Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site

Celastrol Induces Apoptosis of Gastric Cancer Cells by miR-21 Inhibiting PI3K/Akt-NF-κB Signaling Pathway

(2014) Min Sha et al.   PHARMACOLOGY

Cancerous inhibitor of PP2A is targeted by natural compound celastrol for degradation in non-small-cell lung cancer

(2013) Zi Liu et al.   CARCINOGENESIS

Farnesyl Diphosphate Synthase Inhibitors fromIn SilicoScreening

(2013) Steffen Lindert et al.   Chemical Biology & Drug Design

Antiproliferative Activity of Abietane Diterpenoids against Human Tumor Cells

(2013) Olga Burmistrova et al.   JOURNAL OF NATURAL PRODUCTS

Celastrol from ‘Thunder God Vine’ Protects SH-SY5Y Cells Through the Preservation of Mitochondrial Function and Inhibition of p38 MAPK in a Rotenone Model of Parkinson’s Disease

(2013) Bong-Suk Choi et al.   NEUROCHEMICAL RESEARCH

Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones

(2013) C. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytotoxic, immunomodulatory, antimycotic, and antiviral activities of semisynthetic 14-hydroxyabietane derivatives and triptoquinone C-4 epimers

(2013) Bibiana Zapata et al.   MedChemComm

Chemo-Immunotherapeutic Antimalarials Targeting Isoprenoid Biosynthesis

(2013) Yonghui Zhang et al.   ACS Medicinal Chemistry Letters

Celastrol Analogues as Inducers of the Heat Shock Response. Design and Synthesis of Affinity Probes for the Identification of Protein Targets

(2012) Lada Klaić et al.   ACS Chemical Biology

Antimicrobial and anti-biofilm properties of new taxodione derivative from hairy roots of Salvia austriaca

(2012) Ł. Kuźma et al.   PHYTOMEDICINE

Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity

(2012) J. H. No et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Terpene Biosynthesis: Modularity Rules

(2011) Eric Oldfield et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bisphosphonates: The first 40years

(2011) R. Graham G. Russell   BONE

Anticancer activity of Celastrol in combination with ErbB2-targeted therapeutics for treatment of ErbB2-overexpressing breast cancers

(2011) Srikumar M. Raja et al.   CANCER BIOLOGY & THERAPY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Remarkable Stereospecific Conjugate Additions to the Hsp90 Inhibitor Celastrol

(2011) Lada Klaić et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Syntheses and Antibacterial Activities of Diterpene Catechol Derivatives with Abietane, Totarane and Podocarpane Skeletons against Methicillin-Resistant Staphylococcus aureus and Propionibacterium acnes

(2010) Masahiro Tada et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

POVME: An algorithm for measuring binding-pocket volumes

(2010) Jacob D. Durrant et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

(2010) Daniel Paris et al.   Journal of Neuroinflammation

Cytotoxic Terpene Quinones from Marine Sponges

(2010) Marina Gordaliza   Marine Drugs

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

(2010) Wolfgang Jahnke et al.   Nature Chemical Biology

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90-Cdc37, a Kinome Chaperone-Cochaperone, by Triterpene Celastrol

(2009) Sridhar Sreeramulu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lipophilic Pyridinium Bisphosphonates: Potent γδT Cell Stimulators

(2009) Yonghui Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway

(2009) Marta Coscia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

(2009) Oleg Trott et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Thermodynamics of Bisphosphonates Binding to Human Bone: A Two-Site Model

(2009) Sujoy Mukherjee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipophilic Bisphosphonates as Dual Farnesyl/Geranylgeranyl Diphosphate Synthase Inhibitors: An X-ray and NMR Investigation

(2009) Yonghui Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

(2008) C.-I Liu et al.   SCIENCE

Ligand-modulation of the stability of the glucose transporter GLUT 1

(2002) Raquel F. Epand et al.   PROTEIN SCIENCE