Article
Cardiac & Cardiovascular Systems
Hiroyuki Fujii, Yu Taniguchi, Sachiyo Yoneda, Keisuke Miwa, Yoichiro Matsuoka, Kenichi Yanaka, Yasunori Tsuboi, Noriaki Emoto, Kenichi Hirata
Summary: In this study, data from 149 patients with chronic thromboembolic pulmonary hypertension (CTEPH) were analyzed. The results showed that the efficacy and safety of balloon pulmonary angioplasty (BPA) for CTEPH with concurrent chronic obstructive pulmonary disease (COPD) were similar to those without COPD. Oxygenation and forced expiratory volume in 1 second/forced vital capacity showed improvement in patients with COPD. Therefore, BPA should be considered as a treatment option for CTEPH patients with concurrent COPD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Respiratory System
Pramod Sharma, Karlijn Scheffer, Menaka Louis, Craig R. Aitken, Lewis Adams, Norman R. Morris
Summary: This study found that negative affective state worsens dyspnoea in individuals with COPD, suggesting that strategies aimed at reducing negative mood or improving mood may be effective in managing morbidity associated with dyspnoea in COPD.
Review
Pharmacology & Pharmacy
Jiaxing Zhang, Yihong Xie, Joey Sum-Wing Kwong, Long Ge, Rui He, Wenyi Zheng, Jing Han, Rui Zhang, Huaye Zhao, Yuru He, Xiaosi Li
Summary: This study systematically evaluated the efficacy and safety of REV in COPD patients, finding that 175 μg/day REV significantly improved FEV1 without increasing the risk of adverse events or serious adverse events. The effect of REV on FEV1 was dose-dependent, but further research is needed to compare its long-term efficacy and safety with other LAMAs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Yongkang Huang, Yongjian Pei, Yajuan Qian, Zhen Yao, Chen Chen, Juan Du, Minhua Shi, Tong Zhou
Summary: This study investigated the efficacy and safety of bacterial lysates in COPD. The meta-analysis results showed that bacterial lysates can benefit patients by reducing exacerbations and alleviating symptoms. OM-85 is the preferable product based on the existing evidence.
FRONTIERS IN MEDICINE
(2022)
Article
Respiratory System
Yue Liao, Hao Wang, Ke Wang, Kai Zi, Yongchun Shen, Lei Chen, Tao Wang, Jun Chen, Fuqiang Wen
Summary: This study investigated the efficacy of tiotropium bromide inhalation (TBI) in symptomatic Chinese patients with COPD. After 3 months of treatment, patients showed significant improvements in lung function, symptoms, and a decrease in exacerbations.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2023)
Review
Medicine, General & Internal
Kai Zhu, Jagdeep Gill, Ashley Kirkham, Joel Chen, Amy Ellis, Stephanie Crosbie, Holly Denson-Camp, Hannah Peters, Pat Camp
Summary: This study aims to assess the safety and efficacy of in-hospital pulmonary rehabilitation for patients with AECOPD during the acute phase through a systematic review with meta-analysis. Data will be recorded using the Population, Intervention, Comparator, Outcomes and Study characteristics framework, and the quality of evidence will be evaluated using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework. The results will be disseminated through peer-reviewed publications and research conferences.
Review
Pharmacology & Pharmacy
Haichuan Yu, Ting Lei, Xiaojie Su, Lu Zhang, Zhouzhou Feng, Mengya Dong, Zheyu Hou, Hong Guo, Jian Liu
Summary: This systematic review examined the safety and efficacy of Rhodiola L. in COPD patients. The results showed that compared to placebo, patients who received Rhodiola L. experienced significant improvements in lung function, oxygen saturation, and arterial blood gas parameters. Additionally, R. kirilowii provided additional benefits compared to ambroxol. Overall, Rhodiola L. may be a safe and effective treatment for COPD, but further randomized controlled trials are needed for validation.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Matthew D. James, Devin B. Phillips, Sandra G. Vincent, Sara J. Abdallah, Adamo A. Donovan, Juan P. de-Torres, J. Alberto Neder, Benjamin M. Smith, Dennis Jensen, Denis E. O'Donnell
Summary: This study aimed to determine the relationship between dyspnea and COPD severity. The study found that dyspnea intensity was associated with inspiratory neural drive and increased at higher exercise intensities. Measurements of inspiratory capacity and breathing pattern during exercise can provide insights into mechanisms of dyspnea and exercise intolerance in individuals with COPD.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Medicine, General & Internal
Gerard Criner, Sean Duffy
Summary: This study reviewed the clinical evidence supporting the use of dual bronchodilator therapy with tiotropium and olodaterol as the initial and follow-up treatment choice in patients with COPD, as recommended by GOLD 2020. The combination therapy showed therapeutic advantages over monotherapy, especially in the early stages of COPD.
CURRENT MEDICAL RESEARCH AND OPINION
(2021)
Review
Pharmacology & Pharmacy
Marija Gredic, Isabel Blanco, Gabor Kovacs, Zsuzsanna Helyes, Peter Ferdinandy, Horst Olschewski, Joan Albert Barbera, Norbert Weissmann
Summary: This article summarizes the pathophysiology and treatment options for PH in COPD patients, pointing out that current research still does not fully understand its underlying mechanisms, and some of the treatment methods tested in clinical settings have not been effective. Preclinical studies have proposed some treatment approaches.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Stephanie A. Christenson, Benjamin M. Smith, Mona Bafadhel, Nirupama Putcha
Summary: Chronic obstructive pulmonary disease (COPD) is a global health problem that leads to high morbidity, mortality, and healthcare utilization. Its main causes are exposure to harmful particles, such as tobacco smoke and pollutants. Recent research has shown that various factors throughout the life course increase the risk of developing COPD. Innovations in omics and imaging techniques have provided greater understanding of the disease's pathophysiology, potentially leading to advancements in its prevention, diagnosis, and treatment. This review focuses on recent advances in the epidemiology, pathophysiology, imaging, diagnosis, and treatment of COPD.
Article
Medicine, General & Internal
Chin-Ling Li, Mei-Hsin Lin, Yuh-Chyn Tsai, Ching-Wan Tseng, Chia-Ling Chang, Lien-Shi Shen, Ho-Chang Kuo, Shih-Feng Liu
Summary: This study demonstrated the predictive value of the ADO index on the medical burden of COPD. There is a significant correlation between the ADO index and CCI in determining healthcare expenses for COPD patients, with higher ADO scores leading to increased hospitalization costs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Zhiying Li, Lin Zhou, Hui Bi, Qiudi Zhang, Xiong Xu, Yuwen Liu, Hui Qiu
Summary: This study demonstrates that tiotropium bromide has significant therapeutic effects on patients with stable COPD by relieving airway remodeling and improving clinical symptoms and physical function.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2022)
Article
Health Care Sciences & Services
Yoshinobu Matsuda, Tatsuya Morita, Hirotaka Matsumoto, Keita Hosoi, Kayo Kusama, Yasuo Kohashi, Hiroshi Morishita, Sawako Kaku, Keisuke Ariyoshi, Shunsuke Oyamada, Yoshikazu Inoue, Satoru Iwase, Takuhiro Yamaguchi, Mitsunori Nishikawa
Summary: This study aimed to evaluate the efficacy and safety of oral morphine for dyspnoea in Japanese COPD patients. Results showed that oral morphine is effective in alleviating dyspnoea and had good tolerability in this patient population.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2021)
Review
Medicine, General & Internal
Hongkuan Yang, Shuifeng He, Fang Chen, Linbao Liang, Junjie Pan
Summary: The study suggests that nitrate supplementation is safe but ineffective in improving exercise tolerance in individuals with COPD.