Sequence and structure continuity of evolutionary importance improves protein functional site discovery and annotation

Evolution-guided discovery and recoding of allosteric pathway specificity determinants in psychoactive bioamine receptors

(2010) Gustavo J. Rodriguez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant Human Growth Hormone

(2009) Stefano Benedini et al.   BIODRUGS

Evolutionary Trace Annotation Server: automated enzyme function prediction in protein structures using 3D templates

(2009) R. Matthew Ward et al.   BIOINFORMATICS

Protein Sectors: Evolutionary Units of Three-Dimensional Structure

(2009) Najeeb Halabi et al.   CELL

Evolutionary Trace Annotation of Protein Function in the Structural Proteome

(2009) Serkan Erdin et al.   JOURNAL OF MOLECULAR BIOLOGY

Role for the Regulator of G-Protein Signaling Homology Domain of G Protein-Coupled Receptor Kinases 5 and 6 in  2-Adrenergic Receptor and Rhodopsin Phosphorylation

(2009) F. Baameur et al.   MOLECULAR PHARMACOLOGY

Exploitation of binding energy for catalysis and design

(2009) Summer B. Thyme et al.   NATURE

Protein promiscuity and its implications for biotechnology

(2009) Irene Nobeli et al.   NATURE BIOTECHNOLOGY

Functional Rescue of β1-Adrenoceptor Dimerization and Trafficking by Pharmacological Chaperones

(2009) Hiroyuki Kobayashi et al.   TRAFFIC

Joint Evolutionary Trees: A Large-Scale Method To Predict Protein Interfaces Based on Sequence Sampling

(2009) Stefan Engelen et al.   PLoS Computational Biology

INTREPID—INformation-theoretic TREe traversal for Protein functional site IDentification

(2008) Sriram Sankararaman et al.   BIOINFORMATICS

Prediction of enzyme function based on 3D templates of evolutionarily important amino acids

(2008) David M Kristensen et al.   BMC BIOINFORMATICS

Rational Design of Competitive Prolactin/Growth Hormone Receptor Antagonists

(2008) Estelle Tallet et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

De-Orphaning the Structural Proteome through Reciprocal Comparison of Evolutionarily Important Structural Features

(2008) R. Matthew Ward et al.   PLoS One

NMR structures of two designed proteins with high sequence identity but different fold and function

(2008) Y. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De Novo Computational Design of Retro-Aldol Enzymes

(2008) L. Jiang et al.   SCIENCE

Detection of Functionally Important Regions in “Hypothetical Proteins” of Known Structure

(2008) Guy Nimrod et al.   STRUCTURE

Understanding the molecular machinery of genetics through 3D structures

(2007) Roman A. Laskowski et al.   NATURE REVIEWS GENETICS