TYK2 can serve as a novel biomarker for assessing the prognosis of HNSCC patients and aiding in immunotherapy against HNSCC.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Fang Wen, Shuai Ruan, Wenjie Huang, Xiaoxue Chen, Yulan Wang, Suping Gu, Jiatong Liu, Shenlin Liu, Peng Shu
Summary: The study identified gene mutation characteristics in cervical squamous cell carcinoma and the association between tumor mutation burden (TMB) and prognosis. By establishing a prognostic model with five hub genes, the sensitivity of patients to immunotherapy can be predicted.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Zhao Zhang, Yongbo Yu, Pengfei Zhang, Guofeng Ma, Mingxin Zhang, Ye Liang, Wei Jiao, Haitao Niu
Summary: The study revealed a correlation between high TMB scores and poor survival in BLCA, with NTRK3 identified as a key gene with significant prognostic value. Co-expressed genes of NTRK3 were found to be involved in various important pathways related to cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
Junjie Jin, Ke Wu, Xiaoran Li, Yang Yu, Xinghao Wang, Hongzan Sun
Summary: The PET texture features were highly correlated with metabolic tumor volume, with inconsistent variation trends in texture heterogeneity as tumor volume increased in the smaller MTV range. In contrast, the MRI texture heterogeneity consistently decreased with increasing tumor volume. This suggests that MRI may be a better imaging modality compared to PET for determining tumor texture heterogeneity in the small tumor volume range.
NUCLEAR MEDICINE COMMUNICATIONS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-ran Li, Jun-jie Jin, Yang Yu, Xing-hao Wang, Yan Guo, Hong-zan Sun
Summary: This study found that radiomics based on PET-CT scans can predict E-cad expression levels in early-stage cervical cancer patients and is correlated with pelvic lymph node metastasis. The radiomics score can help evaluate patients' prognosis and achieve more individualized medical treatments.
EUROPEAN RADIOLOGY
(2021)
Article
Oncology
Xinghao Wang, Ke Wu, Xiaoran Li, Junjie Jin, Yang Yu, Hongzan Sun
Summary: The study compared the radiomic features and metabolic parameters on 18F-FDG PET/CT between patients with and without Lynch syndrome in endometrial cancer, revealing that metabolic tumor volume, total lesion glycolysis, and GLCMEntropy could potentially predict the risk for Lynch syndrome. Additionally, the radiomic feature of GLCMEntropy in tumors was found to be a potential predictor of PD1 expression.
FRONTIERS IN ONCOLOGY
(2021)
Article
Physiology
Xinghao Wang, Chen Xu, Marcin Grzegorzek, Hongzan Sun
Summary: This study aims to develop and validate a PET/CT image-based radiomics approach to determine the Ki-67 status in high-grade serous ovarian cancer (HGSOC) and improve the model's predictive ability using metabolic subregion evolution. The results demonstrate that texture features extracted using the Habitat method can better predict the Ki-67 state and have the potential to serve as a new marker for Ki-67. Additionally, the radiomics model based on Habitat can effectively stratify the prognosis.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Xinghao Wang, Jing Sun, Jia Li, Linkun Cai, Qian Chen, Yiling Wang, Zhenghan Yang, Wenjuan Liu, Han Lv, Zhenchang Wang
Summary: This study used Mendelian randomization (MR) to analyze the bidirectional relationship between insulin related characteristics and ovarian cancer. The findings showed that the insulin secretion rate has a causal effect on the risk of ovarian cancer, suggesting that the human glucose metabolism cycle represented by insulin secretion plays an important role in the pathogenesis of ovarian cancer.
FRONTIERS IN ENDOCRINOLOGY
(2023)
