Article
Microbiology
Yeon Hee Ban, Myoung Chong Song, Joong Ho Jeong, Min Seok Kwun, Chang Rae Kim, Hwi So Ryu, Eunji Kim, Je Won Park, Dong Gun Lee, Yeo Joon Yoon
Summary: This study synthesized new aminoglycoside antibiotics enzymatically, with structural modifications enhancing their antibacterial activity against multidrug-resistant gram-negative bacteria while reducing nephrotoxicity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Rewan Abdelaziz, Yasmine H. Tartor, Ahmed B. Barakat, Gamal EL-Didamony, Marwa M. Gado, Adina Berbecea, Habil Dr. Isidora Radulov
Summary: This study aimed to discover a broad-spectrum biomaterial for treating multidrug-resistant bacterial and fungal infections. Streptomyces species were isolated from soil samples, and the most active strains with antimicrobial activity were identified. The bioactive metabolites extracted from these strains showed significant inhibitory effects against MDR bacteria and fungi, and demonstrated therapeutic efficacy in mouse models.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Veterinary Sciences
Iqra Nazir, Masood Rabbani, Ali Ahmad Sheikh, Sehrish Firyal, Sohail Raza, Muhammad Ilyas Riaz
Summary: The study demonstrated the significant antibacterial activity of seven different flower ethanolic extracts against MDR E. coli, with Rosa damascena Miller and Bombax ceiba having the lowest MIC values.
PAKISTAN VETERINARY JOURNAL
(2021)
Article
Multidisciplinary Sciences
Jiong Zhang, Xiangxiang Zhao, John R. Cappiello, Yi Yang, Yunfei Cheng, Guang Liu, Wenjing Fang, Yinzhu Luo, Yu Zhang, Jiajia Dong, Lixin Zhang, K. Barry Sharpless
Summary: A series of arylfluorosulfates synthesized via SuFEx, including compounds 3, 81, and 101, showed potent antibacterial activity, the ability to overcome multidrug resistance, and a lack of susceptibility to resistance development. These compounds also demonstrated rapid bactericidal potency, selectivity against gram-positive bacteria, and the capability to disrupt bacterial biofilms and kill persisters. Additionally, compound 3 exhibited synergy with streptomycin and gentamicin, while their anti-MRSA activity was evaluated using the Caenorhabditis elegans model.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Multidisciplinary
Yiwen Zhu, Minzheng Gao, Mengrui Su, Yanzhe Shen, Kai Zhang, Bingran Yu, Fu-Jian Xu
Summary: Traditional photodynamic therapy (PDT) is limited in treating deep infections due to insufficient penetration of light and oxygen. A targeting singlet oxygen delivery system, CARG-Py, was designed for irradiation-free and oxygen-free PDT. The system converted to CARG-O-1(2) released singlet oxygen without external irradiation or oxygen and showed potential in efficient treatment of deep infections. This work provides a new strategy to improve traditional PDT for irradiation- and oxygen-free treatment of deep infections while improving convenience.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Ida M. J. Ng, Suhaili Shamsi
Summary: Infectious diseases pose a major threat due to their high morbidity and mortality rates, and the emergence of multidrug-resistant bacteria has further hindered treatment. Nanoparticles, especially those based on graphene, have shown unique antimicrobial properties and potential biomedical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
M. A. R. Sarker, Young-Ho Ahn
Summary: Photodynamic treatment is a promising approach to control multidrug-resistant bacteria. This study examined the use of two phytochemicals and LED light for the inactivation of MDRB and total coliform in wastewater. The results showed that white LED light was more effective in controlling MDRB, and light intensity was an important parameter in photodynamic disinfection.
ENVIRONMENTAL POLLUTION
(2022)
Article
Medicine, Research & Experimental
Chenchen Wang, Hao Lu, Xiaodan Li, Yongwei Zhu, Yueyue Ji, Wenjia Lu, Gaoyan Wang, Wenqi Dong, Manli Liu, Xiangru Wang, Huanchun Chen, Chen Tan
Summary: The persistent incidence of multidrug-resistant bacteria poses a serious threat to global public health. In this study, oxyclozanide was found to potentiate the activity of tetracycline antibiotics against drug-resistant bacteria by promoting intracellular accumulation of tetracycline. Oxyclozanide was also shown to directly kill bacteria, reduce virulence protein production, and alleviate inflammation caused by bacteria. In animal infection assays, oxyclozanide effectively reversed tetracycline resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Hee-Won Han, Kapil D. Patel, Jin-Hwan Kwak, Soo-Kyung Jun, Tae-Su Jang, Sung-Hoon Lee, Jonathan Campbell Knowles, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee
Summary: The study identified the antibacterial activity of selenium nanoparticles (SeNPs) against multidrug-resistant bacteria, particularly when combined with the conventional antibiotic linezolid. SeNPs demonstrated synergistic effects with linezolid through protein degradation against MRSA and MSSA. These results suggest the potential of SeNPs as antibacterial substitutes and supplements against MDR bacteria.
Article
Nanoscience & Nanotechnology
Xiaohui Liu, Duoyang Fan, Xueping Feng, Yanjun Zheng, Seraphine Wegner, Meihui Liu, Fei Chen, Wenbin Zeng
Summary: A water-soluble probe with membrane-active fluorescence and broad-spectrum antimicrobial actions was designed to inhibit and eradicate microbial biofilms effectively, especially against methicillin-resistant Staphylococcus atoms (MRSA). The probe demonstrated strong antimicrobial effects comparable to vancomycin and effectively inhibited biofilm formation without toxicity to mammalian cells. It could penetrate through biofilm barriers and disrupt existing biofilms, providing a novel theranostic strategy for the treatment of multidrug-resistant bacterial infections and antibiofilm medications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Manpreet Kaur, Yael Cohen, Elena Poverenov, Evgeni Eltzov
Summary: This study found that the combination of N-alkylaminated chitosan nanoparticles and conventional beta-lactam antibiotics has synergistic antibacterial potential against multidrug-resistant pathogens, and can effectively decrease the minimum inhibitory concentration of the antibiotics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Physical
Shuqin Li, Hongqi Huo, Xing Gao, Luntao Liu, Shumin Wang, Jiamin Ye, Jing Mu, Jibin Song
Summary: Photocatalytic antibacterial approach using Janus AuNR-TiO2 NPs has shown great potential in treating multidrug-resistant bacterial infections. The asymmetric nanostructure of Janus AuNR-TiO2 NPs promotes the directional migration of charge carriers and improves the spatial separation of electron-hole pairs. The injection of hot electrons and enhancement of plasmon near-fields from the SPR effect further enhance the photocatalytic efficiency of Janus AuNR-TiO2 NPs. Under simulated sunlight irradiation, Janus AuNR-TiO2 NPs generate large amounts of reactive oxygen species for highly efficient antibacterial activity against MRSA. Moreover, Janus AuNR-TiO2 NPs exhibit superior biocompatibility, structural stability, and accelerate wound healing.
Article
Chemistry, Physical
Shuqin Li, Hongqi Huo, Xing Gao, Luntao Liu, Shumin Wang, Jiamin Ye, Jing Mu, Jibin Song
Summary: Janus AuNR-TiO2 NPs show promising potential in treating multidrug-resistant bacterial infections with high antibacterial efficiency and accelerated wound healing.
Article
Plant Sciences
Vladimir S. Kurcubic, Svetlana V. Raketic, Jelena M. Maskovic, Pavle Z. Maskovic, Luka V. Kurcubic, Volker Heinz, Igor B. Tomasevic
Summary: The present research aimed to screen the antimicrobial activity of Kitaibelia vitifolia extract against multidrug-resistant bacterial strains. The results indicate that the extract showed high resistance against certain bacterial strains.
Article
Infectious Diseases
Sung-Yong Park, Hong-Jae Lee, Hyo-Sung Kim, Dong-Hwi Kim, Sang-Won Lee, Hun-Young Yoon
Summary: This study evaluated the potential of an antimicrobial compound derived from probiotics for treating staphylococcal infections in dogs. The compound showed significant inhibitory effects on multidrug-resistant staphylococci both in vitro and in vivo.
Article
Pharmacology & Pharmacy
Amanda Karine de Sousa, Janaina Esmeraldo Rocha, Thiago Sampaio de Freitas, Priscila Ramos Freitas, Raimundo Luiz Silva Pereira, Francisco Nascimento Pereira Junior, Guilherme Andrade Brancaglion, Daniela Carvalho de Paulo, Diogo Teixeira Carvalho, Irwin Rose Alencar de Menezes, Francisco Antonio Vieira Dos Santos, Henrique Douglas Melo Coutinho, Lucindo Jose Quintans Junior
Summary: The problem of antibiotic resistance is a major threat to human health. This study investigated the bactericidal effect of coumarins derived from eugenol in association with LED, and found that LED exposure enhances the synergism. Four compounds were tested and showed bactericidal activity, with certain compounds exhibiting synergism with LED against specific bacterial strains.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Nara Juliana Santos Araujo, Ana Raquel Pereira da Silva, Maria do Socorro Costa, Camila Aparecida Pereira Silva, Thiago Sampaio de Freitas, Erlanio Oliveira de Sousa, Jose Maria Barbosa Filho, Yedda Maria Lobo Soares de Matos, Henrique Douglas Melo Coutinho, Jacqueline Cosmo Andrade-Pinheiro
Summary: Antimicrobial drugs play a crucial role in controlling bacterial infections, but their excessive use leads to the emergence of antibiotic resistance. Hecogenin acetate, a secondary metabolite found in agave plants, has shown significant antibacterial activity. This study aimed to investigate the antibacterial activity of hecogenin acetate against E. coli, P. aeruginosa, and S. aureus, and to examine its inhibitory effects on NorA and MepA efflux pumps in S. aureus strains. The results showed that hecogenin acetate had minimal inhibitory concentration without significant relevance, and did not interfere with the efflux pump mechanism of the analyzed bacteria.
MICROBIAL PATHOGENESIS
(2023)
Review
Chemistry, Analytical
Josiane F. da Silva, Clara M. G. Lima, Debora L. da Silva, Ivonea S. do Nascimento, Sarah de O. Rodrigues, Leticia A. Goncalves, Renata F. Santana, Waseem Khalid, Silvani Verruck, Talha Bin Emran, Irwin R. A. de Menezes, Henrique D. M. Coutinho, Mayeen U. Khandaker, Mohammad R. I. Faruque, Rafael da C. I. Fontan
Summary: Growing interest in medical, engineering, biochemical, and biological fields has led to continuous research and development of polymeric monolithic structures with densely interconnected pores for purifying bio compounds. Cryogels, generated by freezing a reactive polymerization mixture, offer versatility and cost-effectiveness as macroporous, polymeric, monolithic adsorbents. The conversion of cryogels into affinity adsorbents, particularly using epoxy radicals as supports, provides a promising alternative for biomolecule purification.
Article
Engineering, Environmental
Deepa Devi, Kartikey Kumar Gupta, Harish Chandra, Kamal Kant Sharma, Kalpana Sagar, Edna Mori, Pablo Antonio Maia de Farias, Henrique Douglas Melo Coutinho, Abhay Prakash Mishra
Summary: The resiliency of plastic products against microbial degradation in natural environment often creates devastating changes for humans, plants, and animals on the earth's surface. Biodegradation of plastics using indigenous bacteria may serve as a critical approach to overcome this resulting environmental stress. A polyethylene degrading bacterium Alcaligenes faecalis strain ISJ128 was isolated from partially degraded polyethylene film buried in the soil at a plastic waste disposal site. The bacterium demonstrated high growth response and viability on polyethylene film, indicating its suitability for polyethylene degradation. Significant degradation of polyethylene film was observed within a short period of time, accompanied by changes in surface structure and functional groups. The stable nature of the bacterial strain reflects its potential as a degrader for eco-friendly disposal of polyethylene waste.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Immunology
Ana Luiza A. R. Martin, Irwin R. A. De Menezes, Amanda K. Sousa, Pablo A. M. Farias, Francisco A. V. dos Santos, Thiago S. Freitas, Fernando G. Figueredo, Jaime Ribeiro-Filho, Diogo T. Carvalho, Henrique D. M. Coutinho, Marta M. F. Fonteles
Summary: The increase in antibiotic resistance rates has led researchers to search for antibacterial compounds that can enhance the activity of conventional antibiotics. Coumarin derivatives have been found to be effective antibacterials with potential new mechanisms of action for treating drug-resistant bacterial infections. This study synthesized new coumarin derivatives and evaluated their pharmacokinetic properties, chemical similarity, antimicrobial activity, and potential for modulating antibiotic resistance using in vitro assays.
MICROBIAL PATHOGENESIS
(2023)
Review
Biochemistry & Molecular Biology
Md. Shimul Bhuia, Polrat Wilairatana, Raihan Chowdhury, Asraful Islam Rakib, Hossam Kamli, Ahmad Shaikh, Henrique D. M. Coutinho, Muhammad Torequl Islam
Summary: This study aims to summarize the botanical origins and anticancer properties of magnolin, a naturally occurring, multi-bioactive lignan molecule. Magnolin has been shown to exhibit robust anticancer activity by inhibiting cell cycle, inducing apoptosis, and modulating multiple signaling pathways in various experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.
Article
Plant Sciences
Carla de Fatima Alves Nonato, Emerson Vinicius Silva de Melo, Cicera Janaine Camilo, Maria Kueirislene Amancio Ferreira, Jane Eire Alencar de Meneses, Antonio Wlisses da Silva, Helcio Silva dos Santos, Jaime Ribeiro-Filho, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Irwin Rose Alencar de Menezes, Henrique Douglas Melo Coutinho, Grazyna Kowalska, Tomasz Baj, Radoslaw Kowalski, Jose Galberto Martins da Costa
Summary: This study evaluated the antibacterial and anxiolytic effects of essential oils and ethanolic extracts from three species of Lippia (L. alba, L. sidoides, and L. gracilis). The extracts showed significant antibacterial activity, especially those from L. sidoides, and L. alba extract presented the most significant antibiotic-enhancing effect. Additionally, the extracts exhibited anxiolytic effects through modulation of the GABA(A) and 5-HT receptors. These findings provide new pharmacological evidence for potential therapeutic approaches and food preservation using Lippia species.
Article
Multidisciplinary Sciences
Paulo Ricardo Batista, Andressa de Alencar Silva, Carla Mikevely de Sena Bastos, Renata Evaristo Rodrigues da Silva, Gabriela Lucena Calixto, Luis Pereira de Morais, Gyllyandeson de Araujo Delmondes, Marta Regina Kerntopf, Irwin Rose Alencar de Menezes, Roseli Barbosa
Summary: This study aims to characterize the vasodilatory effect of (E,E)-farnesol in human umbilical arteries (HUA). The results showed that (E,E)-farnesol promoted vasodilation in HUA, possibly through inhibiting calcium and potassium channels. These findings suggest that (E,E)-farnesol may be a potential pharmacological candidate for obstetric hypertensive disorders.
Article
Medicine, Research & Experimental
Bruno Anderson Fernandes da Silva, Renata Torres Pessoa, Roger Henrique Sousa da Costa, Maria Rayane Correia de Oliveira, Andreza Guedes Barbosa Ramos, Maria Gabriely de Lima Silva, Lucas Yure Santos da Silva, Cassio Rocha Medeiros, Sloana Giesta Lemos Florencio, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Antonio Raposo, Sunghoon Yoo, Heesup Han, Irwin Rose Alencar de Menezes, Lucindo Jose Quintans Jr
Summary: This study aimed to evaluate the effects of hydroethanolic barks extract of Ximenia americana (HEXA) on edema and inflammation. The results showed that HEXA has antiedematogenic effects in both acute and chronic inflammation processes, possibly through the suppression or regulation of inflammatory mediators.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maria Gabriely de Lima Silva, Lucas Yure Santos da Silva, Renata Torres Pessoa, Maria Rayane Correia de Oliveira, Francisco Lucas Alves Batista, Isabel Sousa Alcantara, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes
Summary: Abietic acid has analgesic and anti-edematogenic activities related to anti-inflammatory mechanisms. The compound inhibits myeloperoxidase activity and histamine action, as well as exhibits partial inhibition of eicosanoid-dependent pathways.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Immunology
Raimundo Samuel Leite Sampaio, Raimundo Luiz Silva Pereira, Henrique Douglas Melo Coutinho, Jose Weverton Almeida-Bezerra, Maria Flaviana Bezerra Morais-Braga, Mariana dos Santos Santana, Maria Elenilda Paulino da Silva, Antonia Thassya Lucas dos Santos, Victor Juno Alencar Fonseca, Adrielle Rodrigues Costa, Viviane Bezerra da Silva, Felicidade Caroline Rodrigues, Jose Jailson Lima Bezerra, Antonio Raposo, Joao Paulo Martins de Lima, Luiz Marivando Barros
Summary: This study aimed to evaluate the effects of citric acid and nano-calcium silicate suspensions on the growth of Lactobacillus. The results showed that the addition of citric acid and nano-calcium silicate suspensions at different concentrations significantly inhibited the growth of Lactobacillus. The inhibitory effects of citric acid and nano-calcium silicate suspensions were more pronounced at higher concentrations. The findings indicate that citric acid and nano-calcium silicate suspensions may serve as potential methods for inhibiting the growth of Lactobacillus.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Antonia Thassya Lucas dos Santos, Jose Bezerra de Araujo-Neto, Maria Milene Costa da Silva, Maria Elenilda Paulino da Silva, Joara Nalyda Pereira Carneiro, Victor Juno Alencar Fonseca, Henrique Douglas Melo Coutinho, Paulo Nogueira Bandeira, Helcio Silva dos Santos, Francisco Rogenio da Silva Mendes, Debora Lima Sales, Maria Flaviana Bezerra Morais-Braga
Summary: The study aimed to evaluate the antimicrobial and potentiating activity of synthetic chalcones against strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, and Candida tropicalis. Chalcones were synthesized by Claisen-Schimidt aldol condensation and characterized using Nuclear Magnetic Resonance (NMR) and Gas Chromatography Coupled to Mass Spectrometry (GC/MS). The chalcone DB-Acetone showed inhibitory activity against P. aeruginosa, while DB-CNM and DB-Anisal inhibited the growth of S. aureus. The chalcones also showed potentiating activity with fluconazole against fungal strains.
MICROBIAL PATHOGENESIS
(2023)
Article
Infectious Diseases
Maria Gabriely de Lima Silva, Luciene Ferreira de Lima, Victor Juno Alencar Fonseca, Lucas Yure Santos da Silva, Ana Cecilia Calixto Donelardy, Ray Silva de Almeida, Cicera Datiane de Morais Oliveira-Tintino, Anita Oliveira Brito Pereira Bezerra Martins, Jaime Ribeiro-Filho, Maria Flaviana Bezerra Morais-Braga, Saulo Relison Tintino, Irwin Rose Alencar de Menezes
Summary: This study evaluated the antifungal activity of abietic acid against Candida spp and its ability to enhance the activity of fluconazole. The results showed that the combination of abietic acid and fluconazole enhanced the antifungal effect against Candida albicans and Candida tropicalis, suggesting a potential strategy to reduce antifungal resistance.
Article
Chemistry, Multidisciplinary
Maria Rayane Correia de Oliveira, Maria Gabriely de Lima Silva, Cicera Datiane de Morais Oliveira-Tintino, Saulo Relison Tintino, Janaina Esmeraldo Rocha, Francisco Ernani Alves Magalhaes, Roger Henrique Sousa da Costa, Renata Torres Pessoa, Isabel Sousa Alcantara, Anita Oliveira Brito Pereira Bezerra Martins, Henrique Douglas Melo Coutinho, Antonio Raposo, Conrado Carrascosa, Jose Raduan Jaber, Rogerio Aquino Saraiva, Irwin Rose Alencar de Menezes
Summary: The present study evaluated the antibacterial effect and inhibitory capacity of a, b, and d-damascone compounds against multidrug-resistant Staphylococcus aureus. These compounds showed clinically relevant effects against S. aureus standard strain and modulating effects with antibiotics against multidrug-resistant strains. They also demonstrated a modulating effect with antibiotics on efflux pumps, with d-damascone showing an inhibitory effect. In terms of ADME properties, a, b, and d-damascone exhibited favorable physicochemical properties, pharmacokinetic characteristics, and good interactions with the critical residues of the MepA receptor.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jorge Ederson Goncalves Santana, Cicera Datiane de Morais Oliveira-Tintino, Gabriel Goncalves Alencar, Gustavo Miguel Siqueira, Daniel Sampaio Alves, Talysson Felismino Moura, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Joao Pedro Viana Rodrigues, Vanessa Barbosa Pinheiro Goncalves, Roberto Nicolete, Talha Bin Emran, Clara Mariana Goncalves Lima, Sheikh F. Ahmad, Henrique Douglas Melo Coutinho, Teresinha Goncalves da Silva
Summary: The study aimed to investigate the antibacterial and inhibitory activities of sesquiterpenes nerolidol, farnesol, and alpha-bisabolol, either individually or in liposomal nanoformulation, against multi-resistant Staphylococcus aureus strains carrying efflux systems NorA, Tet(K), MsrA, and MepA. The results showed that sesquiterpenes exhibited good antibacterial activity and efflux pump inhibition, while liposomal formulations had limited effectiveness.
