Review
Biochemistry & Molecular Biology
Farzad Sadri, Zohreh Rezaei, Mohammad Fereidouni
Summary: This review summarizes the molecular signature of the SDF-1/CXCR4 pathway and explains how this axis is involved in normal events.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell & Tissue Engineering
Mingxing Sui, Tuo Li, Hanlan Lu, Yanhua Li, Juan Huang, Pei Zhang, Shusen Wang, Li Zeng
Summary: A recent study found that SDF-1 secreted by mesenchymal stromal cells can improve the function of islet grafts, but the presence of SOCS3 reverses the protective effect of SDF-1 on islet grafts. This study reveals a molecular pathway that can elicit localized immunosuppression and delay graft destruction in transplanted islets.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Wu-Xun Chen, Nai-Chen Cheng, Yan-Jun Chen, I-Chi Lee
Summary: In this study, silk fibroin-based microneedle patches were fabricated as carriers for adipose stem cell recruitment. The crystallinity of silk fibroin-based microneedles was determined after water annealing treatment. The results showed that the microneedle patches had sufficient strength to penetrate the skin and demonstrated sustained release of the model drug. Dual-layer microneedles loaded with SDF-1 were prepared to enhance drug release for stem cell recruitment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Astrid S. Jorgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjorto, Sara Rankin, Jon Vabeno, Mette M. Rosenkilde
Summary: Plerixafor exhibits biased action by reversing the CXCL12 gradient across the bone marrow endothelium and showing superior therapeutic effect in HSC mobilization. In contrast, AMD11070, despite having superior antagonism, does not perform as effectively in HSC mobilization in vivo.
COMMUNICATIONS BIOLOGY
(2021)
Correction
Cell Biology
Quan-Jun Deng, Xiao-Feng Xu, Jing Ren
Summary: There was an error in the positive control group of Figure 8 in the original version of the article.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Omaima A. Ahmedy, Marwa W. Kamel, Dalia M. Abouelfadl, Marwa E. Shabana, Rabab H. Sayed
Summary: This study discovered the protective effects of berberine in bleomycin-induced pulmonary fibrosis in mice, and its mechanism involved the activation of adenosine A2a receptor and suppression of SDF-1/CXCR4 signaling pathway. Berberine improved lung fibrosis by modulating the purinergic system, inhibiting epithelial mesenchymal transition, and effectively suppressing inflammation and oxidative stress.
Article
Biochemistry & Molecular Biology
Pierfrancesco Pagella, Cesar Nombela-Arrieta, Thimios A. Mitsiadis
Summary: Specific stem cell populations within dental mesenchymal tissues ensure tooth homeostasis and regeneration, with the decision between renewal and differentiation influenced by interactions with stromal cells and extracellular matrix molecules. The Cxcl12 chemokine, a general marker of stromal cells, plays crucial roles in stem cell maintenance, mobilization, and migration. Using Cxcl12-GFP transgenic mice, this study revealed widespread expression of Cxcl12 in intact and injured teeth, highlighting its significance in various dental mesenchymal stem cell niches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Devki D. Sukhtankar, Juan Jose Fung, Mi-na Kim, Thomas Cayton, Valerie Chiou, Nina G. Caculitan, Piotr Zalicki, Sujeong Kim, Yoonjung Jo, SoHui Kim, Jae Min Lee, Junhee Choi, SeongGyeong Mun, Ashley Chin, Yongdae Jang, Ji Yeong Lee, Gowoon Kim, Eun Hee Kim, Won-Ki Huh, Jae-Yeon Jeong, Dong-Seung Seen, Pina M. Cardarelli
Summary: Autologous Stem Cell Transplant (ASCT) is a common method for treating hematological malignancies. The combination of G-CSF and GPC-100 shows potential for sufficient and rapid collection of stem cells.
Article
Oncology
Chunyan Ma
Summary: Adding bevacizumab to chemotherapy may have a positive impact on the treatment and prognosis of patients with epithelial ovarian cancer. It can significantly decrease the expression of related cancer markers and lower the recurrence rate, without significant safety concerns.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Xin Gao, Dachuan Zhang, Chunliang Xu, Huihui Li, Kathleen M. Caron, Paul S. Frenette
Summary: Nociceptive nerves play a role in enforcing HSC mobilization through CGRP secretion, collaborating with sympathetic nerves to maintain HSCs in the bone marrow. CGRP directly activates HSCs via the G alpha(s)/adenylyl cyclase/cAMP pathway, and consumption of capsaicin-containing food enhances HSC mobilization in mice.
Review
Hematology
Zachary D. Crees, Michael P. Rettig, John F. DiPersio
Summary: Hematopoietic stem-cell transplantation and stem-cell-based gene therapies require sufficient CD34+ hematopoietic stem and progenitor cells (HSPCs) for successful treatment. Current mobilization methods often require multiple days of injections and leukapheresis procedures to collect an adequate number of HSPCs. Motixafortide, a novel CXCR4 inhibitor, has shown promise in mobilizing a large number of HSPCs quickly and may be a promising alternative.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Nan Wu, Jianing Song, Xin Liu, Xiangtao Ma, Xiaoman Guo, Taohong Liu, Mingxuan Wu
Summary: This study found that low-energy Nd:YAG laser can promote the proliferation and migration of periodontal ligament stem cells, and thus improve the success rate of endogenous regeneration.
Article
Cell Biology
Yi Li, Ziqian Feng, Luochen Zhu, Ni Chen, Qin Wan, Jianbo Wu
Summary: Research has shown that SDF-1 and CXCR4 play important roles in regulating platelet activation, mitochondrial respiration, glucose uptake, and ATP production.
Article
Nanoscience & Nanotechnology
Yitong Zhu, Yaqiong Wang, Zhaofeng Lu
Summary: This study explored the efficacy of SDF-1-loaded nanoparticles in traumatic brain injury (TBI) and found that only SDF-1 nanoparticles could induce neural stem/progenitor cells (NSCs) migration to the injured area and enhance healing. These findings suggest the potential application of nanoparticles in the treatment of brain injury.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Pathology
Hailing Tang, Qianfa Long, Kun Zhuang, Kun Han, Xin Zhang, Hanqing Guo, Xiaolan Lu
Summary: RB1 was downregulated in gastric cancer cell lines, and overexpression of RB1 enhanced chemosensitivity to 5-FU in gastric cancer cells by regulating cell autophagy via the SDF-1/CXCR4 pathway. RB1 may serve as a promising therapeutic target in gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
Mateusz Adamiak, Kamila Bujko, Arjun Thapa, Valentina Pensato, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Daryl L. Davies, Henning Ulrich, Magda Kucia, Mariusz Z. Ratajczak
Summary: Recent evidence suggests that extracellular adenosine triphosphate (eATP) plays a crucial role in regulating the mobilization and homing of hematopoietic stem progenitor cells (HSPCs) through activation of P2X4 and P2X7 receptors. Deficiency in either receptor impairs chemotaxis of HSPCs and affects their homing and engraftment post transplantation.
Biographical-Item
Oncology
Mariusz Ratajczak, Eliane Gluckman, Robert Peter Gale
Article
Biochemical Research Methods
Kamila Bujko, Andrzej K. Ciechanowicz, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: Very small embryonic like stem cells (VSELs) are dormant stem cells deposited during embryogenesis in various tissues, including bone marrow. They are released and circulate in peripheral blood at a low level, but increase in number in response to stressors and tissue/organ damage. This study evaluates CD34(+)Lin(-)CD45(-) and CD133(+)Lin(-)CD45(-) VSELs derived from umbilical cord blood, comparing their molecular and proteomic characteristics.
Article
Oncology
Mariusz Z. Ratajczak, Mateusz Adamiak, Ahmed Abdelbaset-Ismail, Kamila Bujko, Arjun Thapa, Vira Chumak, Stephanie Franczak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia
Correction
Oncology
Alison Domingues, Elisa Rossi, Kamila Bujko, Gregoire Detriche, Ulysse Richez, Adeline Blandinieres, Magdalena Kucia, Janina Ratajczak, David M. Smadja, Mariusz Z. Ratajczak
Article
Medicine, General & Internal
Dariusz Starzynski, Sylwia Rzeszotek, Agnieszka Kolasa, Marta Grabowska, Barbara Wiszniewska, Aleksandra Kudrymska, Katarzyna Karpinska, Aleksandra Toloczko-Grabarek, Agnieszka Janiec, Aleksandra Myszka, Pawel Rynio, Anhelli Syrenicz, Elzbieta Sowinska-Przepiera
Summary: The treatment of ANEN is based on tumor size and proliferation markers, with increasing consideration of the role of FSHR from a clinical perspective. FSHR expression is associated with various tumor types and is not found in healthy tissues distant from the tumor site. This study found a higher number of microvessels in the mucosa and submucosa of ANEN, along with higher FSHR expression in women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell & Tissue Engineering
Arjun Thapa, Janina Ratajczak, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: Hematopoietic stem/progenitor cells (HSPCs) express receptors for complement cascade (ComC) cleavage fragments C3a and C5a and respond to inflammation-related cues by sensing PAMPs and DAMPs. The activation of Nox2-ROS-Nlrp3 inflammasome by ComC-derived C3a and C5a plays a role in regulating the responsiveness of HSPCs to stress. Additionally, ComC expressed in HSPCs, known as the complosome, may also contribute to regulating hematopoiesis.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Ahmed Abdelbaset-Ismail, Katarzyna Brzezniakiewicz-Janus, Arjun Thapa, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak
Summary: The study reveals that hematopoietic stem progenitor cells (HSPCs) follow the diurnal circulation rhythm in peripheral blood and melatonin can inhibit the migration of HSPCs by inhibiting Nlrp3 inflammasome activation.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Ahmed Abdelbaset-Ismail, Andrzej K. Ciechanowicz, Kamila Bujko, Janina Ratajczak, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: Proliferation, metabolism, and migration of hematopoietic stem/progenitor cells (HSPCs) are regulated by receptors integrated into membrane lipid rafts (MLRs). The synthesis of MLRs components in HSPCs is regulated by Nox2-ROS-Nlrp3 inflammasome axis, which modulates lipogenesis and the responsiveness of HSPCs to external stimuli.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Himi Tripathi, Alison Domingues, Renee Donahue, Audrey Cras, Coralie L. Guerin, Erhe Gao, Bryana Levitan, Mariusz Z. Ratajczak, David M. Smadja, Ahmed Abdel-Latif, Wadea M. Tarhuni
Summary: Ischemic heart disease, often caused by AMI, is a major cause of morbidity and mortality worldwide. The combination therapy of MSCs and ECFCs can reduce cardiomyocyte apoptosis, scar size, and adverse cardiac remodeling in a pre-clinical model of AMI. This approach shows promise for future human studies during the acute phase of ischemic cardiac injury.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell & Tissue Engineering
Vira Chumak, Katarzyna Sielatycka, Andrzej Ciechanowicz, Kamila Bujko, Mariusz Z. Ratajczak, Magdalena Kucia
Summary: Very small embryonic-like stem cells (VSELs) are dormant stem cells in adult tissues that contribute to tissue/organ repair and regeneration. Proteomic analysis revealed that VSELs express proteins involved in development, signal transduction, and cellular functions, supporting their origin from reproductive lineage.
STEM CELL REVIEWS AND REPORTS
(2023)
Meeting Abstract
Hematology
Andrzej Ciechanowicz, Ahmed Abdelbaset-Ismail, Magda Kucia, Mariusz Z. Ratajczak
Article
Cell & Tissue Engineering
Arjun Thapa, Ahmed Abdelbaset-Ismail, Vira Chumak, Mateusz Adamiak, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: We discovered that sterile inflammation in the bone marrow plays a crucial role in the mobilization, homing, and engraftment of hematopoietic stem/progenitor cells (HSCPs). Extracellular adenosine (eAdo), generated from the conversion of extracellular adenosine triphosphate (eATP), affects HSPCs trafficking by activating the A(2B) receptor. By upregulating heme oxygenase-1 (HO-1), an inhibitor of Nlrp3 inflammasome, the A(2B) receptor inhibition promotes cell migration and proliferation. Blocking the A(2B) receptor could potentially enhance HSPCs mobilization and hematopoietic reconstitution.
STEM CELL REVIEWS AND REPORTS
(2022)
Retraction
Cell & Tissue Engineering
Neeta Shirvaikar, Leah A. Marquez-Curtis, Mariusz Z. Ratajczak, Anna Janowska-Wieczorek
STEM CELLS AND DEVELOPMENT
(2022)
Article
Cell & Tissue Engineering
Mateusz Adamiak, Andrzej Ciechanowicz, Vira Chumak, Kamila Bujko, Janina Ratajczak, Katarzyna Brzezniakiewicz-Janus, Magdalena Kucia, Mariusz Z. Ratajczak
Summary: This study reveals the importance of complement activation in the homing and engraftment of transplanted hematopoietic stem/progenitor cells (HSPCs). The alternative pathway of complement cascade activation plays a role in this process. Deficiency of factor B leads to poor engraftment of HSPCs, possibly due to decreased expression of certain proteins involved in cell migration and immune system.
STEM CELL REVIEWS AND REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Doha M. Beltagy, Nagat F. Nawar, Tarek M. Mohamed, Ehab Tousson, Mai M. El-Keey
Summary: This study aimed to evaluate the protective role of nanocurcumin as an antioxidant and anti-inflammatory agent, and its synergistic effects with Donepezil in the treatment of Alzheimer's disease in rats. The results showed that treatment with nanocurcumin improved memory, locomotion, and neuronal differentiation by activating the PI3K/AKT/GSK-3 beta pathway.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2024)
