Review
Biochemistry & Molecular Biology
Claudia D'Agostino, Dorian Parisis, Clara Chivasso, Maryam Hajiabbas, Muhammad Shahnawaz Soyfoo, Christine Delporte
Summary: Aquaporin-5 (AQP5), a member of the aquaporins family, facilitates water flux and the movement of hydrogen peroxide and CO2. It is regulated by various mechanisms and also regulates downstream effectors involved in cellular processes. This review summarizes the current knowledge of the upstream and downstream effectors of AQP5 for a better understanding of its physiological and pathophysiological roles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lejia Xu, Yuki Nagai, Yotaro Kajihara, Genta Ito, Taisuke Tomita
Summary: Rab proteins can be regulated by phosphorylation, which affects their interactions with regulatory proteins and effector proteins, thus influencing intracellular vesicle trafficking. This phosphorylation-dependent regulation plays a crucial role in determining the physiological and pathological roles of Rab proteins.
Review
Biochemistry & Molecular Biology
Katarzyna M. Grochowska, Maria Andres-Alonso, Anna Karpova, Michael R. Kreutz
Summary: Synaptic function relies on the constant supply and removal of neuronal membranes. Neuronal protein transport faces challenges due to the complexity of neurons, but local micro-secretory systems have evolved to meet the requirements of neuronal membrane protein proteostasis. However, our knowledge of neuronal protein synthesis, trafficking, replacement, and degradation is limited.
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Elena R. Andreeva, Ilya I. Eremin, Alexander M. Markin, Irina I. Nadelyaeva, Alexander N. Orekhov, Alexandra A. Melnichenko
Summary: Pericytes, which wrap microvascular capillaries, not only have structural function and participate in tissue regeneration, but also exhibit immune properties. They respond to pro-inflammatory stimuli and engage in innate immune responses through pattern-recognition receptors. Pericytes also regulate immune cell trafficking across vessel walls by expressing various adhesion molecules. Furthermore, pericytes play a role in modulating adaptive immunity. Interaction between pericytes and cancer cells leads to immunosuppression, facilitating immune evasion, cancer proliferation, and metastasis. However, this complex cross-talk offers potential therapeutic methods for cancer immunotherapy and treatment of autoimmune and auto-inflammatory disorders.
Review
Neurosciences
Bethany J. Rennich, Eric S. Luth, Samantha Moores, Peter Juo
Summary: This article reviews the role of extracellular protein factors in regulating AMPAR trafficking to control synapse development and plasticity. These factors regulate AMPAR clustering and mobility through interaction with the extracellular domain of AMPARs.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Physics, Fluids & Plasmas
Paul C. Bressloff
Summary: In this paper, the relaxation to steady state of intracellular diffusion in a pair of cells with gap junction coupling is analyzed. The local accumulation time is calculated and it is found to be a monotonically increasing function of spatial position. Both static and dynamic gap junction models are considered.
Review
Chemistry, Applied
Holly Allen, Donghui Wei, Ying Gu, Shundai Li
Summary: This review summarizes the major hypotheses and advancements made in the past century regarding the regulation of cellulose biosynthesis, with a focus on Arabidopsis thaliana.
CARBOHYDRATE POLYMERS
(2021)
Article
Multidisciplinary Sciences
Arne Praznik, Tina Fink, Nik Franko, Jan Lonzaric, Mojca Bencina, Nina Jerala, Tjasa Plaper, Samo Roskar, Roman Jerala
Summary: This article presents two genetically encoded secretion systems that can release proteins by chemical signal-regulated proteolytic removal. These systems provide a platform for fast-responsive and tightly-controlled protein secretion in multicellular organisms.
NATURE COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Xiaoqin Wu, Xiude Fan, Megan R. McMullen, Tatsunori Miyata, Adam Kim, Vai Pathak, Jianguo Wu, Le Z. Day, Josiah E. Hardesty, Nicole Welch, Jaividhya Dasarathy, Daniela S. Allende, Arthur J. McCullough, Jon M. Jacobs, Daniel M. Rotroff, Srinivasan Dasarathy, Laura E. Nagy
Summary: MLKL in bone marrow plays a crucial role in regulating ethanol-induced liver injury in ALD. Lack of MLKL in myeloid cells exacerbated hepatic injury, while deficiency in nonmyeloid cells had no effect. Further studies revealed that MLKL deficiency increased bacterial burden and accumulation of immune cells in the liver. Therefore, myeloid MLKL restricts ethanol-induced liver inflammation and injury by regulating immune cell homeostasis and macrophage phagocytosis.
Article
Biochemistry & Molecular Biology
Jae-Sook Park, Nancy M. Hollingsworth, Aaron M. Neiman
Summary: The VPS13 family of proteins play a crucial role in intracellular lipid transport and human health, with studies revealing their involvement in various cellular functions including the promotion of ER-phagy. Humans have four different VPS13 orthologs, and amino acid substitution mutations associated with disease help in understanding the multiple functions of VPS13.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Brittany J. Bisnett, Brett M. Condon, Caitlin H. Lamb, George R. Georgiou, Michael Boyce
Summary: COPII, an ancient and essential pathway in eukaryotes, mediates forward trafficking of protein and lipid cargoes from the endoplasmic reticulum. Despite its broad significance, major aspects of COPII trafficking remain incompletely understood. Recent studies have highlighted the role of post-transcriptional mechanisms in regulating the COPII pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Juan Huang, Andrew C. Tiu, Pedro A. Jose, Jian Yang
Summary: Sorting nexins (SNXs) are a family of proteins that regulate cellular cargo sorting and trafficking, maintain intracellular protein homeostasis, and participate in intracellular signaling. They also play an important role in the regulation of blood pressure and their aberrant expression and dysfunction can lead to hypertension. Genetic studies have shown a correlation between SNX gene variants and the response to antihypertensive drugs. This review summarizes the progress in SNX-mediated regulation of blood pressure, discusses the potential role of SNXs in the pathophysiology and treatment of hypertension, and proposes novel strategies for the medical therapy of hypertension.
Review
Cell Biology
Zehui Lei, Jing Wang, Lingqiang Zhang, Cui Hua Liu
Summary: Membrane trafficking relies on the regulation of small GTPases, which can be modulated through post-translational modifications such as ubiquitination. Dysregulation of small GTPase ubiquitination may lead to various human diseases, highlighting the importance of understanding the molecular mechanisms involved.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bibhas Amatya, Hewang Lee, Laureano D. Asico, Prasad Konkalmatt, Ines Armando, Robin A. Felder, Pedro A. Jose
Summary: The SNX-PXA-RGS-PXC subfamily of sorting nexins are characterized by a PX domain and unique RGS domain, playing roles in cellular signaling and membrane trafficking through GTPase activation and phosphoinositide interactions. These proteins regulate receptor signaling and endosomal trafficking by interacting with G proteins and phospholipids in endosomal membranes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Zhiwei He, Jie Wang, Jian Xu, Xueyi Jiang, Xinyuan Liu, Jianxin Jiang
Summary: The study found that KIF15 can promote the migration and metastasis of pancreatic cancer cells. By controlling the endosome recycling of integrin beta 1, KIF15 interacts with PI3K-C2 alpha, thereby promoting the turnover of focal adhesions and distant metastasis of pancreatic cancer.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Rodrigo Fernandez-Verdejo, Aline M. Vanwynsberghe, Ahmed Essaghir, Jean-Baptiste Demoulin, Tsonwin Hai, Louise Deldicque, Marc Francaux
Article
Biochemistry & Molecular Biology
Z. Wang, Y. He, W. Deng, L. Lang, H. Yang, B. Jin, R. Kolhe, H-F Ding, J. Zhang, T. Hai, C. Yan
Article
Multidisciplinary Sciences
Yi Seok Chang, Swati P. Jalgaonkar, Justin D. Middleton, Tsonwin Hai
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Hematology
Emily K. Nguyen, Olha M. Koval, Paige Noble, Kim Broadhurst, Chantal Allamargot, Meng Wu, Stefan Strack, William H. Thiel, Isabella M. Grumbach
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2018)
Article
Oncology
Sara C. Sebag, Olha M. Koval, John D. Paschke, Christopher J. Winters, Alejandro P. Comellas, Isabella M. Grumbach
EXPERIMENTAL CELL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Steven M. Pennington, Paula R. Klutho, Litao Xie, Kim Broadhurst, Olha M. Koval, Michael L. McCormick, Douglas R. Spitz, Isabella M. Grumbach
Article
Cell & Tissue Engineering
Austin I. McDonald, Aditya S. Shirali, Raquel Aragon, Feiyang Ma, Gloria Hernandez, Don A. Vaughn, Julia J. Mack, Tiffany Y. Lim, Hannah Sunshine, Peng Zhao, Vladimir Kalinichenko, Tsonwin Hai, Matteo Pelegrini, Reza Ardehali, M. Luisa Iruela-Arispe
Article
Multidisciplinary Sciences
Monika Bambouskova, Laurent Gorvel, Vicky Lampropoulou, Alexey Sergushichev, Ekaterina Loginicheva, Kendall Johnson, Daniel Korenfeld, Mary Elizabeth Mathyer, Hyeryun Kim, Li-Hao Huang, Dustin Duncan, Howard Bregman, Abdurrahman Keskin, Andrea Santeford, Rajendra S. Apte, Raghav Sehgal, Britney Johnson, Gaya K. Amarasinghe, Miguel P. Soares, Takashi Satoh, Shizuo Akira, Tsonwin Hai, Cristina de Guzman Strong, Karine Auclair, Thomas P. Roddy, Scott A. Biller, Marko Jovanovic, Eynav Klechevsky, Kelly M. Stewart, Gwendalyn J. Randolph, Maxim N. Artyomov
Review
Biochemistry & Molecular Biology
Justin D. Middleton, Daniel G. Stover, Tsonwin Hai
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Biochemistry & Molecular Biology
Olha M. Koval, Emily K. Nguyen, Velarchana Santhana, Trevor P. Fidler, Sara C. Sebag, Tyler P. Rasmussen, Dylan J. Mittauer, Stefan Strack, Prabhat C. Goswami, E. Dale Abel, Isabella M. Grumbach
Article
Biochemistry & Molecular Biology
Stephen J. Roy, Olha M. Koval, Sara C. Sebag, Karima Ait-Aissa, Bryan G. Allen, Douglas R. Spitz, Isabella M. Grumbach
FREE RADICAL BIOLOGY AND MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Justin D. Middleton, Jared Fehlman, Subhakeertana Sivakumar, Daniel G. Stover, Tsonwin Hai
Summary: In this study using mouse breast cancer models, it was found that the presence or absence of the Atf3 gene determines the activity phenotype of macrophages, which then affects the colonization of cancer cells in the lung under chemotherapy conditions. Chemotherapy can alter the lung's cell retention capacity and affect cancer cell colonization and proliferation by changing the reactive nature of macrophages to cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Justin D. Middleton, Subhakeertana Sivakumar, Tsonwin Hai
Summary: The study indicates that pre-treatment with cyclophosphamide (CTX) can increase the abundance of cancer cells in the lung by enhancing vascular adhesiveness through mechanisms involving increased vascular permeability and matrix metalloproteinase-2 (MMP-2) levels. This results in higher accessibility of critical protein domains in the basement membrane (BM), facilitating cancer cell adhesion to the vascular wall.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Karima Ait-Aissa, Olha M. Koval, Nathanial R. Lindsey, Isabella M. Grumbach
Summary: Radiation therapy increases the risk of atherosclerotic vascular disease, but the mechanisms involved are not well understood. This study shows that radiation induces DNA damage in endothelial cells, particularly in mitochondrial DNA, leading to mitochondrial dysfunction and endothelial dysfunction. Targeting the mitochondrial calcium uniporter and mitochondrial reactive oxygen species could help mitigate radiation-induced vascular disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
R. Fernandez-Verdejo, A. M. Vanwynsberghe, T. Hai, L. Deldicque, M. Francaux
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)