Article
Biotechnology & Applied Microbiology
Qi Liu, Yushan Yao, Mahmoud A. A. Ibrahim, Ali Mahmoud El Halawany, Li Yang, Xuewu Zhang
Summary: Squid processing by-product was hydrolyzed using 6 proteases, with neutral protease producing the most promising ACE inhibitory activity. The optimal hydrolysis conditions were determined, and the hydrolysate showed high ACE and renin inhibitory activities. However, these activities decreased after digestion by simulated gastrointestinal juice.
MARINE BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Armin Mirzapour-Kouhdasht, Marzieh Moosavi-Nasab, Chul Won Lee, Hyosuk Yun, Jong-Bang Eun
Summary: Fish gelatin hydrolysates exhibit multifunctional properties with antibacterial and ACE/DPP-IV enzyme inhibitory activities. The synthesized PEP1, PEP2, and PEP3 peptides demonstrate this multifunctionality, confirmed through in vitro and in silico experiments. The binding energies of these peptides are sufficient to inhibit both ACE and DPP-IV enzymes with excellent three-dimensional conformation in all six docking mechanisms.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bin Zhou, Mengchen Li, Jingyun Zhao, Yujuan Rong, Hongshan Liang, Bin Li
Summary: The study showed that enzymatic treatment significantly improves the foaming properties of duck egg white nanogels, allowing them to maintain excellent foaming capabilities during desalination. Additionally, at pH 5, the foaming capacity can exceed 250%, and the foaming stability is close to 80%.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Pedro Valencia, Silvana Valdivia, Suleivys Nunez, Reza Ovissipour, Marlene Pinto, Cristian Ramirez, Alvaro Perez, Manuel Ruz, Paula Garcia, Paula Jimenez, Sergio Almonacid
Summary: The study evaluated the hydrolysis of salmon frame proteins under different conditions, showing that reducing water content increases the concentration of released alpha-NH groups, but decreases nitrogen recovery. Changing the SF/water ratio has a more significant impact on hydrolysis performance.
Article
Food Science & Technology
Shanshan Li, Lingchen Tao, Shiqin Peng, Xinyu Yu, Xiaobin Ma, Fuliang Hu
Summary: The purpose of this study was to investigate the effects of enzymatic hydrolysis on the structural and antioxidative properties of royal jelly protein (RJP). Different degrees of hydrolysis (DH) were obtained by hydrolyzing RJP for different durations. The antioxidative activity of RJP hydrolysates increased with the DH, while the molecular weight decreased. Enzymolysis led to changes in secondary structures, surface hydrophobicity, fluorescence intensity, and morphology of RJP. The changes followed a DH-dependent manner, but became insignificant beyond 20% DH. The optimum enzymatic duration was determined to be 5 hours.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Food Science & Technology
Jacob Ewert, Thomas Eisele, Timo Stressler
Summary: This paper provides an overview of the techniques for production and analysis of antioxidative peptides from food proteins. Factors such as protein substrate, choice of peptidases or peptidase systems, and specific production processes must be considered in the production of antioxidative peptides. The paper also discusses the potential use of continuous production systems and the need for robust analysis tools. Since there is no standardized methodology for evaluating antioxidative peptides, the pros and cons of various strategies for peptide separation and antioxidative measurement are discussed. Overall, this review serves as a roadmap for the generation of antioxidative peptides for research, development, and potential industrial use.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2022)
Article
Energy & Fuels
Lei Zhong, Chao Wang, Miaomiao Xu, Xingxiang Ji, Guihua Yang, Jiachuan Chen, Srinivas Janaswamy, Gaojin Lyu
Summary: The research proposes an efficient approach for biomass energy production through diluted alkali-aided methanol organosolv treatment, resulting in ultrahigh glucose yield and high value-added lignin. The mild alkali catalytic organosolv treatment and enzymatic hydrolysis achieved simultaneous high glucose yield and efficient delignification, with the recovered lignin showing excellent radical scavenging capacity for potential use in biobased functional materials.
Article
Energy & Fuels
Saleha Al-Mardeai, Emad Elnajjar, Raed Hashaikeh, Boguslaw Kruczek, Bart Van der Bruggen, Sulaiman Al-Zuhair
Summary: A tubular membrane bioreactor was used to enhance the enzymatic hydrolysis of palm date seed waste biomass. The bioreactor effectively handled high solid loadings and simultaneously removed products. The effects of substrate concentrations and water flowrates on total reducing sugar production were examined, and a dynamic model was developed to describe the bioreactor and predict its performance. The novel membrane bioreactor and developed model have potential for industrial bioethanol production from lignocellulosic biomass.
Article
Agriculture, Dairy & Animal Science
R. Nikhita, N. M. Sachindra
Summary: Response surface methodology was used to optimize hydrolysis conditions for the production of antioxidant and ACE inhibitory peptides from chicken red blood cells by both enzymatic and acid hydrolysis. The study indicated that both chemical and enzymatic methods can successfully hydrolyze chicken red blood cells to obtain hydrolysates with antioxidant and ACE inhibitory activity.
Article
Chemistry, Applied
Ludan Hu, Fuyuan Ding, Weiwei Liu, Yang Cheng, Juncheng Zhu, Liang Ma, Yuhao Zhang, Hongxia Wang
Summary: This study shows that introducing chitooligosaccharide into yogurt can improve its microstructure and mechanical properties, enhance its antioxidant activity and product quality, providing new insights for the development of a variety of high-quality nutritional dairy products.
FOOD HYDROCOLLOIDS
(2022)
Review
Biochemistry & Molecular Biology
Azis Boing Sitanggang, Jessica Eka Putri, Nurheni Sri Palupi, Emmanuel Hatzakis, Elvira Syamsir, Slamet Budijanto
Summary: This study presents a systematic review on the enzymatic preparation of Angiotensin-I-Converting Enzyme inhibitory (ACEi) peptides, with soybeans and velvet beans identified as suitable sources for producing these peptides. Specific enzymatic conditions for producing ACEi peptides from soybeans and peptide hydrolysates with high ACEi activity are discussed in detail. Additionally, the study highlights the importance of molecular sizes, amino acid residues, and positions in determining the activity of ACEi peptides derived from soybeans.
Article
Food Science & Technology
Phanat Kittiphattanabawon, Sajid Maqsood, Wonnop Visessanguan, Soottawat Benjakul
Summary: In this study, gelatin hydrolysate (TGH) was prepared from Nile tilapia skin using papaya latex enzymes. The TGH products with different degrees of hydrolysis were obtained. TGH-3 and TGH-6 showed the highest cryoprotective and antioxidative activities. TGH also exhibited increased radical scavenging and chelating activities as the hydrolysis time increased. TGH-3 could maintain the protein structure and slow down lipid oxidation in freeze-thawed shrimp.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Vaibhav Kumar Shukla, Lucas Siemons, D. Flemming Hansen
Summary: Enzymes sample various conformations, and the dynamic sampling of conformations determines both enzymatic activity and inhibitor potency. Precise structures alone often cannot explain the effect of mutations on enzymatic activity and drug potency.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Agricultural Engineering
Xindong Chen, Hailong Li, Shimiao Yao, Can Wang, Xuefang Chen, Haijun Guo, Lian Xiong, Hairong Zhang, Xinde Chen
Summary: This study investigated the impact of cellulose ultrastructure on the inhibition of lignin during enzymatic hydrolysis. It also explored the effects of changing cellulose ultrastructure on cellulose conversion. The results showed that cellulose ultrastructure significantly influenced the degree of lignin inhibition.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Food Science & Technology
Wenhan Zhang, Nan Jia, Zihao Zhu, Yanchao Wang, Jingfeng Wang, Changhu Xue
Summary: This study investigated the effects of enzymatic hydrolysis and activated carbon decoloration on antioxidative activities and peptidomic patterns of microalgae protein hydrolysates using a peptidomic approach. Activated carbon decoloration significantly increased color lightness but decreased antioxidative activities and relative abundances of peptides, particularly aromatic amino acid containing peptides. Understanding the dynamics of production processes at a molecular scale can enhance the production and quality control of bioactive peptides from Auxenochlorella pyrenoidosa.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Young Min Lee, In Sook Kim, Beong Ou Lim
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Chemistry, Medicinal
Yon-Suk Kim, Eun-Kyung Kim, Xin Dong, Jin-Su Park, Woen-Bin Shin, Su-Jin Kim, Eun-Ae Go, Pyo-Jam Park, Beong-Ou Lim
JOURNAL OF MEDICINAL FOOD
(2019)
Article
Chemistry, Medicinal
Al B. Bayazid, Jae G. Kim, Seo H. Park, Beong O. Lim
NATURAL PRODUCT COMMUNICATIONS
(2020)
Article
Chemistry, Medicinal
Dong Wook Shin, Beong Ou Lim
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Chemistry, Medicinal
Young Min Lee, Dong Wook Shin, Beong Ou Lim
JOURNAL OF MEDICINAL FOOD
(2020)
Article
Biochemistry & Molecular Biology
Al Borhan Bayazid, Young Ah Jang, Yu Mi Kim, Jae Gon Kim, Beong Ou Lim
Summary: Sodium butyrate (NaB) shows potential therapeutic effects against neurodegenerative diseases (NDDs) by attenuating cell death, inhibiting inflammation, and improving the expression of apoptotic regulators.
NEUROCHEMICAL RESEARCH
(2021)
Article
Food Science & Technology
Al Borhan Bayazid, Jae Gon Kim, Shofiul Azam, Soo Ah Jeong, Da Hee Kim, Chae Won Park, Beong Ou Lim
Summary: The study evaluated the neuroprotective effects of sodium butyrate (NaB) on high-fat diet (HFD)-fed mice. The results showed that NaB restored bodyweight and attenuated oxidative stress, inflammation, and dysregulation in the brains of HFD-fed mice. NaB also enhanced the expression of endogenous antioxidants and exhibited potential as a therapeutic agent for neurodegenerative diseases (NDDs).
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Al Borhan Bayazid, Soo Ah Jeong, Chae Won Park, Da Hee Kim, Beong Ou Lim
Summary: This study investigates the anti-inflammatory activities of fermented Curcuma, finding that it can alleviate intestinal inflammation, improve the intestinal environment, and help with morphological remodeling.
Review
Nutrition & Dietetics
Al Borhan Bayazid, Beong Ou Lim
Summary: This study discusses the impact of oxidative stress on Alzheimer's disease (AD) and Parkinson's disease (PD), and explores the potential of using nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO1) signaling pathways and quercetin as therapeutic approaches against neurodegenerative diseases (NDDs).
Article
Chemistry, Applied
Al Borhan Bayazid, Eun Mi Chun, Mohammad Al Mijan, Seo Hyun Park, Sung-Kwon Moon, Beong Ou Lim
Summary: Bilberry is known for its high content of beneficial compounds and has been used for various diseases. The study shows that bilberry extract has significant antioxidant and anti-inflammatory properties.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Seo Hyun Park, Jae Gon Kim, Young Ah Jang, Al Borhan Bayazid, Beong Ou Lim
Summary: The study showed that fermented black rice and blueberry with Lactobacillus plantarum (FBBBR) has protective effects against UVB-induced skin damage, improving skin hydration and barrier function.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Jae Gon Kim, Xin Dong, Seo Hyun Park, Al Borhan Bayazid, Soo Ah Jeoung, Beong Ou Lim
Summary: This study investigated the anti-inflammatory and immune-boosting effects of bioconversion material BB made from black rice and blueberry using Lactobacillus plantarum. The results showed that in the presence of LPS, BB inhibited nitric oxide production and reduced cytokine secretion, while in the absence of LPS, its effect was lower compared to LPS stimulation.BB was suggested to have multi-efficacy materials in regulating the immune system.
FOOD AND AGRICULTURAL IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Young Min Lee, In Sook Kim, Beong Ou Lim
Summary: The study demonstrates that sandalwood oil possesses antioxidant activity and may mitigate inflammation induced by ROS by inhibiting the NF-κB-mediated inflammatory signaling pathway.
Article
Biochemistry & Molecular Biology
Seong Min Hong, Min Cheol Kang, Mirim Jin, Taek Hwan Lee, Beong Ou Lim, Sun Yeou Kim
Summary: The study found that fermented blueberry and black rice extract containing syringic acid and kuromanin significantly reduced skin inflammation induced by PM2.5, suggesting that it may serve as an important functional food for atopic dermatitis (AD).
Article
Chemistry, Applied
Al Borhan Bayazid, Seo Hyun Park, Jae Gon Kim, Beong Ou Lim
FOOD AND AGRICULTURAL IMMUNOLOGY
(2020)
