Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry

Non-degradative ubiquitination of the Notch1 receptor by the E3 ligase MDM2 activates the Notch signalling pathway

(2013) Susanne Pettersson et al.   BIOCHEMICAL JOURNAL

Structural characterization of intrinsically disordered proteins by the combined use of NMR and SAXS

(2012) Nathalie Sibille et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The p53 mRNA-Mdm2 Interaction Controls Mdm2 Nuclear Trafficking and Is Required for p53 Activation following DNA Damage

(2012) Madhavsai Gajjar et al.   CANCER CELL

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

(2012) David P. Lane et al.   CELL CYCLE

An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis

(2012) Judith Nicholson et al.   JOURNAL OF PROTEOME RESEARCH

Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2

(2012) S. M. Vogel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemical states of the N-terminal “lid” of MDM2 regulate p53 binding: Simulations reveal complexities of modulation

(2011) Shubhra Ghosh Dastidar et al.   CELL CYCLE

Understanding Small-Molecule Binding to MDM2: Insights into Structural Effects of Isoindolinone Inhibitors from NMR Spectroscopy

(2011) Christiane Riedinger et al.   Chemical Biology & Drug Design

C-Terminal Substitution of MDM2 Interacting Peptides Modulates Binding Affinity by Distinctive Mechanisms

(2011) Christopher J. Brown et al.   PLoS One

Insights into the Conformational Dynamics of the E3 Ubiquitin Ligase CHIP in Complex with Chaperones and E2 Enzymes

(2010) Christian Graf et al.   BIOCHEMISTRY

An ARF-Independent c-MYC-Activated Tumor Suppression Pathway Mediated by Ribosomal Protein-Mdm2 Interaction

(2010) Everardo Macias et al.   CANCER CELL

Design of a novel MDM2 binding peptide based on the p53 family

(2010) Arumugam Madhumalar et al.   CELL CYCLE

The Effects of Phosphomimetic Lid Mutation on the Thermostability of the N-terminal Domain of MDM2

(2010) Erin G. Worrall et al.   JOURNAL OF MOLECULAR BIOLOGY

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

(2009) Shubhra Dastidar et al.   BMC BIOINFORMATICS

ATP stimulates MDM2-mediated inhibition of the DNA-binding function of E2F1

(2008) Craig Stevens et al.   FEBS Journal

Multiple Peptide Conformations Give Rise to Similar Binding Affinities: Molecular Simulations of p53-MDM2

(2008) Shubhra Ghosh Dastidar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

p53 mRNA controls p53 activity by managing Mdm2 functions

(2008) Marco M. Candeias et al.   NATURE CELL BIOLOGY