Article
Neurosciences
Preeti Kar, Jess E. Reynolds, Melody N. Grohs, Rhonda C. Bell, Megan Jarman, Deborah Dewey, Catherine Lebel
Summary: This study found that breastfeeding exclusivity and duration were associated with global and regional white matter microstructure in young children, even after controlling for perinatal and sociodemographic factors. Greater exclusivity was linked to higher fractional anisotropy in females and lower in males.
Article
Clinical Neurology
Jasmina Boban, Majda M. Thurnher, Nikola Boban, Meng Law, Neda Jahanshad, Talia M. Nir, Dajana F. Lendak, Dusko Kozic
Summary: This study investigated the correlation between white matter diffusivity measures and age and education level in healthy volunteers. The results showed that different diffusivity parameters had significant correlations with age, with radial diffusivity (RD) showing the strongest correlation. The patterns of degradation in different fiber tracts varied, suggesting that currently available theories cannot fully explain age-related changes in the brain.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Benita Schmitz-Koep, Aurore Menegaux, Juliana Zimmermann, Melissa Thalhammer, Antonia Neubauer, Jil Wendt, David Schinz, Marcel Daamen, Henning Boecker, Claus Zimmer, Josef Priller, Dieter Wolke, Peter Bartmann, Christian Sorg, Dennis M. Hedderich
Summary: This study investigates cortical organization in preterm-born adults using percent contrast of gray-to-white matter signal intensities. The results suggest widespread altered cortical microstructure, mainly in middle cortical layers, in preterm-born adults, with differential effects on associative and primary cortices.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ayisha Al Busaidi, Emma Gangemi, Stephen Wastling, Aaike S. van den Berg, Laura Mancini, Tarek Yousry
Summary: This retrospective study investigates the correlation between functional and structural lateralisation in language pathways. The results indicate that tractography is not suitable for assessing language lateralisation. The discordant results suggest that either the structural lateralisation is less robust than functional lateralisation, or tractography is not sensitive enough.
EUROPEAN RADIOLOGY
(2023)
Article
Peripheral Vascular Disease
Emilie T. Reas, Gail A. Laughlin, Donald J. Hagler, Roland R. Lee, Anders M. Dale, Linda K. McEvoy
Summary: Midlife vascular disease increases the risk for dementia, with vascular dysfunction affecting brain health differently in men and women. Elevated pulse pressure is linked to cerebrovascular pathology and white matter damage, with associations between pulse pressure and neural integrity differing by sex and age. In this study, higher pulse pressure correlated with lower restricted isotropic diffusion in white matter, particularly in certain brain regions, with stronger effects in younger participants and in women. Monitoring microstructural changes using restriction spectrum imaging could indicate neuronal loss, demyelination, or inflammation associated with age-related cerebrovascular dysfunction.
Article
Anatomy & Morphology
Tory O. Frizzell, Elisha Phull, Mishaa Khan, Xiaowei Song, Lukas A. Grajauskas, Jodie Gawryluk, Ryan C. N. D'Arcy
Summary: This study evaluated white matter neuroplasticity in healthy adults pre-post motor training, specifically focusing on motor learning in the non-dominant hand. Changes in neuroplasticity were observed in the internal capsule and corpus callosum, with significant amplitude reductions in low-frequency oscillations implicating optimized transmission through altered myelination. The findings open new avenues for white matter investigations and advance MRI clinical applications.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Psychiatry
Gang Wu, Bohui Mei, Xiaofang Hou, Fukun Wang, Chen Zang, Xiaoya Zhang, Zhenjiang Zhang
Summary: Using diffusion tensor imaging data and tract-based spatial statistics, this study found microstructural abnormalities in white matter fibre tracts in patients with major depressive disorder (MDD), and these abnormalities were associated with illness duration. The reduced fibrous myelination levels were observed in the corpus callosum, corona radiata, and thalamic radiations in adults with MDD. These findings provide important insights into the understanding and treatment of MDD.
Article
Pediatrics
Camille Letissier, Amandine Crombe, Lydie Cherier, Jean Delmas, Jean-Francois Chateil
Summary: This study investigated T2-based and diffusion-weighted imaging (DWI) measurements for evaluating fetal brain maturation during the last trimester of pregnancy. The frontal T2/thalamus ratio emerged as a potential additional biomarker of fetal brain maturation.
PEDIATRIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiong Xiao, Ne Yang, Guocan Gu, Xianyu Wang, Zhuang Jiang, Tian Li, Xinran Zhang, Longfei Ma, Peng Zhang, Hongen Liao, Liwei Zhang
Summary: The study found that diffusion MRI is valuable in genotyping brainstem gliomas, with white matter tract measurements significantly improving diagnostic performance. Combining tumor and white matter features from diffusion tensor and kurtosis imaging can build the best genotyping model.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Robin B. Brown, Daniel J. Tozer, Marco Egle, Anil M. Tuladhar, Frank-Erik de Leeuw, Hugh S. Markus
Summary: This study investigated the regression of white matter hyperintensity lesions (WMHs) in patients with cerebral small vessel disease (SVD). It found that only a small proportion of patients showed regression, and this regression was associated with smaller initial lesion volume and better white matter microstructural integrity.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Hematology
Melissa C. Caughey, Ye Qiao, Michelle L. Meyer, Priya Palta, Kunihiro Matsushita, Hirofumi Tanaka, Bruce A. Wasserman, Gerardo Heiss
Summary: In older adults, larger arterial diameters in the middle cerebral circulation were associated with greater WMH volume in participants with elevated central artery stiffness. Strategies to reduce central artery stiffness may help mitigate the association between cerebrovascular outward remodeling and microvascular damage.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Clinical Neurology
Janina Wilmskoetter, Julius Fridriksson, Alexandra Basilakos, Lorelei Phillip Johnson, Barbara Marebwa, Chris Rorden, Graham Warner, Gregory Hickok, Argye E. Hillis, Leonardo Bonilha
Summary: Preservation of indirect white matter connections is associated with better post-stroke naming improvements in aphasia, even when direct connections are damaged. The study suggests that individuals with indirect connections may benefit more from language treatment, regardless of the loss of direct connections.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Neurosciences
Rujing Sun, Shi-Yu Zhang, Xu Cheng, Sangma Xie, Peng-Gang Qiao, Gong-Jie Li
Summary: The study investigated structural and network topological changes in MMD patients with limb paresthesia using diffusion kurtosis imaging (DKI). Results showed significant reductions in FA and MK in extensive WM regions, decreased global network efficiency, increased characteristic path length, and increased sigma in patient groups compared to healthy controls. The study suggests that FA is more sensitive in detecting WM injury and identifies key nodes related to the development of acroparesthesia.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Bastian Cheng, Marvin Petersen, Robert Schulz, Marlene Boenstrup, Lutz Krawinkel, Christian Gerloff, Gotz Thomalla
Summary: Recent advancements in higher-order diffusion-weighted imaging models have allowed for estimation of specific white matter fiber populations within a voxel, revealing progressive fiber-specific white matter loss after stroke and its association with functional motor outcome. Using fixel-based analysis, researchers demonstrated a relationship between decreased fiber density and cross-section in specific white matter tracts and lower grip strength in stroke patients over a year. This study highlights the potential of fiber-specific analysis to detect secondary neurodegeneration after stroke and its impact on clinical recovery.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Tiffany C. Ho, Lucinda M. Sisk, Artenisa Kulla, Giana I. Teresi, Melissa M. Hansen, Hua Wu, Ian H. Gotlib
Summary: Adolescents with lifetime depression showed higher R1 values in the uncinate fasciculus and corpus callosum genu compared to healthy controls, with sex significantly moderating this association. Female adolescents with depression had significantly higher R1 values in these tracts compared to healthy females, while there was no significant difference in R1 values between depressed and non-depressed male adolescents. Our results suggest that R1 may be more sensitive to sex-specific effects of depression in adolescents, particularly in females.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Neurosciences
Wi Hoon Jung, Murat Yucel, Je-Yeon Yun, Youngwoo B. Yoon, Kang Ik K. Cho, Linden Parkes, Sung Nyun Kim, Jun Soo Kwon
HUMAN BRAIN MAPPING
(2017)
Article
Neurosciences
Wi Hoon Jung, Sangil Lee, Caryn Lerman, Joseph W. Kable
Article
Neurosciences
Wi Hoon Jung, Tae Young Lee, Youngwoo B. Yoon, Chi-Hoon Choi, Jun Soo Kwon
FRONTIERS IN HUMAN NEUROSCIENCE
(2018)
Article
Psychology, Clinical
Seoyoung Kim, Wi Hoon Jung, Oliver D. Howes, Mattia Veronese, Federico E. Turkheimer, Yun-Sang Lee, Jae Sung Lee, Euitae Kim, Jun Soo Kwon
PSYCHOLOGICAL MEDICINE
(2019)
Article
Neurosciences
Seoyeon Kwak, Tae Young Lee, Wi Hoon Jung, Ji-Won Hur, Dahye Bae, Wu Jeong Hwang, Kang Ik K. Cho, Kyung-Ok Lim, So-Yeon Kim, Hye Yoon Park, Jun Soo Kwon
FRONTIERS IN HUMAN NEUROSCIENCE
(2019)
Article
Psychology, Clinical
Tae Young Lee, Wi Hoon Jung, Yoo Bin Kwak, Youngwoo B. Yoon, Junhee Lee, Minah Kim, Euitae Kim, Jun Soo Kwon
Summary: This study investigated the neural correlates of obsession and delusion using connectome-wide association studies, finding that obsession was associated with the supplementary motor area, precentral gyrus, and superior parietal lobule, while delusion was associated with the precuneus. Further analyses revealed aberrant inter-network connectivity strength related to obsession, highlighting the circuit-level functional dysconnectivity associated with obsession and delusion severity.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Wi Hoon Jung, Nam Hee Kim
FRONTIERS IN PSYCHIATRY
(2020)
Article
Psychiatry
Wi Hoon Jung, Hackjin Kim
FRONTIERS IN PSYCHIATRY
(2020)
Article
Multidisciplinary Sciences
Minah Kim, Wi Hoon Jung, Geumsook Shim, Jun Soo Kwon
SCIENTIFIC REPORTS
(2020)
Article
Psychiatry
Sanghoon Oh, Wi Hoon Jung, Taekwan Kim, Geumsook Shim, Jun Soo Kwon
Summary: Functional neuroimaging studies have shown alterations in frontostriatal and frontoparietal circuits in OCD. A study using fMRI found a positive association between activation in the right dorsolateral prefrontal cortex and total Y-BOCS scores in medication-free OCD patients during a visuospatial task. These findings suggest potential neuromodulation targets for OCD treatment.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Sangho Shin, Wi Hoon Jung, Robert McCutcheon, Mattia Veronese, Katherine Beck, Jae Sung Lee, Yun-Sang Lee, Oliver D. Howes, Euitae Kim, Jun Soo Kwon
Summary: This study investigated the relationship between frontostriatal connectivity and striatal dopamine synthesis in treatment-responsive schizophrenia and treatment-resistant schizophrenia, as well as healthy controls. The results suggest that striatal dopaminergic system dysregulation is related to prefrontal cortex pathology localized to the connectivity of DLPFC-AST in treatment-responsive schizophrenia.
PSYCHIATRY INVESTIGATION
(2022)
Article
Psychology, Multidisciplinary
Hyun Jung Han, Sangil Lee, Wi Hoon Jung
Summary: Motivation plays a critical role in human cognitive function. This study classified individuals' behavioral responses and discovered two distinct groups with different achievement motivation orientations. Structural brain analysis and functional magnetic resonance imaging data revealed neural mechanisms related to achievement motivation.
CURRENT PSYCHOLOGY
(2022)
Article
Behavioral Sciences
Won-Gyo Shin, Choong-Wan Woo, Wi Hoon Jung, Hackjin Kim, Tae Young Lee, Jean Decety, Jun Soo Kwon
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2020)
Article
Psychiatry
Jean-Paul Fouche, Stefan du Plessis, Coenie Hattingh, Annerine Roos, Christine Lochner, Carles Soriano-Mas, Joao R. Sato, Takashi Nakamae, Seiji Nishida, Jun Soo Kwon, Wi Hoon Jung, David Mataix-Cols, Marcelo Q. Hoexter, Pino Alonso, Stella J. de Wit, Dick J. Veltman, Dan J. Stein, Odile A. van den Heuvel
BRITISH JOURNAL OF PSYCHIATRY
(2017)
Article
Psychology, Multidisciplinary
Gideon Nave, Wi Hoon Jung, Richard Karlsson Linner, Joseph W. Kable, Philipp D. Koellinger
PSYCHOLOGICAL SCIENCE
(2019)