Review
Immunology
Eduardo Duarte-Silva, Henning Ulrich, Agatha Oliveira-Giacomelli, Hans-Peter Hartung, Sven G. Meuth, Christina Alves Peixoto
Summary: This article discusses the role of the adenosinergic system in the development of multiple sclerosis and proposes mechanisms by which modulation of this system can support drug development and repurposing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Ladan Dayani, Masoud Sadeghi Dinani, Mehdi Aliomrani, Hossein Hashempour, Jaleh Varshosaz, Azade Taheri
Summary: This study investigated the potential effects of cyclotide-rich fractions from Viola odorata as an immunomodulatory agent in an experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS). The results showed that cyclotides significantly reduced the clinical scores, inflammation, and demyelination in EAE mice, comparable to fingolimod.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Multidisciplinary Sciences
Insha Zahoor, Hamid Suhail, Indrani Datta, Mohammad Ejaz Ahmed, Laila M. Poisson, Jeffrey Waters, Faraz Rashid, Rui Bin, Jaspreet Singh, Mirela Cerghet, Ashok Kumar, Md Nasrul Hoda, Ramandeep Rattan, Ashutosh K. Mangalam, Shailendra Giri
Summary: Metabolic aberrations were found to impact the pathogenesis of relapsing-remitting multiple sclerosis, with changes in multiple metabolic pathways identified in patient samples. Enhanced glycolysis in immune cells of MS patients was observed, and treatment with a glycolytic inhibitor showed promising effects in ameliorating disease progression by promoting an antiinflammatory phenotype. This study highlights the potential of blood-based metabolomic approaches in identifying therapeutic targets for developing new treatment strategies for multiple sclerosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Jin Wang, Kellie Brown, Caroline Danehy, Emmanuel Merigeon, Stephen Goralski, Samuel Rice, Kwame Torgbe, Fridtjof Thomas, David Block, Henrik Olsen, Scott E. Strome, Elizabeth A. Fitzpatrick
Summary: This study tested the efficacy of a recombinant Fc multimer (M019) in treating multiple sclerosis using a murine model. The results showed that M019 effectively reduced clinical symptoms, inhibited immune cell infiltration into the central nervous system, and interacted with Fc gamma R bearing-monocytes.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Eleni Stamoula, Spyridon Siafis, Ioannis Dardalas, Alexandra Ainatzoglou, Alkis Matsas, Theodoros Athanasiadis, Chrysanthi Sardeli, Konstantinos Stamoulas, Georgios Papazisis
Summary: Antidepressants have been found effective in treating depression comorbid to MS, alleviating various MS symptoms, and reducing stress-related relapses. Through promoting neural and glial cell viability and differentiation, reducing proinflammatory cytokines, and exerting neuroprotective activity by eliminating axonal loss, they target multiple aspects of MS pathophysiology in both in vitro and in vivo models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Zhicheng Liu, Jeffrey Waters, Bin Rui
Summary: This review provides an overview of the applications of metabolomics in studying perturbed metabolic pathways in multiple sclerosis (MS) and its potential for personalized treatments. Metabolic alterations associated with MS progression can be revealed through metabolomics, and informative variations of metabolites can serve as potential biomarkers for understanding MS pathogenesis, predicting disease progression, and estimating drug effects.
BIOMEDICAL JOURNAL
(2022)
Article
Immunology
Jinyuan Luoqian, Wenyong Yang, Xulong Ding, Qing-zhang Tuo, Zheng Xiang, Zhaoyue Zheng, Yu-jie Guo, Li Li, Pengbo Guan, Scott Ayton, Biao Dong, Huiyuan Zhang, Hongbo Hu, Peng Lei
Summary: This study discovered a potential role of ferroptosis, an iron-dependent regulated cell death mechanism, in multiple sclerosis (MS), and proposed the possibility of targeting ferroptosis for MS treatment.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dafni Birmpili, Imane Charmarke Askar, Kevin Bigaut, Dominique Bagnard
Summary: Multiple Sclerosis (MS) is a complex chronic autoimmune disease characterized by demyelinating lesions and axonal damage in the central nervous system. The experimental autoimmune encephalomyelitis (EAE) model, which resembles the pathological features of human MS, has been valuable for understanding the mechanisms of MS and identifying molecular biomarkers for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Maxime Donadieu, Hannah Kelly, Diego Szczupak, Jing-Ping Lin, Yeajin Song, Cecil C. C. Yen, Frank Q. Ye, Hadar Kolb, Joseph R. Guy, Erin S. Beck, Steven Jacobson, Afonso C. Silva, Pascal Sati, Daniel S. Reich
Summary: This study characterized cortical lesions in marmosets with EAE using ultrahigh-field MRI and histological analysis, finding that 65% of cortical lesions could be captured with in vivo imaging, and confirming extensive demyelination in the cortical areas of the marmoset brain.
Article
Behavioral Sciences
Aliakbar Mariki, Zahra Barzin, Majid Fasihi Harandi, Kimia Karbasi Ravari, Mahboubeh Davoodi, Seyed Mohammad Mousavi, Soheila Rezakhani, Masoud Nazeri, Mohammad Shabani
Summary: This study found that antigen B from hydatid cyst fluid could reduce the levels of anti-inflammatory cytokines in rats with experimental autoimmune encephalomyelitis (EAE)-induced multiple sclerosis (MS) and increase nerve conduction velocity. The results showed that antigen B modulated the immune system and reduced the inflammatory component of the EAE MS animal model, leading to a decrease in symptoms at the behavioral and electrophysiological level. Antigen B could be used as a potential therapeutic agent to regulate the immune system in MS patients.
BRAIN AND BEHAVIOR
(2023)
Review
Biochemistry & Molecular Biology
Annarita Del Gatto, Michele Saviano, Laura Zaccaro
Summary: Multiple sclerosis is a progressive and highly debilitating disease, with current treatment strategies showing limitations in preventing disease progression. Peptide-based systems offer new therapeutic opportunities for the treatment of MS.
Review
Cell Biology
Amin Daei Sorkhabi, Erfan Komijani, Aila Sarkesh, Pedram Ghaderi Shadbad, Ali Aghebati-Maleki, Leili Aghebati-Maleki
Summary: Immune checkpoint inhibitors have shown promising results and broad clinical applicability in cancer therapy. They also hold great potential for treating autoimmune diseases, particularly multiple sclerosis. Dysregulated expression of immune checkpoints has been observed in patients with multiple sclerosis, suggesting the possibility of developing immunotherapeutic strategies to induce inhibitory immune checkpoints and suppress stimulatory ones.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Biochemistry & Molecular Biology
Michal K. Zarobkiewicz, Izabela Morawska, Adam Michalski, Jacek Rolinski, Agnieszka Bojarska-Junak
Summary: NKT cells, especially iNKT cells, may play a key role in autoimmune diseases. Researchers summarized the results of NKT-oriented studies in major neurological autoimmune diseases such as multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Alessandro Leuti, Emanuela Talamonti, Antonietta Gentile, Marta Tiberi, Alessandro Matteocci, Diego Fresegna, Diego Centonze, Valerio Chiurchiu
Summary: This study demonstrated a shift in the balance of M1/M2 macrophages during MS, with M1 macrophages showing a more proinflammatory profile in EAE compared to control mice, while M2 macrophages lost their M2-like phenotype. Immunization with MOG35-55 led to hyperactivation of M1 macrophages and a shift from anti-inflammatory M2 to pro-inflammatory M1. These findings suggest a potential role for developing new macrophage-centered therapeutic strategies in MS.
Review
Biochemistry & Molecular Biology
Francesco Piacente, Marta Bottero, Andrea Benzi, Tiziana Vigo, Antonio Uccelli, Santina Bruzzone, Giovanni Ferrara
Summary: Myeloid cells, including parenchymal microglia, perivascular and meningeal macrophages, and dendritic cells (DCs), have a crucial role in the central nervous system (CNS). DCs play a critical role in orchestrating the immune response and act as sentinels under steady-state conditions. The exact function of DCs in CNS disease is still debated, but their neuroprotective nature and therapeutic potential for neurological conditions are emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Doha M. Beltagy, Nagat F. Nawar, Tarek M. Mohamed, Ehab Tousson, Mai M. El-Keey
Summary: This study aimed to evaluate the protective role of nanocurcumin as an antioxidant and anti-inflammatory agent, and its synergistic effects with Donepezil in the treatment of Alzheimer's disease in rats. The results showed that treatment with nanocurcumin improved memory, locomotion, and neuronal differentiation by activating the PI3K/AKT/GSK-3 beta pathway.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2024)
