Review
Biochemistry & Molecular Biology
Felix Klawitter, Johannes Ehler, Rika Bajorat, Robert Patejdl
Summary: Mitochondria play a crucial role in providing energy and participating in metabolism and signaling processes. However, mitochondrial dysfunction in critical illness can lead to organ failure and muscle wasting. This review aims to discuss the molecular mechanisms underlying mitochondrial dysfunction in intensive care unit-acquired weakness and critical illness myopathy, and its implications for muscle function and potential therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Multidisciplinary Sciences
Wei Zhang, Yun Tang, Huan Liu, Li ping Yuan, Chu chu Wang, Shu fan Chen, Jin Huang, Xin yuan Xiao
Summary: Most ICU-AW risk prediction models show good efficacy for high-risk groups, but there is bias in their development and verification processes. Large-sample, multi-center studies are needed in the future to provide a reliable basis for ICU-AW risk prediction models.
Article
Nutrition & Dietetics
Matthew F. Mart, Timothy D. Girard, Jennifer L. Thompson, Hannah Whitten-Vile, Rameela Raman, Pratik P. Pandharipande, Daren K. Heyland, E. Wesley Ely, Nathan E. Brummel
Summary: Higher nutritional risk at ICU admission is associated with disability in survivors of critical illness, but the long-term follow-up did not show significant correlation. The mNUTRIC scores are related to discharge destination and disability in basic ADLs but not consistently associated with cognition and health-related quality of life.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Naoya Yanagi, Tomotaka Koike, Kentaro Kamiya, Nobuaki Hamazaki, Kohei Nozaki, Takafumi Ichikawa, Atsuhiko Matsunaga, Masayuki Kuroiwa, Masayasu Arai
Summary: Sarcopenia diagnosed in the ICU, based on low skeletal muscle mass and function, is significantly associated with 1-year mortality, indicating that muscle mass and function assessments at the bedside could help identify higher-risk patients in the ICU.
Article
Critical Care Medicine
Marie Smedberg, Johan Helleberg, Ake Norberg, Inga Tjader, Olav Rooyackers, Jan Wernerman
Summary: A study on 269 patients found that hyperglutaminemia was associated with increased six-month mortality, indicating it is an independent mortality predictor. The study suggests further investigation into the mechanism of hyperglutaminemia and the prognostic value of repeated measurements for ICU patients.
Article
Clinical Neurology
Sophia Wang, Anthony J. Perkins, Rosalyn Chi, Brandon A. Yates, Sikandar H. Khan, Sujuan Gao, Malaz Boustani, Babar A. Khan
Summary: A secondary data analysis of ICU patients revealed that stroke and depression were identified as risk factors for post-ICU dementia, highlighting the need for interventions targeting these factors to reduce dementia incidence.
ALZHEIMERS & DEMENTIA
(2023)
Article
Critical Care Medicine
Barry Burstein, Saraschandra Vallabhajosyula, Bradley Ternus, Dennis Murphree, Gregory W. Barsness, Kianoush Kashani, Jacob C. Jentzer
Summary: The study indicates that mortality is higher among cardiac intensive care unit (CICU) patients with severe shock treated with norepinephrine. For patients requiring high-dose vasopressors, hospital mortality increases with rising peak norepinephrine equivalent doses, while the use of norepinephrine is associated with lower mortality.
Article
Medicine, General & Internal
Kevin Roedl, Dominik Jarczak, Olaf Boenisch, Geraldine de Heer, Christoph Burdelski, Daniel Frings, Barbara Sensen, Axel Nierhaus, Stefan Kluge, Dominic Wichmann
Summary: More than half of critically ill patients with COVID-19 suffer from chronic critical illness (CCI). Patients with CCI have higher short and long-term survival rates compared to patients without CCI, and prolonged therapy should be provided when resources permit.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Sheetal Gandotra, D. Clark Files, Katherine L. Shields, Michael Berry, Rita N. Bakhru
Summary: The study found that physical activity levels increased as critically ill patients transitioned from ICU to hospital wards and back to the community, with significantly higher activity levels post-hospital discharge. Despite poor physical function scores at ICU and hospital discharge, there was moderate correlation with physical activity levels immediately upon return home.
Article
Nutrition & Dietetics
Julia Hilbrands, Mary Beth Feuling, Aniko Szabo, Bi Q. Teng, Nicole Fabus, Melissa Froh, Rebecca Heisler, Olivia Lampone, Amber Smith, Theresa A. Mikhailov, Praveen S. Goday
Summary: In pediatric intensive care units, malnutrition screening is crucial for critically ill children. The Children's Wisconsin Nutrition Screening Tool (CWNST) is a more sensitive tool compared to the Pediatric Nutrition Screening Tool (PNST) and can predict nutrition risk in PICU patients through electronic medical records.
Article
Critical Care Medicine
Anna Lena Fisse, Caroline May, Jeremias Motte, Xiomara Pedreiturria, Thomas G. K. Breuer, Christiane Schneider-Gold, Katrin Marcus, Ralf Gold, Min-Suk Yoon, Kalliopi Pitarokoili
Summary: The exploratory neuromuscular ultrasound and cytokine analyses showed signs of inflammation, such as macrophage and monocyte activation, at the peak of CIPNM, followed by a systemic immune response parallel to axonal damage. This highlights the role of both axonal damage and inflammation in the pathogenesis of CIPNM.
NEUROCRITICAL CARE
(2021)
Review
Pediatrics
Siti Nur Hanim Buang, Sin Wee Loh, Yee Hui Mok, Jan Hau Lee, Yoke Hwee Chan
Summary: Palliative care is an important component of critical care practice for pediatric patients facing life-threatening illness. Integrating palliative care early alongside disease-directed and curative therapies can effectively improve patients' quality of life. A multidisciplinary approach, effective communication, and family support are key in integrating palliative care. This narrative review aims to evaluate the integration of palliative care in pediatric critical care and its impact on patient- and family-centered outcomes.
FRONTIERS IN PEDIATRICS
(2022)
Article
Clinical Neurology
Michael Isfort, Bryan J. McVerry, Lori Shutter, Minji Kim, David Lacomis
Summary: This study surveyed ICU providers to understand their approach to ICU-acquired weakness (ICU-AW) and the utility of electrodiagnostic studies (EDx). The results showed that while ICU providers are familiar with CIM/CIP, they lack a standardized evaluation approach for ICU-AW. Clinical experience was considered the most helpful management tool for ICU-AW.
Article
Nursing
Mu-Hsing Ho, Hui-Chen (Rita) Chang, Megan F. Liu, Kee-Hsin Chen, Shu-Tai Shen Hsiao, Victoria Traynor
Summary: This study investigated the level of knowledge about delirium care among critical care nurses in Taiwan. The results showed that critical care nurses had relatively high levels of knowledge in areas such as symptoms, high-risk groups, and predisposing factors, but there were significant gaps in their knowledge regarding the assessment and detection of delirium.
JOURNAL OF NURSING RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kelly Thompson, Naomi Hammond, Michael Bailey, Jai Darvall, Gary Low, Steven McGloughlin, Lucy Modra, David Pilcher
Summary: This study aimed to investigate the impact of sex on sepsis-related ICU admission and 3-year survival. A retrospective cohort study was conducted on adults admitted to Australian ICUs between 2018 and 2020. The results showed that men were more likely to be admitted to the ICU due to sepsis and had lower 3-year survival rates.
Article
Biotechnology & Applied Microbiology
Melissa Amrein, Stephanie Meier, Ibrahim Schafer, Sabine Schaedelin, Eline Willemse, Pascal Benkert, Joan Walter, Christian Puelacher, Tobias Zimmermann, Daniela Median, Caroline Egli, David Leppert, Raphael Twerenbold, Michael Zellweger, Jens Kuhle, Christian Mueller
Summary: sNfL concentration is not a reliable diagnostic biomarker for fCAD, but it can predict adverse cardiovascular outcomes, including all-cause death, cardiovascular death, and stroke/TIA.
Article
Medical Laboratory Technology
Ulf Andreasson, Johan Gobom, Vincent Delatour, Guy Auclair, Yoav Noam, Stephen Lee, Jason Wen, Andreas Jeromin, Burak Arslan, Aleksandra Maceski, Eline Willemse, Henrik Zetterberg, Jens Kuhle, Kaj Blennow
Summary: This study determined the best certified reference material (CRM) for neurofilament light chain (NfL) in blood by analyzing 40 paired serum and plasma samples. The results showed that using cerebrospinal fluid (CSF) for sample validation was more accurate than using recombinant human NfL protein, and serum was a better choice than plasma as the matrix for a CRM.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexandra Ramona Todea, Lester Melie-Garcia, Muhamed Barakovic, Alessandro Cagol, Reza Rahmanzadeh, Riccardo Galbusera, Po-Jui Lu, Matthias Weigel, Esther Ruberte, Ernst-Wilhelm Radue, Sabine Schaedelin, Pascal Benkert, Yaldizli Oezguer, Tim Sinnecker, Stefanie Mueller, Lutz Achtnichts, Jochen Vehoff, Giulio Disanto, Oliver Findling, Andrew Chan, Anke Salmen, Caroline Pot, Patrice Lalive, Claire Bridel, Chiara Zecca, Tobias Derfuss, Luca Remonda, Franca Wagner, Maria Vargas, Renaud Du Pasquier, Emanuele Pravata, Johannes Weber, Claudio Gobbi, David Leppert, Jens Wuerfel, Tobias Kober, Benedicte Marechal, Ricardo Corredor-Jerez, Marios Psychogios, Johanna Lieb, Ludwig Kappos, Meritxell Bach Cuadra, Jens Kuhle, Cristina Granziera
Summary: This study evaluated the accuracy of LeMan-PV software for detecting new and enlarged white matter lesions in multiple sclerosis patients. The results showed that LeMan-PV had similar sensitivity in detecting new lesions compared to other recent studies using neural networks. Although its performance is not optimal, the main advantage of LeMan-PV is that it provides automated clinical decision support integrated into the routine radiological workflow.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Alessandro Cagol, Nuria Cerda Fuertes, Marc Stoessel, Muhamed Barakovic, Sabine Schaedelin, Marcus D'Souza, Jens Wurfel, Alexander U. Brandt, Ludwig Kappos, Till Sprenger, Yvonne Naegelin, Jens Kuhle, Cristina Granziera, Athina Papadopoulou
Summary: This study investigated the associations among OCT changes, MRI measurements of brain volume loss, and physical and cognitive impairment in patients with multiple sclerosis. The results showed that OCT measures of pRNFL and GCIPL were associated with volumes of gray matter structures, and inversely correlated with T2-lesion volume. These findings highlight the value of OCT as markers of neurodegeneration and disability in multiple sclerosis.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Nils G. Margraf, Justina Dargvainiene, Emily Theel, Frank Leypoldt, Wolfgang Lieb, Andre Franke, Klaus Berger, Jens Kuhle, Gregor Kuhlenbaeumer
Summary: This study investigates the potential of neurofilament light chain (NfL) in serum and cerebrospinal fluid as a biomarker for neurodestruction in status epilepticus. The results suggest that the concentration of NfL is mainly determined by the duration of status epilepticus, rather than the type of status or treatment refractoriness.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Valentin Loser, Pascal Benkert, Alex Vicino, Pansy Lim Dubois Ferriere, Thierry Kuntzer, Jerome Pasquier, Aleksandra Maceski, Jens Kuhle, Marie Theaudin
Summary: Serum neurofilament light chain (sNfL) may serve as an early and reliable biomarker of peripheral neuropathy in hATTR amyloidosis, allowing for assessment of disease severity and treatment response.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
Charidimos Tsagkas, Antal Huck-Horvath, Alessandro Cagol, Tanja Haas, Muhamed Barakovic, Michael Amann, Esther Ruberte, Lester Melie-Garcia, Matthias Weigel, Simon Pezold, Regina Schlaeger, Jens Kuhle, Till Sprenger, Ludwig Kappos, Oliver Bieri, Philippe Cattin, Cristina Granziera, Katrin Parmar
Summary: Spinal cord atrophy of the cervical anterior horn is clinically relevant in multiple sclerosis (MS) patients, particularly in progressive MS (PMS) patients and at the level of cervical SC enlargement.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Jens Kuhle, Tanuja Chitnis, Brenda Banwell, Marc Tardieu, Douglas L. Arnold, Andreea M. Rawlings, Svend S. Geertsen, Alex L. Lublin, Stephane Saubadu, Philippe Truffinet, Ludwig Kappos
Summary: The TERIKIDS study demonstrated that teriflunomide is effective and safe in children with relapsing multiple sclerosis (RMS). Teriflunomide treatment is associated with significantly reduced pNfL levels in children with RMS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Multidisciplinary Sciences
Thomas Grueter, Nuwin Mohamad, Niklas Rilke, Alina Blusch, Melissa Sgodzai, Seray Demir, Xiomara Pedreiturria, Katharina Lemhoefer, Barbara Gisevius, Aiden Haghikia, Anna Lena Fisse, Jeremias Motte, Ralf Gold, Kalliopi Pitarokoili
Summary: In inflammatory neuropathies, treatment with propionate showed immunoregulatory and neuroprotective effects. Activation of FFAR3 and histone acetylation resulted in increased resistance to oxidative stress and enhanced neuroregeneration. This pathway provides potential neuroprotection and neuroregeneration for patients with immune-mediated neuropathies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Clinical Neurology
Xavier Montalban, Paul M. Matthews, Alex Simpson, John L. Petrie, Cormac Sammon, Sreeram Ramagopalan, Giulio Disanto, Jens Kuhle
Summary: Across its clinical development program, ocrelizumab has demonstrated efficacy in improving clinical outcomes in multiple sclerosis. This study systematically collected real-world clinical effectiveness data for ocrelizumab, which consistently showed favorable results, similar to those reported in clinical trials. Initial real-world effectiveness data for ocrelizumab are promising and provide an efficacious treatment option for multiple sclerosis.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Pediatrics
Kasper Jacobsen Kyng, Sven Wellmann, Verena Lehnerer, Laerke Hjollund Hansen, Jens Kuhle, Tine Brink Henriksen
Summary: This study investigated the changes of neurofilament light chain (NfL), a potential biomarker for brain injury, in a newborn piglet model of hypoxic-ischemic encephalopathy (HIE). The results showed an increase in NfL levels after hypoxia-ischemia (HI), with the highest values observed at 72 hours post-HI. NfL at 72 hours had high sensitivity and specificity for predicting moderate-severe brain injury.
FRONTIERS IN PEDIATRICS
(2023)
Article
Health Care Sciences & Services
Markus Siegel, Lisa Bode, Leonard Simon Brandenburg, Andreas Frodl, Hagen Schmal, Jan Kuehle
Summary: This study retrospectively analyzed 31 adult patients to examine the use and effects of autologous and xenogeneic bone grafts in foot surgery. The results showed that although xenogeneic grafts had a lower incorporation rate, they did not increase the risk of hindfoot alignment loss in the first six months after surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Clinical Neurology
Arabella Buchmann, Lukas Pirpamer, Daniela Pinter, Margarete Voortman, Birgit Helmlinger, Alexander Pichler, Aleksandra Maleska Maceski, Pascal Benkert, Gerhard Bachmaier, Stefan Ropele, Markus Reindl, David Leppert, Jens Kuhle, Christian Enzinger, Michael Khalil
Summary: This study findings suggest that elevated levels of sNfL have a significant impact on brain volume changes and can indicate disease progression in pwMS over a short-term period.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Maija Saraste, Markus Matilainen, Anna Vuorimaa, Sini Laaksonen, Marcus Sucksdorff, David Leppert, Jens Kuhle, Laura Airas
Summary: This study found an association between serum neurofilament light (sNfL) and microglial activation in the brain of multiple sclerosis (MS) patients, as measured by TSPO-PET. Increased sNfL levels were correlated with a higher number and larger volume of TSPO-PET-detectable active lesions at the plaque edge and perilesional normal appearing white matter. These findings emphasize the significance of smouldering inflammation and rim-active lesions in promoting neuroaxonal damage and disease progression in MS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Cyrus Daruwalla, Vahid Shaygannejad, Serkan Ozakbas, Eva Kubala Havrdova, Dana Horakova, Raed Alroughani, Cavit Boz, Francesco Patti, Marco Onofrj, Alessandra Lugaresi, Sara Eichau, Marc Girard, Alexandre Prat, Pierre Duquette, Bassem Yamout, Samia J. Khoury, Seyed Aidin Sajedi, Recai Turkoglu, Ayse Altintas, Olga Skibina, Katherine Buzzard, Pierre Grammond, Rana Karabudak, Anneke van der Walt, Helmut Butzkueven, Davide Maimone, Jeannette Lechner-Scott, Aysun Soysal, Nevin John, Julie Prevost, Daniele Spitaleri, Cristina Ramo-Tello, Oliver Gerlach, Gerardo Iuliano, Matteo Foschi, Radek Ampapa, Vincent van Pesch, Michael Barnett, Nevin Shalaby, Marie D'hooghe, Jens Kuhle, Maria Jose Sa, Marzena Fabis-Pedrini, Allan Kermode, Saloua Mrabet, Riadh Gouider, Suzanne Hodgkinson, Guy Laureys, Liesbeth Van Hijfte, Richard Macdonell, Celia Oreja-Guevara, Edgardo Cristiano, Pamela McCombe, Jose Luis Sanchez-Menoyo, Bhim Singhal, Yolanda Blanco, Stella Hughes, Justin Garber, Claudio Solaro, Chris McGuigan, Bruce Taylor, Koen de Gans, Mario Habek, Abdullah Al-Asmi, Simu Mihaela, Tamara Castillo Trivino, Talal Al-Harbi, Juan Ignacio Rojas, Orla Gray, Dheeraj Khurana, Bart Van Wijmeersch, Nikolaos Grigoriadis, Jihad Inshasi, Jiwon Oh, Eduardo Aguera-Morales, Yara Fragoso, Fraser Moore, Cameron Shaw, Seyed Mohammad Baghbanian, Neil Shuey, Barbara Willekens, Todd A. Hardy, Danny Decoo, Angel Perez Sempere, Deborah Field, Ray Wynford-Thomas, Nick G. Cunniffe, Izanne Roos, Charles B. Malpas, Alasdair J. Coles, Tomas Kalincik, J. William L. Brown, MSBase Study Grp
Summary: This study found that early non-disabling relapses in people with RRMS are associated with a higher risk of disability accumulation, which may be mitigated by high-efficacy DMTs. Therefore, treatment decisions should take into account the impact of non-disabling relapses.
MULTIPLE SCLEROSIS JOURNAL
(2023)
