Structure of the EmrE multidrug transporter and its use for inhibitor peptide design

Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides

(2018) Tracy A. Stone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New free-exchange model of EmrE transport

(2017) Anne E. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protonation of a glutamate residue modulates the dynamics of the drug transporter EmrE

(2016) Anindita Gayen et al.   Nature Chemical Biology

Asymmetric protonation of EmrE

(2015) Emma A. Morrison et al.   JOURNAL OF GENERAL PHYSIOLOGY

A Structured Loop Modulates Coupling between the Substrate-binding and Dimerization Domains in the Multidrug Resistance Transporter EmrE

(2014) James R. Banigan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Efflux by Small Multidrug Resistance Proteins Is Inhibited by Membrane-interactive Helix-stapled Peptides

(2014) Kathrin Bellmann-Sickert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance

(2014) Min-Kyu Cho et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

xMDFF: molecular dynamics flexible fitting of low-resolution X-ray structures

(2014) Ryan McGreevy et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Targeted conformational search with map-restrained self-guided Langevin dynamics: Application to flexible fitting into electron microscopic density maps

(2013) Xiongwu Wu et al.   JOURNAL OF STRUCTURAL BIOLOGY

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

(2013) Jun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Equilibrium Sampling Approach to the Interpretation of Electron Density Maps

(2013) Andreas Vitalis et al.   STRUCTURE

Stapled Peptides with Improved Potency and Specificity That Activate p53

(2012) Christopher J. Brown et al.   ACS Chemical Biology

Drug Efflux by a Small Multidrug Resistance Protein Is Inhibited by a Transmembrane Peptide

(2012) Bradley E. Poulsen et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Antiparallel Dimers of the Small Multidrug Resistance Protein EmrE Are More Stable Than Parallel Dimers

(2012) Pilar Lloris-Garcerá et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rational Design of Proteolytically Stable, Cell-Permeable Peptide-Based Selective Mcl-1 Inhibitors

(2012) Avinash Muppidi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stapled BH3 Peptides against MCL-1: Mechanism and Design Using Atomistic Simulations

(2012) Thomas L. Joseph et al.   PLoS One

Modulation of Substrate Efflux in Bacterial Small Multidrug Resistance Proteins by Mutations at the Dimer Interface

(2011) B. E. Poulsen et al.   JOURNAL OF BACTERIOLOGY

Dissecting electrostatic interactions in Bacillus circulans xylanase through NMR-monitored pH titrations

(2011) Lawrence P. McIntosh et al.   JOURNAL OF BIOMOLECULAR NMR

Structure of the Stapled p53 Peptide Bound to Mdm2

(2011) Sohee Baek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antiparallel EmrE exports drugs by exchanging between asymmetric structures

(2011) Emma A. Morrison et al.   NATURE

Probing theα-Helical Structural Stability of Stapled p53 Peptides: Molecular Dynamics Simulations and Analysis

(2010) Zuojun Guo et al.   Chemical Biology & Drug Design

Multidrug Resistance in Bacteria

(2009) Hiroshi Nikaido   Annual Review of Biochemistry

EmrE, a model for studying evolution and mechanism of ion-coupled transporters

(2009) Shimon Schuldiner   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

All-Atom Contact Model for Understanding Protein Dynamics from Crystallographic B-Factors

(2009) Da-Wei Li et al.   BIOPHYSICAL JOURNAL

CHARMM-GUI Membrane Builder for Mixed Bilayers and Its Application to Yeast Membranes

(2009) Sunhwan Jo et al.   BIOPHYSICAL JOURNAL

Diversity and evolution of the small multidrug resistance protein family

(2009) Denice C Bay et al.   BMC EVOLUTIONARY BIOLOGY

The Assembly Motif of a Bacterial Small Multidrug Resistance Protein

(2009) Bradley E. Poulsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ACEMD: Accelerating Biomolecular Dynamics in the Microsecond Time Scale

(2009) M. J. Harvey et al.   Journal of Chemical Theory and Computation

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Molecular dynamics flexible fitting: A practical guide to combine cryo-electron microscopy and X-ray crystallography

(2009) Leonardo G. Trabuco et al.   METHODS

A coordinated network of transporters with overlapping specificities provides a robust survival strategy

(2009) N. Tal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a Glycine Motif Required for Packing in EmrE, a Multidrug Transporter fromEscherichia coli

(2008) Yael Elbaz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small multidrug resistance proteins: A multidrug transporter family that continues to grow

(2007) Denice C. Bay et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES