Article
Pathology
Almudena Burillo, Emilio Bouza
Summary: This review identifies diagnostic methods for the most prevalent infections in ICU patients and discusses the clinical impact and limitations of direct diagnostic systems for expedited microbial identification and antimicrobial susceptibility testing. The field of diagnostic methods for ICU infections is an exciting area with much potential for further exploration.
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS
(2022)
Article
Clinical Neurology
Sophia Wang, Anthony J. Perkins, Rosalyn Chi, Brandon A. Yates, Sikandar H. Khan, Sujuan Gao, Malaz Boustani, Babar A. Khan
Summary: A secondary data analysis of ICU patients revealed that stroke and depression were identified as risk factors for post-ICU dementia, highlighting the need for interventions targeting these factors to reduce dementia incidence.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nursing
Fernanda Cecilia Monroe dos Santo, Adriana Sousa Rego, Widlani Sousa Montenegro, Sarah Tarcisia Rabelo Ferreira de Carvalho, Rodrigo Costa Cutrim, Abraao Albino Mendes Junior, Fabio Henrique Ferreira Pereira, Almir Vieira Dibai-Filho, Daniela Bassi-Dibai
Summary: This study investigated the difficulties encountered by the nursing team in the application of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU) in mechanically ventilated patients. The results identified deficits in academic formation, patient cooperation, and the need for adequate training among nurses. Therefore, nurses should enhance their understanding of delirium and receive appropriate training.
Review
Nursing
Azura Abdul Halain, Li Yoong Tang, Mei Chan Chong, Noor Airini Ibrahim, Khatijah Lim Abdullah
Summary: This study aimed to investigate psychological distress among family members of ICU patients, and found high levels of anxiety, depression, and stress. These psychological issues had negative impacts on both the patient and family members.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Clinical Neurology
Anna Lena Fisse, Kalliopi Pitarokoili, David Leppert, Jeremias Motte, Xiomara Pedreiturria, Ludwig Kappos, Ralf Gold, Jens Kuhle, Min-Suk Yoon
Summary: This study found that serum NfL levels could potentially serve as a biomarker for predicting outcomes of ICU patients, especially for those with central nervous system impairment.
JOURNAL OF NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Nina Buchtele, Elisabeth Lobmeyr, Julia Cserna, Christian Zauner, Gottfried Heinz, Guerkan Sengoelge, Wolfgang R. Sperr, Thomas Staudinger, Peter Schellongowski, Philipp Wohlfarth
Summary: This study revealed that vitamin D deficiency is common in critically ill cancer patients requiring ICU admission, with severe deficiency being an independent predictor of hospital mortality and 1-year mortality. The impact of vitamin D deficiency on short-term mortality in this group remains uncertain, warranting further clinical consideration and study.
Article
Construction & Building Technology
Tingxu Jin, Jun Li, Jun Yang, Jiawei Li, Feng Hong, Hai Long, Qihong Deng, Yong Qin, Jiajun Jiang, Xuan Zhou, Qian Song, Chunliu Pan, Peng Luo
Summary: A study found that air samples collected from an intensive care unit containing a patient ready for discharge tested positive for SARS-CoV-2, even though surface samples tested negative, suggesting that patients may continue shedding the virus in aerosol form after testing negative. This highlights the need for improved clinical and disease management guidelines for recovered COVID-19 patients.
SUSTAINABLE CITIES AND SOCIETY
(2021)
Article
Medicine, General & Internal
Yao Tian, Yang Yao, Jing Zhou, Xin Diao, Hui Chen, Kaixia Cai, Xuan Ma, Shengyu Wang
Summary: This study evaluates the accuracy of APACHE II score on different days in predicting the mortality of critically ill patients and identifies the best time point for the score. The results show that the APACHE II score on day 3 has the highest predictive value for hospital mortality of ICU patients.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Maxens Decavele, Alienor Dreyfus, Nicolas Gatulle, Nicolas Weiss, Caroline Houillier, Sophie Demeret, Julien Mayaux, Isabelle Rivals, Martin Dres, Julie Delemazure, Elise Morawiec, Charles-Edouard Luyt, Khe Hoang-Xuan, Sylvain Choquet, Thomas Similowski, Alexandre Demoule
Summary: The six-month survival rate of PCNSL patients admitted to the ICU appears to be relatively favorable, with predictive factors such as admission for coma, cancer progression, mechanical ventilation, and vasopressors associated with higher mortality. Pre-ICU Karnofsky performance status is independently associated with lower mortality.
JOURNAL OF NEUROLOGY
(2021)
Article
Nursing
Mahnaz Rakhshan, Soodabeh Joolaee, Noushin Mousazadeh, Hamideh Hakimi, Samaneh Bagherian
Summary: This study explores the causes of futile care from the perspective of nurses in Intensive Care Units. The findings provide insights for better management strategies to reduce futile care and solve the specific problems faced by nurses in intensive care units.
Article
Oncology
Marijn Soeteman, Marta F. Fiocco, Joppe Nijman, Casper W. Bollen, Maartje M. Marcelis, Ellen Kilsdonk, Edward E. S. Nieuwenhuis, Teus H. Kappen, Wim J. E. Tissing, Roelie M. Woesten-van Asperen
Summary: This study aimed to identify risk factors at PICU admission for new or progressive multi-organ dysfunction (NPMOD) in pediatric oncology patients. The analysis revealed that hemato-oncological diagnosis, number of failing organs, and unplanned admission were independent risk factors for NPMOD. These findings can help in early identification and intervention of high-risk patients to improve outcomes.
FRONTIERS IN ONCOLOGY
(2023)
Review
Critical Care Medicine
Victoria Metaxa, Despina Anagnostou, Savvas Vlachos, Nishkantha Arulkumaran, Sherihane Bensemmane, Ingeborg van Dusseldorp, Rebecca A. Aslakson, Judy E. Davidson, Rik T. Gerritsen, Christiane Hartog, J. Randall Curtis
Summary: The study evaluated various types of palliative care interventions implemented in ICUs and their impact on practice, finding that strategies to enhance palliative care involvement were associated with beneficial effects on common outcomes for ICU patients. However, the majority of studies were from North America, limiting the generalisability to other healthcare systems.
INTENSIVE CARE MEDICINE
(2021)
Editorial Material
Nursing
A. C. M. Brekelmans, D. Ramnarain, S. Pouwels
Summary: In survey research studies, there are often non-responders, especially in intensive care medicine. It is beneficial to know the predisposing factors of non-response, especially with the increasing incidence of post-intensive care syndrome (PICS).
JOURNAL OF CLINICAL NURSING
(2023)
Article
Anesthesiology
Misgan Mulatie Zewudie, Debas Yaregal Melesse, Tesera Dereje Filatie, Mulualem Endeshaw Zeleke
Summary: This study aimed to assess variables associated with ICU-mortality among patients in a surgical intensive care unit in Ethiopia. The results showed that ICU-mortality was associated with abnormal serum potassium level, lower GCS score, mechanical support, hypoxia, absence of thromboprophylaxis, and enteral feeding.
BMC ANESTHESIOLOGY
(2023)
Review
Multidisciplinary Sciences
Wei Zhang, Yun Tang, Huan Liu, Li ping Yuan, Chu chu Wang, Shu fan Chen, Jin Huang, Xin yuan Xiao
Summary: Most ICU-AW risk prediction models show good efficacy for high-risk groups, but there is bias in their development and verification processes. Large-sample, multi-center studies are needed in the future to provide a reliable basis for ICU-AW risk prediction models.
Correction
Critical Care Medicine
Michael Joannidis, Christian J. Wiedermann, Marlies Ostermann
INTENSIVE CARE MEDICINE
(2022)
Article
Critical Care Medicine
Morten H. Moller, Waleed Alhazzani, Kimberley Lewis, Emilie Belley-Cote, Anders Granholm, John Centofanti, William B. McIntyre, Jessica Spence, Zainab Al Duhailib, Dale M. Needham, Laura Evans, Annika Reintam Blaser, Margaret A. Pisani, Frederick D'Aragon, Manu Shankar-Hari, Mohammed Alshahrani, Giuseppe Citerio, Rakesh C. Arora, Sangeeta Mehta, Timothy D. Girard, Otavio T. Ranzani, Naomi Hammond, John W. Devlin, Yahya Shehabi, Pratik Pandharipande, Marlies Ostermann
Summary: This Intensive Care Medicine Rapid Practice Guideline provides evidence-based guidance on the use of dexmedetomidine for sedation in mechanically ventilated adults, and outlines uncertainties and research priorities.
INTENSIVE CARE MEDICINE
(2022)
Article
Urology & Nephrology
Marlies Ostermann, Sean M. Bagshaw, Nuttha Lumlertgul, Ron Wald
Summary: KRT is considered for patients with severe AKI and associated complications. The exact indications for initiating KRT have been debated for decades. In this review, the latest evidence and strategies for decision making regarding KRT are summarized.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Critical Care Medicine
Ron Wald, William Beaubien-Souligny, Rahul Chanchlani, Edward G. Clark, Javier A. Neyra, Marlies Ostermann, Samuel A. Silver, Suvi Vaara, Alexander Zarbock, Sean M. Bagshaw
Summary: This review provides a comprehensive update on key aspects of renal replacement therapy (RRT) prescription and delivery for critically ill patients. Recent trials have enhanced the evidence base regarding RRT practices, but more evidence is still needed to clarify multiple aspects of care.
INTENSIVE CARE MEDICINE
(2022)
Editorial Material
Critical Care Medicine
Marlies Ostermann, Andrew D. Shaw, Michael Joannidis
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Marlies Ostermann, Rajit K. Basu, Ravindra L. Mehta
INTENSIVE CARE MEDICINE
(2023)
Article
Critical Care Medicine
James C. Doidge, Doug W. Gould, Zia Sadique, Mark Borthwick, Robert A. Hatch, Fergus J. Caskey, Lui Forni, Robert F. Lawrence, Clare MacEwan, Marlies Ostermann, Paul R. Mouncey, David A. Harrison, Kathryn M. Rowan, J. Duncan Young, Peter J. Watkinson
Summary: This study evaluated the clinical and health economic impacts of transitioning from systemic heparin anticoagulation (SHA) to regional citrate anticoagulation (RCA) for continuous kidney replacement therapy (CKRT) in intensive care units (ICUs). The results showed that transition to RCA was not associated with changes in mortality, but was associated with increases in kidney support duration, advanced cardiovascular support duration, and ICU length of stay.
JOURNAL OF CRITICAL CARE
(2023)
Editorial Material
Urology & Nephrology
Marlies Ostermann, Mitchell H. Rosner
Summary: Acute kidney injury (AKI) is a complex syndrome involving various inflammatory cells and mediators. Current research aims to identify important contributing pathways, identify high-risk groups, characterize AKI sub-phenotypes, and develop therapeutic interventions.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Thiago Reis, Federico Ronco, Marlies Ostermann
Summary: Fluid overload is a dangerous condition that can increase morbidity and mortality, especially in patients with heart disease. The available treatment options for decongestion, such as diuretics and mechanical fluid removal, have limitations. This paper provides a comprehensive overview of the challenges in managing fluid overload and discusses the risks and benefits of different pharmacological and extracorporeal techniques, aiming to provide guidance for clinical practice.
CARDIORENAL MEDICINE
(2023)
Article
Urology & Nephrology
Alexander Zarbock, Mitra K. Nadim, Peter Pickkers, Hernando Gomez, Samira Bell, Michael Joannidis, Kianoush Kashani, Jay L. Koyner, Neesh Pannu, Melanie Meersch, Thiago Reis, Thomas Rimmele, Sean M. Bagshaw, Rinaldo Bellomo, Vicenzo Cantaluppi, Akash Deep, Silvia De Rosa, Xose Perez-Fernandez, Faeq Husain-Syed, Sandra L. Kane-Gill, Yvelynne Kelly, Ravindra L. Mehta, Patrick T. Murray, Marlies Ostermann, John Prowle, Zaccaria Ricci, Emily J. See, Antoine Schneider, Danielle E. Soranno, Ashita Tolwani, Gianluca Villa, Claudio Ronco, Lui G. Forni
Summary: Sepsis-associated acute kidney injury (SA-AKI) is a common condition that is strongly associated with poor outcomes in critically ill patients. The exact cause of SA-AKI is still not fully understood, but dysfunction in microcirculation, cellular metabolism, and inflammatory responses are considered to be involved. Early identification of patients at risk and timely initiation of supportive measures are crucial for improving outcomes. Research on biomarkers for early diagnosis and clinical trials on potential therapeutic approaches are ongoing.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Biology
Onn Shaun Thein, Naeman Akbar Ali, Rahul Y. Mahida, Rachel C. A. Dancer, Marlies Ostermann, Karin Amrein, Gennaro Martucci, Aaron Scott, David R. Thickett, Dhruv Parekh
Summary: This study aims to investigate the relationship between Fibroblast Growth Factor 23 (FGF23) levels and mortality in critically ill patients. The results showed that patients with high FGF23 levels are more likely to die, regardless of chronic kidney disease. This suggests that FGF23 may affect our immune system in a previously unexplored way. Further research may help improve the survival rate of intensive care patients by targeting FGF23 levels.
Article
Nutrition & Dietetics
Lynda K. Cameron, Nuttha Lumlertgul, Danielle E. Bear, Enya Cooney, Catherine McKenzie, Marlies Ostermann
Summary: This survey aimed to understand the prescribing practice of micronutrients in UK critical care units. The results showed that micronutrient prescribing in UK ICUs is heterogeneous, with clinical scenarios often guiding decisions to use these products. Further research is needed to examine the potential benefits and harms on patient-oriented outcomes of micronutrient product administration.
CLINICAL NUTRITION ESPEN
(2023)
Review
Urology & Nephrology
Alexander Zarbock, Lui G. Forni, Marlies Ostermann, Claudio Ronco, Sean M. Bagshaw, Ravindra L. Mehta, Rinaldo Bellomo, John A. Kellum
Summary: Acute kidney injury (AKI) is a common clinical condition associated with increased mortality and the risk of developing chronic kidney disease and kidney failure. Currently, there is no specific therapy for AKI and novel interventions targeting the underlying pathophysiology are needed. Well-designed clinical trials with appropriate end points are crucial to evaluate the efficacy of these new interventions and improve outcomes.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Critical Care Medicine
Peter B. Sherren, Luigi Camporota, Barnaby Sanderson, Andrew Jones, Manu Shankar-Hari, Chris I. S. Meadows, Nicholas Barrett, Marlies Ostermann, Nicholas Hart
Summary: This article describes the outcomes of COVID-19 patients admitted to Guy's and St. Thomas' NHS Foundation Trust critical care service. The patients were managed according to a local respiratory failure management pathway and tailored ventilatory strategies. The study shows that 71.1% of the patients admitted through the Emergency Department survived to critical care discharge.
JOURNAL OF THE INTENSIVE CARE SOCIETY
(2022)
Review
Critical Care Medicine
Daniel De Backer, Maurizio Cecconi, Michelle S. Chew, Ludhmila Hajjar, Xavier Monnet, Gustavo A. Ospina-Tascon, Marlies Ostermann, Michael R. Pinsky, Jean-Louis Vincent
Summary: Management of patients with septic shock should include personalized hemodynamic monitoring and support, fluid therapy based on shock phases, and individualized vasopressor therapy. Additional questions remain regarding optimal vasopressor selection, combination therapy, and adjunctive treatments such as hydrocortisone and inotropes.