Article
Clinical Neurology
Olivier Corbeil, Stephanie Corbeil, Michel Dorval, Pierre-Hugues Carmichael, Isabelle Giroux, Christian Jacques, Marie-France Demers, Marc-Andre Roy
Summary: This study found that individuals with first-episode psychosis and a history of gambling are at increased risk of developing problem gambling when receiving aripiprazole. The results emphasize the importance of systematically screening for problem gambling in all individuals with psychotic disorders, as this comorbidity hinders recovery.
Article
Psychiatry
Tianhang Zhou, Chengcheng Pu, Zetao Huang, Tianqi Gao, Enpeng Zhou, Yue Zheng, Dan Zhang, Bingjie Huang, Zhang Cheng, Chuan Shi, Xin Yu
Summary: This study assessed weight changes following antipsychotic treatment in first-episode schizophrenia patients and compared the effects of aripiprazole, risperidone, and olanzapine. The results showed that body weight increased at an average rate of 0.93% per month, with the highest growth rate in the first 3 months. Clinically relevant weight gain (CRW) was observed in 79% of patients. Olanzapine was associated with significantly higher weight gain compared to risperidone and aripiprazole. Predictors for first-year CRW included smaller baseline BMI, family history of mental disorder, receiving olanzapine, and CRW in the first month. Aripiprazole may not be the ideal choice for long-term metabolic side effects.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Marcos Gomez-Revuelta, Jose Maria Pelayo-Teran, Javier Vazquez-Bourgon, Victor Ortiz-Garcia de la Foz, Jacqueline Mayoral-van Son, Rosa Ayesa-Arriola, Benedicto Crespo-Facorro
Summary: This study compared the effectiveness of aripiprazole and risperidone in the acute-phase treatment of FEP and found no differences in treatment discontinuation rates and mean time until discontinuation between the two drugs. However, risperidone showed better performance in terms of clinical efficacy, but patients on risperidone were more likely to experience sex-related adverse events.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Psychiatry
Xinzhe Du, Jinzhi Lv, Jianping Feng, Xinrong Li, Yao Gao, Xiao Wang, Wentao Zhao, Zhiyong Ren, Ruifang Zhang, Xiaohua Cao, Sha Liu, Yong Xu
Summary: This study examined the expression levels of lncRNA, miRNA, and mRNA in exosomes derived from first episode schizophrenia (FOS) patients, and explored their potential as biomarkers for FOS. The results showed significant differences in the expression of these molecules between FOS patients and healthy controls. The ceRNA network constructed in this study demonstrated a higher AUC value compared to individual lncRNA, miRNA, and mRNA, indicating its potential as a biomarker for FOS.
Article
Clinical Neurology
Javier Vazquez-Bourgon, Victor Ortiz-Garcia De la Foz, Marcos Gomez-Revuelta, Jacqueline Mayoral-van Son, Maria Juncal-Ruiz, Nathalia Garrido-Torres, Benedicto Crespo-Facorro
Summary: Aripiprazole and risperidone have similar long-term metabolic profiles, leading to a higher prevalence of metabolic disorders such as metabolic syndrome and hypertriglyceridemia.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Review
Psychiatry
Laura Lockwood, Brian Miller, Nagy A. Youssef
Summary: This systematic review examined 17 studies related to epigenetic changes in first-episode psychosis, finding evidence of epigenetic alterations in certain portions of the genome in early psychosis patients. Further research in this area is warranted for more definitive epigenetic correlations.
PSYCHIATRY RESEARCH
(2022)
Article
Clinical Neurology
Lucia Garrido-Sanchez, Marcos Gomez-Revuelta, Victor Ortiz-Garcia De la Foz, Jose Maria Pelayo-Teran, Maria Juncal-Ruiz, Miguel Ruiz-Veguilla, Jacqueline Mayoral-Van Son, Rosa Ayesa-Arriola, Javier Vazquez-Bourgon, Benedicto Crespo-Facorro
Summary: This study compared the short-term effectiveness of aripiprazole and risperidone in patients with first episode psychosis (FEP). The results showed no statistically significant differences in treatment discontinuation rates and time to discontinuation between the two drugs. However, aripiprazole required higher dosage and extended time to achieve clinical response.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaoe Lang, Mei Xue, Xiaocui Zang, Fengchun Wu, Meihong Xiu, Xiangyang Zhang
Summary: This study aimed to examine the efficacy, safety, and tolerability of low-dose risperidone combined with sertraline in reducing serious adverse effects in first-episode and medication-naive schizophrenia patients. The results showed that the combination of low-dose risperidone and sertraline was more effective in reducing psychotic symptoms and improving psychosocial functioning, with significantly fewer adverse effects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Clinical Neurology
Yingtan Wang, Zhe Lu, Guanglei Xun
Summary: This study aimed to explore the effect of escitalopram combined with aripiprazole on cognitive function in patients with major depressive disorder (MDD). The results showed that combination therapy improved executive function and continuous attention, but had no significant effect on alleviating depressive and anxiety symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Neuroimaging
Yongfeng Yang, Yuqing Sun, Yuliang Zhang, Xueyan Jin, Zheng Li, Minli Ding, Han Shi, Qing Liu, Luwen Zhang, Xi Su, Minglong Shao, Meng Song, Yan Zhang, Wenqiang Li, Weihua Yue, Bing Liu, Luxian Lv
Summary: This study investigated regional activity and functional connectivity alterations in adolescent first-episode SZ, adult first-episode SZ, and adult chronic SZ. Abnormal patterns in the medial frontal gyrus and putamen were found to be common across all stages of SZ. The abnormal functional connectivity between ventromedial prefrontal cortex and dorsolateral prefrontal cortex was also observed in adolescence and adulthood, potentially indicating a shared neurodevelopmental abnormality.
NEUROIMAGE-CLINICAL
(2022)
Article
Psychiatry
Franck Schurhoff, Cecile Corfdir, Baptiste Pignon, Mohamed Lajnef, Jean-Romain Richard, Elisabeth Marcos, Antoine Pelissolo, Marion Leboyer, Serge Adnot, Stephane Jamain, Andrei Szoke
Summary: This study compared telomere length between first-episode schizophrenia patients and controls, finding no significant association after adjusting for confounders. The results suggest that psycho-social stress may impact telomere length in individuals with schizophrenia, rather than telomere erosion contributing to the development of the disorder.
PSYCHIATRY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
John Wang, Kamber L. Hart, Wei Qi, Babak A. Ardekani, Chenxiang Li, Julia Marx, Oliver Freudenreich, Corinne Cather, Daphne Holt, Iruma Bello, Erica D. Diminich, Yingying Tang, Michelle Worthington, Botao Zeng, Renrong Wu, Xiaoduo Fan, Jingping Zhao, Jijun Wang, Donald C. Goff
Summary: Aripiprazole may protect against hippocampal atrophy and reduce inflammation in patients with early schizophrenia, but further replication in larger randomized trials is needed to establish the clinical relevance of hippocampal volume loss.
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
(2021)
Article
Psychology, Clinical
Brian O'Donoghue, John Lyne, Eric Roche, Nathan Mifsud, Laoise Renwick, Caragh Behan, Mary Clarke
Summary: This study found that migrants from Africa have a nearly twofold increased risk of developing a psychotic disorder compared to those born in the Republic of Ireland, while migrants from certain Asian countries have a reduced risk. Further research into the factors behind this increased risk in specific migrant groups could provide insights into the cause of psychotic disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Katherine G. Welch, Bryan J. Stiles, Olafur S. Palsson, Piper S. Meyer-Kalos, Diana O. Perkins, Tate F. Halverson, David L. Penn
Summary: This study extends prior outcome research on I-CAT and suggests that diaries are a valuable method of data collection in FEP.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Xin Gao, Li Yao, Fei Li, Chengmin Yang, Fei Zhu, Qiyong Gong, Su Lui
Summary: In first-episode antipsychotic-naive schizophrenia patients, widespread cortical local gyrification index (LGI) alterations were found, and specific risk genes associated with LGI deficits were identified. Lower LGI values were observed in frontotemporal and limbic regions. These findings may contribute to understanding the neurobiological basis of cortical impairments in early-stage schizophrenia.
Article
Biochemistry & Molecular Biology
Kyung-Jun Boo, Edson Luck Gonzales, Chilly Gay Remonde, Jae Young Seong, Se Jin Jeon, Yeong-Min Park, Byung-Joo Ham, Chan Young Shin
Summary: Despite the various medications used in clinics, efforts to develop more effective treatments for depression have increased in recent decades due to treatment-resistant patients and the exploration of new hypotheses and target-based treatments. In this study, the researchers focused on the role of neuroinflammation in depression, proposing that inhibiting the interferon pathway with the drug hycanthone may be a novel therapeutic mechanism for treating depression. Through in vitro and in vivo experiments, it was found that hycanthone attenuated the inflammatory response and improved depressive-like behaviors induced by lipopolysaccharide. These findings suggest a potential new approach for the treatment of depression.
BIOMOLECULES & THERAPEUTICS
(2023)
Article
Chemistry, Analytical
Hyunku Shin, Youbin Kang, Kwan Woo Choi, Seungmin Kim, Byung-Joo Ham, Yeonho Choi
Summary: In vitro diagnosis using biomarkers offers advantages for depression detection and treatment. This study introduces plasma exosomes as novel biomarkers for major depressive disorder (MDD) diagnosis using deep learning analysis and surface-enhanced Raman spectroscopy (SERS). The system shows excellent performance in predicting MDD and suggests a potential pre-screening technique for psychiatric disorders.
ANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Wooyoung Kang, Youbin Kang, Aram Kim, Hyeyoung Kim, Kyu-Man Han, Byung-Joo Ham
Summary: This study aimed to identify gray and white matter abnormalities in MDD patients who experienced childhood adversity. The results showed decreased gray matter in the left rectus and reduced white matter connectivity in various regions including the corpus callosum and superior longitudinal fasciculus. Childhood adversity was found to be negatively correlated with white matter connectivity. These findings suggest that MDD is associated with gray matter atrophy and white matter connectivity changes.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Hee-Kyung Park, Lan Phuong Nguyen, Thai Uy Nguyen, Minyeong Cho, Huong Thi Nguyen, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Summary: CXCL12 is an essential chemokine for organ development and homeostasis, and its receptor CXCR4 is widely expressed on target cells. Multiple splice variants of CXCR4 have been identified, and these variants have different expression patterns and cellular functions. The variants may also interact with each other during cellular responses to CXCL12. Therefore, further investigation of the functional roles of CXCR4 variants could contribute to the development of novel drug interventions.
Article
Psychiatry
Kwang-Sig Lee, Hae-In Kim, Byung-Joo Ham
Summary: This study used machine learning and population-based data to examine the major factors of antidepressant medication, including the seasonality of nitrogen dioxides (NO2). The results showed that antidepressant medication is strongly associated with neighborhood conditions such as NO2 seasonality and welfare support.
PSYCHIATRY INVESTIGATION
(2023)
Article
Psychiatry
Jinyi Kim, Chanju Lee, Youbin Kang, Wooyoung Kang, Aram Kim, Woo-Suk Tae, Byung-Joo Ham, Jisoon Chang, Kyu-Man Han
Summary: This study aimed to investigate the effect of different types of childhood abuse on the cortical thickness in patients with major depressive disorder (MDD) and healthy controls (HCs). The results showed that exposure to childhood sexual abuse (CSA) was significantly associated with cortical thinning in several brain regions involved in emotion regulation, indicating that CSA may have a stronger impact on the dorsolateral prefrontal cortex.
PSYCHIATRY INVESTIGATION
(2023)
Article
Neurosciences
Minsoo Ko, Su-hyuk Chi, Jong -ha Lee, Sang-il Suh, Moon -Soo Lee
Summary: This study investigated the resting-state functional connectivity in adolescents with cyber addiction and found that they showed altered functional connectivity during the resting state. These findings may contribute to a better understanding of the neuropathology of cyber addiction in adolescents.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Junhyung Kim, Hyun-Ghang Jeong, Moon-Soo Lee, Seung-Hoon Lee, Sang-Won Jeon, Changsu Han
Summary: The Brief Resilience Scale was translated into Korean and its reliability and validity were evaluated. The results showed that the Korean version of the Brief Resilience Scale has high internal consistency and construct validity, and is strongly correlated with resilience, depression, and perceived stress. The study also found that the Brief Resilience Scale is sensitive to suicidal risk.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Seung-Hoon Lee, Cheolmin Shin, Young-Hoon Ko, Moon -Soo Lee, Moon Ho Park, Chi-Un Pae, Ho-Kyoung Yoon, Changsu Han
Summary: This study examined the blood adipokine levels in geriatric depression, taking into account the effects of metabolic syndrome. The results showed that metabolic syndrome significantly affected the blood adipokine levels and only PAI-1 was associated with the diagnosis of depression.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Psychiatry
Junhyung Kim, Cheolmin Shin, Kyu-Man Han, Moon-Soo Lee, Hyun-Ghang Jeong, Chi-Un Pae, Ashwin A. A. Patkar, Prakash M. M. Masand, Changsu Han
Summary: This study aims to determine whether the integrated mobile application, inMind, can reduce stress for patients with mild to moderate major depressive disorder during the pharmacological treatment period. The application provides interventions for stress reduction through three modules based on mindfulness-based stress reduction, cognitive behavior therapy, and relaxation sounds. The study will be conducted over 8 weeks, with participants randomized into groups to either use the application first or be on a waitlist.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Youngsoo Jang, Hye-mi Cho, Young-Eun Mok, Su-hyuk Chi, Changsu Han, Hyun-suk Yi, Moon -Soo Lee
Summary: This study investigated the impact of prolonged COVID-19 on school mental health. It found that prolonged COVID-19 had a significant impact on the mental health of adolescents, especially those aged 13-18, who spent a lot of time at school.
JOURNAL OF THE KOREAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Neurosciences
Suhyuk Chi, Young Eun Mok, June Kang, Jeong-An Gim, Changsu Han, Moon-Soo Lee
Summary: This study aimed to identify the cytokines involved in the pathogenesis of tic disorders. The results showed that tic disorder patients and healthy controls exhibit different cytokine profiles, and significant correlations were found only in patients with mild symptoms.
Article
Immunology
Edson Luck Gonzales, Se Jin Jeon, Kyu-Man Han, Seung Jin Yang, Yujeong Kim, Chilly Gay Remonde, Tae Jin Ahn, Byung-Joo Ham, Chan Young Shin
Summary: A growing body of evidence suggests that immune-related genes play a pivotal role in the pathophysiology of depression. This study investigated the connection between gene expression, DNA methylation, and brain structural changes in depression. The findings showed that genes involved in immune responses, especially interferon signaling pathways, were significantly correlated with depression behaviors. Moreover, DNA methylation analysis in human blood samples revealed differential methylation of interferon-related genes in patients with depression compared to healthy controls. Cortical thickness analyses further showed a negative correlation between DNA methylation scores and cortical thickness. These results highlight the importance of the interferon pathway in depression and suggest potential candidate targets.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Lan Phuong Nguyen, Minyeong Cho, Thai Uy Nguyen, Hee-Kyung Park, Huong Thi Nguyen, Kateryna Mykhailova, Sunghoon Hurh, Hong-Rae Kim, Jae Young Seong, Cheol Soon Lee, Byung-Joo Ham, Jong-Ik Hwang
Summary: This study provides the first direct evidence of an interaction between NK1 and NK2, highlighting the functional relevance of their heterodimerization in cellular responses. Through dimerization, NK2 exerts negative effects on downstream signaling and cellular response mediated by NK1. Moreover, this study has significant implications for understanding the complexity of GPCR dimerization and its effect on downstream signaling and cellular responses. Given the important roles of tachykinins and NKs in pathophysiology, these insights may provide clues for developing NKs-targeting drugs.
CELL AND BIOSCIENCE
(2023)
Article
Clinical Neurology
Suhyuk Chi, Young Eun Mok, Jong-ha Lee, Sang-il Suh, Changsu Han, Moon-Soo Lee
Summary: This study analyzed the differences in functional connectivity and brain network parameters between suicidal and non-suicidal major depressive disorder (MDD) patients using a data-driven whole-brain approach. The results showed that suicidal patients had different functional connectivity profiles compared to non-suicidal patients, and they may overthink future risks and have a more pronounced egocentric bias. These features can disrupt cognitive recovery and resilience, leading to more suicidal behaviors.
JOURNAL OF AFFECTIVE DISORDERS
(2023)