Article
Cell & Tissue Engineering
Zuping Wu, Yuying He, Sirui Chen, Li Zhu, Jiahe Wang, Demao Zhang, Jing Xie, Shujuan Zou, Chenchen Zhou
Summary: This study found that CTGF promotes cementum repair and cementogenesis through activation of the Cx43/beta-catenin signaling axis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Taejin Kim, Jin-Kyu Kang, Chang-Gu Hyun
Summary: We investigated the effects of four similar coumarin derivatives on melanogenesis and found that only 6-methylcoumarin significantly increased melanin synthesis in a concentration-dependent manner. Additionally, 6-methylcoumarin activated the GSK3 beta/beta-catenin signal pathway to stimulate melanin synthesis. This suggests that 6-methylcoumarin may be a valuable pigmentation stimulator for cosmetics and medical treatments.
Article
Medicine, Research & Experimental
Ruili Guo, Xue Wang, Yani Fang, Xiongjian Chen, Kun Chen, Wenting Huang, Jun Chen, Jian Hu, Fei Liang, Jingting Du, Confidence Dordoe, Xianxi Tian, Li Lin
Summary: In this study, it was found that rhFGF20 can reduce brain edema, Evans blue penetration, and upregulate the expression of BBB-related tight junction proteins after TBI. rhFGF20 promotes angiogenesis and contributes to neurological and cognitive function recovery in the TBI repair phase. Through the Wnt/beta-catenin pathway, rhFGF20 may prevent vascular repair and angiogenesis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Safaa A. Faheem, Yasser M. Moustafa, Noha M. Saeed, Reem M. Hazem, Norhan M. El-Sayed
Summary: The aim of this study was to investigate whether pyrvinium pamoate (PP) could protect against cyclosporin A (CsA)-induced hepatotoxicity. The results showed that PP has antioxidant, anti-inflammatory, and antiapoptotic properties, which can reduce CsA-induced liver damage.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Madhuri Rudraraju, Shengshuai Shan, Fang Liu, Jennifer Tyler, Ruth B. Caldwell, Payaningal R. Somanath, S. Priya Narayanan
Summary: The study found that ICG001 treatment can improve the stability of cell connections after inflammation, enhance the barrier resistance of retinal endothelial cells, and reduce blood-retinal barrier leakage. The results of the mouse model experiment showed that ICG001 treatment can reduce albumin leakage, decrease the synthesis of inflammatory factors, and inhibit the activation of macrophages.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Li Han, Huaiqing Luo, Wenjie Huang, Jiang Zhang, Di Wu, Jinmei Wang, Jiao Pi, Chi Liu, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Yang Xiang
Summary: Persistent injury and improper repair in bronchial epithelial cells contribute to airway inflammation and remodeling in asthma. E-cadherin plays a role in regulating the balance between EMT and MET during injury repair by inhibiting EMT features, enhancing MET features, and decreasing TGF-beta 1 secretion and Snail expression, ultimately facilitating epithelial repair.
Article
Oncology
Teresa Catalano, Emira D'Amico, Carmelo Moscatello, Maria Carmela Di Marcantonio, Alessio Ferrone, Giuseppina Bologna, Federico Selvaggi, Paola Lanuti, Roberto Cotellese, Maria Cristina Curia, Rossano Lattanzio, Gitana Maria Aceto
Summary: The dysregulation of Wnt pathways in colorectal cancer is influenced by oxidative stress, leading to modulation of APC and beta-Catenin proteins. This study sheds light on the potential impact of oxidative distress on Wnt signaling functions in CRC and suggests avenues for developing personalized therapeutic approaches.
Article
Chemistry, Medicinal
Xingcai Zhang, Lifang Ye, Wan Tang, Yiqin Ji, Li Zheng, Yijun Chen, Qidong Ge, Changshun Huang
Summary: The study aimed to investigate the antifibrotic effects of mesenchymal stem cell microvesicles (MSC MVs) in acute respiratory distress syndrome (ARDS) and the underlying mechanisms. The results showed that MSC MVs significantly suppressed pathological progression of ARDS, reversed abnormal expression of epithelial-mesenchymal transition (EMT)-related proteins, and attenuated activation of the Wnt/β-catenin signaling pathway. These findings suggest that MSC MVs have the potential to ameliorate early pulmonary fibrosis associated with ARDS by regulating EMT and the Wnt/β-catenin signaling pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Physiology
Zhi-Hui Xu, Chang Wang, Yi-Xin He, Xin-Yue Mao, Man-Zhu Zhang, Yan-Pei Hou, Bing Li
Summary: This study investigates the role of hypoxia-inducible factor (HIF) in acute kidney injury (AKI), and finds that HIF expression is more rapid and sufficient in the adaptive repair group compared to the maladaptive repair group during the early repair phase. In cell experiments, HIF is found to promote renal repair by interacting with the Wnt/β-catenin signaling pathway. This research highlights the importance of HIF in promoting adaptive repair in AKI.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Oncology
Jhalak Dholakia, Carly B. Scalise, Ashwini A. Katre, Whitney N. Goldsberry, Selene Meza-Perez, Troy D. Randall, Lyse A. Norian, Lea Novak, Rebecca C. Arend
Summary: The study showed that Wnt/beta-catenin pathway modulation increases MHC I expression and promotes tumor leukocytic infiltration, facilitating a pro-immune TME associated with decreased tumor burden. This intervention overcomes common tumor immune-evasion mechanisms and may render ovarian tumors susceptible to immunotherapy.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Integrative & Complementary Medicine
Yi Zhang, Jingjing Wang, Yong Qu, Yunzhong Chen
Summary: The study showed that 6-Shogaol inhibits the progression of liver cancer by mediating the Wnt/beta-catenin signaling pathway. The expression of TLR4 and FOXO3a in liver cancer cells is influenced by 6-Shogaol treatment, and 6-Shogaol can reverse their expression.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Hua Miao, Yan-ni Wang, Wei Su, Liang Zou, Shou-gang Zhuang, Xiao-yong Yu, Fei Liu, Ying-yong Zhao
Summary: This study investigates the regulatory mechanisms of Sirt in podocyte injury in membranous nephropathy (MN) patients, CBSA-induced MN rats, and ZAS-stimulated podocytes. The results demonstrate that Sirt6 ameliorates podocyte injury by blocking RAS signaling via the Wnt1/β-catenin pathway.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Jiateng Sun, Tongtong Yang, Tianwen Wei, Liuhua Zhou, Tiankai Shan, Jiawen Chen, Lingfeng Gu, Bingrui Chen, Liu Liu, Qiqi Jiang, Chong Du, Yao Ma, Hao Wang, Feng Chen, Xuejiang Guo, Yong Ji, Liansheng Wang
Summary: This study identified cyclin-dependent kinase 9 (CDK9) as a novel therapeutic target in regeneration therapy for myocardial infarction. CDK9 promoted cardiac repair by directly activating SGK3 and the downstream GSK-3 beta/beta-catenin pathway.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lingchen Fu, Jia Fan, Sudipa Maity, Grant McFadden, Yixin Shi, Wei Kong
Summary: PD-L1 interacts with Frizzled 6 receptor to activate beta-catenin signaling and increase the expression of stem cell markers, thereby maintaining and expanding the population of cancer stem cells. Blocking PD-L1 function can inhibit tumor progression by reducing the CSC population.
Article
Biochemistry & Molecular Biology
Changhai Liu, Mayire Nueraihemaiti, Deng Zang, Salamet Edirs, Guoan Zou, Haji Akber Aisa
Summary: The flavonoid compound quercetin 3-O-(6 ''-O-E-caffeoyl)-beta-D-glucopyranoside (CC7) promotes melanogenesis in B16 cells by activating the expression of key regulatory factors and enzymes involved in melanin synthesis. This effect is mediated through the phosphorylation of p38, JNK, and Akt/GSK-3 beta/beta-catenin signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
