Article
Neurosciences
Rachel Chudoba, Joanna Dabrowska
Summary: Defensive behaviors in response to threats are common across the animal kingdom. Different populations of CRF neurons in the CeA and BNST play divergent but complementary roles in mediating defensive responses, such as vigilance, avoidance, and active escape. Understanding the contributions of specific CRF neurons is important for understanding their dysregulation in fear and anxiety disorders.
Article
Biology
Alisson P. de Almeida, Marcus V. C. Baldo, Simone C. Motta
Summary: In nature, confrontations between conspecifics are recurrent and related to the lack of resources. Repeated social defeat can lead to changes in social defence behaviour. The balance of activity between the amygdala, hypothalamic nuclei, and the hypothalamic pre-mammillary nucleus (PMD) may determine the pattern of social defence behaviour.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Raoni Conceicao dos-Santos, Brook L. W. Sweeten, Claire E. Stelly, Jeffrey G. Tasker
Summary: Stress has effects on the nervous system at different signaling levels and time scales. Glucocorticoids, the main effectors of stress plasticity, act on multiple receptor subtypes in different cellular compartments, leading to changes in synaptic transmission and neuronal excitability. This review focuses on the rapid actions of acute stress-induced glucocorticoids in modulating synaptic and intrinsic neuronal properties. The stress-related brain structures, such as the hypothalamus, hippocampus, amygdala, and prefrontal cortex, exhibit synaptic plasticity in response to single or short-term stress exposure.
Review
Neurosciences
Justin M. Moscarello, Mario A. Penzo
Summary: The article proposes that mutually inhibitory circuits within the central nucleus of the amygdala implement a 'winner-takes-all' mechanism that guides transitions across defensive modes defined by threat-imminence theory.
NATURE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Johannes Kornhuber, Iulia Zoicas
Summary: NPY reduces social fear expression by acting on DLS and CeA, not effective in DH, MeA, and BLA regions. It also exhibits anxiolytic effects when administered in DH, DLS, CeA, and BLA, but not in MeA. This suggests that different neural circuitries are involved in the effects of NPY on social fear expression and anxiety-like behavior.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Matthew C. Valdez, Danielle L. Freeborn, Joseph M. Valdez, Andres R. Henriquez, Samantha J. Snow, Thomas W. Jackson, Prasada Rao S. Kodavanti, Urmila P. Kodavanti
Summary: Individuals with psychosocial stress have an exaggerated response to air pollutants, and this study found that preexistent mild chronic stress and social isolation can exacerbate the acute effects of ozone exposure on hormones and gene expression, with variations in different brain regions.
Article
Anatomy & Morphology
Antonia Alonso, Carmen Maria Trujillo, Luis Puelles
Summary: The prethalamic eminence is a transient embryonic structure that plays a significant role in neuronal migration and distribution, although it is undetectable in the adult brain. Through experimental methods, the study confirmed the presence of three migratory streams originating from the PThE, which target different areas of the brain and may influence the selection of neuronal targets.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Medicine, Research & Experimental
Yi-Hua Chen, Jian-Lin Wu, Neng-Yuan Hu, Jia-Pai Zhuang, Wei-Peng Li, Sheng-Rong Zhang, Xiao-Wen Li, Jian-Ming Yang, Tian-Ming Gao
Summary: The study was supported by grants from the National Natural Science Foundation of China, the Key Area Research and Development Program of Guangdong Province, the Guangdong Basic and Applied Basic Research Foundation, the Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence Fund, and the Science and Technology Program of Guangzhou.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Plant Sciences
Isabel Sollozo-Dupont, Erika Estrada-Camarena, Miguel Carro-Juarez, Carolina Lopez-Rubalcava
JOURNAL OF ETHNOPHARMACOLOGY
(2015)
Article
Plant Sciences
Carolina Lopez-Rubalcava, Erika Estrada-Camarena
JOURNAL OF ETHNOPHARMACOLOGY
(2016)
Article
Neurosciences
D. Islas-Preciado, C. Lopez-Rubalcava, J. Gonzalez-Olvera, A. Gallardo-Tenorio, E. Estrada-Camarena
Article
Biochemistry & Molecular Biology
Brenda Valdes-Sustaita, Carolina Lopez-Rubalcava, Maria Eva Gonzalez-Trujano, Cristina Garcia-Viguera, Erika Estrada-Camarena
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Neurosciences
F. Guzman-Mejia, C. Lopez-Rubalcava, C. Gonzalez-Espinosa
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2018)
Article
Plant Sciences
Erika Estrada-Camarena, Isabel Sollozo-Dupont, Dannia Islas-Preciado, Maria Eva Gonzalez-Trujano, Miguel Carro-Juarez, Carolina Lopez-Rubalcava
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Neurosciences
Melissa Hernandez-Frausto, Carolina Lopez-Rubalcava, Emilio J. Galvan
Article
Neurosciences
Berenice Marquez-Valadez, Guillermo Aquino-Miranda, Mijail-Oliver Quintero-Romero, Helena Papacostas-Quintanilla, Antonio Bueno-Nava, Carolina Lopez-Rubalcava, Nestor Fabian Diaz, Jose-Antonio Arias-Montano, Anayansi Molina-Hernandez
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Pharmacology & Pharmacy
Monserrat Armenta-Resendiz, Elvira Rios-Leal, Maria Teresa Rivera-Garcia, Carolina Lopez-Rubalcava, Silvia Lorenia Cruz
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Brenda Valdes-Sustaita, Erika Estrada-Camarena, Maria Eva Gonzalez-Trujano, Carolina Lopez-Rubalcava
Summary: Pomegranate extract can induce antidepressant-like effects when administered orally or intraperitoneally, with involvement of ER beta and the serotonergic system.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Behavioral Sciences
Nancy Cervantes-Anaya, Gabriel Azpilcueta-Morales, Erika Estrada-Camarena, Daniela Ramirez Ortega, Veronica Perez de la Cruz, Maria Eva Gonzalez-Trujano, C. Lopez-Rubalcava
Summary: The study found that the aqueous extract of pomegranate and its active compounds punicalagin and ellagic acid can attenuate oxidative damage, prevent cellular dysfunction, and promote antidepressant-like actions.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Estrada-Camarena Erika, Carolina Lopez-Rubalcava
Summary: Around 80% of women worldwide experience mild Premenstrual Disorders (PMD) during their reproductive life, with up to a quarter affected by moderate to severe symptoms. Ovarian hormones participate in PMDD symptoms, and their regulation may be altered. PMDD is a complex condition that requires consideration of multiple factors, particularly in animal models.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Luis A. Marquez, Ernesto Griego, Carolina Lopez Rubalcava, Emilio J. Galvan
Summary: Blocking NMDARs with MK-801 during early postnatal development impairs NMDAR-dependent long-term plasticity in the hippocampus, mimicking behavioral and neurophysiological abnormalities of schizophrenia. This study demonstrates that transient hypofunction of NMDARs also affects other forms of hippocampal plasticity, such as AMPAR-mediated short- and long-term potentiation.
Article
Behavioral Sciences
Soledad Recamier-Carballo, Erika Estrada-Camarena, Carolina Lopez-Rubalcava
BEHAVIOURAL PHARMACOLOGY
(2017)
Article
Nutrition & Dietetics
Helena Papacostas-Quintanilla, Victor Manuel Ortiz-Ortega, Carolina Lopez-Rubalcava
FRONTIERS IN NUTRITION
(2017)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)