Partial Agonistic Actions of Sex Hormone Steroids on TRPM3 Function

TRPM3 channels play roles in heat hypersensitivity and spontaneous pain after nerve injury

(2021) Songxue Su et al.   JOURNAL OF NEUROSCIENCE

A Chinese patient with developmental and epileptic encephalopathies (DEE) carrying a TRPM3 gene mutation: a paediatric case report

(2021) Qingyun Kang et al.   BMC Pediatrics

Description of a novel patient with the TRPM3 recurrent p.Val837Met variant

(2021) Lucas W Gauthier et al.   European Journal of Medical Genetics

Defining the TRPM3 related spectrum: Possible ocular and joints defects, and inconstant epilepsy

(2020) Jean-Madeleine de Sainte Agathe et al.   European Journal of Medical Genetics

Steroids and TRP Channels: A Close Relationship

(2020) Karina Angélica Méndez-Reséndiz et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

(2020) Siyuan Zhao et al.   eLife

Gain of channel function and modified gating properties in TRPM3 mutants causing intellectual disability and epilepsy

(2020) Evelien Van Hoeymissen et al.   eLife

Pharmacological properties of TRPM3 isoforms are determined by the length of the pore loop

(2020) Katharina Held et al.   BRITISH JOURNAL OF PHARMACOLOGY

Minipuberty: Why Does it Happen?

(2020) Marianne Becker et al.   Hormone Research in Paediatrics

Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries

(2019) Lucía Alonso-Carbajo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

De novo substitutions of TRPM3 cause intellectual disability and epilepsy

(2019) David A. Dyment et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mutations in the voltage-sensing domain affect the alternative ion permeation pathway in the TRPM3 channel

(2018) Katharina Held et al.   JOURNAL OF PHYSIOLOGY-LONDON

A TRP channel trio mediates acute noxious heat sensing

(2018) Ine Vandewauw et al.   NATURE

Rapid steroid hormone actions via membrane receptors

(2016) Nofrat Schwartz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

TRPA1 Mediates Aromatase Inhibitor–Evoked Pain by the Aromatase Substrate Androstenedione

(2016) Francesco De Logu et al.   CANCER RESEARCH

Progesterone Receptor Signaling Mechanisms

(2016) Sandra L. Grimm et al.   JOURNAL OF MOLECULAR BIOLOGY

Oestrogens and Progestagens: Synthesis and Action in the Brain

(2016) M. F. Rossetti et al.   JOURNAL OF NEUROENDOCRINOLOGY

Natural Variation in Testosterone is Associated With Hypoalgesia in Healthy Women

(2015) Emily J. Bartley et al.   CLINICAL JOURNAL OF PAIN

Activation of TRPM3 by a potent synthetic ligand reveals a role in peptide release

(2015) Katharina Held et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The TRPM8 Protein Is a Testosterone Receptor

(2014) Swapna Asuthkar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Opening of an alternative ion permeation pathway in a nociceptor TRP channel

(2014) Joris Vriens et al.   Nature Chemical Biology

Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels

(2013) A Drews et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Quantitative analysis of TRP channel genes in mouse organs

(2012) Yongwoo Jang et al.   ARCHIVES OF PHARMACAL RESEARCH

Membrane Progesterone Receptors: Evidence for Neuroprotective, Neurosteroid Signaling and Neuroendocrine Functions in Neuronal Cells

(2012) Peter Thomas et al.   NEUROENDOCRINOLOGY

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

(2011) Yasser Majeed et al.   CELL CALCIUM

TRPM3 Is a Nociceptor Channel Involved in the Detection of Noxious Heat

(2011) Joris Vriens et al.   NEURON

Cis-isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels

(2010) Y Majeed et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction

(2010) Jacqueline Naylor et al.   CIRCULATION RESEARCH

Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABAA receptors

(2009) Seo-Yeon Yoon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic β cells

(2008) Thomas F.J. Wagner et al.   NATURE CELL BIOLOGY

Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord

(2007) Cherkaouia Kibaly et al.   FASEB JOURNAL