Journal
CATALYSIS SCIENCE & TECHNOLOGY
Volume 5, Issue 7, Pages 3822-3828Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cy00627a
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- Spanish MICINN [CTQ2011-23333]
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Platinum complexes modified with a chiral non-racemizing SPO preligand 1 have been applied in the hydration of aromatic nitriles. [Pt(1)(3)Cl]Cl formed readily from Pt(COD)Cl-2. The chiral secondary phosphine oxide complex showed moderate activity in the hydration of para- and meta-substituted benzonitriles, but failed in converting the ortho-substituted derivatives. The hydride complex PtH(PR2OH)(PR2O-H center dot center dot center dot OR2P) (PR2OH = 1) formed from Pt(PPh3)(4) and 1, and the cationic complex derived from.Pt(1)(3)Cl]Cl via direct chloride abstraction with AgNO3 were proven to be considerably more active, allowing us to extend the scope to the hydration of ortho-substituted aromatic nitriles, including axially chiral [1,1'-binaphthalene]2,2'-dicarbonitrile. In the hydration of the racemic dinitrile, successful kinetic resolution has been achieved. The catalysts derived from non-racemizing 1 are the first chiral transition metal-SPO complexes that provide kinetic resolution in the hydration of a racemic chiral nitrile.
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