Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 20, Issue 14, Pages 4104-4107Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.05.072
Keywords
P2Y(1); Purinergic; Thrombosis; Antiplatelet; Urea
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Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation. (C) 2010 Elsevier Ltd. All rights reserved.
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