Both protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fit

Conformational Selection Is a Dominant Mechanism of Ligand Binding

(2013) Austin D. Vogt et al.   BIOCHEMISTRY

Interplay between conformational selection and induced fit in multidomain protein–ligand binding probed by paramagnetic relaxation enhancement

(2013) G. Marius Clore   BIOPHYSICAL CHEMISTRY

Ligand Concentration Regulates the Pathways of Coupled Protein Folding and Binding

(2013) Kyle G. Daniels et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A single-molecule dissection of ligand binding to a protein with intrinsic dynamics

(2013) Eunkyung Kim et al.   Nature Chemical Biology

Crystal Structure, SAXS and Kinetic Mechanism of Hyperthermophilic ADP-Dependent Glucokinase from Thermococcus litoralis Reveal a Conserved Mechanism for Catalysis

(2013) Jaime Andrés Rivas-Pardo et al.   PLoS One

Conformational Motions Regulate Phosphoryl Transfer in Related Protein Tyrosine Phosphatases

(2013) S. K. Whittier et al.   SCIENCE

Protein dynamics and conformational selection in bidirectional signal transduction

(2012) Ruth Nussinov et al.   BMC BIOLOGY

Dynamics and mechanisms of coupled protein folding and binding reactions

(2012) Thomas Kiefhaber et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Induced Fit or Conformational Selection? The Role of the Semi-closed State in the Maltose Binding Protein

(2011) Denis Bucher et al.   BIOCHEMISTRY

Theory and simulation on the kinetics of protein–ligand binding coupled to conformational change

(2011) Lu Cai et al.   JOURNAL OF CHEMICAL PHYSICS

Rapid search for specific sites on DNA through conformational switch of nonspecifically bound proteins

(2011) H.-X. Zhou   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for Both Conformational Selection and Induced Fit in Ligand Binding by the LAO Protein

(2011) Daniel-Adriano Silva et al.   PLoS Computational Biology

Conformational Selection in G-Proteins: Lessons from Ras and Rho

(2010) Barry J. Grant et al.   BIOPHYSICAL JOURNAL

From Induced Fit to Conformational Selection: A Continuum of Binding Mechanism Controlled by the Timescale of Conformational Transitions

(2010) Huan-Xiang Zhou   BIOPHYSICAL JOURNAL

Many Local Motions Cooperate to Produce the Adenylate Kinase Conformational Transition

(2010) Michael D. Daily et al.   JOURNAL OF MOLECULAR BIOLOGY

Induced fit, conformational selection and independent dynamic segments: an extended view of binding events

(2010) Peter Csermely et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selection

(2008) S. M. Sullivan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA