Review
Biochemistry & Molecular Biology
Danny J. Soares
Summary: Biocompatible hyaluronic acid gel implants have revolutionized surgery and medicine, particularly in cosmetic applications. However, the increased use of injectable dermal fillers has led to a rise in complications, including vascular occlusion. This article reviews the mechanisms and treatment strategies for filler-induced vascular occlusion, as well as recent advances in prevention and management.
Article
Dermatology
Raffaele Rauso, Nicola Zerbinati, Romolo Fragola, Giovanni Francesco Nicoletti, Gianpaolo Tartaro
Summary: HYAL has the capability to degrade crosslinked HA injected into human vessels, relieving vascular obstruction. In case of embolism, multiple high doses of HYAL may be required to restore blood flow.
DERMATOLOGIC SURGERY
(2021)
Review
Surgery
Haodong Xiao, Wei Kou, Yuan Yang, Erkuan Dai, Xuerui Zhang, Yanjun Wen, Jie Peng, Ping Fei, Peiquan Zhao
Summary: This study reviewed cases of vision loss related to filler injections and discussed the potential efficacy of hyaluronidase treatment using different administration methods. The results showed that subcutaneous and intra-arterial administration of hyaluronidase helped with visual recovery to varying extents.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Dermatology
Alexandra Bowles, Sabrina Ghalili, Oben B. Ojong, Gabriella F. Vasile, Yumeng M. Li, Shino Bay Aguilera
Summary: This study presents a case series of three patients who were successfully treated for granulomatous foreign body reaction (GFBR) caused by dermal filler. The treatment involved intralesional injection, oral medication, and laser therapy. The results showed significant improvement in both aesthetic and functional outcomes for the patients.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Review
Dermatology
Kathryn Rentfro, Dillon Clarey, Emily J. Glenn, Ronald Sulewski, Ashley Wysong
Summary: This study systematically compiles cases of necrosis caused by soft tissue fillers and collects data on injection, treatment, and outcomes. The majority of necrosis cases analyzed were a result of hyaluronic acid injections in the nasolabial fold. Hyaluronidase was the most commonly used initial treatment agent for necrosis. This review serves as a valuable reference for clinicians and providers encountering necrosis from soft tissue fillers.
DERMATOLOGIC SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Sandip P. Patil, Leena P. Shirsath, Bhushan L. Chaudhari
Summary: A halotolerant bacterium isolated from dental caries was found to produce the enzyme hyaluronidase, which showed high activity and stability at pH 7.0 and 40 degrees C, as well as in 2M NaCl solution. The enzyme exhibited wide substrate specificity with hyaluronic acid as the best substrate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Aditya Kaul, Walker D. Short, Xinyi Wang, Sundeep G. Keswani
Summary: This article discusses the important role of hyaluronidases in human tissues, especially in promoting disease progression, and the potential benefits as clinical treatments currently and in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Engineering, Biomedical
Fernanda Zamboni, Chun Kwok Wong, Maurice N. Collins
Summary: This article discusses the interaction between hyaluronic acid and pathogenic microorganisms, as well as the antimicrobial activity of different molecular weights of hyaluronic acid in biomedical and pharmaceutical applications. These studies are crucial for the development of next generation antimicrobial therapeutic strategies.
BIOACTIVE MATERIALS
(2023)
Review
Dermatology
Javier Anido, Jose Manuel Fernandez, Ignacio Genol, Natalia Ribe, Gema Perez Sevilla
Summary: This interdisciplinary consensus document aims to improve safety standards and help professionals successfully resolve tear trough deformities by providing relevant issues and recommendations. The increasing interest in eye appearance has led to a rise in diagnosis and treatment of tear trough deformity through hyaluronic acid filler injection, requiring proper anatomical knowledge and clinical assessment by attending physicians.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Surgery
Christine Ryu, Jonathan E. Lu, Sandy Zhang-Nunes
Summary: This study evaluated the in vitro responses of 12 HA fillers to varying doses of recombinant human hyaluronidase (RHH). Results showed different levels of resistance of different fillers to hyaluronidase.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Chemistry, Physical
Pushap Raj, Seon-yeong Lee, Tae Yoon Lee
Summary: Bladder cancer is the leading cause of death in patients with genitourinary cancer. Elevated levels of hyaluronidase (HAase) can serve as an important biomarker for early diagnosis. A simple, sensitive, and ratiometric fluorescence assay for HAase detection has been developed, with a detection limit below normal human body fluid levels. The assay may be useful for diagnosing HAase-related diseases.
Review
Oncology
Kevin Domanegg, Jonathan P. Sleeman, Anja Schmaus
Summary: CEMIP is a protein that has been implicated in the pathogenesis of various diseases, particularly colorectal cancer. It plays a role in tumor growth and metastasis, and its expression is associated with poor prognosis. CEMIP contributes to tumor progression and metastasis through multiple mechanisms.
Article
Dermatology
Marina Aguilar-Gonzalez, Juan Davo-Cabrera, Nuria Rausell-Fontestad, Rafael Botella-Estrada, Enrique Espana-Gregori, Marta Perez-Lopez
Summary: The application of hyaluronidase in periocular skin leads to the presence of deposits, but does not alter the structure of elastin and collagen dermis.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Review
Surgery
Qiang Fu, Can Zheng, Gui-wen Zhou, Xiao Xu, Lin-ying Lai, Xu-er Sun, Li-xia Zhang, Qian Wu, Hong-fan Ding, Yi Yang, Hui-juan Fu, Min-liang Chen
Summary: Percutaneous intra-arterial hyaluronidase injection is an effective treatment for vascular embolism caused by HA fillers, but there is currently a lack of a unified treatment protocol.
AESTHETIC PLASTIC SURGERY
(2023)
Review
Materials Science, Multidisciplinary
Mujahid Iqbal, Aqeela Yasin, Ambreen Akram, Jing-An Li, Kun Zhang
Summary: Hyaluronic acid (HA) is a versatile material that can be modified to enhance its stability. Sulfated hyaluronic acid (S-HA) can be synthesized and has slower degradation by hyaluronidase compared with HA. S-HA has numerous applications in medical and cosmetic fields as biomaterials and coatings.