Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development

Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency

(2013) Kandice L. Tessneer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HECT Domain-containing E3 Ubiquitin Ligase NEDD4L Negatively Regulates Wnt Signaling by Targeting Dishevelled for Proteasomal Degradation

(2013) Yi Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling

(2013) H Jung et al.   Oncogenesis

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: The lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules

(2012) Xuanhua Xie et al.   DEVELOPMENTAL BIOLOGY

Disabled-2 (Dab2) inhibits Wnt/β-catenin signalling by binding LRP6 and promoting its internalization through clathrin

(2012) Yong Jiang et al.   EMBO JOURNAL

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

(2012) Satish Pasula et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch1 counteracts WNT/β-catenin signaling through chromatin modification in colorectal cancer

(2012) Hyun-A Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Dvl2 Promotes Intestinal Length and Neoplasia in the ApcMin Mouse Model for Colorectal Cancer

(2010) C. Metcalfe et al.   CANCER RESEARCH

FZD4 as a Mediator of ERG Oncogene-Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells

(2010) S. Gupta et al.   CANCER RESEARCH

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

The tumor microenvironment of colorectal cancer: stromal TLR-4 expression as a potential prognostic marker

(2010) Rosaria Cammarota et al.   Journal of Translational Medicine

Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation

(2010) Chan Gao et al.   NATURE CELL BIOLOGY

Selective high-level expression of epsin 3 in gastric parietal cells, where it is localized at endocytic sites of apical canaliculi

(2010) G. Ko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells

(2009) K Ueno et al.   BRITISH JOURNAL OF CANCER

Dishevelled: The hub of Wnt signaling

(2009) Chan Gao et al.   CELLULAR SIGNALLING

Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice

(2009) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression

(2008) Qiang Wei et al.   LUNG CANCER

Epsin 1 is Involved in Recruitment of Ubiquitinated EGF Receptors into Clathrin-Coated Pits

(2008) Maja Kazazic et al.   TRAFFIC