Review
Neurosciences
Bingsen Xiong, Changming Chen, Yanqiu Tian, Shouwen Zhang, Chao Liu, Tanya M. Evans, Guillen Fernandez, Jianhui Wu, Shaozheng Qin
Summary: The cortisol awakening response (CAR) is a crucial point in the healthy cortisol circadian rhythm, preparing the brain for challenges and promoting neurocognitive efficiency. Studies have found a causal link between CAR and its proactive role in optimizing functional brain networks.
PROGRESS IN NEUROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Joonyoung Kang, Wonjun Kang, Sue-Hyun Lee
Summary: This study reveals that hippocampal processing during memory retrieval is different from memory reinstatement. After cortical memory reinstatement, the representation of associative memory becomes stronger in CA3/DG, while CA1 shows significant memory representation at the onset of retrieval but not afterwards. This tendency is not observed in the condition without active retrieval. Moreover, subsequent long-term memory performance is dependent on the delayed CA3/DG representation during retrieval.
Article
Neurosciences
Adrian W. Gilmore, Anna M. Agron, Estefania Gonzalez-Araya, Stephen J. Gotts, Alex Martin
Summary: In recent years, there has been an increasing use of multi-echo fMRI designs in cognitive neuroscience. Acquiring multiple echoes provides various benefits such as increased contrast-to-noise ratio, reduced signal dropout and thermal noise, as well as the identification of nuisance signal components in BOLD data. However, the use of multi-echo acquisitions also comes with increased data processing complexity and potential trade-offs in temporal and spatial resolution. This study reexamines a multi-echo dataset and demonstrates the practical benefits of multi-echo denoising in a naturalistic memory paradigm, specifically in understanding hippocampal activity during autobiographical recall.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Bridget Callaghan, Camille Gasser, Jennifer A. Silvers, Michelle VanTieghem, Tricia Choy, Kaitlin O'Sullivan, Alexa Tompary, Lila Davachi, Nim Tottenham
Summary: Episodic memory is crucial to human functioning, with the hippocampus playing a central role in adults. Developmental studies have shown that while the hippocampus supports memory in middle childhood and adolescence, the contribution of ongoing maturation in the hippocampus to changes in memory abilities is still unclear. Age-related increases in temporal activation profiles in the posterior hippocampus are associated with the recall of detailed memories, suggesting that granularity may promote memory stabilization.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Paul F. Hill, Sarah E. Seger, Hye Bin Yoo, Danielle R. King, Bradley C. Lega, Michael D. Rugg, David X. Wang
Summary: The study found that the neurophysiological correlates of the BOLD signal differ between different brain regions, with a negative correlation between BOLD signal and high gamma SMEs in the hippocampus, and a positive correlation in the neocortex.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Christian Baeuchl, Franka Gloeckner, Christoph Koch, Johannes Petzold, Nicolas W. Schuck, Michael N. Smolka, Shu-Chen Li
Summary: The aging process leads to changes in spatial navigation behavior, with older adults relying more on proximal location cues instead of environmental boundaries. Deficient dopaminergic modulation may contribute to errors during spatial navigation in older adults. Administering levodopa in young and older adults affected brain responses and memory retrieval differently, with older adults showing upregulation in the medial temporal lobe and brainstem. While L-DOPA had no effect on older adults' overall memory performance, it improved spatial memory and increased boundary processing in some individuals.
Article
Multidisciplinary Sciences
Adrian W. Gilmore, Alina Quach, Sarah E. Kalinowski, Estefania Gonzalez-Araya, Stephen J. Gotts, Daniel L. Schacter, Alex Martin
Summary: The study demonstrates that the activity patterns of the hippocampus in recalling recent events differ from remote events, supporting predictions of the standard model of consolidation. By utilizing overt spoken recall, researchers found that the posterior hippocampal regions exhibit more active patterns during the recall of recent events.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Behavioral Sciences
Valerio Santangelo, Tiziana Pedale, Paola Colucci, Giovanni Giulietti, Simone Macri, Patrizia Campolongo
Summary: While many studies have shown that aging is associated with cognitive decline in the general population, little is known about this association in elderly individuals with enhanced memory capabilities. A 75-year-old individual with highly superior autobiographical memory (HSAM) showed no signs of memory decline over a five-year period, suggesting that highly superior memory performance can occur without noticeable physiological aging.
Article
Behavioral Sciences
Preston P. Thakral, Ryan Bottary, Elizabeth A. Kensinger
Summary: This study aimed to examine the processing and encoding of multisensory emotional experiences in memory. The results showed that negative emotions were more closely associated with activity in visual and auditory processing regions, and the amplification of negative emotion signals was related to the activity in the hippocampus and amygdala. However, for neutral stimuli, stronger representations in visuo-auditory regions were related to subsequent memory, while they were related to subsequent forgetting of positive and negative stimuli.
Article
Behavioral Sciences
Keita Umejima, Takuya Ibaraki, Takahiro Yamazaki, Kuniyoshi L. Sakai
Summary: This study found that participants who used paper notebooks to record schedules had higher accuracy in easier questions and higher brain activations during the retrieval phase. This suggests that using pen and paper promotes deeper and more solid cognitive processes, as well as the acquisition of richer encoding information, leading to higher activation levels in specific brain regions.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Anni Richter, Joram Soch, Jasmin M. Kizilirmak, Larissa Fischer, Hartmut Schutze, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Lea Knopf, Matthias Raschick, Annika Schult, Constanze I. Seidenbecher, Renat Yakupov, Emrah Duezel, Bjorn H. Schott
Summary: In this study, we investigated the associations between two single-value scores and brain function and cognitive changes in middle-aged and older adults. The results showed that these scores were related to memory recall performance and one of the scores also correlated with brain gray matter and other neuropsychological measures. This suggests that single-value scores of memory-related fMRI provide valuable information about network dysfunction in individuals and age-related cognitive decline.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Joram Soch, Anni Richter, Hartmut Schuetze, Jasmin M. Kizilirmak, Anne Assmann, Gusalija Behnisch, Hannah Feldhoff, Larissa Fischer, Julius Heil, Lea Knopf, Christian Merkel, Matthias Raschick, Clara-Johanna Schietke, Annika Schult, Constanze Seidenbecher, Renat Yakupov, Gabriel Ziegler, Jens Wiltfang, Emrah Duezel, Bjoern H. Schott
Summary: As older adults, especially those at risk for dementia, show declines in memory performance, fMRI can be used to detect alterations in memory network activity. The FADE and FADE-SAME scores are developed as potential biomarkers for successful aging and are correlated with behavioral measures of cognitive aging.
HUMAN BRAIN MAPPING
(2021)
Article
Endocrinology & Metabolism
Li Lin, Liang Zhang, Lars Schwabe
Summary: Emotion regulation strategies can influence cognitive responses to stress, particularly memory formation for stressful events. The reappraisal strategy enhances both the physiological response to stress and the memory formation for central features of the stressful event, especially in individuals with high working memory capacity.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neuroimaging
Jason Bini, Lisa Parikh, Cheryl Lacadie, Janice J. Hwang, Saloni Shah, Samuel B. Rosenberg, Dongju Seo, Katherine Lam, Muhammad Hamza, Renata Belfort De Aguiar, Todd Constable, Robert S. Sherwin, Rajita Sinha, Ania M. Jastreboff
Summary: Stress can lead to changes in appetite, resulting in weight gain. Understanding the effects of stress on metabolic, neural, and behavioral factors can help uncover the association between stress, appetite, and obesity risk.
NEUROIMAGE-CLINICAL
(2022)
Review
Oncology
Michael M. Wollring, Jan-Michael Werner, Garry Ceccon, Philipp Lohmann, Christian P. Filss, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: PET imaging using radiolabeled amino acids combined with MRI is a valuable diagnostic tool in managing brain tumor patients. This review provides an overview of PET studies in glioma patients with IDH mutation, which typically do not show contrast enhancement on MRI. The review focuses on the role of amino acid PET in differential diagnosis, treatment planning, and response assessment in patients with IDH-mutant gliomas.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Clinical Neurology
Ann-Katrin Schild, Yasemin Goereci, Daniel Scharfenberg, Kim Klein, Joachim Luelling, Dix Meiberth, Finja Schweitzer, Sophie Stuermer, Philip Zeyen, Derya Sahin, Gereon R. Fink, Frank Jessen, Christiana Franke, Oezguer A. Onur, Josef Kessler, Clemens Warnke, Franziska Maier
Summary: The aim of this study was to assess the neuropsychological profile of patients with asymptomatic to mild/moderate acute COVID-19 disease. The study found that approximately 60% of participants reported cognitive deficits, particularly in the domains of learning/memory and executive functions. These deficits were associated with daytime sleepiness but not with depression, anxiety, sleep quality, general health status, or fatigue.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Marie Madlener, Christine Strippel, Franziska S. Thaler, Kathrin Doppler, Klaus P. Wandinger, Jan Lewerenz, Marius Ringelstein, Rosa Roessling, Til Menge, Jonathan Wickel, Christoph Kellingshaus, Sigrid Mues, Andrea Kraft, Andreas Linsa, Simone C. Tauber, Florian Then Berg, Stefan T. Gerner, Asterios Paliantonis, Alexander Finke, Josef Priller, Ingo Schirotzek, Marie Suesse, Kurt W. Suehs, Christian Urbanek, Makbule Senel, Claudia Sommer, Tania Kuempfel, Harald Pruess, Gereon R. Fink, Frank Leypoldt, Nico Melzer, Michael P. Malter
Summary: This study investigated 101 patients with suspected autoimmune neurological syndromes (AINS) associated with glutamic acid decarboxylase (GAD) antibodies. The results showed that immunotherapy had moderate effectiveness in these patients, and serum GAD antibody levels and intrathecal GAD antibody synthesis did not predict clinical characteristics or treatment outcomes.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Review
Psychiatry
Eric Ettore, Philipp Mueller, Jonas Hinze, Michel Benoit, Bruno Giordana, Danilo Postin, Amandine Lecomte, Hali Lindsay, Philippe Robert, Alexandra Koenig
Summary: This article reviews the current application of digital tools for MDE diagnosis and highlights the shortcomings for further research. The study focuses on digital devices that are easy to use during clinical interviews and mental health issues where depression is common. The findings suggest that a digital phenotype of MDE can be identified based on modifications in speech features, nonverbal behavior, and physiological measurements. However, further longitudinal and prospective studies are needed to validate the potential of these markers.
JMIR MENTAL HEALTH
(2023)
Article
Oncology
Alexander Heinzel, Felix M. Mottaghy, Christian Filss, Gabriele Stoffels, Philipp Lohmann, Michel Friedrich, Nadim J. Shah, Svenja Caspers, Carolin Weiss Lucas, Maximilian I. Ruge, Norbert Galldiks, Gereon R. Fink, Karl-Josef Langen, Martin Kocher
Summary: This study investigated the impact of tumor development and multimodality therapy on health-related quality of life (HRQoL) in glioma patients. The results showed that right hemisphere gliomas were associated with less favorable outcomes in most functional domains except communication ability. This relationship was mainly observed in T2/FLAIR lesions involving structural and functional networks in the right hemisphere.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Immunology
Felix Kohle, Robin Ackfeld, Franziska Hommen, Ines Klein, Martin K. R. Svacina, Christian Schneider, Gereon R. R. Fink, Mohammed Barham, David Vilchez, Helmar C. C. Lehmann
Summary: This study evaluated the neuro-regenerative effects of the small molecule kinesin-5 inhibitor monastrol in a rodent model of acute autoimmune neuropathies. The results showed that treatment with monastrol improved the functional and histological recovery of neuropathies and promoted the regeneration of nerve terminals, possibly through accelerated motor neurite outgrowth.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Norbert Galldiks, Philipp Lohmann, Gereon R. Fink, Karl-Josef Langen
Summary: For decades, amino acid PET tracers have been used to optimize diagnostics in brain tumor patients, with clinical indications including differentiation of neoplasm from nonneoplastic etiologies, delineation of tumor extent for further diagnostic and treatment planning, differentiation of treatment-related changes, and assessment of response to anticancer therapy. This article focuses on the diagnostic value of amino acid PET for patients with glioblastoma or metastatic brain cancer.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Clinical Neurology
Aline Seger, Anja Ophey, Wiebke Heitzmann, Christopher E. J. Doppler, Marie-Sophie Lindner, Corinna Brune, Johanna Kickartz, Haidar S. Dafsari, Wolfgang H. Oertel, Gereon R. Fink, Stefanie T. Jost, Michael Sommerauer
Summary: This study aimed to optimize the identification of subjects with isolated rapid eye movement (REM) sleep behavior disorder (iRBD) from the general population. An accurate questionnaire-based algorithm was developed to improve recruitment efficiency in research. The algorithm displayed high diagnostic accuracy and could be a convenient tool in research and clinical settings.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Christian Schneider, Meike K. K. Wassermann, Martin K. R. Svacina, Gilbert Wunderlich, Gereon R. R. Fink, Helmar C. C. Lehmann
Summary: In this study, the subclinical motor involvement in the upper extremity muscles of patients with lower limb-predominant nonsystemic vasculitic neuropathy (NSVN) was investigated using the MScanFit method. The results showed that the number of motor units and peak CMAP amplitudes were significantly reduced in patients with NSVN. However, there was no evidence of significant reinnervation, and the number of motor units did not correlate with clinical scores.
Article
Clinical Neurology
Ann-Katrin Schild, Daniel Scharfenberg, Lukas Kirchner, Kim Klein, Anton Regorius, Yasemin Goereci, Dix Meiberth, Lena Sannemann, Joachim Luelling, Finja Schweitzer, Gereon R. Fink, Frank Jessen, Christiana Franke, Oezguer Onur, Stefanie Jost, Clemens Warnke, Franziska Maier
Summary: Cognitive impairment is a common symptom of post-COVID syndrome (PCS), but there is inconsistency between subjective cognitive complaints (SCC) and objective results. This study investigated this discrepancy and found a 40% difference between subjective reports and test results. Patients with SCC and objective impairment showed elevated fatigue and reduced quality of life. The study suggests that more patients will likely request neuropsychological assessments even after mild infections.
ZEITSCHRIFT FUR NEUROPSYCHOLOGIE
(2023)
Article
Geriatrics & Gerontology
Julian Dronse, Anna Ohndorf, Nils Richter, Gerard N. Bischof, Ronja Fassbender, Qumars Behfar, Hannes Gramespacher, Kim Dillen, Heidi I. L. Jacobs, Juraj Kukolja, Gereon R. Fink, Oezguer A. Onur
Summary: A study found that elevated cortisol levels are associated with memory decline in Alzheimer's disease patients, as well as hippocampal atrophy and memory impairment in healthy seniors.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Correction
Psychiatry
Eric Ettore, Philipp Mueller, Jonas Hinze, Matthias Riemenschneider, Michel Benoit, Bruno Giordana, Danilo Postin, Rene Hurlemann, Amandine Lecomte, Michel Musiol, Hali Lindsay, Philippe Robert, Alexandra Koenig
JMIR MENTAL HEALTH
(2023)
Article
Clinical Neurology
Lothar Burghaus, Marie Madlener, Felix Kohle, Emanuel F. Bruno, Volker Limmroth, Gereon R. Fink, Michael P. Malter
Summary: Status epilepticus (SE) is a neurological emergency characterized by prolonged seizure activity. Prehospital management of SE is crucial, and this study investigated the impact of different treatment strategies, specifically focusing on levetiracetam. The results showed that the use of levetiracetam in the prehospital setting did not have a significant additional effect on SE parameters.
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Neuroimaging
Janusz L. Koob, Shivakumar Viswanathan, Maike Mustin, Imon Mallick, Sebastian Krick, Gereon R. Fink, Christian Grefkes, Anne K. Rehme
Summary: This study aims to investigate the factors in the early post-acute stage that may increase the risk of depression symptoms in stroke patients. The results show that more severe motor impairment promotes reward-dependent motor engagement, while depression and corticostriatal lesions may disrupt incentive motivational behavior, thereby increasing the risk of chronic depressive symptoms.
NEUROIMAGE-CLINICAL
(2023)
Article
Neurosciences
Hendrik Theis, Stephane Prange, Gerard N. Bischof, Merle C. Hoenig, Marc Tittgemeyer, Lars Timmermann, Gereon R. Fink, Alexander Drzezga, Carsten Eggers, Thilo van Eimeren
Summary: Impulsive-compulsive behavior (ICB) is frequently observed in early Parkinson's disease after starting dopamine replacement therapy, while apathy occurs even before treatment initiation. This study explored the relationship and underlying factors between these two behavioral conditions. The severity of ICB was positively correlated with the severity of apathy, and apathy and the Ser9Gly polymorphism of DRD3 were interactive risk factors for ICB severity.
NPJ PARKINSONS DISEASE
(2023)