Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells

Dynamic Recruitment of Protein Tyrosine Phosphatase PTPD1 to EGF Stimulation Sites Potentiates EGFR Activation

(2014) Pedro Roda-Navarro et al.   PLoS One

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

(2013) Lan K Nguyen et al.   Cell Communication and Signaling

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Computational Analysis of the Regulation of EGFR by Protein Tyrosine Phosphatases

(2012) Calixte S. Monast et al.   BIOPHYSICAL JOURNAL

Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization

(2012) Yibing Shan et al.   CELL

Governance of Endocytic Trafficking and Signaling by Reversible Ubiquitylation

(2012) Michael J. Clague et al.   DEVELOPMENTAL CELL

Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics

(2012) Harish Shankaran et al.   Molecular BioSystems

Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl

(2012) Hao Dou et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rapid Phospho-Turnover by Receptor Tyrosine Kinases Impacts Downstream Signaling and Drug Binding

(2011) Laura B. Kleiman et al.   MOLECULAR CELL

BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models

(2010) Chen Li et al.   BMC Systems Biology

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

(2010) Lai Kuan Goh et al.   JOURNAL OF CELL BIOLOGY

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

An ultrasensitive sorting mechanism for EGF Receptor Endocytosis

(2008) Hannah Schmidt-Glenewinkel et al.   BMC Systems Biology

Deregulated EGFR Signaling during Lung Cancer Progression: Mutations, Amplicons, and Autocrine Loops

(2008) A. F. Gazdar et al.   Cancer Prevention Research

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL