Article
Biotechnology & Applied Microbiology
Chanchan Gao, Yazhou Wen, Feng Jiang, Xuyu Gu, Xinhua Zhu
Summary: This study found that circ_0008274 is highly expressed in HCC, promoting proliferation, migration, and invasion of HCC cells. Depleting circ_0008274 inhibits malignant behaviors, with the mechanism involving upregulation of GRN to expedite HCC progression.
Review
Biochemistry & Molecular Biology
Laura Gramantieri, Francesca Fornari, Catia Giovannini, Davide Trere
Summary: miRNAs in HCC play a bidirectional role in both immune-related pathways and oncogenic pathways. Understanding their function can help identify patient subgroups and design personalized treatment strategies.
Review
Oncology
Laura Gramantieri, Catia Giovannini, Fabio Piscaglia, Francesca Fornari
Summary: miRNAs play crucial roles in hepatocellular carcinoma as both biomarkers and therapeutic targets. However, discrepancies between preclinical and clinical findings need to be carefully considered when translating miRNA-based approaches for clinical use.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Virology
Amal Ahmed Mohamed, Omnia Ezzat Esmail, Aya Mohamed Ahmed Ibrahim, Sahar Makled, Eman Al-Hussain, Ali Elsaid, Mohamed Alboraie, Rehab R. El-Awady
Summary: PRDM1 gene polymorphism is associated with the progression of hepatitis C virus (HCV) and hepatocellular carcinoma (HCC) in Egyptians. This case-control study identified the association between PRDM1 polymorphism and HCC risk and prognosis through genotyping and multivariate analysis.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Oncology
Fenfen Guo, Hong Li, Lizhong Wang, Xiaoping Song, Jiangfeng Wang, Qingqing Feng, Jinbao Zong
Summary: The study found a significant association between rs6757 and the risk of HCC in the South Chinese population. When miR-3976 binds to the CD147 3'-UTR, the rs6757 T allele has lower free energies and significantly reduces luciferase activity.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Huayue Li, Zhongwu Chen, Yanan Zhang, Ping Yuan, Jie Liu, Lihua Ding, Qinong Ye
Summary: The study demonstrates that miR-4310 inhibits lipid synthesis by targeting FASN and SCD1, leading to suppressed HCC cell proliferation, migration, and invasion. Low expression of miR-4310 is associated with poor prognosis in HCC patients, highlighting its potential role as a therapeutic target for HCC treatment.
Review
Oncology
Francesca Fornari, Catia Giovannini, Fabio Piscaglia, Laura Gramantieri
Summary: The study reported multiple mechanisms supporting resistance to sorafenib in HCC patients, including activation of oncogenic pathways. Most of the data so far has been derived from laboratory studies, indicating the need for extensive validation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2021)
Article
Biology
Jingya Yu, Haibin Zhang, Yan Zhang, Xiaolu Zhang
Summary: Hepatitis B virus (HBV) infection plays a significant role in the development of hepatocellular carcinoma (HCC) by regulating the non-coding RNA (ncRNA) network. This study identified differentially expressed lncRNAs, miRNAs, and mRNAs between HBsAg-positive and HBsAg-negative HCC, and further explored their regulatory role in cancer-related pathways.
Review
Oncology
Laura Gramantieri, Catia Giovannini, Fabrizia Suzzi, Ilaria Leoni, Francesca Fornari
Summary: The heterogeneity and lack of druggable mutations in hepatocellular carcinoma (HCC) make molecular classification and personalized therapeutic treatments difficult. The absence of circulating biomarkers for treatment guidance and drug resistance in HCC remains a clinical need. Cancer stem cells (CSCs) play a crucial role in tumor heterogeneity, recurrence, and resistance, emphasizing the importance of developing novel therapeutic strategies and targets for HCC management.
Article
Medical Laboratory Technology
M. Neamatallah, M. S. Serria, M. El-Bendary, A. -h. El-Gilany, A. Alhawarey, S. Abed, Y. A. Setate, O. A. Ammar
Summary: This study found that certain SNPs in VDR are associated with the risk of hepatocellular carcinoma in patients with hepatitis C virus infection. These SNPs could serve as molecular markers to predict the risk of HCC.
BRITISH JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Oncology
Jessica Yun, Yun Seok Kim, Mi Jeong Heo, Min Joo Kim, Aree Moon, Sang Geon Kim
Summary: ERα inhibits the worsening of hepatocellular carcinoma (HCC) by inhibiting the transcription of Gα12. Gα12 promotes HCC metastasis and amoeboidal movement, which is antagonized by the expression of ERα. In addition, microRNA-141 and microRNA-200a are downstream targets of the Gα12 signaling axis and regulate the malignancy of HCC.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Matthias Stechele, Henrike Link, Heidrun Hirner-Eppeneder, Marianna Alunni-Fabbroni, Moritz Wildgruber, Lukas Salvermoser, Stefanie Corradini, Regina Schinner, Najib Ben Khaled, Daniel Roessler, Eithan Galun, Shraga Nahum Goldberg, Jens Ricke, Philipp Maximilian Kazmierczak
Summary: This study investigates the potential of circulating miR-21 and miR-210 levels as prognostic biomarkers for HCC treatment. The results suggest that increased miR-21 levels are associated with poor response and shorter time to systemic progression.
RADIATION ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Chenxing Peng, Yufei Zhao, Xiaoyun Zhang, Jingjing Zhang, Ziyue Sha, Shasha Zhang
Summary: This study investigated the association between SNPs in the miRNA binding site of SET8 and KRT81 genes and the occurrence of RA. Results showed that the distribution of the CC genotype of SNP rs16917496 in SET8 was significantly higher in RA patients, indicating an increased risk of RA. The CC genotype carriers had lower SET8 expression, higher ROS levels, and lower IL-10 levels. The study suggested that SNP rs16917496 in the 3'-UTR of SET8 is a predictor of RA risk and may regulate RA development by mediating SET8 expression and affecting ROS and IL-10 levels.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Takeshi Matsui, Susumu Hamada-Tsutsumi, Yutaka Naito, Masanori Nojima, Etsuko Iio, Akihiro Tamori, Shoji Kubo, Tatsuya Ide, Yasuteru Kondo, Yuichiro Eguchi, Atsumasa Komori, Yuji Morine, Mitsuo Shimada, Tohru Utsunomiya, Ken Shirabe, Koichi Kimura, Yoichi Hiasa, Natthaya Chuaypen, Pisit Tangkijvanich, Aya Naiki-Ito, Satoru Takahashi, Takahiro Ochiya, Yasuhito Tanaka
Summary: The miRNA clusters miR-183/96/182 and miR-217/216a/216b are significantly upregulated in nonviral hepatocellular carcinoma (NBNC-HCC). High levels of miR-182-5p and miR-217-5p, but low levels of miR-96-5p, in tumor tissues are associated with poor recurrence-free survival of NBNC-HCC patients. Further upregulation of miR-96-5p in tumors may have an inhibitory effect on recurrence, suggesting its potential as a tumor suppressor in NBNC-HCC patients at high risk of recurrence. Transfection of miR-96-5p mimic induced apoptosis of HepG2 cells and suppressed proliferation and invasion, indicating its potential antitumor effects.
HEPATOLOGY RESEARCH
(2022)
Article
Oncology
Christian Bergamini, Ilaria Leoni, Nicola Rizzardi, Mattia Melli, Giuseppe Galvani, Camelia Alexandra Coada, Catia Giovannini, Elisa Monti, Irene Liparulo, Francesca Valenti, Manuela Ferracin, Matteo Ravaioli, Matteo Cescon, Francesco Vasuri, Fabio Piscaglia, Massimo Negrini, Claudio Stefanelli, Romana Fato, Laura Gramantieri, Francesca Fornari
Summary: This study aims to prove the involvement of miR-494 in the metabolic reprogramming of HCC, identify novel therapeutic combinations, and evaluate miR-494 potential as a circulating biomarker. The results showed that miR-494 induced metabolic shift in HCC cells, leading to cell survival under harsh conditions and sorafenib resistance. MiR-494 could be a potential biomarker for predicting the response to sorafenib treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)