The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion

The dopamine reuptake inhibitor MRZ-9547 increases progressive ratio responding in rats

(2014) S. Sommer et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs

(2014) Patrick A. Randall et al.   PLoS One

Negative Symptoms of Schizophrenia Are Associated with Abnormal Effort-Cost Computations

(2013) James M. Gold et al.   BIOLOGICAL PSYCHIATRY

Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression

(2013) E. J. Nunes et al.   JOURNAL OF NEUROSCIENCE

Resolution of sleepiness and fatigue: A comparison of bupropion and selective serotonin reuptake inhibitors in subjects with major depressive disorder achieving remission at doses approved in the European Union

(2013) James A Cooper et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Anhedonia revisited: Is there a role for dopamine-targeting drugs for depression?

(2013) Spilios V Argyropoulos et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

(2013) P Trifilieff et al.   MOLECULAR PSYCHIATRY

Invigoration of Reward Seeking by Cue and Proximity Encoding in the Nucleus Accumbens

(2013) Vincent B. McGinty et al.   NEURON

The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor

(2013) S.J. Podurgiel et al.   NEUROSCIENCE

Measuring reinforcement learning and motivation constructs in experimental animals: Relevance to the negative symptoms of schizophrenia

(2013) Athina Markou et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: Effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors

(2013) Eric J. Nunes et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Antidepressant-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002), in the forced swim test and the tail suspension test in rodents

(2013) Koji Yamada et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task

(2013) Eric J. Nunes et al.   PSYCHOPHARMACOLOGY

Venlafaxine enhances the effect of bupropion on extracellular dopamine in rat frontal cortex

(2012) Alan L. Hudson et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tetrabenazine for the Treatment of Hyperkinetic Movement Disorders: A Review of the Literature

(2012) Jack J. Chen et al.   CLINICAL THERAPEUTICS

The Mysterious Motivational Functions of Mesolimbic Dopamine

(2012) John D. Salamone et al.   NEURON

Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice

(2012) M. Pardo et al.   NEUROPHARMACOLOGY

Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making

(2012) Naghmeh Shafiei et al.   NEUROPSYCHOPHARMACOLOGY

The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

(2012) Jessica L. Santerre et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences

(2012) Patrick A. Randall et al.   PLoS One

Coffee, Caffeine, and Risk of Depression Among Women

(2011) Michel Lucas   ARCHIVES OF INTERNAL MEDICINE

Motivational states influence effort-based decision making in rats: The role of dopamine in the nucleus accumbens

(2011) Bettina Mai et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Amping Up Effort: Effects of d-Amphetamine on Human Effort-Based Decision-Making

(2011) M. C. Wardle et al.   JOURNAL OF NEUROSCIENCE

Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders

(2010) David R.P. Guay   American Journal Geriatric Pharmacotherapy

Differential effects on effort discounting induced by inactivations of the nucleus accumbens core or shell.

(2010) Sarvin Ghods-Sharifi et al.   BEHAVIORAL NEUROSCIENCE

Choosing to Make an Effort: The Role of Striatum in Signaling Physical Effort of a Chosen Action

(2010) I. T. Kurniawan et al.   JOURNAL OF NEUROPHYSIOLOGY

The Flexible Approach Hypothesis: Unification of Effort and Cue-Responding Hypotheses for the Role of Nucleus Accumbens Dopamine in the Activation of Reward-Seeking Behavior

(2010) S. M. Nicola   JOURNAL OF NEUROSCIENCE

Tetrabenazine is neuroprotective in Huntington's disease mice

(2010) Hongyu Wang et al.   Molecular Neurodegeneration

Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats

(2010) Yoshihisa Kitamura et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism

(2010) E.J. Nunes et al.   NEUROSCIENCE

Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors

(2010) A.M. Farrar et al.   NEUROSCIENCE

Reconsidering anhedonia in depression: Lessons from translational neuroscience

(2010) Michael T. Treadway et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease

(2010) Samuel Frank   Neuropsychiatric Disease and Treatment

Dopamine modulates effort-based decision making in rats.

(2009) Mark E. Bardgett et al.   BEHAVIORAL NEUROSCIENCE

Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism

(2009) John D. Salamone et al.   BEHAVIOURAL BRAIN RESEARCH

Tetrabenazine as anti-chorea therapy in Huntington Disease: an open-label continuation study. Huntington Study Group/TETRA-HD Investigators

(2009) Samuel Frank   BMC Neurology

Prefrontostriatal Circuitry Regulates Effort-Related Decision Making

(2009) W. Hauber et al.   CEREBRAL CORTEX

Clinical Presentation and Outcome of Geriatric Depression in Subcortical Ischemic Vascular Disease

(2009) R. Bella et al.   GERONTOLOGY

Effort-Based Cost-Benefit Valuation and the Human Brain

(2009) P. L. Croxson et al.   JOURNAL OF NEUROSCIENCE

Characterization of the Potent and Highly Selective A2A Receptor Antagonists Preladenant and SCH 412348 [7-[2-[4-2,4-Difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in Rodent Models of Movement Disorders and Depression

(2009) R. A. Hodgson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure

(2009) Allison M. Mott et al.   PSYCHOPHARMACOLOGY

Longitudinal changes of day-time and night-time gross motor activity in clinical responders and non-responders of major depression

(2009) Doron Todder et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY

An Update on Adenosine A2A-Dopamine D2 Receptor Interactions: Implications for the Function of G Protein-Coupled Receptors

(2008) S. Ferre et al.   CURRENT PHARMACEUTICAL DESIGN

Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway

(2008) S. Mingote et al.   JOURNAL OF NEUROSCIENCE

Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior

(2008) A.M. Farrar et al.   NEUROSCIENCE

The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists

(2008) Lila T. Worden et al.   PSYCHOPHARMACOLOGY

Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats

(2008) Laura Font et al.   PSYCHOPHARMACOLOGY