The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs

Negative Symptoms of Schizophrenia Are Associated with Abnormal Effort-Cost Computations

(2013) James M. Gold et al.   BIOLOGICAL PSYCHIATRY

Toward the future of psychiatric diagnosis: the seven pillars of RDoC

(2013) Bruce N Cuthbert et al.   BMC Medicine

CLINICAL RELEVANCE OF FATIGUE AS A RESIDUAL SYMPTOM IN MAJOR DEPRESSIVE DISORDER

(2013) Maurizio Fava et al.   DEPRESSION AND ANXIETY

Predictors of relapse in patients with major depressive disorder in a 52-week, fixed dose, double blind, randomized trial of selegiline transdermal system (STS)

(2013) Saeheon Jang et al.   JOURNAL OF AFFECTIVE DISORDERS

Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression

(2013) E. J. Nunes et al.   JOURNAL OF NEUROSCIENCE

Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

(2013) P Trifilieff et al.   MOLECULAR PSYCHIATRY

Invigoration of Reward Seeking by Cue and Proximity Encoding in the Nucleus Accumbens

(2013) Vincent B. McGinty et al.   NEURON

Measuring reinforcement learning and motivation constructs in experimental animals: Relevance to the negative symptoms of schizophrenia

(2013) Athina Markou et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Neural substrates underlying effort computation in schizophrenia

(2013) Gagan Fervaha et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Antidepressant-like activity of the adenosine A2A receptor antagonist, istradefylline (KW-6002), in the forced swim test and the tail suspension test in rodents

(2013) Koji Yamada et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task

(2013) Eric J. Nunes et al.   PSYCHOPHARMACOLOGY

Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making

(2012) M. T. Treadway et al.   JOURNAL OF NEUROSCIENCE

Translational approaches to treatment-induced symptoms in cancer patients

(2012) Robert Dantzer et al.   Nature Reviews Clinical Oncology

The Mysterious Motivational Functions of Mesolimbic Dopamine

(2012) John D. Salamone et al.   NEURON

Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice

(2012) M. Pardo et al.   NEUROPHARMACOLOGY

Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making

(2012) Naghmeh Shafiei et al.   NEUROPSYCHOPHARMACOLOGY

The novel adenosine A2A antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

(2012) Jessica L. Santerre et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences

(2012) Patrick A. Randall et al.   PLoS One

Motivational states influence effort-based decision making in rats: The role of dopamine in the nucleus accumbens

(2011) Bettina Mai et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Dopaminergic enhancement of local food-seeking is under global homeostatic control

(2011) Jeff A. Beeler et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amping Up Effort: Effects of d-Amphetamine on Human Effort-Based Decision-Making

(2011) M. C. Wardle et al.   JOURNAL OF NEUROSCIENCE

Appetitive motivational deficits in individuals with Parkinson's Disease

(2011) Danielle M. Shore et al.   MOVEMENT DISORDERS

Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists

(2011) Patrick A. Randall et al.   PSYCHOPHARMACOLOGY

MAO-inhibitors in Parkinson's Disease

(2011) Peter Riederer et al.   Experimental Neurobiology

Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders

(2010) David R.P. Guay   American Journal Geriatric Pharmacotherapy

Antidepressant monotherapy: A claims database analysis of treatment changes and treatment duration

(2010) Dominique Milea et al.   CLINICAL THERAPEUTICS

The functional Val158Met polymorphism in catechol-O-methyltransferase (COMT) is associated with depression and motivation in men from a Swedish population-based study

(2010) Elin Åberg et al.   JOURNAL OF AFFECTIVE DISORDERS

Choosing to Make an Effort: The Role of Striatum in Signaling Physical Effort of a Chosen Action

(2010) I. T. Kurniawan et al.   JOURNAL OF NEUROPHYSIOLOGY

The Flexible Approach Hypothesis: Unification of Effort and Cue-Responding Hypotheses for the Role of Nucleus Accumbens Dopamine in the Activation of Reward-Seeking Behavior

(2010) S. M. Nicola   JOURNAL OF NEUROSCIENCE

Differential effects of selective adenosine antagonists on the effort-related impairments induced by dopamine D1 and D2 antagonism

(2010) E.J. Nunes et al.   NEUROSCIENCE

Nucleus accumbens and effort-related functions: behavioral and neural markers of the interactions between adenosine A2A and dopamine D2 receptors

(2010) A.M. Farrar et al.   NEUROSCIENCE

In vivo studies of the SERT-selective [18F]FPBM and VMAT2-selective [18F]AV-133 radiotracers in a rat model of Parkinson's disease

(2010) Julie L. Wang et al.   NUCLEAR MEDICINE AND BIOLOGY

Effect of the adenosine A2A receptor antagonist MSX-3 on motivational disruptions of maternal behavior induced by dopamine antagonism in the early postpartum rat

(2010) Mariana Pereira et al.   PSYCHOPHARMACOLOGY

Tetrabenazine: the first approved drug for the treatment of chorea in US patients with Huntington disease

(2010) Samuel Frank   Neuropsychiatric Disease and Treatment

Levodopa/carbidopa and entacapone in the treatment of Parkinson’s disease: efficacy, safety and patient preference

(2010) Thomas Müller   Patient Preference and Adherence

Dopamine modulates effort-based decision making in rats.

(2009) Mark E. Bardgett et al.   BEHAVIORAL NEUROSCIENCE

Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism

(2009) John D. Salamone et al.   BEHAVIOURAL BRAIN RESEARCH

Prefrontostriatal Circuitry Regulates Effort-Related Decision Making

(2009) W. Hauber et al.   CEREBRAL CORTEX

Effort discounting in human nucleus accumbens

(2009) M. M. Botvinick et al.   COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE

Effort-Based Cost-Benefit Valuation and the Human Brain

(2009) P. L. Croxson et al.   JOURNAL OF NEUROSCIENCE

Characterization of the Potent and Highly Selective A2A Receptor Antagonists Preladenant and SCH 412348 [7-[2-[4-2,4-Difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in Rodent Models of Movement Disorders and Depression

(2009) R. A. Hodgson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cognitive aspects of congenital learned helplessness and its reversal by the monoamine oxidase (MAO)-B inhibitor deprenyl

(2009) Daniela Schulz et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Worth the ‘EEfRT’? The Effort Expenditure for Rewards Task as an Objective Measure of Motivation and Anhedonia

(2009) Michael T. Treadway et al.   PLoS One

The adenosine A2A antagonist MSX-3 reverses the effects of the dopamine antagonist haloperidol on effort-related decision making in a T-maze cost/benefit procedure

(2009) Allison M. Mott et al.   PSYCHOPHARMACOLOGY

Mechanisms of cytokine-induced behavioral changes: Psychoneuroimmunology at the translational interface

(2008) Andrew H. Miller   BRAIN BEHAVIOR AND IMMUNITY

Nucleus Accumbens Adenosine A2A Receptors Regulate Exertion of Effort by Acting on the Ventral Striatopallidal Pathway

(2008) S. Mingote et al.   JOURNAL OF NEUROSCIENCE

Quality of life in early Parkinson's disease treated with levodopa/carbidopa/entacapone

(2008) Victor S.C. Fung et al.   MOVEMENT DISORDERS

Forebrain circuitry involved in effort-related choice: Injections of the GABAA agonist muscimol into ventral pallidum alter response allocation in food-seeking behavior

(2008) A.M. Farrar et al.   NEUROSCIENCE

The adenosine A2A antagonist MSX-3 reverses the effort-related effects of dopamine blockade: differential interaction with D1 and D2 family antagonists

(2008) Lila T. Worden et al.   PSYCHOPHARMACOLOGY

Intra-accumbens injections of the adenosine A2A agonist CGS 21680 affect effort-related choice behavior in rats

(2008) Laura Font et al.   PSYCHOPHARMACOLOGY