Article
Veterinary Sciences
Dawei Wei, Sayed Haidar Abbas Raza, Xingping Wang, Rajwali Khan, Zhaoxiong Lei, Guijie Zhang, Jiupan Zhang, Zhuoma Luoreng, Yun Ma, Muna O. Alamoudi, Bandar Hamad Aloufi, Ahmed Mohajja Alshammari, Ayman Hassan Abd El-Aziz, Majid Alhomrani, Abdulhakeem S. Alamri
Summary: This study investigated the tissue expression patterns and functional promoter of bovine LATS1, and identified the key transcription factors in the core promoter region. It revealed the regulatory mechanisms of bovine LATS1 transcription in mediating skeletal muscle growth. Bovine LATS1 was highly expressed in the longissimus thoracis and upregulated in infancy muscle.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Alyce J. Mayfosh, Tien K. Nguyen, Mark D. Hulett
Summary: The extracellular matrix plays crucial roles in maintaining tissue structure, immune defense, and acting as a reservoir for bioactive molecules, with heparan sulfate proteoglycans (HSPGs) and their component heparan sulfate being essential in these processes. Understanding the regulation of heparanase and its downstream targets is important for potential therapeutic strategies in inflammatory diseases, atherosclerosis, fibrosis, and cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Annapurna Bhattacharjee, Prabhakar Lal Srivastava, Onkar Nath, Mukesh Jain
Summary: OsHOX24 mediates regulation of desiccation stress response in rice through binding to multiple target genes involved in various biological processes, such as plant development and abiotic stress responses. The involvement of OsHOX24 in complex regulatory networks is indicated by the enrichment of cis-regulatory motifs representing binding sites of other transcription factors.
PLANT MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Valentin Schmidt, Tobias Sieckmann, Karin M. Kirschner, Holger Scholz
Summary: In this study, it was found that WT1 regulates the HOXB9 gene in a bidirectional manner. Depending on the endogenous expression of WT1, forced changes in WT1 can stimulate or repress HOXB9, and the inhibitory effect of WT1 on transcription of HOXB9 involves BASP1. This regulation may play a role in kidney development and cancer progression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2021)
Article
Biochemical Research Methods
Ingrida Kutraite, Naglis Malys
Summary: This study reports the characterization of a transcription factor-based inducible system that responds to gallic acid in a dose-dependent manner. The activation of this system requires gallate dioxygenase activity and the effector molecule is identified as an intermediate of gallic acid metabolism. Furthermore, the applicability of the P. putida-based biosensor is demonstrated by detecting and measuring gallic acid in tea leaf extracts.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
K. Mohamed Shafi, Ramanathan Sowdhamini
Summary: This study identified and analysed potential cold stress response genes across ten Rosaceae family members, revealing differences in TFBS patterns among species and gene families, even among functionally related genes. Different combinations of transcription factors may play a role in the regulation and expression of genes within the same family.
Article
Plant Sciences
Dong Guo, Hui-Liang Li, Jia-Hong Zhu, Ying Wang, Shi-Qing Peng
Summary: This study identified 14 genes encoding TGA transcription factors in the rubber tree and revealed their differential expression in different tissues. HbTGA1, expressed at its highest level in latex, was found to specifically bind with the promoters of multiple NR biosynthesis genes and regulate their promoter activities.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Chandra Sekhar Bhol, Shankargouda Patil, Binod Bihari Sahu, Samir Kumar Patra, Sujit Kumar Bhutia
Summary: PAX9 gene is essential for tooth and craniofacial development, with mutations and polymorphisms associated with abnormal tooth development risk. Additionally, PAX9 plays a role in tumorigenesis, differentiation, and drug sensitivity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Plant Sciences
Malgorzata Majewska, Lukasz Kuzma, Piotr Szymczyk
Summary: Salvia miltiorrhiza synthesises tanshinones with multidirectional therapeutic effects. In this study, a new sequence of the HMGR4 gene in S. miltiorrhiza was isolated and characterised, providing valuable information for understanding the transcription regulation of this gene and further exploring the medicinal value of S. miltiorrhiza.
Article
Neurosciences
Sascha H. Duttke, Patricia Montilla-Perez, Max W. Chang, Hairi Li, Hao Chen, Lieselot L. G. Carrette, Giordano de Guglielmo, Olivier George, Abraham A. Palmer, Christopher Benner, Francesca Telese
Summary: Substance abuse and addiction have significant impacts on healthcare, the economy, and the workforce. Understanding the gene regulatory mechanisms underlying addiction is crucial for effective treatments. This study used advanced transcriptomics methods to explore how drug exposure alters gene regulatory networks in the brain. The findings highlight the disruption of gene regulatory programs by addiction and the potential role of glial cells in driving addiction-related phenotypes.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Plant Sciences
Chen Bo, Ronghao Cai, Xiu Fang, Hao Wu, Zhongxian Ma, Haotian Yuan, Beijiu Cheng, Jun Fan, Qing Ma
Summary: In this study, a salt-tolerant maize mutant ZmWRKY20 was identified through screening of ethyl methanesulfonate-induced mutants. Further analysis revealed that the mutant exhibited higher resistance to wilting and lower reactive oxygen species levels compared to the inbred line B73. ZmWRKY20 regulates the response of maize to salt stress through interactions with other transcription factors and reprogramming of genes involved in defense and oxidation-reduction responses. This study enhances our understanding of the mechanisms underlying maize responses to salt stress.
Article
Immunology
Molly Javier Uyeda, Robert A. A. Freeborn, Brandon Cieniewicz, Rosa Romano, Ping (Pauline) Chen, Jeffrey Mao-Hwa Liu, Benjamin Thomas, Esmond Lee, Alma-Martina Cepika, Rosa Bacchetta, Maria Grazia Roncarolo
Summary: This study reveals that BHLHE40 is highly expressed in human Tr1 cells and regulates CD4(+) T cells by inhibiting IL-10 and promoting IFN-gamma secretion. Although BHLHE40 is not essential for differentiation of CD4(+) T cells into Tr1 cells, its overexpression induces the expression of specific surface markers. These findings highlight a novel mechanism for BHLHE40 as a regulator of IL-10 and IFN-gamma in human T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Xiangli Niu, Han Lu, Youhong Fan, Wenjie Wang, Yulin Yuan, Madigan Hawkins, Junhong Zhang, Zhibiao Ye, Min Miao, Yongsheng Liu, Fangming Xiao
Summary: The tomato transcription factor SlNAC1 plays a crucial role in abiotic stress response and its instability is attributed to the acidic amino acid-rich transactivation domain TAD1. By manipulating SlNAC1 at both gene and protein levels, the researchers were able to enhance tomato's tolerance to cold, drought, and salt stresses, providing a successful example for developing crops adapted to abiotic stress.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Ke Liu, Weifang Li, Yuqing Xiao, Ming Lei, Ming Zhang, Jinrong Min
Summary: The molecular mechanism by which Nuclear respiratory factor 1 (NRF1) recognizes specific DNA sequences in promoters to regulate gene expression has been elucidated. NRF1 utilizes a flexible linker to connect its dimerization domain (DD) and DNA binding domain (DBD), forming a U-turn conformation and specifically binding to the two TGCGC motifs in the GCGCATGCGC consensus sequence. The cooperation between DD and DBD is essential for the binding of the intact GCGCATGCGC sequence and the transcriptional activity of NRF1.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hye Kyung Lee, Michaela Willi, Tyler Kuhns, Chengyu Liu, Lothar Hennighausen
Summary: Enhancers that activate gene expression in the lactating mouse mammary gland were investigated, revealing the importance of a lactation-specific distal enhancer and a super-enhancer in coordinating with the promoter for gene activation. The study provides insights into the regulatory mechanisms of enhancers and super-enhancers during lactation.
NATURE COMMUNICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
T. Kouskoura, Y. El Fersioui, M. Angelini, D. Graf, C. Katsaros, M. Chiquet
JOURNAL OF DENTAL RESEARCH
(2016)
Article
Dentistry, Oral Surgery & Medicine
Matthias Chiquet, Christos Katsaros, Dimitris Kletsas
PERIODONTOLOGY 2000
(2015)
Article
Cell Biology
Kim S. Midwood, Matthias Chiquet, Richard P. Tucker, Gertraud Orend
JOURNAL OF CELL SCIENCE
(2016)
Article
Physiology
Matthias Chiquet, Susan Blumer, Manuela Angelini, Thimios A. Mitsiadis, Christos Katsaros
FRONTIERS IN PHYSIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Sabrina Ruggiero, Raluca Cosgarea, Jan Potempa, Barbara Potempa, Sigrun Eick, Matthias Chiquet
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2013)
Article
Biochemistry & Molecular Biology
Neha Gadhari, Mirren Chamley, Mattia Marelli, Juergen Brugger, Matthias Chiquet
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Matthias Chiquet, David E. Birk, Carsten G. Boennemann, Manuel Koch
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2014)
Article
Biochemical Research Methods
Mattia Marelli, Neha Gadhari, Giovanni Boero, Matthias Chiquet, Juergen Brugger
Review
Biochemistry & Molecular Biology
Ruth Chiquet-Ehrismann, Gertraud Orend, Matthias Chiquet, Richard P. Tucker, Kim S. Midwood
Article
Multidisciplinary Sciences
Thaleia Kouskoura, Anastasiia Kozlova, Maria Alexiou, Susanne Blumer, Vasiliki Zouvelou, Christos Katsaros, Matthias Chiquet, Thimios A. Mitsiadis, Daniel Graf
Article
Multidisciplinary Sciences
Joel Beyeler, Isabelle Schnyder, Christos Katsaros, Matthias Chiquet
Article
Physiology
Joel Beyeler, Christos Katsaros, Matthias Chiquet
FRONTIERS IN PHYSIOLOGY
(2019)
Editorial Material
Immunology
Matthias Chiquet
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Thomas Imhof, Anamaria Balic, Juliane Heilig, Ruth Chiquet-Ehrismann, Matthias Chiquet, Anja Niehoff, Bent Brachvogel, Irma Thesleff, Manuel Koch
Summary: The continuously growing mouse incisor provides a model for studying stem cell regulation and organ renewal. Deficiency in tenascin-W/TNN in mice leads to reduced body weight and lifespan, major defects in periodontal tissues, and decreased hedgehog signaling in mesenchymal stem cells of the incisor. This deficiency affects periodontal remodeling, increases nerve fiber branching, reduces food intake through periodontal pain, and impacts the rate of incisor renewal and neurovascular sonic hedgehog secretion.
FRONTIERS IN IMMUNOLOGY
(2021)