Journal
PSYCHOLOGICAL MEDICINE
Volume 40, Issue 4, Pages 611-619Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033291709990985
Keywords
Ageing; Alzheimer's disease; dementia; Down's syndrome; magnetic resonance imaging
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Funding
- South London
- Maudsley National Health Service (NHS) Trust (National Division)
- Baily Thomas Charitable Fund
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Background. People with Down's syndrome (DS) are at high risk for developing dementia in middle age. The biological basis for this is unknown. It has been proposed that non-demented adults with DS may undergo accelerated brain ageing. Method. We used volumetric magnetic resonance imaging (MRI) and manual tracing to compare brain anatomy and ageing in 39 non-demented adults with DS and 42 healthy controls. Results. Individuals with DS had significant differences in brain anatomy. Furthermore, individuals with DS had a significantly greater age-related reduction in volume of frontal, temporal and parietal lobes, and a significantly greater age-related increase in volume of peripheral cerebrospinal fluid (CSF). Conclusions. Non-demented adults with DS have differences in brain anatomy and 'accelerated' ageing of some brain regions. This may increase their risk for age-related cognitive decline and Alzheimer's disease (AD).
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