Article
Immunology
Alessandra M. da Fonseca-Martins, Phillipe de Souza Lima-Gomes, Maisa Mota Antunes, Renan Garcia de Moura, Luciana P. Covre, Carolina Caloba, Vivian Grizente Rocha, Renata M. Pereira, Gustavo Batista Menezes, Daniel Claudio Oliveira Gomes, Elvira M. Saraiva, Herbert L. de Matos Guedes
Summary: Leishmania parasites induce PD-L1 expression in neutrophils, inhibiting immune response and potentially promoting parasite survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Xu, Elodi Dielubanza, Amanda Maisel, Kai Leung, Thomas Mustoe, Seok Hong, Robert Galiano
Summary: Chronic wounds are often caused by bacterial contamination, with Staphylococcus aureus being a common strain. Inhibition of keratinocyte migration by S. aureus exudate may involve the upregulation of connexin-43 (Cx43). The treatment of bacterium-infected wounds may be improved by targeting Cx43 and Akt to overcome wound closure impairment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fengze Miao, Ying Li, Zongguang Tai, Yong Zhang, Yue Gao, Menghong Hu, Quangang Zhu
Summary: Chronic wound infections have become a significant issue, and the development of functional wound dressings has made progress. Antimicrobial peptides are attracting attention as an emerging therapeutic option for wound healing.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Immunology
Pauline Formaglio, Mohamad Alabdullah, Anastasios Siokis, Juliane Handschuh, Ina Sauerland, Yan Fu, Anna Krone, Patricia Gintschel, Juliane Stettin, Sandrina Heyde, Juliane Mohr, Lars Philipsen, Anja Schroeder, Philippe A. Robert, Gang Zhao, Sahamoddin Khailaie, Anne Dudeck, Jessica Bertrand, Gerald F. Spaeth, Sascha Kahlfuss, Philippe Bousso, Burkhart Schraven, Jochen Huehn, Sebastian Binder, Michael Meyer-Hermann, Andreas J. Mueller
Summary: Nitric oxide plays a dual role in controlling Leishmania major by directly killing the pathogen and restricting the supply of host cells necessary for pathogen proliferation.
Review
Cell Biology
Kehinde Ross
Summary: miRNAs play a critical role in wound healing, particularly in influencing the behavior of epidermal keratinocytes. Combining multiple miRNA mimics targeting different but complementary wound healing processes may be more effective in promoting wound repair.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Biology
Lucas Fernando Sergio Gushiken, Fernando Pereira Beserra, Jairo Kenupp Bastos, Christopher John Jackson, Claudia Helena Pellizzon
Summary: The article discusses the physiological mechanisms, interfering factors, and treatment methods of skin wound healing. The success of wound healing depends on the correct balance and is influenced by various factors.
Review
Biotechnology & Applied Microbiology
Jianghui Qin, Fang Chen, Pingli Wu, Guoming Sun
Summary: Wound healing is a complex biological process with bioengineered scaffolds playing a key role in regenerative therapy. Although advancements have been made, challenges remain in achieving ideal treatment for deep cutaneous injuries. Designing innovative scaffolds, precursor development, and therapeutic interventions hold promise for future wound healing strategies.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Biology
Pedro Cecilio, Anabela Cordeiro-da-Silva, Fabiano Oliveira
Summary: This review discusses various aspects of sand flies as vectors of Leishmania parasites, including their basic biology, ecology, and interactions with the parasites. It highlights the need to study the vectors as well as the diseases and etiological agents.
COMMUNICATIONS BIOLOGY
(2022)
Article
Engineering, Biomedical
Yuzhen Wang, Xingyu Yuan, Bin Yao, Shuoji Zhu, Ping Zhu, Sha Huang
Summary: This review discusses the potential and limitations of extrusion-based bioprinting (EBB) for skin regeneration, and introduces strategies for improving the physical properties of bioinks and reinforcing bioinks in EBB approaches. It highlights the applications and effects of current EBB-based bioinks on wound healing, wound scar formation, vascularization, and the regeneration of skin appendages, along with the challenges and future perspectives.
BIOACTIVE MATERIALS
(2022)
Article
Infectious Diseases
Geovanna Vioti, Mariana Dantas da Silva, Fredy Galvis-Ovallos, Maria Luana Alves, Diogo Tiago da Silva, Joao Augusto Franco Leonel, Nuno Wolfgang Balbini Pereira, Julia Cristina Benassi, Julio Cesar Pereira Spada, Carla Maia, Eunice Aparecida Bianchi Galati, Wilma Aparecida Starke-Buzetti, Tricia Maria Ferreira de Sousa Oliveira
Summary: The study demonstrates that naturally infected cats are capable of transmitting L. infantum to sand flies. Through clinical evaluation and diagnosis of 240 cats, the research examined the role of cats in the transmission of visceral leishmaniasis.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Parasitology
Hasna Riyal, Tiago R. Ferreira, Andrea Paun, Kashinath Ghosh, Nilakshi Samaranayake, David L. Sacks, Nadira D. Karunaweera
Summary: Leishmaniasis, caused by Leishmania parasites and transmitted by sand flies, has many different species that can cause disease in humans and animals. Recent research has found evidence of genetic exchange and hybridization in L. donovani parasites within the sand fly vector, Phlebotomus argentipes. This discovery provides new insight into the mechanisms for the diversity of clinical manifestations in humans affected by L. donovani.
Article
Immunology
Marco Antonio Cabrera Gonzalez, Ana Alice Maia Goncalves, Jennifer Ottino, Jaqueline Costa Leite, Lucilene Aparecida Resende, Otoni Alves Melo-Junior, Patricia Silveira, Mariana Santos Cardoso, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Renato Lima Santos, Tatiane Furtado de Carvalho, Giani Martins Garcia, Paulo Ricardo de Oliveira Paes, Alexsandro Sobreira Galdino, Miguel Angel Chavez-Fumagalli, Marilia Martins Melo, Denise Silveira-Lemos, Olindo Assis Martins-Filho, Walderez Ornelas Dutra, Vanessa Carla Furtado Mosqueira, Rodolfo Cordeiro Giunchetti
Summary: Visceral leishmaniasis (VL) is a fatal disease caused by Leishmania infantum, and dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) is important in controlling human and CVL infections by reducing L. infantum infection. This study evaluated the potential of two polymeric nanoformulations loaded with Leishmania amazonensis antigens as a VL vaccine using golden hamsters as a model. The results showed that the vaccines had no adverse reactions and significantly reduced the parasitic load in the liver and spleen. These vaccines may be promising candidates for a VL vaccine.
Review
Parasitology
Taylon Felipe Silva, Fernanda Tomiotto-Pellissier, Aline Kuhn Sbruzzi Pasquali, Fernanda Pinto-Ferreira, Wander Rogerio Pavanelli, Ivete Conchon-Costa, Italmar Teodorico Navarro, Eloiza Teles Caldart
Summary: The study revealed that the exact mechanism leading to different clinical manifestations among strains of the same species is still uncertain, and future studies are needed to better elucidate this phenomenon.
Article
Public, Environmental & Occupational Health
Ilka Grewe, Thomas Theo Brehm, Benno Kreuels, Oliver M. Steinmetz, Bernhard Dumoulin, Anne Marie Asemissen, Dennis Tappe, Michael Ramharter, Stefan Schmiedel
Summary: We report a case of Leishmania infantum reactivation in an immunocompetent patient who developed visceral leishmaniasis with secondary IgA nephropathy nine years after an initial episode of mucosal leishmaniasis, which had been treated with liposomal amphotericin B.
JOURNAL OF TRAVEL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sun-Hye Choi, Kyung-Jong Won, Rami Lee, Han-Sung Cho, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study demonstrates that gintonin promotes wound healing by enhancing migration and proliferation of skin cells, as well as increasing vascular endothelial growth factor release, possibly through activation of LPA receptors and downstream signaling pathways involving VEGF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)