Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus

A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

(2017) Matthew Brecher et al.   PLoS Pathogens

The role of surface basic amino acids of dengue virus NS3 helicase in viral RNA replication and enzyme activities

(2016) Pao-Yin Chiang et al.   FEBS LETTERS

A Proline-Rich N-Terminal Region of the Dengue Virus NS3 Is Crucial for Infectious Particle Production

(2016) Leopoldo G. Gebhard et al.   JOURNAL OF VIROLOGY

Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens

(2016) Caleb D. Marceau et al.   NATURE

Virus Variation Resource – improved response to emergent viral outbreaks

(2016) Eneida L. Hatcher et al.   NUCLEIC ACIDS RESEARCH

Antiviral activities of 15 dengue NS2B-NS3 protease inhibitors using a human cell-based viral quantification assay

(2015) Justin Jang Hann Chu et al.   ANTIVIRAL RESEARCH

Membrane topology of NS2B of dengue virus revealed by NMR spectroscopy

(2015) Yan Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Dominant drug targets suppress the emergence of antiviral resistance

(2014) Elizabeth J Tanner et al.   eLife

Autocatalytic Cleavage within Classical Swine Fever Virus NS3 Leads to a Functional Separation of Protease and Helicase

(2013) B. Lamp et al.   JOURNAL OF VIROLOGY

The global distribution and burden of dengue

(2013) Samir Bhatt et al.   NATURE

Development of a strand specific real-time RT-qPCR assay for the detection and quantitation of murine norovirus RNA

(2012) Surender Vashist et al.   JOURNAL OF VIROLOGICAL METHODS

Increasing Rate of Cleavage at Boundary between Non-structural Proteins 4B and 5A Inhibits Replication of Hepatitis C Virus

(2011) Morgan R. Herod et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anthracene-based inhibitors of dengue virus NS2B–NS3 protease☆

(2010) Suzanne M. Tomlinson et al.   ANTIVIRAL RESEARCH

Flexibility between the Protease and Helicase Domains of the Dengue Virus NS3 Protein Conferred by the Linker Region and Its Functional Implications

(2010) Dahai Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-based discovery of dengue virus protease inhibitors

(2009) Suzanne M. Tomlinson et al.   ANTIVIRAL RESEARCH

Structural proteomics of dengue virus

(2008) Rushika Perera et al.   CURRENT OPINION IN MICROBIOLOGY